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International Journal of Ophthalmology(English edition) 2023年第6期16卷 939-946页

作者： Qin Zhu guang-Yong Tang Zhi-Juan Hua Li-Ping Xue Yuan Zhou Jie-Ying Zhang Ying-Ting Zhu Xiao-Fan Zhang Department of Pediatric Ophthalmology Affiliated Hospital of Yunnan UniversityKunming 650021Yunnan ProvinceChina Department of Ophthalmology People’s Hospital of Xundian CountyKunming 655200Yunnan ProvinceChina BioTissue(Tissue Tech Inc.)Ocular Surface Centerand Ocular Surface Research&Education FoundationMiamiFL 33126USA

·AIM:To evaluate the effect of 0.05%atropine on the control of myopia for 2y(phase I)and on spherical equivalent refraction(SER)progression for 1y(phase II)after its withdrawal in Chinese myopic children.·METHODS:Totally 142 children with myopia were randomly assigned to the 0.05%atropine group or to the placebo group.In phase I,children received 1 treatment for each eye daily.In phase II,the patients received no treatment.Axial length(AL),SER,intraocular pressure(IOP)and atropine-related side effects were assessed at 6 months’intervals.·RESULTS:During phase I,the mean change of SER was-0.46±0.30 D in the atropine group,compared to-1.72±1.12 D in the placebo group(P0.05).Furthermore,the change in SER from the atropine group was 0.50±0.41 D,which was significantly lower than 0.72±0.60 D from placebo group,(P0.05).·CONCLUSION:The use of 0.05%atropine for two consecutive years may effectively control elongation of AL and thus progression of myopia,without significant SER progression 1y after atropine withdrawal.Therefore,treatment with 0.05%atropine daily for 2y is effective and safe.

关键词： atropine axial length spherical equivalent refraction children myopia

Hemodynamics in Transplant Renal Artery Stenosis and its Alteration after Stent Implantation Based on a Patient-specific Computational Fluid Dynamics Model

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Chinese Medical Journal 2017年第1期130卷 23-31页

作者： Hong-yang Wang Long-Shan Liu Hai-Ming Cao Jun Li Rong-Hai Deng Qian Fu Huan-Xi Zhang Ji-guang Fei Chang-Xi Wang Organ Transplant Center The First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China guangdong Provincial Key Laboratory on Organ Donation and Transplant Immunology Guangzhou Guangdong 510080 China

Background： Accumulating studies on computational fluid dynamics （CFD） support the involvement of hemodynamic factors in artery stenosis. Based on a patient-specific CFD model, the present study aimed to investigate the hemodynamic characteristics of transplant renal artery stenosis （TRAS） and its alteration after stent treatment. Methods： Computed tomography angiography （CTA） data of kidney transplant recipients in a single transplant center from April 2013 to November 2014 were reviewed. The three-dimensional geometry of transplant renal artery （TRA） was reconstructed from the qualified CTA images and categorized into three groups： the normal, stenotic, and stented groups. Hemodynamic parameters including pressure distribution, velocity, wall shear stress （WSS）, and mass flow rate （MFR） were extracted. The data of hemodynamic parameters were expressed as median （interquartile range）, and Mann-Whitney U-test was used for analysis. Results： Totally, 6 normal, 12 stenotic, and 6 stented TRAs were included in the analysis. TRAS presented nonuniform pressure distribution, adverse pressure gradient across stenosis throat, flow vortex, and a separation zone at downstream stenosis. Stenotic arteries had higher maximal velocity and maximal WSS （2.94 [2.14, 3.30] vs. 1.06 /0.89, 1.15] m/s, 256.5 [149.8, 349.4] vs. 41.7 [37.8, 45.3] Pa at end diastole, P - 0.001 ; 3.25 [2.67, 3.56] vs. 1.65 [ 1.18, 1.72] m/s, 281.3 [ 184.3,364.7] vs. 65.8 [61.2, 71.9] Pa at peak systole, P - 0.001 ） and lower minimal WSS and MFRs （0.07 [0.03, 0.13] vs. 0.52 [0.45, 0.67] Pa, 1.5 [1.0, 3.0] vs. 11.0 [8.0, 11.3] g/s at end diastole, P = 0.001 ; 0.08 [0.03, 0.19] vs. 0.70 [0.60, 0.81] Pa, 2.0 [1.3, 3.3] vs. 16.5 [13.0, 20.3] g/s at peak systole, P 0.001） as compared to normal arteries. Stent implantation ameliorated all the alterations of the above hemodynamic factors except low WSS. Conclusions： Hemodynamic factors were significantly changed in severe TRAS. Stent implantation can restore or ameliorate deleterious change of hemodynamic factor

