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稀土发光材料的研究进展

人工晶体学报 2015年第10期44卷 2641-2651页

作者：洪广言中国科学院长春应用化学研究所长春130022

稀土发光材料已在众多领域获得广泛的应用,并且已成为稀土应用的主要领域之一。本文归纳了白光LED用稀土荧光粉、稀土光转换材料、稀土上转换发光材料、稀土纳米发光材料、真空紫外发光材料、稀土配合物电致发光材料和稀土闪烁体等的研... 详细信息

稀土发光材料已在众多领域获得广泛的应用,并且已成为稀土应用的主要领域之一。本文归纳了白光LED用稀土荧光粉、稀土光转换材料、稀土上转换发光材料、稀土纳米发光材料、真空紫外发光材料、稀土配合物电致发光材料和稀土闪烁体等的研究最新进展,并对未来发展趋势进行了展望。

关键词：稀土发光材料荧光粉白光LED

Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis

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World Journal of Gastroenterology 2021年第28期27卷 4722-4737页

作者： Xu-Xia He Ying-He Li Peng-guang yan Xiang-Chen Meng Chu-yan Chen Ke-Min Li Jing-Nan Li Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China

BACKGROUND Dysbacteriosis may be a crucial environmental factor for ulcerative colitis(UC).Further study is required on microbiota alterations in the gastrointestinal tract of patients with UC for better clinical management and *** To analyze the relationship between different clinical features and the intestinal microbiota,including bacteria and fungi,in Chinese patients with *** Eligible inpatients were enrolled from January 1,2018 to June 30,2019,and stool and mucosa samples were *** was diagnosed by endoscopy,pathology,Mayo Score,and Montreal *** amplicon sequencing of 16S rRNA gene and fungal internal transcribed spacer gene was used to detect the intestinal microbiota *** diversity,principal component analysis,similarity analysis,and Metastats analysis were employed to evaluate differences among *** A total of 89 patients with UC and 33 non-inflammatory bowel disease(IBD)controls were *** bacterial analysis,72 stool and 48 mucosa samples were obtained from patients with UC and 21 stool and 12 mucosa samples were obtained from the *** fungal analysis,stool samples were obtained from 43 patients with UC and 15 controls.A significant difference existed between the fecal and mucosal bacteria of patients with ***α-diversity of intestinal bacteria and the relative abundance of some families,such as Lachnospiraceae and Ruminococcaceae,decreased with the increasing severity of bowel inflammation,while Escherichia-Shigella showed the opposite *** intermicrobial correlations in UC in remission than in active patients were *** bacteriafungi correlations became single and uneven in patients with *** The intestinal bacteria flora of patients with UC differs significantly in terms of various sample types and disease *** intermicrobial correlations change in patients with UC compared with non-IBD controls.

关键词： Ulcerative colitis Intestinal microbiota Intermicrobial correlation Bacteria Fungi Chinese

Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells

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World Journal of Gastrointestinal Oncology 2023年第3期15卷 464-489页

作者： Jia-Xiang Zhang Sheng-Chuan Bao Juan Chen Ting Chen Hai-Liang Wei Xiao-yan Zhou Jing-Tao Li Shu-guang yan College of Basic Medicine Shaanxi University of Chinese MedicineXianyang 712046Shaanxi ProvinceChina Key Laboratory of Gastrointestinal Diseases and Prescriptions in Shaanxi Province Shaanxi University of Chinese MedicineXianyang 712046Shaanxi ProvinceChina Department of General Surgery The Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Department of Gastroenterology The Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Departments of Infectious Disease The Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina

BACKGROUND Gastric precancerous lesions(GPL)precede the development of gastric cancer(GC).They are characterized by gastric mucosal intestinal metaplasia and dysplasia caused by various factors such as inflammation,bacterial infection,and *** in autophagy and glycolysis affect GPL progression,and their effective regulation can aid in GPL treatment and GC *** decoction(XJZ)is a classic compound for the treatment of digestive system diseases in ancient China which can inhibit the progression of ***,its specific mechanism of action is still *** To investigate the therapeutic effects of XJZ decoction on a rat GPL model and the mechanisms underlying its effects on autophagy and glycolysis regulation in *** Wistar rats were randomly divided into six groups of five rats each and all groups except the control group were subjected to GPL model construction for 18 *** rats’body weight was monitored every 2 wk starting from the beginning of *** histopathology was examined using hematoxylin-eosin staining and Alcian blue-periodic acid-Schiff *** was observed using transmission electron *** expressions of autophagy,hypoxia,and glycolysis related proteins in gastric mucosa were detected using immunohistochemistry and *** expressions of the following proteins in gastric tissues:B cell lymphoma/Leukemia-2 and adenovirus E1B19000 interacting protein 3(Bnip-3),microtubule associated protein 1 light chain 3(LC-3),moesin-like BCL2-interacting protein 1(Beclin-1),phosphatidylinositol 3-kimase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),p53,AMP-activated protein kinase(AMPK),and Unc-51 like kinase 1(ULK1)were detected using western *** relative expressions of autophagy,hypoxia,and glycolysis related mRNA in gastric tissues was detected using reverse transcription-polymerase chain *** Treatment with XJZ increased the rats’body we

关键词： Xiaojianzhong decoction Gastric precancerous lesions Autophagy Glycolysis Gastric mucosal cells Herb

Application of internal fixation of steel-wire limited loop in early Achilles tendon rupture

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Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 902-907页

作者： Zhe Chen Jia-Sen Wei Zhao-yang Hou Jiong Hu yan-guang Cao Qi-Xin Chen Department of Orthopaedics The Second Affiliated Hospital of Zhejiang Chinese Medical University Department of Orthopaedics The Second Affiliated Hospital of Zhejiang University School of Medicine

Objective:To explore the clinical effect and safety of internal fixation of steel-wire limited loop in early Achilles tendon ***:Seventy-six patients respectively with early transected and avulsed types of Achilles tendon rupture were selected and treated with internal fixation of steel-wire limited *** patients began to take exercise for their lower limbs through continous passive motion as early as possible after surgical repair,and the loops were removed after 3-5 *** months later,the condition of complications including Achilles tendon re-rupture,wound fistula,wound infection and skin necrosis,cutaneous sensation in sural nerve dominance region,time back to preinjury work or learning as well as time to physical activities were *** year later,the therapeutic effect was evaluated,and the maximum circumferences of bilateral legs and raptured plane circumferences of Achilles tendon were ***:The wound of all patients healed well,no complications like Achilles tendon re-rupture,wound fistula,wound infection and skin necrosis occured,and the cutaneous sensation in sural nerve dominance region was *** mean time back to preinjury work or learning as well as to pysical activities of all patients were respectively 10 and 22 *** out of 76 patients(92.1%) achieved an excellent effect,and 6(7.9%) good *** excellent and good rate came up to 100%.The maximum circumference in the affected leg decreased to 2 mm averagely compared with the offside,while the ruptured plane circumferences of Achilles tendon in the affected side increased to 2.2 mm compared with the ***:Kor early Achilles tendon rupture,internal fixation of steel-wire limited loop can recover the ankle function better,return to the preinjury state in the shortest lime,and has few complications.

关键词： Achilles tendon rupture Steel-wire limited loop Internal fixation Ankle function

Seepage-heat transfer coupling process of low temperature return water injected into geothermal reservoir in carbonate rocks in Xian County,China

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Journal of Groundwater Science and Engineering 2020年第4期8卷 305-314页

作者： WANG yan LIU yan-guang BIAN Kai ZHANG Hong-liang QIN Shen-jun WANG Xiao-jun Key Laboratory of Resource Exploration Research of Hebei Province Hebei University of EngineeringHandan 056038Hebei ProvinceChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological Sciences Shijiazhuang 050061China Technology Innovation Center for Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China Hydrological Geological Team of Hebei Province Coal Geology Bureau Handan 056000China

