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Role of contrast-enhanced ultrasound in follow-up assessment after ablation for hepatocellular carcinoma

World Journal of Gastroenterology 2013年第6期19卷 855-865页

作者： Shu-guang Zheng Hui-Xiong Xu Ming-De Lu Xiao-Yan Xie Zuo-Feng Xu guang-jian liu Lin-Na liu Department of Medical Ultrasound Tenth People's Hospital of Tongji University Department of Medical Ultrasonics the First Affiliated HospitalSun Yat-Sen University

AIM:To assess the usefulness of contrast-enhanced ultrasound (CEUS) during follow-up after percutaneous ablation therapy for hepatocellular carcinoma (HCC).METHODS:A total of 141 patients with HCCs who received percutaneous ablation therapy were assessed by paired follow-up CEUS and contrast-enhanced computed tomography (CECT).The follow-up scheme was designed prospectively and the intervals between CEUS and CECT examinations were less than 14 *** im-ages of follow-up CEUS and CECT were reviewed by *** ablated lesions were evaluated and classified as local tumor progression (LTP) and *** was defined as regrowth of tumor inside or adjacent to the successfully treated *** detected new intrahepatic recurrences were also evaluated and defined as presence of intrahepatic new *** CEUS and CECT,LTP and new intrahepatic recurrence both were displayed as typical enhancement pattern of HCC (i.e.,hyper-enhancing during the arterial phase and washout in the late phase).With CECT as the reference standard,the ability of CEUS in detecting LTP or new intrahepatic recurrence during follow-up was ***:During a follow-up period of 1-31 mo (median,4 mo),169 paired CEUS and CECT examinations were carried out for the 141 *** a total of 221 ablated lesions,266 comparisons between CEUS and CECT findings were ***-three LTPs were detected on CEUS whereas 40 LTPs were detected on CECT,there was significant difference (P < 0.001).In comparison with CECT,the numbers of false positive and false negative LTPs detected on CEUS were 6 and 13,respectively;the sensitivity,specificity,positive predictive value (PPV),negative predictive value (NPV) and overall accuracy of CEUS in detecting LTPs were 67.5%,97.4%,81.8%,94.4% and 92.3%,***,131 new intrahepatic recurrent foci were detected on CEUS whereas 183 were detected on CECT,there was also significant difference (P < 0.05).In comparison with CECT,the numbers of

关键词： Contrast-enhanced ultrasound Contrastenhanced computed tomography Hepatocellular carcinoma Radiofrequency ablation Microwave ablation

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Bacterial Community Structure in a Mollisol Under Long-Term Natural Restoration, Cropping, and Bare Fallow History Estimated by PCR-DGGE

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Pedosphere 2009年第2期19卷 156-165页

作者： WANG guang-Hua JIN jian liu Jun-Jie CHEN Xue-Li liu Ju-Dong liu Xiao-Bing Key Laboratory of Black Soil Ecology Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Harbin 150081 China

Soil microbial biomass and community structures are commonly used as indicators for soil quality and fertility. A investigation was performed to study the effects of long-term natural restoration, cropping, and bare fallow managements on the soil microbial biomass and bacterial community structures in depths of 0-10, 20 30, and 40-50 cm in a black soil （Mollisol）. Microbial biomass was estimated from chloroform fumigation-extraction, and bacterial community structures were determined by analysis of 16S rDNA using polymerase chain reaction-denaturing gradient gel electrophoresis （PCR- DGGE）. Experimental results showed that microbial biomass significantly declined with soil depth in the managements of restoration and cropping, but not in the bare fallow. DGGE profiles indicated that the band number in top 0-10 cm soils was less than that in depth of 20-30 or 40-50 cm. These suggested that the microbial population was high but the bacterial community structure was simple in the topsoil. Cluster and principle component analysis based on DGGE banding patterns showed that the bacterial community structure was affected by soil depth more primarily than by managements, and the succession of bacterial community as increase of soil depth has a similar tendency in the three managements. Fourteen predominating DGGE bands were excised and sequenced, in which 6 bands were identified as the taxa of Verrueomicrobia, 2 bands as Actinobacteria, 2 bands as α-Proteobacteria, and the other 4 bands as 8-Proteobacteria, Aeidobacteria, Nitrospira, and unclassified bacteria. In addition, the sequences of 11 DGGE bands were closely related to uncultured bacteria. Thus, the bacterial community structure in black soil was stable, and the predominating bacterial groups were uncultured.