关键词： Hemodynamics Kidney Transplantation Patient-specific Modeling Renal Artery Obstruction

Nickel-Catalyzed Cross-Electrophile Vinyl–Vinyl Coupling:An Approach to Structurally Versatile Dienylboronates

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CCS Chemistry 2022年第3期4卷 864-871页

作者： guang-Li Xu Chun-Yan Liu Xiaobo Pang Xue-Yuan Liu Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry(SKLAOC) College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000

Cross C–C bond formation of two vinyl electrophiles is a long-standing challenge in synthetic chemistry.Herein,we report a nickel-catalyzed reductive vinyl–vinyl coupling between vinyl triflates and boron-substituted vinyl bromides.This new protocol offers facile access to dienylboronates with high structural complexity and molecular diversity.The reaction proceeds with a broad substrate scope under very mild conditions.The synthetic utility of the method is highlighted by its gram-scale reaction,modification of complex molecules,and diverse transformation of the products.

关键词： nickel boron dienes cross-coupling reductive coupling

海南沉香灸治疗轻度抑郁性失眠患者的疗效观察

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世界中西医结合杂志 2024年第1期19卷 150-155页

作者：张光彩潘佳慧张海英郑卜通海南省中医院康复科海南海口570203 海南医学院海南海口571199 海南省中医院脑病科海南海口570203 海南省中医院推拿科海南海口570203

目的探讨海南沉香灸对轻度抑郁性失眠患者的影响。方法选取2020年11月—2022年1月期间因抑郁性失眠于海南省中医院康复科门诊就诊的85例患者,按随机数字表法分为沉香灸组30例、艾灸组30例、安慰灸组25例。沉香灸组采用针刺、耳穴埋针联... 详细信息

目的探讨海南沉香灸对轻度抑郁性失眠患者的影响。方法选取2020年11月—2022年1月期间因抑郁性失眠于海南省中医院康复科门诊就诊的85例患者,按随机数字表法分为沉香灸组30例、艾灸组30例、安慰灸组25例。沉香灸组采用针刺、耳穴埋针联合海南沉香灸治疗,艾灸组采用针刺、耳穴埋针联合艾灸治疗,安慰灸组采用针刺、耳穴埋针联合安慰灸治疗。治疗2、4、8周后和随访期间,观察比较两组患者临床疗效及治疗前后汉密尔顿抑郁评分(Hamilton depression score,HAMD)、匹兹堡睡眠质量指数量表评分(Pittsburgh sleep quality index,PSQI)、抑郁自评量表评分(Self-rating depressive scale,SDS)。结果治疗后沉香灸组总有效率93.33%(28/30)、艾灸组总有效率73.33%(22/30)均明显高于安慰灸组44.00%(11/25),差异有统计学意义(P<0.05);且沉香灸组总有效率明显高于艾灸组,差异有统计学意义(P<0.05)。治疗2、4、8周后及随访期间,3组患者HAMD评分均较治疗前降低,差异有统计学意义(P<0.05);沉香灸组和艾灸组HAMD评分均低于安慰灸组,差异有统计学意义(P<0.05);治疗8周后及随访期间,沉香灸组HAMD评分低于艾灸组,差异有统计学意义(P<0.05)。治疗2、4、8周后及随访期间,3组患者PSQI评分均较治疗前降低,差异有统计学意义(P<0.05);沉香灸组和艾灸组PSQI评分均低于安慰灸组,差异有统计学意义(P<0.05);沉香灸组PSQI评分低于艾灸组,差异有统计学意义(P<0.05)。治疗2、4、8周后及随访期间,3组患者SDS评分均较治疗前降低,差异有统计学意义(P<0.05);沉香灸组和艾灸组SDS评分均低于安慰灸组,差异有统计学意义(P<0.05);治疗4、8周后及随访期间,沉香灸组SDS评分均低于艾灸组,差异有统计学意义(P<0.05)。结论沉香灸和艾灸可改善轻度抑郁性失眠患者的抑郁症状和睡眠,沉香灸对抑郁症状和睡眠改善优于艾灸。

关键词：海南沉香灸抑郁性失眠艾灸汉密尔顿抑郁评分匹兹堡睡眠质量指数量表抑郁自评量表

叶黄素衍生物替代叶黄素对肉鸡着色、组织色素含量、抗氧化、肝功能的影响

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饲料研究 2024年第11期47卷 44-50页

作者：刘伊笑付连港石玉祥刘华赵剑刘秀斌宋伟光曾建国河北工程大学生命科学与食品工程学院河北邯郸056038 湖南农业大学动物科学技术学院湖南长沙410128 晨光生物科技集团股份有限公司河北邯郸057250 湖南农业大学动物医学院湖南长沙410128 河北省植物源动物保健品技术创新中心河北邯郸057250