Fracture seepage and heat transfer in the geothermal reservoir of carbonate rocks after the reinjection of low temperature geothermal return water is a complex coupling process,which is also the frontier of geothermal production and reinjection *** on the research of cascade comprehensive development of geothermal resources in Beijing-Tianjin-Hebei(Xian County),the carbonate geothermal reservoir of Wumishan formation in the geothermal field in Xian County is *** the development of the discrete fracture network model and the coupling model of seepage and heat transfer,the numerical solution of seepage field and temperature field with known fracture network is reached using the finite element software COMSOL,and the coupling process of seepage flow and heat in carbonate rocks is *** results show that the distribution of temperature field of fractured rocks in geothermal reservoir of carbonate rocks has strong non-uniformity and *** fracture network is interpenetrated,which constitutes the dominant channel of water conduction,and along which the fissure water moves *** the influence of convective heat transfer and conductive heat transfer,one of the main factors to be considered in the study of thermal breakthrough is to make the cold front move forward *** the reinjection and production process continues for a long time and the temperature of the geothermal reservoir on the pumping side drops to a low level,the temperature of bedrocks is still relatively high and continues to supply heat to the fissure water,so that the temperature of the thermal reservoir on the pumping side will not decrease rapidly to the water temperature at the inlet of reinjection,but will gradually decrease after a long period of time,showing an obvious long tail *** distribution of fractures will affect the process of seepage and heat transfer in carbonate reservoirs,which should be considered in the study of fluid thermal

关键词： Carbonate reservoir Geothermal reinjection Fractured rock mass Fluid thermal coupling

Sepsis one-hour bundle management combined with psychological intervention on negative emotion and sleep quality in patients with sepsis

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World Journal of Psychiatry 2024年第2期14卷 266-275页

作者： Ming Xia guang-yan Dong Shi-Chao Zhu Huan-Min Xing Li-Ming Li Department of Intensive Care Unit Henan Provincial Key Medicine Laboratory of NursingHenan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Nursing Henan Provincial Key Medicine Laboratory of NursingHenan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou 450003Henan ProvinceChina

BACKGROUND Sepsis is a serious infectious disease caused by various systemic inflammatory responses and is ultimately *** usually experience depression and anxiety,which affect their sleep quality and post-traumatic growth *** To investigate the effects of sepsis,a one-hour bundle(H1B)management was combined with psychological intervention in patients with *** This retrospective analysis included 300 patients with sepsis who were admitted to Henan Provincial People’s Hospital between June 2022 and June *** to different intervention methods,the participants were divided into a simple group(SG,n=150)and combined group(CG,n=150).H1B management was used in the SG and H1B management combined with psychological intervention was used in the *** changes of negative emotion,sleep quality and post-traumatic growth and prognosis were compared between the two groups before(T0)and after(T1)*** After intervention(T1),the scores of the Hamilton Anxiety scale and Hamilton Depression scale in the CG were significantly lower than those in the SG(P<0.001).Sleep time,sleep quality,sleep efficiency,daytime dysfunction,sleep disturbance dimension score,and the total score in the CG were significantly lower than those in the SG(P<0.001).The appreciation of life,mental changes,relationship with others,personal strength dimension score,and total score of the CG were significantly higher than those of the SG(P<0.001).The scores for mental health,general health status,physiological function,emotional function,physical pain,social function,energy,and physiological function in the CG were significantly higher than those in the SG(P<0.001).The mechanical ventilation time,intensive care unit stay time,and 28-d mortality of the CG were significantly lower than those of the SG(P<0.05).CONCLUSION H1B management combined with psychological intervention can effectively alleviate the negative emotions of patients with sepsis and inc

关键词： Cluster management Psychological intervention Sepsis Negative emotions Sleep quality Post-traumatic growth

The PcERF5 promotes anthocyanin biosynthesis in red-fleshed pear(Pyrus communis)through both activating and interacting with PcMYB transcription factors

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Journal of Integrative Agriculture 2023年第9期22卷 2687-2704页

作者： CHANG Yao-jun CHEN Guo-song yanG guang-yan SUN Cong-rui WEI Wei-lin Schuyler S.KORBAN WU Jun College of Horticulture State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjing 210095P.R.China Department of Natural Resources and Environmental Sciences University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

As there is a strong interest in red-skinned pears,the molecular mechanism of anthocyanin regulation in red-skinned pears has been widely investigated;however,little is known about the molecular mechanism of anthocyanin regulation in red-fleshed pears due to limited availability of such germplasm,primarily found in European pears(Pyrus communis).In this study,based on transcriptomic analysis in red-fleshed and white-fleshed pears,we identified an ethylene response factor(ERF)from ***,PcERF5,of which expression level in fruit flesh was significantly correlated with anthocyanin *** then verified the function of PcERF5 in regulating anthocyanin accumulation by genetic transformation in both pear skin and apple ***5 regulated anthocyanin biosynthesis by different regulatory *** the one hand,PcERF5 can activate the transcription of flavonoid biosynthetic genes(PcDFR,PcANS and PcUFGT)and two key transcription factors encoding genes PcMYB10 and *** the other hand,PcERF5 interacted with PcMYB10 to form the ERF5-MYB10 protein complex that enhanced the transcriptional activation of PcERF5 on its target *** results suggested that PcERF5 functioned as a transcriptional activator in regulating anthocyanin biosynthesis,which provides new insights into the regulatory mechanism of anthocyanin *** new knowledge will provide guidance for molecular breeding of red-fleshed pear.

