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Hepatitis B virus X protein promotes proliferation and upregulates TGF-β1 and CTGF in human hepatic stellate cell line,LX-2

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Hepatobiliary & Pancreatic diseases International 2009年第1期8卷 59-64页

作者： guang-hui guo,de-ming tan,{2.,xiangya hospital,Central South University,changsha 4.0008,china department of infectious {2. Xiangya Hospital Central South University Changsha 410008 China. guanghuiguo2008@***

BACKGROUND:Chronic hepatitis B virus(HBV)infection is a major cause of liver fibrosis,but the mechanisms underlying HBV-related fibrogenesis are still unknown. Although the roles of HBV X protein(HBx)remain poorly understood,it is thought to play an impor{2.t role in the regulation of cellular growth and hepatocarcinogenesis. The aim of this study was to determine the role of HBx in liver fibrogenesis by studying the effect of HBx on the proliferation and expression of fibrosis-related molecules in the human hepatic stellate cell line,LX-2. METHODS:We established an in vitro co-culture system with LX-2.cells and a stable QSG7701-HBx cell line which had been transfected with the HBx gene. 3 H-TdR incorporation and flow cytometry were used to determine the effects of HBx on the proliferation of LX-2.cells. α-smooth muscle actin(α-SMA),transforming growth factor-β1(TGF-β1),transforming growth factor-βreceptor Ⅱ(TGF-βRⅡ),and connective tissue growth factor (CTGF)in LX-2.cells were analyzed by Western *** addition,the expression levels of collagen typeⅠ(ColⅠ) from the co-cultured media were measured by ELISA. RESULTS: 3 H-TdR incorporation increased significantly in LX-2.cells co-cultured with QSG7701-HBx cells compared to those cultured with QSG7701-pcDNA3 and QSG7701 (non-tumorigenic human liver cell line).Cell cycle results revealed that HBx accelerated the progression of G1 to S in LX-2.*** expressions ofα-SMA,TGF-β1,TGF-βR Ⅱ,CTGF and ColⅠwere significantly increased in the co- cultures of LX-2.cells with stable QSG7701-HBx cells. CONCLUSION:These results suggest that HBx may facilitate liver fibrosis by promoting hepatic stellate cell proliferation and upregulating the expression of fibrosis- related molecules.

关键词： hepatitis B virus HBx liver cirrhosis hepatic stellate cell proliferation

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The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

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Cancer Communications 2021年第11期41卷 1195-1227页

作者： Ling-Long tang Yu-Pei Chen Chuan-Ben Chen ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao {2. Han Xia He Chao-Su Hu de-sheng Hu guang-Yuan Hu Hao Jiang Wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu liu Qiu-Fang liu Lin Ma Hai-Qiang Mai Ji-Yong Qin Liang-Fang Shen Ying Sun Pei-guo Wang Ren-Sheng Wang Ruo-Zheng Wang Xiao-Shen Wang Ying Wang hui Wu Yun-{2. Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin Yi Xiao-Dong zhu Jun Ma department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China department of Radiation Oncology Fujian Provincial Cancer HospitalFujian Medical University Department of Radiation OncologyTeaching Hospital of Fujian Medical University Provincial Clinical CollegeCancer Hospital of Fujian Medical UniversityFuzhouFujian 350014P.R.China department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China Cancer hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of Sciences HangzhouZhejiang 310000P.R.China State Key Laboratory of Oncology in South china Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060P.R.China department of Radiation Oncology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610041P.R.China department of Radiation Oncology Anhui Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui 230001P.R.China department of Clinical Laboratory Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Cancer HospitalJiangsu Institute of Cancer ResearchNanjingJiangsu 210000P.R.China department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China department of Radiotherapy Hubei Cancer HospitalTong

Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North *** develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the *** on the findings of evidencebased medicine in china and abroad,domestic experts have iteratively developed these guidelines to provide proper management of ***,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC.

