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Mitochondrial sirtuins,metabolism,and aging

Journal of Genetics and Genomics 2022年第4期49卷 287-298页

作者： Zhejun Ji Guang-Hui Liu Jing Qu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China

Maintaining metabolic homeostasis is essential for cellular and organismal health throughout life.Multiple signaling pathways that regulate metabolism also play critical roles in aging,such as PI3K/AKT,mTOR,AMPK,and sirtuins(SIRTs).Among them,sirtuins are known as a protein family with versatile functions,such as metabolic control,epigenetic modification and lifespan extension.Therefore,by understanding how sirtuins regulate metabolic processes,we can start to understand how they slow down or accelerate biological aging from the perspectives of metabolic regulation.Here,we review the biology of SIRT3,SIRT4,and SIRT5,known as the mitochondrial sirtuins due to their localization in the mitochondrial matrix.First,we will discuss canonical pathways that regulate metabolism more broadly and how these are integrated with aging regulation.Then,we will summarize the current knowledge about functional differences between SIRT3,SIRT4,and SIRT5 in metabolic control and integration in signaling networks.Finally,we will discuss how mitochondrial sirtuins regulate processes associated with aging and aging-related diseases.

关键词： Metabolism and aging regulation Mitochondrial sirtuins Aging-related diseases SIRT3 SIRT4 SIRT5

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For the sake of longevity:eating less and eating at the right time

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3616-3617页

作者： Fei Sun Si Wang Guang-Hui Liu Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Department of Cell Biology Duke University Medical CenterDurhamNCUSA Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China The Fifth People’s Hospital of Chongqing Chongqing 400062China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

In a recent issue of Science,Acosta-Rodriguez et al.defined a feeding paradigm to maximize the effects of caloric restriction(CR)on lifespans.Aligning feeding with the circadian rhythm and imposing>12-hour fasting daily on caloric-restricted animals can optimally extend lifespans.While embracing the projection of our life expectancy in the last 100~150 years,we are facing aging,an all-new challenge in human evolution.Aging-associated diseases have gradually replaced communicable diseases,becoming the top cause of death globally.The increasing social and medical burdens call for not only novel therapies for chronic diseases but also early interventions that mitigate the progression of aging and extend life and health spans.

关键词： life aging globally

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First stem cell transplantation to regenerate human lung

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Protein & Cell 2018年第3期9卷 244-245页

作者： Si Wang Jun Wu Guang-Hui Liu National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China National Clinical Research Center for Geriatric Disorders Xuanwu Hospital of Capital Medical University Beijing 100053 China Department of Molecular Biology University of Texas Southwestern Medical Center Dallas TX 75390 USA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical Center Dallas TX 75390 USA

Lung-related diseases are the third-leading cause of human death throughout the world. Lethal lung diseases such as chronic obstructive pulmonary disease （COPD）, pulmonary fibrosis and bronchiectasis are characteriz... 详细信息

关键词： Human Lung Stem Cells Airway Basal Cells Injured Mouse Lung Lethal Lung Disease Idiopathic Pulmonary Fibrosis

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Inhomogeneous Besov and Triebel-Lizorkin spaces associated with a para-accretive function and their applications

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Applied Mathematics(A Journal of Chinese Universities) 2023年第4期38卷 493-509页

作者： LIAO Fang-hui liu Zong-guang ZHANG Xiao-jin School of Mathematics and Computational Science Xiangtan UniversityXiangtan 411105China Department of Mathematics China University of Mining and TechnologyBeijing 100083China Department of basic curriculum North China Institute of Science and TechnologyLangfang 065201China

In this paper,using inhomogeneous Calderon’s reproducing formulas and the space of test functions associated with a para-accretive function,the inhomogeneous Besov and TriebelLizorkin spaces are established.As applic... 详细信息

关键词： para-accretive function Calderon's reproducing formula Besov space Triebel-Lizorkin space pointwise multiplier

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Adenine base editing disease mutations in to mimic or correcl rodents

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Protein & Cell 2018年第9期9卷 752-753页

作者： Ruotong Ren Juan Carlos Izpisua Belmonte Guang-Hui Liu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital of Capital Medical University Beijing 100053 China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla California 92037 USA Institute of Stem cell and Regeneration Chinese Academy of Sciences Beijing 100101 China

Cytidine base editors （CBEs, rAPOBECI-nCas9-UGI） and adenine base editors （ABEs, TadA-TadA＊-nCas9） are newly developed genome-editing tools that have enabled highly efficient base conversions （CoG to T·A or A·T to G·C） at designated target sites （Komor et al., 2016; Gaudelli et al., 2017）. Both types of base editors enzymatically catalyze deamination of target bases and respectively replace C with U or A with I.

