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Effects and complications of placement of motility coupling post in porous polyethylene orbital implants

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 464-469页

作者： hong-guang cui Rong-rong HU Hui-yan LI Wei HAN Department of Ophthalmology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To investigate the effects and complications of primary and secondary placements of motility coupling post （MCP） in the unwrapped porous polyethylene orbital implant （PPOI） following enucleation. Methods： We investigated 198 patients who received PPOI implantation following the standard enucleation procedure in the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, from 2002 to 2004. These patients were subgrouped into PPOI-only patients （112 cases, received PPOI following enucleation）, primary MCP patients （46 cases, received primary placement of MCP during PPOI operation）, and secondary MCP patients （40 cases, received secondary placement ofMCP 6 months after the initial surgery）. Effects and complications among these three groups were compared. Results： The PPOI-only patients took shorter treatment course when compared with other two MCP groups （P〈0.001）, without significant difference noted between the two MCP groups. However, the two MCP groups had better prosthetic motility than PPOI-only group （P〈0.001）, without significant difference between the two MCP groups. In the early stage, 2 eyes in the PPOI-only group and l eye in the primary MCP group had PPOI infection. In PPOI-only group, 3 （2.68%） eyes had PPOI exposure, which occurred after fitting the prostheses; 4 eyes （8.70%） in primary MCP group and 1 eye （2.50%） in secondary MCP had PPOI exposure, which occurred before fitting the prostheses. After prosthesis was fit successfully, the excessive discharge and granuloma were 33.9% and 1.79% in PPOI group-only, 53.3% and 8.9% in primary MCP group, and 52.5% and 7.5% in secondary MCP group, respectively. Conclusion： Both primary and secondary placements of MCP into the PPOI following enucleation can help patients to obtain desirable prosthetic motility, but may be associated with more complications. The primary placement of MCP with skilled operation in selected patients is more recommendable than secondary placemen

关键词： Porous polyethylene orbital implant (PPOI) Motility coupling post (MCP)

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Potential candidate cells for constructing tissue-engineered lacrimal duct epithelium: a histological and cytological study in rabbits

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第11期16卷 904-913页

作者： Chen XIE Xiu-yi LI hong-guang cui Department of Ophthalmology the First Affiliated Hospital School of Medicine Zhejiang University

Objective： Injury and deficiency of the lacrimal duct epithelium （LDE） can lead to a variety of lacrimal diseases. The purpose of this study was to characterize potential candidate cells for constructing a tissue-engineered LDE. Methods： Different areas of the conjunctiva and lacrimal duct tissue were removed from male adult New Zealand white rabbits for histological evaluation. Hematoxylin and eosin staining and immunohistochemical staining of cytokeratin AEI＋AE3, cytokeratin 4, Ki-67, and MUC5AC were observed by light microscopy. The surface morphologies of different epithelial tissues and cellular structures were examined using field-emission scanning electron microscopy and transmission electron microscopy. Epithelial cells were isolated from tissues and identified by specific markers. In vitro, proliferative ability and Western blot analyses of the proliferating cell nuclear antigen （PCNA） of different epithelial cells cultured in identical environments were investigated and compared. Results： Histologically, the epithelial specific markers, cytokeratin AEI＋AE3 and cytokeratin 4, were expressed in the conjunctiva epithelium and the LDE. Notably, highly proliferative cells stained with Ki-67 were concentrated under the epithelium in a dome structure of the posterior palpebral conjunctiva. Differentiated goblet cells were also found to a lesser extent in this region. Primary palpebral and fornical conjunctival epithelial cells （PFCECs）, bulbar conjunctival epithelial cells （BCECs）, and lacrimal duct epithelial cells （LDECs） were successfully separated from tissues. In vitro, rabbit PFCECs and LDECs grew faster and expressed more PCNA than BCECs. Conclusions： PFCECs are anatomically similar to LDECs. They also have similar morphological characteristics, immune phenotypes, and proliferation features. PFCECs are therefore potential candidate cells to replace LDECs in tissue engineering to treat lacrimal duct diseases.