关键词： Chinese Society of Clinical Oncology CSCO Nasopharyngeal carcinoma Diagnosis Staging Risk Radiotherapy Chemotherapy Surgery Immunotherapy

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Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2.2. edition)

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 227-252,I0011-I0014页

作者： hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng liu Qing Xie Weidong Jia {2. Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping guo Wenzhi guo Chunyi Hao Tao Huang Zhiyong Huang deyu Li Gang Li Tao Li Xiangcheng Li {2.{2. Li Xiao Liang Jingfeng liu Fubao liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao guoliang Shao Yinghong Shi Tianqiang Song {2. tan Yunqiang tang Kaishan Tao Chidan Wan {2.yi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina department of Medical Oncology of PLA Cancer Center Jinling HospitalNanjingChina department of infectious Disease Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Liver Surgery The First Affiliated Hospital of USTCHefeiChina Minimally Invasive Interventional Division Sun Yat-sen University Cancer CenterGuangzhouChina department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina department of Radiation Oncology Beijing Tsinghua Changgung HospitalBeijingChina department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina department of Pathology Fudan University Shanghai Cancer CentreShanghaiChina department of Liver Surgery Sun Yat-sen University Cancer CentreGuangzhouChina department of Hepatobiliary Surgery Clinical Medical CollegeYangzhou UniversityYangzhouChina department of Hepatobiliopancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Division of Hepatobiliary Surgery Department of General SurgeryRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina department of Hepatobiliary and Splenic Surgery Shengjing Hospital Affiliated to China Medical UniversityShenyangChina The department of Hepatobiliary Oncology of Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouChina department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Sarcoma CenterPeking University Cancer Hospital and InstituteBeijingChina department of Hepatobili

Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response *** has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’***,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being *** the evidence for conversion therapy in HCC and develop consensus statements to guide clinical *** review:Many research centers in china have accumulated significant experience implementing HCC conversion *** findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related *** order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2.2. Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical *** consensus statements on the implementation of conversion therapy for HCC were *** statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.

关键词： Hepatocellular carcinoma(HCC) conversion therapy surgical resection systematic treatment locoregional treatment consensus china

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Anti-cyclic citrullinated peptide antibody predicts the development of rheumatoid arthritis in patients with undifferentiated arthritis

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Chinese Medical Journal 2019年第24期132卷 2899-2904页

作者： Chun Li Yan Zhang hui Song Jie Gao Dong-Bao Zhao Qi zhu Dong-Yi He Li Wang Xiang-Pei Li Xu-Dong {2. Wei-guo Xiao Xin-Yu Wu Hua-Xiang Wu Wei Tu Shao-Xian Hu Xin Wang Zhi-Jun Li Zhi-Min Lu Zhan-Yun Da Bo Liang Xiao-Min {2. Jin-Wei Zhao Ling Li Feng Han Wu-Fang Qi Wei Wei Xu Ma Zhen-Bin Li Gui-Min Zheng Feng-Xiao Zhang Yi Li You-Lian Wang guang-hui Ling Jin-Wei Chen Xiao-Qiang Hou Jing Zhang Qing-ping Chen Chang-Lian {2. Yan Zhang Jia-Shun Zeng Qing-Hua Zou Yong-fei Fang Yin Su Zhan-guo Li department of Rheumatology and Immunology Peking University People's HospitalBeijing 100044China department of Rheumatology and Immunology Beijing Jishuitan HospitalBeijing 100035China department of Rheumatology and Immunology Changhai HospitalShanghai 200433China department of Rheumatology Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western MedicineShanghai 200052China department of Rheumatology and Immunology Anhui Provincial HospitalHefeiAnhui 230001China department of Rheumatology and Immunology The First Hospital of China Medical UniversityShenyangLiaoning 110001China department of Rheumatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China department of Rheumatology and Immunology Tongji HospitalWuhanHubei 430030China department of Rheumatology The First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui 233004China department of Rheumatology and Immunology Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China department of Rheumatology and Immunology The Hospital of Shunyi District BeijingBeijing 101300China department of Infection and Immunology Tianjin Union Medical CenterTianjin 300121China department of Rheumatology and Immunology Tianjin First Central HospitalTianjin 300192China department of Rheumatology and Immunology Tianjin Medical University General HospitalTianjin 300052China department of Rheumatology and Immunology Peace HospitalShijiazhuangHebei 050000China department of Rheumatology and Immunology Hebei General HospitalShijiazhuangHebei 050051China department of Rheumatology Jiangxi Provincial People's HospitalNanchangJiangxi 330006China Division of Rheumatology and Immunology The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China department of Rheumatology and Immunology The First College of Clinical Medical Science of China Three Gorges University&Yichang Central People's HospitalYichangHubei 443003China department of Rheu

