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Rare Metals 2017年第9期36卷 746-752页

作者： guang-jie feng Zhuo-Ran Li Shi-Cheng feng Wei-jie Zhang State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

In this study, Cf/Al composites and TiAl alloys were joined by a new method named laser-ignited selfpropagating synthesis（SHS）. Mixed powders of 63.0Ni-31.9Al-5.1Ti（wt%） were used as joining *** joint was got. The microstructure evolution and formation mechanism of the SHS joint were investigated by scanning electron microscopy（SEM）, energy-dispersive spectroscopy（EDS） and X-ray diffraction（XRD）. Results show that localized melting occurs on both sides. One γ-Ni（0.35）Al（0.30）Ti（0.35） and two Ni-Al reaction layers form,respectively, in the TiAl/interlayer and Cf/Al/interlayer interfaces. The combustion of Ni-Al-Ti interlayer begins with the sharp reaction of Ni and Al. The interlayer product is a eutectic organization of NiAl and Al-rich γ.

关键词： SHS Joining Microstructure Formationmechanism Ni-Al-Ti interlayer

Effects of Joining Conditions on Microstructure and Mechanical Properties of C_f/Al Composites and TiAl Alloy Combustion Synthesis Joints

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Acta Metallurgica Sinica(English Letters) 2015年第4期28卷 405-413页

作者： guang-jie feng Zhuo-Ran Li Rui-Hua Liu Shi-Cheng feng State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology

Cf/Al composites and TiAl alloy were joined by combustion synthesis in different joining conditions. Effects of additive Cu, joining temperature and holding time on joint microstructure and shear strength were characterized by employing DTA, SEM, EDS, XRD and shear test. Results show that the additive Cu in the Ti-Al-C interlayer could significantly decrease the reaction temperature owing to the emergence of Al--Cu eutectic liquid. Reaction degree of the interlayer was influenced by joining temperature and holding time. Due to the barrier action of formed TiAl3 layer, reaction rate of Ti and Al was determined by the atoms diffusion. The reaction between Ti and AI was more sensitive to the joining temperature rather the holding time. The joints shear strength was influenced by joining condition directly. The maximum shear strength of CS joints was 25.89 MPa at 600 ℃ for 30 rain under 5 MPa. Interface evolution mechanism of the CS joint was analyzed based on the experimental results and phase diagram.

关键词： C/Al composite TiAl alloy Combustion synthesis Interface microstructure Formationmechanism

Microstructure and formation mechanism of SHS joining between C_f/Al composites and TiAl intermetallic with Al–Ni–CuO interlayer

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Rare Metals 2015年第1期34卷 17-21页

作者： Zhuo-Ran Li guang-jie feng Kai Xu Xiang-Long Zhang State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology

In this study, it was reported a novel approach for joining Cf/A1 composites and TiA1 intermetallic by self- propagating high-temperature synthesis （SHS）. Mixed powders of 14A1-2Ni-3CuO were used as the SHS inter- layer, and differential thermal analysis test of A1-Ni-CuO interlayer was conducted to analyze the exothermic char- acteristic. Sound joint was got by SHS joining under the conditions of 600 ℃, 30 min, and 5 MPa. The joint was characterized by scanning electron microscopy （SEM）, energy dispersive spectroscopy （EDS）, and X-ray diffrac- tion （XRD）. TiA13 and NiA13 are, respectively, formed in the TiA1/interlayer and Cf/A1/interlayer interfaces. Reac- tion products of Ni2Al3, NiAl3, A1203, and Cu were observed in the interlayer. And the formation mechanism of SHS joining was investigated.

关键词： SHS Joining Microstructure Formationmechanism A1-Ni-CuO interlayer

Self-propagating synthesis joining of C_(f)/Al composites and TC4 alloy using AgCu filler with Ni-Al-Zr interlayer

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Rare Metals 2021年第7期40卷 1817-1824页

作者： Lei Shen Zhuo-Ran Li guang-jie feng Shu-Ye Zhang Zhi Zhou Peng He State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The successful joining of carbon fiber-reinforced aluminum matrix(C_(f)/Al)composites and TC4 alloy can produce composite structure and meet the demands of lightweight in aerospace *** to now,few experimental researches have been reported on the joining of C_(f)/Al composites and TC4 *** this study,the AgCu foils and Ni-Al-Zr compact were designed for the self-propagating high-temperature synthesis joining of these two materials.C_(f)/Al composites were joined with a reactive Ti plated on its joining *** typical microstructure of TC4/(AgCu/Ni-Al-Zr/AgCu)/Ti/C_(f)/Al joint was analyzed,and the effects of joining condition on microstructural evolution of the SHS joint were investigated.A thin reaction layer of Ni-Al-Ti intermetallic compounds was formed adjacent to the TC4 *** a result,AgCu foils could reduce the effect of reaction heat on the substrates and improve the joint shear *** the thickness of AgCu foils reaches 150 lm,the Ni-Al-Zr interlayer mainly acts as auxiliary heat *** joining pressure caused the active elements to diffuse into C_(f)/Al composites and weakened the shear strength of the ***,the joint shear strength could reach 36.4 MPa when the AgCu foils were 50 lm and the joining pressure was 2 MPa.