关键词： Conjunctival epithelial cells Cytokeratin Lacrimal duct epithelial cells Mucin Proliferating cell nuclearantigen Tissue engineering

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Limitation standard of toxic aconitines in Aconitum proprietary Chinese medicines using on-line extraction electrospray ionization mass spectrometry

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1511-1520页

作者： Zi-Dong Qiu Xu-Ya Wei Rui-Qi Sun Jin-Long Chen Ting Tan Jia-Quan Xu guang-hong cui Tong Chen Juan Guo Chang-Jiang-Sheng Lai Lu-Qi Huang State Key Laboratory Breeding Base of Dao-di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330006China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation College of ChemistryBiology and Material SciencesEast China Institute of TechnologyNanchang 330013China

Development of rapid analytical methods and establishment of toxic component limitation standards are of great importance in quality control of traditional Chinese medicine. Herein, an online extraction electrospray ionization mass spectrometry(oEESI-MS) coupled with a novel whole process integral quantification strategy was developed and applied to direct determination of nine key aconitine-type alkaloids in 20 Aconitum proprietary Chinese medicines(APCMs). Multi-type dosage forms(e.g., tablets, capsules, pills, granules, and liquid preparation) of APCM could be determined directly with excellent versatility. The strategy has the characteristics of high throughput, good tolerance of matrix interference, small amount of sample(~0.5 mg) and reagent(~240 μL) consumption, and short analysis time for single sample(<15 min). The results were proved to be credible by high performance liquid chromatographyàmass spectrometry(LC-MS) and electrospray ionization mass spectrometry, respectively. Moreover, the limitation standard for the toxic aconitines in 20 APCMs was established based on the holistic weight toxicity(HWT) evaluation and the Chinese Pharmacopoeia severally, and turned out that HWT-based toxicity evaluation results were closer to the real clinical applications. Hence,a more accurate and reliable APCM toxicity limitation was established and expected to play an important guiding role in clinics. The current study extended the power of ambient MS as a method for the direct quantification of molecules in complex samples, which is commonly required in pharmaceutical analysis,food safety control, public security, and many other disciplines.

关键词： Aconitum dosage tablets

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Use of the Metabolomics Approach to Characterize Chinese Medicinal Material Huangqi

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Molecular Plant 2012年第2期5卷 376-386页

作者： Li-Xin Duan Tian-Lu Chen Ming Li Min Chen Ye-Qing Zhou guang-hong cui Ai-Hua Zhao Wei Jia Lu-Qi Huang Xiaoquan Qi The Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of Sciences20 Nanxincun Xiangshan RoadBeijing 100093China Shanghai Center for Systems Biomedicine(Ministry of Education Key Laboratory of Systems Biomedicine) Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Institute of Chinese Materia Medica Chinese Academy of Chinese Medical Sciences16 Nanxiao RoadBeijing 100700China School of Pharmacy Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China

Integration of the genetic and metabolic fingerprinting can provide a new approach to differentiate similar Traditional Chinese Medical （TCM） materials. Two leguminous plants, Mojia Huangqi and Menggu Huangqi, are important medical herbs and share great similarities in morphology, chemical constituent, and genomic DNA sequence. The taxonomy of Mojia Huangqi and Menggu Huangqi has been debated for more than 50 years and discrimination of TCM materials directly affects the pharmacological and clinical effects. AFLP based genetic fingerprinting and GC-TOF/MS-based meta- bolic fingerprinting were used to successfully discriminate the two species. The results of AFLP supported the opinion that Menggu Huangqi was a variant of Mojia Huangqi. The metabolic fingerprinting showed growth locations have greater impacts on the metabolite composition and quantity than the genotypes （cultivated versus wild） in Menggu Huangqi. The difference of some soluble sugars, fatty acids, proline, and polyamine reflected plant adaptation to different growth environments. Using multivariate and univariate statistical analysis, three AFLP markers and eight metabolites were identified as candidate DNA and metabolic markers to distinguish the two herb materials. The correlation network between AFLP markers and metabolites revealed a complex correlation network, which indicated the special metabolic pathways and the regulation networks of Huangqi.

关键词： Astragalus membranaceus metabolic fingerprinting amplified fragment length polymorphisms gas chromatography time-of-flight mass spectrometry.

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Effect of Packing Parameters and Gate Size on Shrinkage of Aspheric Lens Parts

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Journal of Shanghai Jiaotong university(Science) 2010年第1期15卷 84-87页

作者：胡广洪崔振山 National Mold and Die Engineering Research Center Shanghai Jiaotong University

In order to produce the high quality optical aspheric lens,the shrinkage of lens should be strictly controlled during the injection *** of experiments are done to find the factors that affect the lens shrinkage during the injection molding *** study is focused on the effect of gate size,packing time and pressure on the *** gate size decides the effective packing *** when the effective packing time is enough,the shrinkage size will be decreased along with the packing pressure *** the packing time is determined by the gate *** big gate size is not easily to be cut and the cutting difficulty will cause the part quality *** experiments show that packing pressure not only determines the part shrinkage size and also affects the part shrinkage *** the packing pressure is more than a critical one,the effect of packing pressure on the shrinkage size becomes *** the shrinkage uniformity is guaranteed.