Background:Clinical outcomes of undifferentiated arthritis(UA)are diverse,and only 40%of patients with UA develop rheumatoid arthritis(RA)after 3 *** predictive markers at disease onset for further intervention is ***,our objective was to analyze the clinical outcomes of UA and ascertain the predictors for RA ***:We performed a prospective,multi-center study from January 2.13 to October 2.16 among Chinese patients diagnosed with UA in 2. tertiary-care *** and serological parameters were obtained at ***-up was undertaken in all patients every 12.weeks for 2.*** factors of disease progression were identified using multivariate Cox proportional hazards ***:A total of 2.4 patients were recruited in this study,and 17(7.3%)patients failed to follow up during the *** the 2.7 patients who completed the study,83(38.2.)patients went into *** patients who developed RA had a higher rheumatoid factor(RF)-positivity(42.9%vs.16.8%,χ^2.8.2.8,P=0.008),anti-cyclic citrullinated peptide(CCP)antibodypositivity(66.7%vs.10.7%,χ^2.43.897,P2.32.131,Pdependent predictor for RA development(hazard ratio 18.017,95%confidence interval:5.803–55.938;Pdependent predictor of RA,anti-CCP antibody should be tested at disease onset in all patients with UA.

关键词： Anti-cyclic citrullinated peptide antibody Arthritis,Rheumatoid Rheumatoid factor Undifferentiated arthritis

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The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： Xiao Chen Bin Lu hui-Xian Li Xue-Ying Li Yu-Wei Wang Francisco Xavier Castellanos Li-ping Cao Ning-Xuan Chen Wei Chen Yu-Qi Cheng Shi-Xian Cui Zhao-Yu {2.ng Yi-Ru Fang Qi-Yong Gong Wen-Bin guo Zheng-Jia-Yi Hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian Yi-Fan Liao Yan-Song liu Zhe-Ning liu Jian-ping Lu Qing-Hua Luo Hua-Qing Meng Dai-hui Peng Jiang Qiu Yue-Di Shen Tian-Mei Si Yan-Qing tang Chuan-Yue Wang fei Wang Hua-Ning Wang Kai Wang Xiang Wang Ying Wang Zi-Han Wang Xiao-ping Wu Chun-ming Xie {12.-Rong Xie Peng Xie Xiu-Feng Xu Hong Yang Jian Yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang Zhang Wei Zhang Zhi-Jun Zhang Jun-Juan zhu Xi-Nian Zuo Jing-ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s hospital Zhejiang University School of

despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2.2. functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

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中国细菌耐药监测(CARST)研究2.19-2.2.革兰氏阴性菌监测报告

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中国临床药理学杂志 2022年第5期38卷 432-452页