关键词： Basic Editing Adenine Base GSD II Hereditary Tyrosinemia Type Target Site Identification

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ROR1, an embryonic protein with an emerging role in cancer biology

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Protein & Cell 2014年第7期5卷 496-502页

作者： Nicholas Borcherding David Kusner Guang-Hui Liu Weizhou Zhang Department of Pathology College of Medicine University of Iowa Iowa City IA 52242 USA Department of Molecular and Cellular Biology College of Medicine University of Iowa Iowa City IA 52242 USA National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Beijing Institute for Brain Disorders Brain Tumor Center. Beiiina 100101. China

Receptor tyrosine kinase-Uke orphan receptor 1 （ROR1） is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteinerich domains and one transmembrane domain. Within the intracellular portion, ROR1 possesses a tyrosine kinase domain, two serine/threonine-rich domains and a proline-rich domain. RORs have been studied in the context of embryonic patterning and neurogenesis through a variety of homologs. These physiologic functions are dichotomous based on the requirement of the kinase domain. A growing literature has established ROR1 as a marker for cancer, such as in CLL and other blood malignancies. In addition, ROR1 is critically involved in progression of a number of blood and solid malignancies. RORt has been shown to inhibit apoptosis, potentiate EGFR signaling, and induce epithelialmesenchymal transition （EMT）. Importantly, ROR1 is only detectable in embryonic tissue and generally absent in adult tissue, making the protein an ideal drug target for cancer therapy.

关键词： ROR1 embryogenesis cancer,immunotherapy

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A narrative review of organoids for investigating organ aging:opportunities and challenges

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Journal of Bio-X Research 2023年第1期6卷 3-14页

作者： Xiaoyan Sun Fei Sun Yixin Zhang Jing Qu Weiqi Zhang Guang-Hui Liu CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences China National Center for Bioinformation BeijingChina Department of Cell Biology Duke University Medical CenterDurhamNCUSA State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijingChina

Aging research has shifted from studying phenotypes to studying in-depth mechanisms in recent decades.However,extrapolating cellular and molecular bases of aging from studying traditional model systems to humans has been challenging.The advent of organoids holds promise for overcoming the limitations of monolayer cell culture and bridging the gap between animal models and humans.Here,we mainly discuss recent paradigms for using organoid models in studying organ aging.Pluripotent stem cells-derived organoid provides a promising platform for simulating the pathophysiology of several aging-related diseases,especially neurodegenerative diseases,and adult stem cells organoids derived from different age groups have been applied to detect aging-related functional changes.We also assess the value of organoid model systems in understanding human aging and aging-related diseases,and identify challenges to be addressed in the future,such as the immaturity of organoids,and effective methods of inducing aging.

关键词： aging disease modeling organoid senescence stem cell

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Evolution of iPSC disease models

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Protein & Cell 2012年第1期3卷 1-4页

作者： Weiqi Zhang Zhichao Ding Guang-Hui Liu National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Human induced pluripotent stem cells(iPSCs)hold unprecedented potential to model human development and genetic disorders due to their capability to self-renew and differentiate into any somatic cell type.In the year of 2011,a number of iPSC disease models have been successfully developed for studying the mechanism of human diseases as well as establishing platforms for drug screening and testing(Batista et al.,2011;Brennand et al.,2011;Devine et al.,2011;Itzhaki et al.,2011;Koch et al.,2011;liu et al.,2011a;Mazzulli et al.,2011;Nguyen et al.,2011;Paşca et al).

关键词： al. diseases establishing

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Potential approaches for intervening aging

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National Science Open 2022年第2期1卷 80-85页

作者： Jianghua Shen Guang-Hui Liu Moshi Song State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Though immortality and regeneration were ludicrous and far-fetched in an age of ignorance and superstition,people have never stopped looking for the elixir of longevity.As a result of advancements in lifestyle and medical care,the average human life expectancy has risen in recent decades,along with the increasingly higher incidence of aging-related diseases.With the advance in biological techniques,our understanding of aging and aging-related diseases has expanded significantly.

关键词： aging life expanded

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Modulation of Self-healing of Polyion Complex Hydrogel by Ion-specific Effects

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Chinese Journal of Chemical Physics 2016年第6期29卷 725-728,I0002页

作者： hui-li liu guang-ming liu guang-zhao Zhang DepartmentofChemicalPhysics HefeiNationalLaboratoryforPhysicalSciencesattheMicroscaleUniversityofScienceandTechnologyofChinaHefei230026China FacultyofMaterialsScienceandEngineering SouthChinaUniversityofTechnologyGuangzhou510640China

我们准备了 polyion 建筑群(照片) hydrogel 由组成 poly (3-(methacryloylamino ) propyl-trimethylamonium 氯化物) 并且 poly (钠 p-styrenesulfonate ) 经由一个二拍子的圆舞聚合过程的聚合电解质并且在 PIC hydrogel 的 self-healing 上调查了特定的离子效果。我们的学习证明 PIC hydrogel 的机械性质强烈依赖于在 hydrogel 做的离子的类型。离子特定的效果能被用来调制 PIC hydrogel 的 self-healing 效率。当做的阴离子从 kosmotrops 改变到 chaotropes， PIC hydrogel 的 self-healing 效率增加。一个更多的 chaotropic 阴离子有一个更强壮的能力打破在 hydrogel 以内形成的离子的契约，导致在愈合期间的更高的效率。

关键词：聚离子复合物复合水凝胶调制自愈苯乙烯磺酸钠掺杂离子 PIC 聚合过程

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