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Mechanically Reinforced Chitosan/Cellulose Nanocrystals Composites with Good Transparency and Biocompatibility

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Chinese Journal of Polymer Science 2015年第1期33卷 61-69页

作者： Cheng-zhen Geng Xin Hu guang-hui yang Qin Zhang Feng Chen 傅强 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

Chitosan/cellulose nanocrystals（CS/CNCs） composites were prepared with different contents of CNCs. Due to the homogeneous dispersion of CNCs and the strong interfacial interactions resulting from hydrogen bonding between CS chains and CNCs, the transparency of CS is well retained and the overall mechanical properties of CS are significantly improved. Furthermore, because both CS and CNCs are biocompatible materials, cell proliferation test shows that the obtained composites are noncytotoxic and can potentially meet safety requirements of biomedical applications. These advantages pave the way of potential applications of CS in the field of commercial plastics and encourage the use of CS as environmentfriendly material and biomedical material.

关键词： Chitosan Cellulose nanocrystals Reinforcement Cytotoxicity.

Isoflavone genistein protects high glucose-induced human aortic endothelial cell apoptosis through estrogen receptor-mediated pathway

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Journal of Geriatric Cardiology 2008年第2期5卷 86-90页

作者： Wenwen Zhong yang Liu guang yang hui Tian Department of Geriatric Endocrinology Chinese PLA General Hospital Beijing100853China Department of Geriatric EndocrinologyChinese PLA General Hospital Beijing100853China Department of Geriatric EndocrinologyChinese PLA General Hospital Beijing100853China Department of Geriatric EndocrinologyChinese PLA General Hospital Beijing100853China

Objective The aim of this study was to determine if isoflavone genistien has protective effects against high glucose-induced cell apoptosis in human aortic endlthelial cells, and investigate the possible mechanism for this protection. Methods Human aortic endothelial cells subjected to normal (5mmol/L) or high glucose (25mmol/L) were treated with genistein at 0, 50, 100nmol/L. Parallel experiments were performed with 100nM 17b-estradiol, and also in the presence and absence of the pure anti-estrogen ICI-182,780 (100nmol/L). The effects on cell apoptotic DNA fragmentation were determined using cell death ELISA, and the effects on cellular proliferation were determined using tritiated thymidine incorporation assay. Estrogen receptor expression was detected by Taqman quantitative PCR. Results Genistein at 100nmol/L significantly reduced high glucose-induced DNA fragmentation, and reversed cell DNA synthesis inhibition (P <0.001) after 24 hours' incubation. The effect of genistein was completely blocked by ICI-182,780 administration. Estrogen receptor beta, but not alpha was found to be expressed in these cells. Conclusion Isoflavone genistein shows protection against high glucose-induced cell damage through estrogen receptor beta, reducing apoptotic DNA damage and protecting from the inhibition of cell proliferation.

关键词： phytoestrogen endothelial cell high glucose estrogen receptor apoptosis

Size Distribution and Anisotropy of the Minor Phase Droplets in Polypropylene/Ethylene-Octene Copolymer Blends: Effects of Shear and Component Miscibility

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Chinese Journal of Polymer Science 2014年第1期32卷 9-20页

作者： Cheng-zhen Geng Yan-ling Zhu guang-hui yang 傅强 Chao-liang Zhang Ke Wang Tian-nan Zhou College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University

In this work, polypropylene （PP）/octene-ethylene copolymer （POE） blends were injection-molded using the so- called dynamic packing injection technique, which imposed oscillatory shear on the gradually cooling melt during the packing solidification stage. In this way, the effect of shear on the size distribution and anisotropy of the minor phase droplets could be investigated. Besides, by using two kinds of POE with different octene contents, the effect of component miscibility was also studied. The results show that the droplet size is mainly determined by composition and miscibility, and droplet anisotropy is mainly determined by droplet size and shear. Most importantly, under the same processing condition, droplet anisotropy increases with droplet size, and there seems a linear fit between them, disregarding the miscibility factor. These results may provide guidance for preparing polymer blends with desired properties by tailoring their phase morphologies.

关键词： Shear Miscibility Size distribution Anisotropy Phase morphology.

A numerical study of dynamics in thin hopper flow and granular jet

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Chinese Physics B 2020年第4期29卷 494-504页

作者： Meng-Ke Wang guang-hui yang Sheng Zhang Han-Jie Cai Ping Lin Liang-Wen Chen Lei yang Institute of Modern Physics Chinese Academy of Sciences(CAS)Lanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

The dynamics of granular material discharging from a cuboid but thin hopper,including the hopper flow and granular jet,are investigated via discrete element method(DEM)*** slot width is varied to study its influence on the *** is found the flow in the cuboid hopper has similarity with the flow in two-dimensional(2D)*** the slot width is large,the flowrate is higher than the predicted value from Beverloo’s law and the velocity distribution is not *** granular jet,there is a transition with varying slot *** large slot width,there is a dense core in the jet and the variations of velocities and density are relatively ***,the availability of continuum model is assessed and the results show that the performance with large slot width is better than that with small slot width.