作者：李耘郑波吕媛薛峰张秀珍胡云建金玉芬胡志东赵建宏潘世扬李华茵俞云松李艳刘文恩刘德华费樱刘智勇徐修礼裴凤艳孟灵季萍汤进符惠群朱镭王珊张佳王青刘姚姚北京大学第一医院临床药理研究所北京100034 北京医院检验科北京100730 吉林大学第二医院检验科吉林长春130041 天津医科大学总医院检验科天津300052 河北医科大学第二医院检验科河北石家庄050000 南京医科大学第一附属医院检验科江苏南京210029 复旦大学中山医院呼吸科上海200023 浙江大学邵逸夫医院感染科浙江杭州310003 武汉大学人民医院检验科湖北武汉430060 中南大学湘雅医院检验科湖南长沙410008 昆明市第一人民医院检验科云南昆明650011 贵州医科大学附属医院检验科贵州贵阳550001 陆军军医大学第一附属医院检验科重庆400038 空军军医大学西京医院检验科陕西西安710032 山东大学附属济南市中心医院检验科山东济南250013 兰州大学第二医院检验科甘肃兰州730030 新疆医科大学第一医院检验科新疆维吾尔自治区乌鲁木齐830054 汉中市中心医院检验科陕西汉中723000 海南省人民医院检验科海南海口570311 山西省儿童医院检验科山西太原300012

目的监测我国主要城市三级甲等医院住院患者分离的革兰氏阴性菌的细菌耐药状况,掌握耐药流行趋势,为抗生素合理使用提供科学数据。方法定点收集来自全国19家医院临床分离细菌,由中心实验室统一用平皿/肉汤二倍稀释法测定抗菌药物最低抑... 详细信息

目的监测我国主要城市三级甲等医院住院患者分离的革兰氏阴性菌的细菌耐药状况,掌握耐药流行趋势,为抗生素合理使用提供科学数据。方法定点收集来自全国19家医院临床分离细菌,由中心实验室统一用平皿/肉汤二倍稀释法测定抗菌药物最低抑菌浓度(MIC)值。结果对2.19年7月至2.2.年6月来自全国19座城市19家医院的4795株临床分离致病菌进行了MIC测定。结果显示,大肠埃希菌和肺炎克雷伯菌中超广谱β内酰胺酶(ESBLs)表型检出率分别为52.8%和2..6%,均持续下降,碳青霉烯类耐药肺炎克雷伯菌比例与前次监测持平。对肠杆菌目细菌抗菌作用较好的药物包括碳青霉烯类、阿米卡星、拉氧头孢、β内酰胺类合剂、磷霉素氨丁三醇和西他沙星等。非发酵革兰阴性菌中铜绿假单胞菌和鲍曼不动杆菌对亚安培南的耐药率分别为2..1%和70.7%,多重耐药菌(MDR)检出率分别为39.7%和74.9%,泛耐药菌(XDR)检出率分别为11.8%和69.0%。不同病房、不同年龄以及不同标本来源菌株耐药率比较提示,重症监护病房分离肺炎克雷伯菌、鲍曼不动杆菌和铜绿假单胞菌中MDR占比更高,儿童患者分离肺炎克雷伯菌中ESBLs检出率高于成人和老年人,我国儿童中细菌耐药问题不容忽视。结论ESBLs检出率有所下降;碳青霉烯类耐药肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌比例稳定;鲍曼不动杆菌对米诺环素耐药率有所升高,值得注意。

关键词：细菌耐药监测革兰氏阴性菌最低抑菌浓度敏感率耐药率最低抑菌浓度分布

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中国细菌耐药监测研究2.17-2.18革兰氏阴性菌监测报告

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中国临床药理学杂志 2019年第19期35卷 2508-2528页

作者：李耘吕媛郑波薛峰张秀珍胡云建金玉芬胡志东赵建宏潘世扬李华茵俞云松李艳刘文恩刘德华费樱府伟灵徐修礼裴凤艳孟灵季萍汤进符惠群朱镭刘健杨维维张佳王青北京大学第一医院临床药理研究所北京100034 北京医院检验科北京100730 吉林大学第二医院检验科吉林长春130041 天津医科大学总医院检验科天津300052 河北医科大学第二医院检验科河北石家庄050000 南京医科大学第一附属医院检验科江苏南京210029 复旦大学中山医院呼吸科上海200023 浙江大学邵逸夫医院感染科浙江杭州310003 武汉大学人民医院检验科湖北武汉430060 中南大学湘雅医院检验科湖南长沙410008 昆明市第一人民医院检验科云南昆明650011 贵州医科大学附属医院检验科贵州贵阳550001 陆军军医大学第一附属医院检验科重庆400038 空军军医大学西京医院检验科陕西西安710032 山东大学附属济南市中心医院检验科山东济南250013 兰州大学第二医院检验科甘肃兰州730030 新疆医科大学第一医院检验科新疆维吾尔自治区乌鲁木齐830054 汉中市中心医院检验科陕西汉中723000 海南省人民医院检验科海南海口570311 山西省儿童医院检验科山西太原300012