试验研究饲粮添加叶黄素和叶黄素衍生物对黄羽肉鸡皮肤着色、组织色素含量及抗氧化能力的调控作用。将432只37日龄的三黄肉鸡随机分为4组,每组6个重复,每个重复18只鸡。对照组饲喂小麦-豆粕型基础饲粮,各试验组分别在基础饲粮中添加叶黄... 详细信息

试验研究饲粮添加叶黄素和叶黄素衍生物对黄羽肉鸡皮肤着色、组织色素含量及抗氧化能力的调控作用。将432只37日龄的三黄肉鸡随机分为4组,每组6个重复,每个重复18只鸡。对照组饲喂小麦-豆粕型基础饲粮,各试验组分别在基础饲粮中添加叶黄素40 mg/kg(叶黄素组)、24 mg/kg叶黄素与16 mg/kg叶黄素衍生物(叶黄素+叶黄素衍生物组)、40 mg/kg叶黄素衍生物(叶黄素衍生物组)。试验期28 d。结果表明:与对照组相比,各试验组肉鸡的喙、鸡胫和翅下皮肤的黄度值显著升高(P0.05);各试验组肉鸡血清胆固醇(TC)含量显著升高(P<0.05);肉鸡翅下皮肤G蛋白偶联受体143(GPR143)基因表达量显著下降(P<0.05)。研究表明,叶黄素和叶黄素衍生物可以改善肉鸡皮肤的色度值,提高机体的抗氧化能力,对肉鸡肝脏无不良影响,叶黄素衍生物(16 mg/kg)部分替代叶黄素不影响叶黄素的着色效果和抗氧化效果。

关键词：叶黄素衍生物肉鸡抗氧化皮肤颜色

The effects of gas models on the predicted performance and flow of a centrifugal refrigeration compressor stage

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Science China(Technological Sciences) 2008年第8期51卷 1160-1168页

作者： WANG ZhiHeng XI guang School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

In this paper three perfect gas models with constant specific heat or with variable specific heat and one real gas model based on the gas property tables are respec- tively considered to implement into the three-dimensional CFD (computational fluid dynamics) analysis of a centrifugal refrigeration compressor stage. The results show that the gas models applied to the CFD code have significant influences on the performance of stage and the flow structures in the stage. Although the ther- modynamics operating condition of evolving fluid in the centrifugal refrigeration compressor has a significant deviation from the perfect gas, the perfect gas model with the modified value of gas constant and the variable specific heat offers a good prediction of stage performance. To predict some basic fluid flow parameters and flow structure accurately, the real gas effects should be considered and the rea- sonably accurate thermodynamic properties based on the analytical gas equation of state or numerical interpolation of gas tables should be applied to the CFD code.

关键词： gas model numerical analysis centrifugal refrigeration compressor

Theoretical study on the reaction of NbS^+(~3∑^-,~1Γ) with CO

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Chinese Chemical Letters 2009年第6期20卷 755-758页

作者： Shi Wen Yu TaoHong Li Xiao Mei yang Li Qing Yin Li Feng Yao Xiao guang Xie Department of Chemistry Yunnan University Kunming 650091 China Department of Chemistry Qujing Normal University Qujing 650011 China Faculty of Chemistry Southwest Forestry University Kunming 650224 China Yunnan University of Traditional Chinese Medicine Kunming 650091 China

Two possible reactions of NbS＋（3∑^-, 1Г） with CO in the gas phase have been studied by using B3LYP and CCSD（T） methods： the O/S exchange reaction （NbS^＋＋ CO → NbO^＋＋ CS） and the S-transfer reaction （NbS＋＋ CO → Nb^＋＋ COS）. The two reactions have a one-step mechanism. The barriers of the O/S exchange reaction on the triplet and singlet surfaces are 51.2 and 52.4 kcal/mol, respectively, and the barriers of the S-transfer reaction are 58.3 and 78.0 kcal/mol, respectively. The results indicate that the Stransfer and the O/S exchange reaction of the 3∑^- ground state of NbS＋ are competing, but, for the S-transfer reaction, the 1F exited state is more reactive. The differences between the reactions of NbS＋（3∑^_, 1Г） and VS＋（3∑^_, 1Г） are discussed.