关键词： cuboid hopper granular jet velocity field discrete element method continuum model

Parametric study of the clustering transition in vibration driven granular gas system

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Chinese Physics B 2020年第5期29卷 361-367页

作者： Qi-Lin Wu Mei-Ying Hou Lei yang Wei Wang guang-hui yang Ke-Wei Tao Liang-Wen Chen Sheng Zhang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Soft Matter Physics Beijing National Laboratory for Condense Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China

A parametric study of the clustering transition of a vibration-driven granular gas system is performed by *** parameters studied include the global volume fraction of the system,the size of the system,the friction coefficient,and the restitution coefficient among particles and among *** periodic boundary and fixed boundary of sidewalls are also checked in the *** simulation results provide us the necessary“heating”time for the system to reach steady state,and the friction term needed to be included in the“cooling”time.A gas-cluster phase diagram obtained through Kolmogorov-Smirnov(K-S)test analysis using similar experimental parameters is *** influence of the parameters to the transition is then investigated in *** simulation investigation helps us gain understanding which otherwise cannot be obtained by experiment alone,and makes suggestions on the determination of parameters to be chosen in experiments.

关键词： granular gas clustering phase diagram

Genome-wide transcriptional analysis of maize endosperm in response to ae wx double mutations

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Journal of Genetics and Genomics 2010年第11期37卷 749-762页

作者： Xiang Li guang hui Chen Wei yang Zhang Xiansheng Zhang State Key Laboratory of Crop Biology College of Life Sciences Shandong Agricultural University Taian 271018 China

Starch biosynthesis is important during endosperm development. Much has been known for the regulation of gene expression involved in starch synthesis, less information is available on the genome-wide expression profiles as a consequence of impaired starch synthesis. In this study, we examined the transcriptional responses through microarray analysis in an ae wx double-mutant with loss-of-function starch branching enzyme IIb （SBEIIb） and granule-bound starch synthase I （GBSSI）. Through Gene Ontology enrichment analysis, we identified differentially expressed genes （DEGs） involved in chromatin organization and lipid transport. The DEGs also include alcohol dehydrogenase genes and pyruvate decarboxylase genes involved in sugar metabolism. In summary, the ae wx double mutations caused pleiotropic effects and transcriptional changes for a number of genes involved in metabolism, cellular response and organization. Therefore, a block in starch synthesis triggers transcriptional responses to favour the flux of excess carbohydrates into glycolysis, pentose phosphate pathway, and cell wall biosynthesis, but not toward the synthesis of alternative storage compounds.

关键词： transcriptional regulation starch biosynthesis carbohydrate metabolism

Efficacy and safety of the treatment： combination of benazepril/ lercanidipine vs. benazepril alone in patients with mild-to-moderate hypertension

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Chinese Medical Journal 2013年第12期126卷 2286-2290页

作者： CHEN Ting CHEN guang-hui yang Ting-shu ZHONG Zhen-yu AN Wei-shuai ZHANG Xiao-xia LI Jia-dan Department of Cardiology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Combination therapy is an effective method to reduce the blood pressure （BP） for patients with *** study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate *** One hundred and eighty-one patients with mild-to-moderate primary hypertension were assigned in this randomized,single-blind,parallel-group study and were randomly divided into group A （benazepril 10 mg/lercanidipine 10 mg） and group B （benazepril 10 mg） for 8 *** 4 weeks,the dosage of Benazepril was titrated up to 20 mg if the diastolic blood pressure （DBP） remained ≥90 *** control and side effects were evaluated at the end of 1,4 and 8 *** The baseline characteristics of the two groups were *** BP in both groups decreased from the baseline （P 〈0.05）.At the end of 4 and 8 weeks,Benazepril/Lercanidipine produced greater BP reduction than Benazepril alone （P 〈0.05）.The comparison of the rate of BP control for the benazepril/lercanidipine and benazepril groups at the end of 1,4,and 8 weeks were 41.2% vs.37.6% （P 〉0.05）,67.1% vs.44.7% （P 〈0.05）,and 71.8% vs.45.9% （P 〈0.05）.There was no significant difference of side effects between the two *** The benazepril/lercanidipine combination is more effective in reducing BP than benazepril alone,while it does not increase the incidence of side effects.

关键词： hypertension combination therapy benazepril lercanidipine

Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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校园足球运动中常见损伤的解剖学特征研究

南京体育学院学报（自然科学版） 2017年第2期16卷 44-48页

作者：安广辉杨光东北师范大学体育学院吉林长春130024

了解校园足球运动中学生常见运动损伤部位及类型,为今后在校园足球运动中预防和治疗损伤提供参考依据。运用文献资料法对以往文献进行整理、归纳,并以运动解剖学为切入点,运用解剖学知识根据损伤发生几率高低的顺序对损伤发生的内部原... 详细信息

了解校园足球运动中学生常见运动损伤部位及类型,为今后在校园足球运动中预防和治疗损伤提供参考依据。运用文献资料法对以往文献进行整理、归纳,并以运动解剖学为切入点,运用解剖学知识根据损伤发生几率高低的顺序对损伤发生的内部原因进行剖析,总结得到校园足球运动中损伤几率由高到低依次是足踝部、膝关节、小腿、大腿、上肢、躯干,足踝部、膝关节和上肢腕关节主要是韧带损伤,而小腿、大腿及躯干髋关节处多以不同程度肌肉拉伤为主。基于损伤多发部位及损伤机制,在今后校园足球教学中应采取对损伤多发部位的针对性训练、加强对学生安全教育等预防损伤的发生。

关键词：校园足球运动损伤解剖学