目的监测我国主要城市三级甲等医院住院患者的细菌耐药状况,掌握耐药流行趋势,为抗生素合理使用提供科学数据。方法定点收集来自全国19家医院临床分离致病菌,由中心实验室统一用平皿/肉汤二倍稀释法测定抗菌药物最低抑菌浓度(MIC)值,参... 详细信息

目的监测我国主要城市三级甲等医院住院患者的细菌耐药状况,掌握耐药流行趋势,为抗生素合理使用提供科学数据。方法定点收集来自全国19家医院临床分离致病菌,由中心实验室统一用平皿/肉汤二倍稀释法测定抗菌药物最低抑菌浓度(MIC)值,参照美国临床和实验室标准协会(CLSI)或欧洲抗菌药物敏感性试验委员会(EUCAST) 2.19年标准判定细菌敏感、耐药率。结果对来自全国19座城市19家三级甲等医院的4602.临床分离革兰氏阴性致病菌进行了MIC测定。结果显示,大肠埃希菌和肺炎克雷伯菌中超广谱β内酰胺酶(ESBLs)表型检出率分别为54. 6%和2.. 1%,大肠埃希菌较前次下降约5个百分点,肺炎克雷伯菌持平。对肠杆菌科细菌抗菌作用较好的药物包括碳青霉烯类、阿米卡星、拉氧头孢、β内酰胺类合剂、替加环素、磷霉素氨丁三醇等,但碳青霉烯类耐药肺炎克雷伯菌比例继续增加。非发酵革兰氏阴性菌中铜绿假单胞菌和鲍曼不动杆菌对亚安培南的耐药率分别为2.. 7%和71. 4%,多重耐药菌(MDR)检出率分别为31. 8%和75. 1%,泛耐药菌(XDR)检出率分别为9. 1%和69. 9%。不同病房、不同年龄以及不同标本来源菌株耐药率比较提示,儿童患者分离菌中肺炎克雷伯菌对β内酰胺类等药物耐药率显著高于成年人与老年人,我国儿童中细菌耐药问题不容忽视。结论大肠埃希菌ESBLs检出率有所下降;碳青霉烯类耐药肺炎克雷伯菌有继续增加趋势;多黏菌素E耐药肺炎克雷伯菌增加明显,值得注意。

关键词：细菌耐药监测革兰氏阴性菌最低抑菌浓度敏感率耐药率 MIC分布

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中国细菌耐药监测研究2.17-2.18年革兰氏阳性菌监测报告

引用

中国临床药理学杂志 2019年第19期35卷 2494-2507,2528页

目的监测我国主要城市三级甲等医院住院患者的细菌耐药状况,掌握耐药流行趋势,为抗生素合理使用提供科学数据。方法定点收集来自全国19家医院临床分离致病菌,由中心实验室统一用平皿/肉汤二倍稀释法测定抗菌药物最低抑菌浓度(MIC)值,参照美国临床和实验室标准协会或欧洲抗菌药物敏感性试验委员会2.19年标准判定细菌敏感率和耐药率。结果对来自全国19座城市19家三级甲等医院的2.2.株临床分离革兰氏阳性致病菌进行了MIC测定。结果显示,甲氧西林耐药金黄色葡萄球菌(MRSA)和甲氧西林耐药表皮葡萄球菌(MRSE)检出率分别为33. 2.和85. 7%。未发现万古霉素不敏感葡萄球菌。金葡菌对利奈唑胺、替考拉宁100%敏感,凝固酶阴性葡萄球菌对万古霉素以外的其他测试药物均出现耐药或不敏感。粪肠球菌、屎肠球菌对氨苄西林的耐药率分别为3. 2.和88. 2.。万古霉素耐药肠球菌(VRE)检出率1. 4%,利奈唑胺不敏感率粪肠球菌比例为5. 0%。青霉素不敏感肺炎链球菌(PNSSP)检出率按非脑膜炎、非肠道系统给药折点计算为11. 0%,按口服青霉素V折点计算为74. 6%,较前次监测略有增加。不同病房、不同年龄以及不同标本来源菌株耐药率比较均无显著差异。结论 VRE检出率稳定在低水平;MRSA检出率持续下降;虽然新抗菌药物如利奈唑胺、替加环素、达托霉素不敏感菌株均有检出,但革兰氏阳性菌总体耐药状况稳定。