关键词： Pyrus communis red-fleshed anthocyanin biosynthesis PcERF5 PcMYB10/PcMYB114

Reconstruction of deep fluid chemical constituents for estimation of geothermal reservoir temperature using chemical geothermometers

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Journal of Groundwater Science and Engineering 2017年第2期5卷 173-181页

作者： LIU yan-guang LIU Bing LU Chuan ZHU Xi WANG Gui-ling Institute of Hydrogeology and Environmental Geology CAGS Shijiazhuang 050061 China

This paper elaborates the chemical constituent change principles of deep geothermal fluid during the process of upward movement. It summarizes research methods of hydrochemistry, isotope and numerical modelling technique for the physiochemical processes such as decreasing temperature, shallow groundwater infusion, and degassing. The multi-component chemical geothermometry methods including gas geochemical method are discussed. High-temperature geothermal fields in China are mostly located in the southwest with frequent new tectonic movements, especially in Tibet high-temperature geothermal areas. Therefore the paper also focuses the status of high-temperature geothermal fluid research. At last, it's pointed out in the paper that in the future we can start from typical high-temperature geothermal zones and geothermal fields to explore optimization of the multi-component geothermometry method and use it in the reconstruction and analogue of the formation mechanism and internal relevancy of regional geothermal systems.

关键词： High temperature geothermal fluid Multi-component geothermometer optimization Geothermal gases Analogue

Inhibition of the immunoproteasome LMP_(2) ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

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Military Medical Research 2022年第4期9卷 404-418页

作者： Xing-Yong Chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin yan-guang Mao Xiao-Hua Yu Yin-Zhou Wang Department of Neurology Fujian Provincial HospitalShengli Clinical Medical College of Fujian Medical UniversityNo.134DongjieGulou DistrictFuzhou 350001China Fujian Academy of Medical Science Fuzhou 350o01China Key Testing Laboratory of Fujian Province Fuzhou 350001China.

Background:Disruption of the blood–brain barrier(BBB)after a stroke can lead to brain injury and neurological *** work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2(LMP2)in the pathophysiology of ischemia ***,the relationship between the immunoproteasome LMP2 and the BBB remains ***:Adult male Sprague–Dawley rats were subjected to transient middle cerebral artery occlusion/reperfusion(MCAO/R).Three days before MCAO,the rats were treated with lentivirus-mediated LMP2 shRNA preparations by stereotactical injection into the ipsilateral hemispheric *** rat brain microvascular endothelial cell(RBMVEC)line was exposed to oxygen–glucose deprivation/reperfusion(OGD/R)to mimic ischemic conditions in *** RNA interference-mediated knockdown of LMP2 orβ-catenin was analysed in vivo and in *** of the quantity of extravasated Evans blue(EB)and cerebral fluorescent angiography were performed to evaluate the integrity of the *** and Western blotting were employed to detect the expression of target *** migration was evaluated using a scratch migration *** results of immunofluorescence,Western blotting and cell migration were quantified using the software ImageJ(Version 1.53).Parametric data from different groups were compared using one-way ANOVA followed by the least significant difference(LSD)***:Cerebral ischemia led to lower levels of structural components of the BBB such as tight junction proteins[occludin,claudin-1 and zonula occludens(ZO-1)]in the MCAO/R group compared with the sham group(P<0.001).However,inhibition of the immunoproteasome LMP2 restored the expression of these proteins,resulting in higher levels of occludin,claudin-1 and ZO-1 in the LMP2-shRNA group compared with the control-shRNA group(P<0.001).In addition,inhibition of the immunoproteasome LMP2 contributed to higher microvascular density and decreased BBB perm

关键词： Immunoproteasome Blood–brain barrier Wnt/β-catenin pathway Oxygen–glucose deprivation/reperfusion Cerebral ischemia