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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan bai Hui Ma yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

An efficient stiffness analysis model based on shear deformation theory for flexible skin shear variable-sweep wing

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Chinese Journal of Aeronautics 2024年第10期37卷 445-458页

作者： yue bai guang YANG Hong XIAO Hongwei GUO Rongqiang LIU Bei LIU State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China China Aerodynamics Research and Development Center Institute of High-Speed AerodynamicsMianyang 621000China

Fixed-wing aircraft cannot maintain optimal aerodynamic performance at different flight speeds. As a type of morphing aircraft, the shear variable-sweep wing(SVSW) can dramatically improve its aerodynamic performance by altering its shape to adapt to various flight *** order to achieve smooth continuous shear deformation, SVSW's skin adopts a flexible composite skin design instead of traditional aluminum alloy materials. However, this also brings about the non-linear difficulty in stiffness modeling and calculation. In this research, a new SVSW design and efficient stiffness modeling method are proposed. Based on shear deformation theory, the flexible composite skin is equivalently modeled as diagonally arranged nonlinear springs, simulating the elastic force interaction between the skin and the mechanism. By shear loading tests of flexible composite skin, the accuracy of this flexible composite skin modeling method is verified. The SVSW stiffness model was established, and its accuracy was verified through static loading tests. The effects of root connection, sweep angles, and flexible composite skin on the SVSW stiffness are analyzed. Finally, considering three typical flight conditions of SVSW: low-speed flow(Ma = 0.3,Re = 5.82 × 10^(6)), transonic flow(Ma = 0.9, Re = 3.44 × 10^(6)), and supersonic flow(Ma = 3,Re = 7.51 × 10^(6)), the stiffness characteristics of SVSW under flight conditions were *** calculated results guide the application of SVSW.

关键词： Shear variable-sweep wing(SVSW) Flexible composite skin Morphing mechanism Stiffness analysis Loading tests Structure

Ti_(3)C_(2)T_(x)/SnO_(2)P–N heterostructure construction boosts room-temperature detecting formaldehyde

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Rare Metals 2024年第1期43卷 267-279页

作者： yue Zhang Ming-yue Wang Xiao-guang San Yan-bai Shen Guo-Sheng Wang Lei Zhang Dan Meng College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang 110142China Institute for Superconducting and Electronic Materials(ISEM) Australian Institute for Innovative Materials(AIIM)University ofWollongongWollongongNSW2500Australia College of Resources and Civil Engineering Northeastern UniversityShenyang 110819China

Formaldehyde is a common atmospheric pollutant produced in industrial production and daily ***,the traditional semiconductor formaldehyde gas sensor cannot work at room temperature,which limits its practical ***,developing high-performance gas sensors for rapidly and accurately detecting formaldehyde at room temperature is an important *** this study,Ti_(3)C_(2)Tx/SnO_(2)heterostructures were constructed,which could selectively detect formaldehyde at room temperature with a response value of 29.16%(10×10^(-6)).In addition,the sensor shows a remarkable theoretical detection limit of 5.09×10^(-9)and good longterm *** functional theory(DFT)simulations reveal that SnO_(2)nano spheres provide the majority of adsorption sites that strongly interact with ***,Ti_(3)C_(2)T_(x)acting as a conductive layer facilitates the transfer of charge carriers so that they show a sensing response to formaldehyde at room ***,the formation of p-n heterostructures between SnO_(2)and Ti_(3)C_(2)T_(x)boosts the Schottky barrier at the interface,which is the critical factor in enhancing the sensing properties by turning the Schottky barrier upon introducing formaldehyde *** perspective is expected to provide instructive guidance for utilizing MXene/metal oxide nanocomposites to improve the gas sensing performance at room temperature.

