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In vitro corrosion resistance and antibacterial performance of noveltin dioxide-doped calcium phosphate coating on degradable Mg-1Li-1Ca alloy

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Journal of Materials Science & Technology 2019年第3期35卷 254-265页

作者： Lan-Yue Cui guang-bin wei Zhuang-Zhuang Han Rong-Chang Zeng Lei Wang Yu-Hong Zou Shuo-Qi Li Dao-Kui Xu Shao-Kang Guan College of Materials Science and Engineering Shandong University of Science and Technology College of Chemical and Environmental Engineering Shandong University of Science and Technology CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academy of Sciences School of Materials Science and Engineering Zhengzhou University

A SnO_2-doped calcium phosphate(Ca-P-Sn) coating was constructed on Mg-1 Li-1 Ca alloy by a hydrothermal process. The fabricated functional coatings were investigated using scanning electron microscopy(SEM), X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FT-IR). A triple-layered structure, which is composed of Ca_3(PO_4)_2,(Ca, Mg)_3(PO_4)_2, SnO_2, and MgHPO_4·3 H_2O, is evident and leads to the formation of Ca_(10)(PO_4)_6(OH)_2 in Hank's solution. Electrochemical measurements, hydrogen evolution tests and plating counts reveal that the corrosion resistance and antibacterial activity were improved through the coating treatment. The embedded SnO_2 nanoparticles enhanced crystallisation of the *** formation and degradation mechanisms of the coating were discussed.

关键词： Magnesium alloys Coatings Corrosion Biomedical materials

In vitro corrosion of Ca-P-Sn coatings on biomedical Mg-1Li-1Ca alloy

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In vitro corrosion of Ca-P-Sn coatings on biomedical Mg-1Li-...

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

第二届海峡两岸功能材料科技与产业峰会（2015）

作者：曾荣昌 Lei Wang guang-bin wei Shuo-Qi Li Fen Zhang Hong-Zhi Cui College of Materials Science and Engineering Shandong University of Science and Technology State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology

A novel Ca-P-Sn coating was prepared to improve the corrosion resistance of biomedical Mg-1Li-1Ca alloy. The Ca-P-Sn coating were prepared on the Mg-1Li-1Ca alloy using hydrothermal *** phase composition,microstructure and corrosion resistance were investigated using SEM,EDS,XRD,FTIR and electrochemical corrosion testing. The results demonstrated that the Ca-P-Sn coating consisted of two layers. The bottom layer was composed by Mg,O and Ca with a thickness of about 16 μm,while the top layer Ca,P and Sn with a thickness of approximately 50 μm. The coatings presented various morphologies such as nano-spheres,flowers and sheets. The coatings improved the corrosion resistance of Mg-1Li-1Ca alloy significantly. The formation mechanism of the coating was discussed. The novle Ca-P-Sn coating may be found in biomedical applications.

关键词： Magnesium alloy Biomaterial Corrosion Coating

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong Yang Haochen Shen Xiaoming Xiao Zhichao Li Qi Zhou wei Yang bin Jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

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全要素配置视角下锦州旅游产业发展路径探析

鞍山师范学院学报 2017年第1期19卷 25-27页

作者：王辉陈光魏斌渤海大学辽宁锦州121013

基于全域旅游要素配置角度,考量辽西走廊区域中心城市——锦州的旅游产业发展现状与存在问题,从文化根基所在、主题形象凝练、旅游功能区划整合优化、产品谱系设计、接待结构、品牌建设、行业组织联合以及校企智库协作创新等几大方面,... 详细信息

基于全域旅游要素配置角度,考量辽西走廊区域中心城市——锦州的旅游产业发展现状与存在问题,从文化根基所在、主题形象凝练、旅游功能区划整合优化、产品谱系设计、接待结构、品牌建设、行业组织联合以及校企智库协作创新等几大方面,提出未来"十三五"期间锦州旅游产业进一步做大做强的发展路径。

关键词：全要素配置锦州旅游产业发展路径

4,5-二(1H-5-四唑基)-1,2,3-三唑及其含能盐的合成与表征

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火炸药学报 2017年第2期40卷 41-46页

作者：张艳芳熊华林林秋汉程广斌杨红伟南京理工大学化工学院江苏南京210094

以4,5-二氰基-1,2,3-三唑为原料,经过重氮化偶联反应和[2+3]偶氮环加成反应合成了4,5-二(1H-5-四唑基)-1,2,3-三唑,并经过复分解反应合成了7种高氮含能盐。采用IR、~1 H NMR、^(13) C NMR对化合物的结构进行了表征;采用DSC法研究了它们... 详细信息