关键词： aspheric lens packing time packing pressure gate size part shrinkage

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关苍术氮磷钾优化施肥模式研究

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中药材 2016年第6期39卷 1207-1211页

作者：赵虹然具红光崔馨月朴锦延边大学农学院吉林延吉133002

目的:优化关苍术氮磷钾施肥模式,为关苍术规范化栽培技术体系及专用肥生产提供科学依据。方法:以一年生和两年生关苍术为试验材料,采用氮磷钾三因素二次饱和-D最优设计研究氮磷钾对关苍术株高、根茎性状及有效成分的影响。结果:1)综合... 详细信息

目的:优化关苍术氮磷钾施肥模式,为关苍术规范化栽培技术体系及专用肥生产提供科学依据。方法:以一年生和两年生关苍术为试验材料,采用氮磷钾三因素二次饱和-D最优设计研究氮磷钾对关苍术株高、根茎性状及有效成分的影响。结果:1)综合考虑产量和有效成分,筛选关苍术最优氮磷钾配施方案,确定N_0P_2K_2(N 0 g/m^2、P_2O_540.227 g/m^2、K_2O 40.227 g/m^2)和N_1P_3K_3(N 15.939 g/m^2、P_2O_567.467 g/m^2、K_2O 67.467 g/m^2)处理为最优;2)求出氮磷钾配比与关苍术产量(根茎鲜重)的回归模型,发现氮、磷、钾单效应中钾肥是主要因素,其次是氮肥;3)根据回归模型得出氮、磷、钾三因素的最优组合,氮、磷、钾的施用水平分别为38.4301 kg/hm^2、181.4750 kg/hm^2、128.5584 kg/hm^2时,关苍术单株根茎鲜重最高为27.4066 g;4)模型寻优结果选定关苍术单株根茎鲜重目标26.00~27.41 g(目标产量1 040.0~1 096.4 kg/hm^2)在95%的置信区间,优化施肥组合为:X1=-0.2912±0.0825,X2=0.2764±0.1054,X3=0.1325±0.0645。结论:据关苍术产量和有效成分,建议人工种植关苍术时施肥量为:N 46.951~59.320 kg/hm^2,P 131.673~155.377 kg/hm^2,K 120.091~134.597 kg/hm^2。

关键词：关苍术氮磷钾施肥模式有效成分产量

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自发性颈动脉海绵窦瘘眼部表现的临床分析

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国际眼科杂志 2013年第4期13卷 801-803页

作者：沈剑琴崔红光浙江大学医学院附属第一医院眼科中国浙江省杭州市310003

目的:探讨自发性颈动脉海绵窦瘘眼部表现特点及诊断要点,提高对该病的认识,减少临床漏诊、误诊。方法:回顾分析14例就诊于我院的自发性颈动脉海绵窦瘘患者的眼部症状及体征、影像学检查、治疗方法等。结果:所选14例病例中最常见的眼部... 详细信息

目的:探讨自发性颈动脉海绵窦瘘眼部表现特点及诊断要点,提高对该病的认识,减少临床漏诊、误诊。方法:回顾分析14例就诊于我院的自发性颈动脉海绵窦瘘患者的眼部症状及体征、影像学检查、治疗方法等。结果:所选14例病例中最常见的眼部表现为眼球突出(100%)、结膜及浅层巩膜充血扩张(93%)。行CT或MRI检查的12例病例中,眼上静脉增粗者9例,海绵窦增宽或高信号者6例。4例行栓塞治疗者眼部症状和体征得到明显改善。结论:自发性颈动脉海绵窦瘘的眼部临床谱广泛多样,特征性眼部表现结合影像学检查可有效提高诊断。栓塞治疗对改善眼部表现效果明显。

关键词：自发性颈动脉海绵窦瘘眼部表现诊断

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Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui hong Wei Quan Xinyu Qiao Chun cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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分布式虚拟战场环境中的仿真模型

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系统仿真学报 2000年第4期12卷 337-339页

作者：龚光红崔武伦北京航空航天大学先进仿真技术航空科技重点实验室!北京100083

主要论述分布式虚拟战场环境中的五类仿真模型 (实体模型、作战模型、环境模型、评估模型和仿真管理模型 )含义 ,各自的研究内容、特点 ,不同对象之间模型的区别 ,以及五类模型之间的相互关系

关键词：分布式虚拟战场环境仿真模型计算机生成兵力人在回路仿真器

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