关键词： Ti_(3)C_(2)T_(x)/SnO_(2)nanocomposites p-n heterostructures Formaldehyde sensing Room temperature DFT calculations

Effect of sintering temperature on the electrolysis of TiO_2

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International Journal of Minerals,Metallurgy and Materials 2012年第7期19卷 636-641页

作者： Ze-quan Li Li-yue Ru Cheng-guang bai Na Zhang Hai-hua Wang College of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 China College of Materials Science and Engineering Chongqing University Chongqing 400044 China

The effects of sintering temperature on the microstructure and the conductivity of TiO2 cathodes were studied by examining the phase composition, microstructure, and element contents of the sintered cathodes and the cathodic products using X-ray diffraction and scan- ning electronic microscopy-energy dispersive spectrometry. The oxygen vacancy, conductivity, average pore diameter, and specific surface area of the sintered cathodes were detected by X-ray photoelectron spectroscopy, four-point probe, and ASPA 2010. The results showed that TiO2 phase transformations occurred, and oxygen vacancies formed with the increase of sintering temperature. The cathodic conductivity improved, but the average pore diameter and the effective response area of the TiO2 cathode were reduced when the sintering temperature in- creased. These phenomena could weaken the contact between reaction ions and electrons and also had the same effect on the cathodes and the molten salt. Moreover, they were disadvantageous to ion migration, so a lower sintering temperature was favorable for the microstructure of electrolysis. Consequently, the cathodic conductivity may be improved, but the microstrucatre became compact with the increase of sin- tering temperature. The cathodic products at different temperatures indicated that the cathodic conductivity was more important for electroly- sis.

关键词： titanium dioxidegelectrolysis sintering microstructure

Fast FOCUSS method based on bi-conjugate gradient and its application to space-time clutter spectrum estimation

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Science China(Information Sciences) 2017年第8期60卷 163-175页

作者： Gatai bai Ran TAO Juan ZHAO Xia bai yue WANG School of Mathematics and Statistics Beijing Institute of Technology Beijing Key Laboratory of Fractional Signals and Systems School of Information and Electronics Beijing Institute of Technology

The focal underdetermined system solver(FOCUSS) is a powerful tool for sparse representation in complex underdetermined systems. This paper presents the fast FOCUSS method based on the bi-conjugate gradient(BICG), termed BICG-FOCUSS, to speed up the convergence rate of the original FOCUSS. BICGFOCUSS was specifically designed to reduce the computational complexity of FOCUSS by solving a complex linear equation using the BICG method according to the rank of the weight matrix in FOCUSS. Experimental results show that BICG-FOCUSS is more efficient in terms of computational time than FOCUSS without losing accuracy. Since FOCUSS is an efficient tool for estimating the space-time clutter spectrum in sparse recoverybased space-time adaptive processing(SR-STAP), we propose BICG-FOCUSS to achieve a fast estimation of the space-time clutter spectrum in mono-static array radar and in the mountaintop system. The high performance of the proposed BICG-FOCUSS in the application is demonstrated with both simulated and real data.

关键词： focal underdetermined system solver(FOCUSS) sparse recovery(SR) bi-conjugate gradient(BICG) space-time adaptive processing(STAP) space-time clutter spectrum

RELAXED ASYNCHRONOUS ITERATIONS FOR THE LINEAR COMPLEMENTARITY PROBLEM

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Journal of Computational Mathematics 2002年第1期20卷 97-112页

作者： Zhong-zhi bai Yu-guang Huang LSEC ICMSECAcademy of Mathematics and Systems SciencesChinese Academy of SciencesBeijing 100080China Oxford University Computing Laboratory Wolfson BuildingParks RoadOxford OX1 3QDU.K.