关键词： bacterial community black soil denaturing gradient gel electrophoresis (DGGE) polymerase chain reaction (PCR) soil depth

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Modulation of the stereoselectivity and reactivity of glycosylation via (p-Tol)2SO/Tf2O preactivation strategy:From O-, C-sialylation to general O-,N-glycosylation

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Chinese Chemical Letters 2018年第1期29卷 1-10页

作者： guang-jian liu Cui-Yun Li Xiao-Tai Zhang Wei Du Zhen-Yuan Gu Guo-Wen Xing College of Chemistry Beijing Normal University Beijing 100875 China The Institute of Seawater Desalination and Multipurpose Utilization State Oceanic Administration Tianjin 300192 China

The synthesis of O-, C-, and N-glycoconjugates has continuously been an attractive research subject due to the growing biological importance of various glycoconjugates. In recent years, by careful changing the glycosylation reaction conditions, especially the amount of activators and the preactivation temperature, （p-Tol）2SO/Tf2O preactivition strategy was developed as a general method for the synthesis of various 0-, C-, and N-glycoconjugates, including related biological active glycoconjugates, such as nucleosides and antigen Lewisa etc. High yields and excellent stereoselectivities were obtained even without the anchimeric assistance at the adjacent position of anomeric carbon. In this review, we predominantly make a review on the progress of the （p-Tol）2SO/Tf2O preactivition strategy from O-, C-sialylation to general O-, N-glvcosvlation.

关键词： Glycosylation SialylationSulfoxideStereoselectivityNucleosicle

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Percutaneous ultrasound-guided drainage of pneumomediastinum through the retropharyngeal space:a case report

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Gastroenterology Report 2022年第1期10卷 647-649页

作者： Si Qin Xu-Tao Lin Yi-Min Wang Yao Chen Rui Cui guang-jian liu Department of Medical Ultrasonics The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastrointestinal Endoscopy The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Introduction Esophageal perforation(EP)is a rare but potentially lethal clinical condition with a mortality rate as high as 20%[1].The most common causes of EP are iatrogenic,spontaneous,and foreign body ingestion[2].EP is often accompanied by serious complications such as hemorrhagic pericardial effusion,mediastinal abscesses,and sepsis[3].Management is multidisciplinary and involves emergency physicians,thoracic surgeons,otaorhinolaryngologists,gastroenterologists,anesthesiologists,and radiologists[1].We herein report a case of pneumomediastinum caused by EP and discuss the effect of percutaneous ultrasound(US)-guided drainage through the retropharyngeal space.

关键词： mortality clinical media

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Diagnosis of liver cirrhosis with contrast-enhanced ultrasound

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World Journal of Radiology 2010年第1期2卷 32-36页

作者： guang-jian liu Ming-De Lu guang-jian liu Department of Medical Ultrasonics Institute of Diagnostic and Interventional Ultrasound The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080 Guangdong Province China.

The assessment of the extent of liver fibrosis is very important for the prognosis and clinical management of chronic liver *** liver biopsy is the gold standard for the assessment of liver fibrosis,new non-invasive diagnostic methods are urgently needed in clinical work due to certain limitations and complications of *** imaging studies play an important role in the diagnosis of focal liver disease and diffuse liver *** them,ultrasonography is the first choice for study of the liver in clinical *** the development of ultrasound contrast agents and contrast specific imaging techniques,contrastenhanced ultrasound(CEUS) shows good performance and great potential in the evaluation of liver *** have tried different kinds of contrast agent and imaging method,such as arrival time of contrast agent in the hepatic vein,and quantitative analysis of the enhancement level of liver parenchyma,to evaluate the degree of liver fibrosis during the past 10 *** review mainly summarizes the clinical studies concerning the assessment of liver fibrosis using CEUS.