关键词：细菌耐药监测革兰氏阳性球菌最低抑菌浓度敏感率耐药率最低抑菌浓度分布

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穿支皮瓣修复口腔颌面-头颈部缺损专家共识

引用

中国口腔颌面外科杂志 2020年第5期18卷 385-389页

作者：何悦蒋灿华侯劲松王慧明彭歆刘冰李劲松郑磊徐中飞吴煜农胡镜宙秦兴军艾松涛周辉红李春洁张世周王军李晓光刘忠龙祝奉硕上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科上海200011 中南大学湘雅医院口腔颌面外科湖南长沙410008 中山大学光华口腔医学院附属口腔医院口腔颌面外科广东广州510055 浙江大学口腔医学院浙江大学医学院附属第一医院口腔颌面外科浙江杭州310006 北京大学口腔医学院口腔颌面外科北京100081 武汉大学口腔医院口腔颌面外科湖北武汉430070 中山大学孙逸仙纪念医院口腔颌面外科广东广州510120 中国医科大学附属口腔医院口腔颌面-头颈外科辽宁沈阳110002 南京医科大学附属口腔医院口腔颌面外科江苏南京210029 上海交通大学医学院附属第九人民医院影像科上海200011 上海交通大学医学院附属第九人民医院超声科上海200011 四川大学华西口腔医院头颈肿瘤外科四川成都610041 山东第一医科大学附属省立医院口腔颌面外科山东济南250021 甘肃省肿瘤医院头颈二科甘肃兰州730050

穿支皮瓣由皮肤穿支血管供血,是常用的组织缺损修复形式,但头颈部解剖复杂、缺损形式多样以及穿支血管解剖变异等,阻碍了穿支皮瓣在口腔颌面-头颈部缺损修复中的进一步应用。迄今为止,国内外对于穿支皮瓣修复口腔颌面-头颈部缺损临床应... 详细信息

穿支皮瓣由皮肤穿支血管供血,是常用的组织缺损修复形式,但头颈部解剖复杂、缺损形式多样以及穿支血管解剖变异等,阻碍了穿支皮瓣在口腔颌面-头颈部缺损修复中的进一步应用。迄今为止,国内外对于穿支皮瓣修复口腔颌面-头颈部缺损临床应用缺少相关治疗指南,穿支血管的术前评价缺乏统一标准,穿支皮瓣的应用设计缺乏科学的规范,穿支皮瓣修复术后缺少客观的监测和评价体系。为进一步统一和规范穿支皮瓣在口腔颌面-头颈部缺损修复中的应用,提高重建效果,本共识总结全国多家著名医学院校及附属医院口腔颌面外科专家团队的实践经验,供临床医师参考。

关键词：穿支皮瓣口腔颌面-头颈部缺损修复重建专家共识

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新型冠状病毒肺炎药物预防、诊断、治疗与出院管理临床指南计划书

