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Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway

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Acta Pharmacologica Sinica 2007年第1期28卷 19-27页

作者： Qing WANG Quan-guang ZHANG dong-na wu Xiao-hui YIN guang-yi ZHANG~2 Research Center for Biochemistry and Molecular Biology,Xuzhou Medical College,Xuzhou 221002,China ResearchCenterforBiochemistryandMolecularBiology XuzhouMedicalCollegeXuzhou221002China

Aim:To investigate whether selenite,a known antioxidant,could decrease theactivation of apoptosis signal regulating kinase 1/c-jun N-terminal kinase(ASK1/JNK)signaling cascade in cerebral ischemia/reperfusion(I/R)by activating thephosphatidylinositol 3-kinase(PI3K)/AKT pathway in rat hippocampi,and theneuroprotective effect of selenite against ischemic injury after 15 min of transientbrain ***:Transient global brain ischemia was induced by4-vessel occlusion into adult male Sprague-Dawley rats weighing 250-300 *** were pretreated only with selenite(0.3 mg/kg dissolved in 0.9% saline)every24 h for 7 d by means of intravenous injection of the tail or combined with LY294002from d 5 by left cerebral ventricle injection before ***:Selenitesignificantly increased AKT 1 activation and decreased the activation of ASK1/JNK cascade via phosphorylating ASK1 at Ser-83 residue by AKT1 during earlyreperfusion after 15 min transient global brain *** the contrary,com-bined pretreatment of the rats with LY294002(a specific PI3K inhibitor)and selen-ite significantly inhibited the effects solely with ***:The activa-tion of the pro-apoptotic ASK1/JNK cascade,which is closely associated withoxidative stress,could be suppressed by selenite through activating the anti-apoptotic PI3K/AKT pathway during early reperfusion after cerebral ischemia inrat hippocampi.

关键词： cerebral ischemia PI3K/AKT ASK1/JNK LY294002 selenite

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing wu guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

A Hybrid Approach for Pavement Crack Detection Using Mask R-CNN and Vision Transformer Model

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Computers, Materials & Continua 2025年第1期82卷 561-577页

作者： Shorouq Alshawabkeh Li wu Daojun dong Yao Cheng Liping Li Faculty of Engineering China University of GeosciencesWuhan430074China

Detecting pavement cracks is critical for road safety and infrastructure *** methods,relying on manual inspection and basic image processing,are time-consuming and prone to *** deep-learning(DL)methods automate crack detection,but many still struggle with variable crack patterns and environmental *** study aims to address these limitations by introducing the Masker Transformer,a novel hybrid deep learning model that integrates the precise localization capabilities of Mask Region-based Convolutional Neural Network(Mask R-CNN)with the global contextual awareness of Vision Transformer(ViT).The research focuses on leveraging the strengths of both architectures to enhance segmentation accuracy and adaptability across different pavement *** evaluated the performance of theMaskerTransformer against other state-of-theartmodels such asU-Net,TransformerU-Net(TransUNet),U-NetTransformer(UNETr),SwinU-NetTransformer(Swin-UNETr),You Only Look Once version 8(YoloV8),and Mask R-CNN using two benchmark datasets:Crack500 and *** findings reveal that the MaskerTransformer significantly outperforms the existing models,achieving the highest Dice SimilarityCoefficient(DSC),precision,recall,and F1-Score across both ***,the model attained a DSC of 80.04%on Crack500 and 91.37%on DeepCrack,demonstrating superior segmentation accuracy and *** high precision and recall rates further substantiate its effectiveness in real-world applications,suggesting that the Masker Transformer can serve as a robust tool for automated pavement crack detection,potentially replacing more traditional methods.

关键词： Pavement crack segmentation transportation deep learning vision transformer Mask R-CNN image segmentation

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun dongfang Hou Meidi Wang Xueqian wu Tao wu dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

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论文化主体性助力中国网球文化自信

体育文化导刊 2024年第12期 8-14页

作者：董光武储志东刘东升史曙生南京师范大学体育科学学院南京210023

运用文献资料、逻辑分析等方法,阐明文化主体性助力中国网球文化自信的内在逻辑、困境与路径。内在逻辑:文化记忆是遗产基础,文化景观是符号表达,社会结构是延续载体,非遗文化是永续活力。困境:历史文化资源挖掘不足,中外网球文化传播不... 详细信息