关键词： Cf/Al composites TC4 alloy Self-propagating high-temperature synthesis joining Microstructure Shear strength

A novel method for AFRPs burrs removal:Principle of mechanochemo-induced fiber fracture

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Chinese Journal of Aeronautics 2024年第7期37卷 522-538页

作者： jie XU Bo LI Pingfa feng Qiang WANG feng feng Division of Advanced Manufacturing Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Changhe Aircraft Industry(Group)Co.Ltd Jingdezhen 333000China

Burrs generated during the machining of Aramid-Fiber-Reinforced Composites(AFRPs)pose a challenge for the production efficiency of aircraft and helicopter housing *** studies have generally attempted to suppress burrs by referring to delamination suppression *** contrast to stratification,burrs are remediable machining *** such,a mechanochemical method with burrs trimming technological strategy are implemented to effectively combat ***,we clarify the mechanism by which aramid fibers cannot be cut off using analytical and numerical *** addition,the mechanism of fiber fracture with Modified Polyurethane Reactive Polymer(M-PUR),and development of anti-burr devices(thermostatic adhesive sealed generator)are ***,the experimental results show that the reduction rate in burr length is 87%-91%through the mechanochemical *** method not only opens a new avenue to solve the burr problem of aramid fibers but also builds an interdisciplinary bridge between polymer science and composite machining.

关键词： Mechanochemical method Burrs Orthogonal cutting Aramid fiber-reinforced composites Milling

Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

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Military Medical Research 2024年第1期11卷 98-114页

作者： guang-Long Ma Wei-feng Lin Faculty of Medicine Centre for Cancer ImmunologyUniversity of SouthamptonSouthampton SO166YDUK Department of Molecular Chemistry and Materials Science Weizmann Institute of Science76100 RehovotIsrael Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

Immune checkpoint blockade(ICB)therapy for cancer has achieved great success both in clinical results and on the *** the same time,success drives more attention from scientists to improve ***,only a small portion of patients are responsive to this therapy,and it comes with a unique spectrum of side effects termed immunerelated adverse events(irAEs).The use of nanotechnology could improve ICBs’delivery to the tumor,assist them in penetrating deeper into tumor tissues and alleviate their *** nanomedicine has been investigated and used for decades,and is well-recognized as the most successful nano-drug delivery *** successful combination of ICB with liposomal nanomedicine could help improve the efficacy of ICB *** this review,we highlighted recent studies using liposomal nanomedicine(including new emerging exosomes and their inspired nanovesicles)in associating ICB therapy.

关键词： Liposome Exosome Immune checkpoint blockade(ICB)

Precisely modulating covalent and coordination bonds in the porous network for highly selective metal ion extraction

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Science China Chemistry 2024年第4期67卷 1039-1040页

作者： jie Li Xiao feng Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster ScienceMinistry of EducationAdvanced Technology Research Institute(Jinan)Frontiers Science Center for High Energy MaterialSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Scandium(Sc)is recognized as a“strategic”and“critical”element by several countries,including the *** Russia,owing to its wide range of applications in high-tech fields such as superconductivity,alloys,lasers,nucle... 详细信息

关键词： alloys coordination network

Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： LI jie CHEN Ya-feng GAO Lei LI Yi-jie feng Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(ELISA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(P<0.01).Studies of Caco-2 cells indicated that LPS increased the levels of occludin and claudin-1 as well as tight junction permeability,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

A model reduction approach for discrete-time linear time-variant systems with delayed inputs

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Science China(Information Sciences) 2024年第4期67卷 197-217页

作者： Ai-Guo WU guang-Ren DUAN Yu WANG jie ZHANG School of Mechanical Engineering and Automation Harbin Institute of Technology(Shenzhen) HIT Wuhu Robot Technology Research Institute Center for Control Science and Technology Southern University of Science and Technology

A model reduction approach is presented for discrete-time linear time-variant input-delayed systems. According to this proposed approach, a dynamical variable is constructed by taking advantage of the current state and historical information of input. It is revealed that the behavior of this dynamical variable is governed by a discrete-time linear delay-free system. It is worth noting that the presented variable transformation does not require the system matrix to be invertible. Based on the reduced delay-free models,stabilizing control laws can be easily obtained for the original delayed system. For the case with a single input delay, the constructed variable is an exact prediction for the future state, and thus the stabilizing control law could be designed by replacing the future state with its prediction. Finally, three discrete-time periodic systems with delayed input are employed to illustrate how to utilize the presented model reduction approaches.

关键词： reduction approach predictor-based feedback time-varying systems delayed input periodic system

Laser-induced combustion joining of C_(f)/Al composites and TC4 alloy

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Transactions of Nonferrous Metals Society of China 2022年第2期32卷 461-471页

作者： guang-jie feng Zhuo-ran LI Peng HE Lei SHEN Zhi ZHOU State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The C_(f)/Al composites were joined to the TC4 alloy via the laser-induced combustion joining *** exothermic reaction of the interlayer provided the required energy for the joining *** combining the theoretical calculation and experiment,the chemical composition of the Ni−Al−Zr interlayer was *** microstructure and mechanical properties of the joint were *** results show that the addition of Zr slightly weakened the combustion reaction of exothermic interlayer but played a key role in the successful ***−Al−Zr interlayer reacted with substrates,forming a TiAl_(3)layer adjacent to TC4 alloy and NiAl_(3),Ni_(2)Al_(3)layers adjacent to the C_(f)/Al *** content dominated the microstructure and shear strength of the *** the Zr content was 5 wt.%under the joining pressure of 2 MPa,the joint had a maximum shear strength of 19.8 MPa.

关键词： C_(f)/Al composites TC4 alloy combustion joining interfacial microstructure shear strength