引用

医学新知 2020年第3期30卷 209-226页

作者：靳英辉李宏军詹庆元彭志勇袁玉峰蔡林尹训涛岳冀蓉杨启文纪建光夏剑李一荣周福祥高亚东余追徐峰张笑春涂明利谭力铭任学群杨旻陈芳张晓菊曾玫朱渝刘新灿杨简赵东赤丁玉峰侯宁汪付兵陈昊张永刚李玮陈文施月仙杨秀芝王学军钟燕军邓通高锦萍余绍福范曼如薛竑飏余临心李柄辉李路遥马琳璐任相颖王娜翁鸿赵明娟訾豪黄笛罗丽莎黄桥王云云曾宪涛程真顺姚晓梅王行环武汉大学中南医院循证与转化医学中心武汉430071 武汉大学循证与转化医学中心武汉430071 首都医科大学附属北京佑安医院影像中心北京100069 中日友好医院国家呼吸系统疾病临床研究中心北京100029 中日医院呼吸与危重症医学科北京100029 武汉雷神山医院武汉430200 武汉大学中南医院重症医学科武汉430071 贵州省人民医院医学影像科贵阳550002 四川大学华西医院国家老年疾病临床医学研究中心成都610041 四川大学华西医院老年医学中心成都610041 中国医学科学院/北京协和医学院检验学系·北京协和医院检验科北京100730 瑞典隆德大学临床研究中心·斯科讷大学医院瑞典马尔默25002 武汉大学中南医院急救中心武汉430071 武汉大学中南医院医学检验科武汉430071 武汉大学中南医院肿瘤放化疗科武汉430071 武汉大学中南医院过敏反应科武汉430071 武汉大学人民医院重症医学科武汉430060 山东大学齐鲁医院急诊科与胸痛中心济南250002 武汉大学中南医院医学影像中心武汉430071 湖北医药学院附属随州市中心医院呼吸与重症医学科湖北随州441300 湖南省怀化市第二人民医院药学部湖南怀化418000 河南大学循证医学与临床转化研究院河南开封475000 安徽医科大学第二附属医院重症医学科合肥230601 郑州大学医院内科郑州450001 河南省人民医院呼吸与危重症医学科郑州450003 复旦大学附属儿科医院感染传染科上海201102 四川大学华西第二医院感染儿科成都610041 河南中医学院第一附属医院心脏中心郑州450000 三峡大学人民医院·宜昌市第一人民医院心内科湖北宜昌443000 武汉大学中南医院儿科武汉430071 华中科技大学同济医学院附属同济医院药学部武汉430030 山东第一医科大学附属省立医院·山东省立医院药学部济南250021 南京中医药大学教育部针药结合重点实验室南京210023 四川大学华西医院华西期刊社成都610041 青岛大学附属烟台毓璜顶医院检验医学中心山东烟台264000 十堰市太和医院(湖北医药学院附属医院)医学影像中心湖北十堰442000 北京大学护理学院北京100191 开封市中心医院呼吸与危重症医学科河南开封475000 北京电力医院急诊科北京100073 中南大学湘雅二医院重症医学科长沙410008 山西医科大学护理学院太原030001 河南大学医学院护理与健康学院河南开封475000 武汉大学中南医院呼吸与危重症医学科武汉430071 麦克马斯特大学卫生研究方法证据及影响系加拿大安大略省哈密尔顿市L8S 4L8

本计划书为《新型冠状病毒(2.19-nCoV)感染的肺炎诊疗快速建议指南(标准版)》更新版的研究方案。计划书涵盖指南制定方法学、指南的目标用户、指南的目标人群、利益冲突调查与声明、临床问题和结局指标的遴选与确定、证据的检索、合成... 详细信息

本计划书为《新型冠状病毒(2.19-nCoV)感染的肺炎诊疗快速建议指南(标准版)》更新版的研究方案。计划书涵盖指南制定方法学、指南的目标用户、指南的目标人群、利益冲突调查与声明、临床问题和结局指标的遴选与确定、证据的检索、合成与评价、证据与推荐意见分级标准、推荐意见的形成、指南的更新,并附录指南临床问题清单、文献检索策略及利益冲突调查表。

关键词：新型冠状病毒新型冠状病毒肺炎药物预防诊断治疗出院管理临床实践指南

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