关键词： Niobium sulfide cation CO Reaction CCSD（T）

Risk factors for postoperative recurrence of cardiac myxoma and the clinical managements： a report of 5 cases in one center and review of literature

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Chinese Medical Journal 2012年第16期125卷 2914-2918页

作者： SHENG Wen-bo LUO Bei-er LiU yang ZHANG Hao ZOU Liang-jian XU Zhi-yun ZHANG Hai-yan JI guang-yu Department of Cardiothoracic Surgery Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Cardiothoracic Surgery Department of Prevention and Health Care Changhai Hospital Second Military Medical University Shanghai 200433 China

Background Recurrence or metastasis of myxomas is not rare risk factors for postoperative cardiac myxoma recurrence and to classification. and can lead to malignancy. We aimed to analyze the summarize its clinical characteristics, treatments and Methods The clinical data of 5 patients with recurrent cardiac myxoma were retrospectively analyzed and our clinical experience was summarized. Moreover, the relevant literatures were reviewed. Results All the five cases of primary myxomas were derived from atypical positions. One patient had early distant metastasis, one had family history, and two suffered malignant recurrence. The recurrence interval was （2.30＋2.16） years and the recurrent tumors were all found in different chambers from those of the corresponding primary tumors. Re-operation was performed after recurrence. One patient died of heart failure after malignant recurrence, and the other 4 cases had satisfactory therapeutic outcomes after re-operations. Our experience advocated a clinical classification of ＂typical＂ and ＂atypical＂ cardiac myxoma, the typical myxomas referred to the tumors locating at the left atria, with single pedicle, rooted at or around the fossa ovalis, involving no genetic causes, and the atypical myxomas included the familial tumors, tumors stemming from multiple chambers, rooted in abnormal positions of the left atrium, with evident genetic mutation, or with malignant tendency.

关键词： cardiac myxoma recurrence,＂ classification,＂ clinical management

Contralateral C7 Nerve Root Transfer for Function Recovery in Adults： A Meta-analysis

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Chinese Medical Journal 2017年第24期130卷 2960-2968页

作者： Wen-Jun Li Li-Yue He Shan-Lin Chen Yan-Wei Lyu Shu-Feng Wang yang Yong Wen Tian guang-Lei Tian Yu-Dong Gu Department of Hand Surgery Beijing Jishuitan Hospital Beijing 100035 China Department of Health Policy and Management School of Public Health Peking University Health Science Center Beijing 100191 China Department of Hand surgery Huashan Hospital Fudan University Shanghai 200040 China

Background：Root avulsion to all 5 roots of the brachial plexus is a common presentation and keeps a major reconstructive challenge.The contralateral C7 （CC7） nerve transfer has been used in treating brachial plexus avulsion injury （BPAI） since 1986.However,the effectiveness of the procedure remains a subject of controversy.The aim of this meta-analysis was to study surgical outcomes regarding motor and sensory recovery after CC7 nerve transfer.Methods：Chinese or English （i.e.,＂contralateral c-7＂,＂contralateral c7＂,＂c7 nerve root＂,and ＂seventh cervical nerve root＂） keywords were used for a literature search for articles related to CC7 nerve transfer in several databases （i.e.,PubMed,Cochrane,Embase,CNKI,CQVIP,and Wanfang Data）.Clinical research articles were screened,and animal studies as well as duplicate publications were excluded.Muscle strength and sensory recovery were considered to be effective only when the scores on the United Kingdom Medical Research Council scale were equal to or higher than M3 and S3,respectively.Results：The overall ipsilateral recipient nerve recovery rates were as follows：the efficiency rate for muscle strength recovery after CC7 nerve transfer was 0.57 （95% confidence interval [CI]：0.48-0.66） and for sensory recovery was 0.52 （95% CI：0.46-0.58）.When the recipient nerve was the median nerve,the efficiency rate for muscle strength recovery was 0.50 （95% CI：0.39-0.61） and for sensory was 0.56 （95% CI：0.50-0.63）.When the recipient nerve was the musculocutaneous nerve and the radial nerve,the efficiency rate for muscle strength recovery was 0.74 （95% CI：0.65-0.82） and 0.50 （95% CI：0.31-0.70）,respectively.Conclusions：Transfer of CC7 nerves to musculocutaneous nerves leads to the best results.CC7 is a reliable donor nerve,which can be safely used for upper limb function reconstruction,especially for entirely BPAI.When modifying procedures,musculocutaneous nerves and median nerve can be combined as recipient nerves.

关键词： Contralateral C7 Functional Recovery Meta-analysis Nerve Transfer