以4,5-二氰基-1,2,3-三唑为原料,经过重氮化偶联反应和[2+3]偶氮环加成反应合成了4,5-二(1H-5-四唑基)-1,2,3-三唑,并经过复分解反应合成了7种高氮含能盐。采用IR、~1 H NMR、^(13) C NMR对化合物的结构进行了表征;采用DSC法研究了它们的热行为;基于B3LYP/6-311G**方法计算了各化合物的理论密度、标准生成焓,并通过EXPLO5预估了各化合物的爆速和爆压。结果表明,8种化合物均具有较好的热稳定性;生成焓为647.4~1 579.4kJ/mol;爆速为7 652~8 389m/s;爆压除化合物2外均高于20GPa;除化合物1、7、8外,其他化合物标准状况下的气体产生量均大于800L/kg,是潜在的气体发生剂。

关键词：有机化学高氮化合物四唑三唑含能离子盐

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

DWI、MRA和FAIR灌注成像在早期脑缺血中的诊断价值

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实用放射学杂志 2008年第4期24卷 433-436页

作者：刘素兰赵斌王光彬李春卫于台飞赵光宇孙建山东大学医学院山东省医学影像学研究所山东省立医院神经外科山东大学医学院山东省医学影像学研究所山东济南250021

目的探讨磁共振弥散加权成像(DWI)、3D-TOF法MRA脑血管成像及流动敏感交互式反转恢复(FAIR)MR灌注成像在早期脑缺血中的诊断价值。方法对27例早期脑缺血患者行DWI、3D-TOF法MRA和FAIR检查。并对27例患者FAIR灌注图的患侧及对侧灰白质作... 详细信息

目的探讨磁共振弥散加权成像(DWI)、3D-TOF法MRA脑血管成像及流动敏感交互式反转恢复(FAIR)MR灌注成像在早期脑缺血中的诊断价值。方法对27例早期脑缺血患者行DWI、3D-TOF法MRA和FAIR检查。并对27例患者FAIR灌注图的患侧及对侧灰白质作感兴趣区(ROI)分析。结果27例患者DWI全部出现异常高信号,而在常规T2WI及FLAIR检查中,9例为阴性,病灶检出率为67%;MRA发现异常27例,表现为血管闭塞、狭窄、硬化;FAIR发现异常27例,表现为缺血区血流灌注的减低,患侧灰质及白质平均灌注信号强度分别为172.71±18.74、88.90±10.95,对侧灰质及白质平均灌注信号强度分别为248.52±15.99、107.50±9.98。患侧和对侧灰、白质信号强度的差异均有统计学意义(P<0.005),患者患侧与志愿者灰、白质信号强度的差异亦均有统计学意义(P<0.005)。结论FAIR与DWI和3D-TOF法MRA联合运用,对脑缺血早期诊断更全面和更准确。

关键词：脑脑缺血磁共振成像磁共振血管成像(MRA)

Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期 308-316页

作者： Sili Wang Jiancheng Huang Yanan Du wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan Shi bin Hong Xiaoying Bian Wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

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脑裂畸形的MRI诊断与鉴别诊断

实用放射学杂志 2007年第5期23卷 581-583页

作者：崔光彬王玮宋立军杜滂郭炜秦越李玮熊晓双魏经国第四军医大学唐都医院放射科第四军医大学唐都医院放射科陕西西安710038

目的探讨脑裂畸形的MRI表现特征及其诊断价值。方法回顾性分析21例脑裂畸形的MRI表现特征与鉴别诊断。结果本组21例患者,其中Ⅰ型12例,Ⅱ型9例。MRI特征性表现为由灰质相衬的裂隙横跨半球。绝大多数病例有不对称性侧脑室扩大(19例)。裂... 详细信息

目的探讨脑裂畸形的MRI表现特征及其诊断价值。方法回顾性分析21例脑裂畸形的MRI表现特征与鉴别诊断。结果本组21例患者,其中Ⅰ型12例,Ⅱ型9例。MRI特征性表现为由灰质相衬的裂隙横跨半球。绝大多数病例有不对称性侧脑室扩大(19例)。裂隙多位于中央前、后回附近。有20例伴发透明隔缺如、灰质异位等其它脑发育异常。结论脑裂畸形的MR表现具有特征性,能良好显示脑裂畸形的病理解剖特征,是脑裂畸形的首选检查方法。

关键词：脑脑裂畸形磁共振成像