关键词： Diagnosis Liver cirrhosis Contrast media Ultrasound

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Formability of AA5052/polyethylene/AA5052 sandwich sheets

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Transactions of Nonferrous Metals Society of China 2013年第4期23卷 964-969页

作者：刘建光薛卫哈尔滨工业大学金属精密热加工国家级重点实验室哈尔滨150001 哈尔滨工业大学材料科学与工程学院哈尔滨150001

The formability of AA5052/polyethylene/AA5052 sandwich sheets was experimentally studied. Three kinds of AA5052/polyethylene/AA5052 sandwich specimens with different thicknesses of core materials were prepared by the hot pressing adhesive method. Then, the uniaxial tensile tests were conducted to investigate the mechanical properties of AA5052/polyethylene/ AA5052 sandwich sheets, and the stretching tests were carried out to investigate the influences of polymer core thickness on the limit dome height of the sandwich sheet. The forming limit curves for three kinds of sandwich sheets were obtained. The experimental results show that the forming limit of the AA5052/polyethylene/AA5052 sandwich sheet is higher than that of the monolithic AA5052 sheet, and it increases with increasing the thickness of polyethylene core.

关键词： AA5052 aluminum alloy sandwich sheets polyethylene formability forming limit diagram

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The Dynamics Changes of vWF A1 Domain Induced by Gain-of-function Mutation

The Dynamics Changes of vWF A1 Domain Induced by Gain-of-fun...

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第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： guang-jian liu Ying Fang jian-hua Wu School of Bioscience and Bioengineering South China Univerisity of Technology

The initiation of platelet deposition at sites of vascular injury relies on the interaction of von Willebrand factor(vWF) with platelet glycoprotein Iba(GPIba).This interaction does not occur under normal conditions because the GPIba binding site on vWF A1 domain is shielded by other vWF *** gain-of-function mutations in the A1 domain,which cause a minor bleed-

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MOLECULAR BEAM STUDIES ON ADSORPTION-DESORPTION KINETICS OF CO AND H_2 ON Ni SURFACE

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Chinese Chemical Letters 1993年第11期4卷 965-968页

作者： guang Kang XI jian liu Sheng Lin LI Tian Xi HE Department of Electron Science, Nankai University, Tianjin 300071

Adsorption-desorption kinetics of CO and H_2 on Ni surface were studied with molecular beam relaxation spectrometry. It is found that there are two adsorbed states in the substrate temperature range 330K 详细信息

关键词： MOLECULAR BEAM STUDIES ON ADSORPTION-DESORPTION KINETICS OF CO AND H2 ON Ni SURFACE high CO Ni

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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu guang-Hui liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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肝静脉压力梯度测定对食管静脉曲张套扎术后早期再出血的预测价值

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中国内镜杂志 2016年第7期22卷 39-41页

作者：姜红梅刘建光湖北医药学院附属东风医院消化内科湖北十堰442008 湖北医药学院附属东风医院神经内科湖北十堰442008

目的研究肝静脉压力梯度(HVPG)对食管静脉曲张套扎术(EVL)后早期再出血的预测价值。方法选取该院2014年1月-2015年1月收治的120例EVL后早期再出血患者作为研究对象,收集其各项临床重要参数,并进行HVPG测量,采用Logistic回归分析的方法... 详细信息

目的研究肝静脉压力梯度(HVPG)对食管静脉曲张套扎术(EVL)后早期再出血的预测价值。方法选取该院2014年1月-2015年1月收治的120例EVL后早期再出血患者作为研究对象,收集其各项临床重要参数,并进行HVPG测量,采用Logistic回归分析的方法对评估阈值进行分析。结果饮酒、早期出血、胆红素、心率、输血量、Child-Pugh评分和自终末期肝病模型(MELD)评分组间比较差异有统计学意义(P<0.05);HVPG=16.98 mm Hg,为预测再出血的阈值,且在该时间内的预测准确性最高。结论 HVPG对EVL术后早期再出血具有预测价值。

关键词：肝静脉压力梯度内镜下食管静脉曲张套扎术早期再出血阈值

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