Presents a class of relaxed asynchronous parallel multisplitting iterative methods for solving the linear complementarity problem on multiprocessor systems. Establishment of the methods; Convergence theories; Numerica... 详细信息

关键词： linear complementarity problem matrix multisplitting relaxation method asynchronous iteration convergence theory

Counterion-Mediated Hydrogen Bonding Making Strong Polyelectrolytes pH-Responsive:Current Understanding and Perspectives

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Chinese Journal of Polymer Science 2024年第9期42卷 1270-1277,I0005页

作者： yue Huang guang-Tao Mei Zan Hua guang-Ming Liu Hefei National Research Center for Physical Sciences at the Microscale Department of Chemical PhysicsKey Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei230026China The Key Laboratory of Functional Molecular Solids Ministry of Educationand Department of Materials ChemistrySchool of Chemistry and Materials ScienceAnhui Normal UniversityWuhu214002China

The counterion-mediated hydrogen bonding(CMHB)is related to the hydrogen bonding between bound counterions and polyelectrolyte chains in polyelectrolyte systems,where the counterions can both electrostatically bind to the charged groups of polyelectrolyte chains and act as hydrogen bond donors or acceptors to form hydrogen bonds with the hydrogen bond sites associated with polyelectrolyte chains simultaneously.A large number of literatures illustrate that strong polyelectrolytes(SPs)are insensitive to pH,which severely limmits the applications of SPs as smart ***,our studies have demonstrated that the CMHB makes SPs *** perspective discusses the mechanism of pH responsiveness of SPs and the pH-tunable properties of SPs,based on the pH-controlled CMHB *** future research directions on the pH responsiveness of SPs are also discussed *** is anticipated that the study of the pH responsiveness of SPs not only will provide a new understanding of the fundamental properties of SPs,but also will greatly expand the applications of SPs in the field of smart materials.

关键词： Counterion binding Hydrogen bond Polyelectrolyte brush Polyelectrolyte complexation

Artificial Intelligence: Enabling Technology to Empower Society

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Engineering 2020年第3期6卷 205-206页

作者： yue-guang Lyu Department of Information and Electronic Engineering Chinese Academy of EngineeringBeijing 100088China

Artificial intelligence(AI)can be used to tackle problems that are difficult or impractical to solve using traditional *** general,the fundamental goals of AI are to enable machines to possess sensing(e.g.,speech recognition,natural language understanding,and/or computer vision),problem-solving/decision-making(e.g.,searching and/or planning),and acting(e.g.,robotics)capabilities that only humans or other intelligent creatures would naturally have.

关键词： computer searching enable

Distributions and sources of n-alkanes in PM_(2.5) at urban,industrial and coastal sites in Tianjin,China

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Journal of Environmental Sciences 2010年第10期22卷 1551-1557页

作者： Weifang Li yue Peng Zhipeng bai State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control College of Environmental Science and Engineering Nankai University Tianjin 300071 China. Tianjin Academy of Environmental Protection Science Tianjin 300191 China Liaoning Provincial Environmental Monitoring Center Shenyang 110031 China

Aliphatic hydrocarbons （n-alkanes） associated with fine particulate matter were determined in the ambient air of urban, industrial and coastal areas in Tianjin, China, where intensive coal burning for industrial and domestic purpose takes place, n-Alkane homologues from C12 to C35 were quantifiable in all samples with C20-C31 being the most abundant species. Average concentrations of the total n-alkanes were 148.7, 250.1 and 842.0 ng/m3 in July, April and January, respectively. Seasonal variations were mainly attributed to ambient temperature changes and coal combustion for residential heating. Among the three studied areas, the highest levels of n-alkanes were observed in the industrial complex in winter and spring, but in summer the coastal alkane concentration moved up to the highest. A mono-modal distribution for n-alkanes was observed in spring and summer with odd carbon number predominance and a maximum centered at C27-C31, suggesting the release of plant wax into the atmosphere. The bimodal distribution with maxima at C22 and C26 observed in winter indicated a substantial influence of fossil fuel sources. All the CPIs （CPI1, CPI2, CPI3） values, varying between 0.64 and 1.97, indicated the influence of anthropogenic emissions on fine organic aerosols. The estimated contributions of plant wax to total n-alkanes were on average of 12.9%, 19.1% and 26.1% for winter, spring and summer, respectively.

关键词： PM2.5 n-alkanes distribution pattern CPIs plant wax