运用文献资料、逻辑分析等方法,阐明文化主体性助力中国网球文化自信的内在逻辑、困境与路径。内在逻辑:文化记忆是遗产基础,文化景观是符号表达,社会结构是延续载体,非遗文化是永续活力。困境:历史文化资源挖掘不足,中外网球文化传播不均,群众网球社会根基不牢,文化代理人影响力不济。路径:共同推进网球记忆载体的具化与活化,重点深化网球赛事景观的挖掘与呈现,协调竞技网球与群众网球的社会结构,增强网球传播者与实践者的非遗属性。

关键词：运动项目文化网球文化文化主体性

分子靶向药物在晚期NSCLC患者中的疗效探讨

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临床肺科杂志 2016年第9期21卷 1682-1685页

作者：童光武蕲春县人民医院肿瘤内科湖北黄冈435300

目的探析单抗类分子靶向药物在晚期非小细胞肺癌(NSCLC)患者化疗治疗期间的临床应用价值。方法分析2014年2月至2015年12月在我院接受治疗的NSCLC患者的临床资料。根据治疗方案的不同,将入选者分为观察组(化疗+单抗类分子靶向药物)和对照... 详细信息

目的探析单抗类分子靶向药物在晚期非小细胞肺癌(NSCLC)患者化疗治疗期间的临床应用价值。方法分析2014年2月至2015年12月在我院接受治疗的NSCLC患者的临床资料。根据治疗方案的不同,将入选者分为观察组(化疗+单抗类分子靶向药物)和对照组(化疗)两组。比较两组患者的基线资料、临床疗效、临床特征(包括表皮生长因子受体EGFR、癌胚抗原CEA以及癌抗原125)以及不良反应发生率。结果本研究共入组患者72例,其中观察组和对照组各36例。两组患者的基线资料无显著差异(P>0.05)。观察组患者的临床有效率(86.1%)明显高于对照组(52.8%)(P0.05),而治疗后观察组患者的CA125、CEA、EGFR的表达水平均明显低于对照组(P<0.01)。观察组患者的不良反应发生率(5.6%)明显低于对照组(22.2%)(P<0.05)。结论接受化疗治疗的晚期NSCLC患者添加使用单抗类分子靶向药物进行治疗的疗效更加确切,且不良反应发生率更低,值得临床推广。

关键词：非小细胞肺癌分子靶向药物西妥昔单抗疗效

Modeling tactile perceived intensity for vibration from a coin eccentric rotating mass motor

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Science China Technological Sciences 2025年

作者： Yun FANG Jingchen HUANG Yujun wu Jiaqi dong Weichao GUO Xinjun SHENG State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Meta Robotics Institute Shanghai Jiao Tong University

Establishing the relationship between vibrotactile parameters and perceived intensity（PI） is of great significance in the regulation of desired sensations, which contribute to haptic interfaces in practical applications. Coin eccentric rotating mass（ERM） motors are routinely utilized due to their lightweight design and efficient ability to evoke strong tactile sensations. By adjusting input voltages, ERMs can yield different stimuli, but the effects of their physical properties on PI remain ***, we developed the physical model of the ERM-skin system and optimized the parameters affecting PI. Moreover, the relationship between stimulus and perception was derived based on Fechner?s law. Three experiments were conducted on fifteen subjects（ten males and five females, aged 24.40 ± 2.87 years） to identify the vibration parameters and corresponding PI to verify the proposed PI model. ERMs in this study were attached to phantom skin/forearm with slim adhesive tape to minimize the interference. Experiment 1 performed vibration calibration with ERM attached to the skin phantom to simulate the actual configuration. Then, the relative and absolute PI of subjects on specific stimuli were acquired in Experiments 2 and *** fitting reliability of the proposed PI model was evaluated on fifteen subjects with R2of 0.73 ± 0.07 and root mean squared error（RMSE） of 1.35 ± 0.28. Overall, the proposed PI model established the quantitative relationship between stimulus parameters（vibration parameters and physical parameters） and subjective PI, which provided theoretical support for ERM optimization and vibrotactile modulation.

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Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

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Science China Life Sciences 2025年第1期 219-231页

作者： Yingying Feng Yuying wu Jialu Wang Zhenglin dong Qian Yu Shuangshuang Xia Chunxue Liu Haihua Wang Xin wu Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of Sciences ANYOU Biotechnology Group Co.Ltd Qingdao Seawin Biotech Group Co. LTD

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC) signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S r RNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides＿fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin dong Bin Duan Feiyang Xing Jun wu Minmin Xiao Fangqing Zhao Jing-dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening