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Changes of Anti-tuberculosis Herbs Formula during Past Three Decades in Contrast to Ancient Ones

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chinese Journal of Integrative medicine 2021年第5期27卷 388-393页

作者： XU Yu-hui Dai guang-ming TANG Shi-huan YANG Hong-jun SUN Zhao-gang Institute of chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Translational medicine Center Beijing Chest HospitalCapital Medical UniversityBeijing 101149China beijing Key Laboratory in Drug Resistant Tuberculosis Research Beijing Tuberculosis&Thoracic Tumor Research InstituteBeijing 101149China

Objective:To investigate the evolution of herbal medicine in treating tuberculosis(TB)and encourage anti-TB drug discovery and ***:In this study,477 ancient traditional chinese medicine formulae were collected from the Dictionary of traditional chinese medicine Prescriptions and 172 modern chinese medicine formulae(from 1986 to 2016)were collected by searching 4 databases:Wan Fang Data Knowledge Service Platform,china National Knowledge Infrastructure Database(CNKI),china Science and Technology Journal Database(VIP)and chinese Bio-medical Literature and Retrieval System(Sino Med)in *** restricted the search to publications in *** data analysis was done using the traditional chinese medicine Inheritance Support System version 2 ***:There were 425 herbs in the 477 ancient formulae and 257 herbs in the 172 modern *** of the top 30 herbs were shared by both modern and ancient *** are Radix Ophiopogonis,Astragalus membranaceus,Fritillaria cirrhosa,Dried rehmannia glutinosa,Poria cocos,Angelica sinensis,Prepared rehmannia glutinosa,Platycodon Root,Radix paeoniae alba,Schisandra chinensis,Bighead atractylodes rhizome,Rhizoma anemarrhenae,Cortex lycii radicis and Radix *** two groups of herbs with a high correlation coefficient were found in both modern and ancient prescriptions,the Dried rehmannia glutinosa with Radix ophiopogonis,and Radix ophiopogonis with Prepared rehmannia *** were 9 and 15 core herb combinations in modern and ancient prescriptions,respectively,but no one was found simutaniously in both modern and ancient ***:Although there were wide variations in the herb groups and herb combinations in the formulae,half of the top 30 herbs were found in both modern and ancient *** core herb combinations in modern and ancient prescriptions could help us to improve the priscription for treatment of TB.

关键词： herbal formula tuberculosis chinese materia medica anti-tuberculosis herbs

Clinical value of needleless sling in treatment of female stress urinary incontinence

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World Journal of Clinical Cases 2020年第18期8卷 4043-4050页

作者： Yu-Guo Chen Yao-guang Zhang Wei Zhang Xin Li Xia Wang Dressing Room of Surgical Outpatient Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Urology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Nursing Department Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Stress urinary incontinence(SUI)is a common disease in *** emergence of the needle-free sling has led to a new clinical treatment for SUI in *** To explore the clinical value of the needleless sling without acupuncture in the treatment of SUI in *** From February 2017 to November 2018,according to the order of admission,44 patients(mid-suspension group)were treated by tension-free transobturator urethral suspension,and 44 patients(non-acupuncture group)were treated with a needleless non-acupuncture *** clinical effects of the two treatments were *** There was no significant difference between the two groups in the total clinical effectiveness rate(P=0.374),but intraoperative blood loss and visual analogue scale score at postoperative day 1 were significantly lower in the non-acupuncture suspension group than in the middle urethral suspension group(P=0.396).The incidence of complications in the needle-free sling group was significantly lower than that in the middle urethral suspension group(P=0.025).CONCLUSION The clinical effectiveness of acupuncture-free suspension in treating SUI in female patients is better than that of traditional tension-free transobturator mid-urethral suspension.

关键词： No needle sling Female stress urinary incontinence Mid-urethral suspension Controlled study Complications Application value

芪药消渴胶囊逆转2型糖尿病慢性肾脏疾病白蛋白尿的临床观察

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中国糖尿病杂志 2014年第9期22卷 808-810页

作者：倪青姜山肖月星冯兴中李建民朱章志刘敏魏爱生苏秀海高天舒胡筱娟袁志敏张效科中国中医科学院广安门医院内分泌科北京100053 北京世纪坛医院内分泌科北京中西医结合医院内分泌科广州中医药大学第一附属医院内分泌科广东佛山市中医院内分泌科河北省沧州中西医结合医院内分泌科辽宁中医药大学附属医院内分泌科陕西省中医医院内分泌科陕西中医学院附院内分泌科

目的观察芪药消渴胶囊对糖尿病慢性肾脏疾病（CKD）白蛋白尿的影响. 方法采用多中心、随机、双盲、安慰剂对照试验,共224例UAlb/Cr 30～299 mg/24 h患者纳入研究,其中试验（Tre）组116例,对照（PC）组108例,两组在接受常规治疗的基础... 详细信息

目的观察芪药消渴胶囊对糖尿病慢性肾脏疾病（CKD）白蛋白尿的影响. 方法采用多中心、随机、双盲、安慰剂对照试验,共224例UAlb/Cr 30～299 mg/24 h患者纳入研究,其中试验（Tre）组116例,对照（PC）组108例,两组在接受常规治疗的基础上,Tre组加用芪药消渴胶囊,PC组加用安慰剂,治疗16周.比较两组治疗前后UAlb/Cr、肾功能、血糖、血脂等指标的变化. 结果与治疗前相比,治疗后两组UAlb/Cr、肾功能、血糖、血脂等指标均有所改善（P＜0.05）,Tre组与PC组相比差异有统计学意义（P＜0.05）. 结论芪药消渴胶囊能够逆转患者UAlb/Cr 30～299 mg/24 h水平,保护肾功能,延缓CKD的进展.

关键词：芪药消渴胶囊糖尿病慢性肾脏疾病白蛋白尿中药

Effects of Rapamycin on the Differentiation and Function of Macrophages In Vitro

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Agricultural Sciences in china 2009年第5期8卷 620-627页

作者： SHEN Hong WU Guo-juan LIU guang-wei MA Hai-xia LIAO An-yan ZHAO Yong Department of Animal Science and Technology Beijing University of Agriculture Beijing 102206 P.R.China State Key Laboratory of Biomembrane and Membrane Biotechnology/Institute of Zoology Chinese Academy of Sciences Beijing 100101 P.R. China The Third hospital Affiliated to beijing University of chinese medicine Beijing 100029 P.R.China

Macrophages have been generated from bone marrow progenitor cells （BMPCs） with macrophage colony-stimulating factor （M-CSF）. Rapamycin （rapa） is an immunosuppressive drug, which could prevent renal graft rejection and inhibit tumor growth to yield antiproliferative activity in a variety of malignancies. However, the direct effect of rapa on the development of macrophages is unknown. In this study, we explored the direct effect of rapa on the differentiation and function of macrophages differentiated from mouse BMPCs in vitro in the presence of M-CSF. The experimental data showed that rapa prevented the differentiation of macrophagcs by down-regulating CD80 and CD86 expression but upregulating F4/80 expression, as well as by reducing the capacity of differentiated macrophages to stimulate lymphocyte proliferation in the allogeneic mixed lymphocyte reaction. Furthermore, the phagocytic capacity of differentiated macrophages was significantly reduced by rapa. Therefore, rapa may directly inhibit macrophage differentiation and function, which may have been one of the major targets for rapa to mediate its immunosuppressive properties.

关键词： function macrophages rapamycin differentiation

Transcutaneous Electrical Acupoint Stimulation Combined with Warm Acupuncture for Breast Cancer Related Upper Limb Lymphedema:A Retrospective Cohort Study

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chinese Journal of Integrative medicine 2023年第6期29卷 534-539页

作者： LU Chao LI guang-liang DENG De-hou BAO Wen-long WANG Yan ZHANG Ai-qin Department of traditional chinese medicine the Cancer Hospital of University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Hangzhou(310022)China Institute of Basic medicine and Cancer Chinese Academy of SciencesHangzhou(310022)China Department of Breast Medical Oncology the Cancer Hospital of University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Hangzhou(310022)China

Objective To observe the clinical efficacy of transcutaneous electrical acupoint stimulation(TEAS)combined with warm acupuncture in treating breast cancer associated with upper limb lymphedema(BCRL).Methods This was a retrospective cohort study using a paired control ***-two BCRL patients were assigned to the control group(27 cases)and the treatment group(25 cases).The patients in the control group were treated with lymphedema comprehensive detumescence treatment(CDT)for 4 weeks,including systematic therapy composed of manual lymphatic drainage,compression bandage,skincare,and functional *** patients in the treatment group were treated with TEAS combined with warm acupuncture based on the control group *** treatment lasted for 30 min and was applied twice a week for 4 *** arm circumference(AC)of different positions of the affected limb and the degree of swelling of the affected limb were evaluated before the first treatment and after the last *** clinical efficacy was evaluated according to the degree of edema before and after *** adverse events during treatment were *** The patients’AC and the swelling feeling of the affected limb in the treatment group and the control group were both reduced compared with those before *** with the control group,AC of the wrist joint transverse stria,the midpoint between the wrist joint transverse stria and the elbow joint transverse stria in the treatment group were significantly reduced(Pment group was significantly lower than before treatment,and was significantly lower compared with the control group after treatment(Pment group,significantly higher than that in the control group(55.56%,P<0

关键词： transcutaneous electrical acupoint stimulation warm acupuncture breast cancer related upper limb lymphedema comprehensive detumescence treatment clinical efficacy

基于数据挖掘分析中药复方治疗淋巴瘤处方用药规律

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中医肿瘤学杂志 2024年第3期6卷 69-77页

作者：张柏钰杨怀中胡广域杨哲坤中国中医科学院西苑医院北京100091 北京中医药大学东方学院北京061108

目的基于数据挖掘方法分析中药治疗淋巴瘤用药规律,通过总结用药频次、剂量、性味归经及药物间潜在关联和配伍关系等,为临床治疗淋巴瘤组方用药提供参考。方法本文通过检索中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普中... 详细信息

目的基于数据挖掘方法分析中药治疗淋巴瘤用药规律,通过总结用药频次、剂量、性味归经及药物间潜在关联和配伍关系等,为临床治疗淋巴瘤组方用药提供参考。方法本文通过检索中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普中文期刊数据服务平台(VIP)从建库至2023年11月运用口服中药复方治疗淋巴瘤的文献,将符合标准的数据录入Excel 2019,运用古今医案云平台(V2.3.7)、SPSS Modeler 18.0、Origin pro 2021、Gephi V0.9.2,从用药频次、用药剂量、性味归经、药物关联规则、聚类分析、复杂网络分析角度对文献数据进行统计分析。结果最终筛选得到符合标准的文献共172篇,整理并录入中药复方307首,涉及中药共381味,总用药频次4897次。使用频次最高的前10味中药分别是甘草、黄芪、白术、茯苓、半夏、白花蛇舌草、地黄、当归、夏枯草、浙贝母。四气主要为寒、温、平,五味主要为甘、苦、辛,归经主要为肝经、脾经、肺经。关联规则共得到2味药对组合共7组,3味药组合共33组,4味药组合共11组。聚类分析得到6组聚类中药组合。复杂网络分析获得由9个关联性较强中药组成的核心药物组合。结论淋巴瘤患者以肺脾肾不足为本,气滞、痰凝、瘀血、毒邪为标,病位主要在肺、肝、脾、肾,以扶正祛邪、行气健脾、调和气血、化痰散结、化瘀消瘤、清热解毒为法,处方以六君子汤、当归补血汤、四逆散、二陈汤、白术茯苓汤、半夏白术汤、消瘰丸加减。

关键词：淋巴瘤数据挖掘复杂网络分析用药规律

Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia

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Neuroscience Bulletin 2022年第4期38卷 386-402页

作者： Xiang Cui guang Sun Honglei Cao Qun Liu Kun Liu Shuya Wang Bing Zhu Xinyan Gao Department of Physiology Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China Research Center of traditional chinese medicine The Affiliated Hospital of Changchun University of Chinese MedicineChangchunJilin 130021China Department of Cardiology Jining No.1 People’s HospitalJining 272100ShandongChina Department of Needling Manipulation Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China

Myocardial ischemia(MI)causes somatic referred pain and sympathetic hyperactivity,and the role of sensory inputs from referred areas in cardiac function and sympathetic hyperactivity remain ***,in a rat model,we showed that MI not only led to referred mechanical hypersensitivity on the forelimbs and upper back,but also elicited sympathetic sprouting in the skin of the referred area and C8–T6 dorsal root ganglia,and increased cardiac sympathetic tone,indicating sympathetic-sensory ***,intensifying referred hyperalgesic inputs with noxious mechanical,thermal,and electro-stimulation(ES)of the forearm augmented sympathetic hyperactivity and regulated cardiac function,whereas deafferentation of the left brachial plexus diminished *** injection of the α_(2) adrenoceptor(α_(2)AR)antagonist yohimbine and agonist dexmedetomidine in the forearm attenuated the cardiac adjustment by ***,these findings suggest that sensory inputs from the referred pain area contribute to cardiac functional adjustment via peripheral α_(2)AR-mediated sympathetic-sensory coupling.

关键词： Sympathetic-sensory coupling Neuromodulation Referred pain α_(2)adrenoceptor Cardioprotectio

Protective effect of Shouwu Yizhi decoction against vascular dementia by promoting angiogenesis

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chinese Journal of Natural medicines 2017年第10期15卷 740-750页

作者： YANG Xiao-Ni LI Chang-Sheng CHEN Chao TANG Xiao-Yong CHENG guang-Qing LI Xia Department of Tranditional chinese medicine Shandong Qianfoshan hospital Jinan 250014 China Department of Internal medicine Ⅷ Shandong Tumor Hospital Jinan 250014 China Key Laboratory for Tumor Immunology and traditional chinese medicine Immunology Institute of Basic medicine Shandong academy of Medical Sciences Jinan 250062 China

Shouwu is a traditional chinese medicine(TCM)with neuroprotective *** Yizhi decoction(SYD)was designed based on TCM ***,little is known about the roles of SYD in Vascular dementia(Va D).The present study aimed to evaluate the potential effects of SYD on the vascular cognitive impairment and explore the underlying mechanism by establishing focal cerebral ischemia/reperfusion(I/R)rat model to induce Va *** administration(54 mg·kg^(-1))for 40 days obviously improved the vascular cognitive impairment in the middle cerebral artery occlusion(MCAO)rats as evidenced by the declined neurological deficit score and shortened escape latency via neurological deficit assessment and Morris water maze ***,SYD decreased neuron damage-induced cell death and ameliorated the ultrastructure of endothelial cells in the MCAO rats,thereby alleviating Va ***,SYD caused increases in the expression of vascular endothelial growth factor(VEGF),CD34 and CD31,compared with the MCAO rats in coronal ***,the expression level of mi R-210 was elevated significantly after SYD administration,compared with the vehicle rats(Pment of Va D.

关键词： Shouwu Yizhi decoction Vascular dementia Angiogenesis VEGF-Notch signaling pathway

chinese medicine formulas for nonalcoholic fatty liver disease: Overview of systematic reviews

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World Journal of Clinical Cases 2021年第1期9卷 102-117页

作者： Liang Dai Wen-Jun Zhou Linda L D Zhong Xu-Dong Tang guang Ji Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Hong Kong chinese medicine Clinical Study Centre School of Chinese MedicineHong Kong Baptist UniversityHong KongChina Department of Gastroenterology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)affects more than one-quarter of the global *** to the lack of approved chemical agents,many patients seek treatment from traditional chinese medicine(TCM)formulas.A variety of systematic reviews have been published regarding the effectiveness and safety of TCM formulas for *** To critically appraise available systematic reviews and sort out the high-quality evidence on TCM formulas for the management of *** Seven databases were systematically searched from their inception to 28 February *** search terms included“non-alcoholic fatty liver disease,”“chinese medicines,”“systematic review,”and their *** reviews involving TCM formulas alone or in combination with conventional medications were *** methodological quality and risk of bias of eligible systematic reviews were evaluated by using A Measure Tool to Assess Systematic Reviews 2(AMSTAR 2)and Risk of Bias in Systematic Review(ROBIS).The quality of outcomes was assessed by the Grading of Recommendations Assessment,Development and Evaluation(GRADE)*** Seven systematic reviews were ultimately *** systematic reviews were conducted based on randomized controlled trials and published in the last *** to the AMSTAR 2 tool,one systematic review was judged as having a moderate confidence level,whereas the other studies were rated as having a low or extremely low level of *** ROBIS tool showed that the included systematic reviews all had a high risk of bias due to insufficient consideration of identified *** to the GRADE system,only two outcomes were determined as high quality;namely,TCM formulas with the HuoXueHuaYu principle were better than conventional medications in ultrasound improvement,and TCM formulas were superior to antioxidants in alanine aminotransferase *** outcomes were downgraded to lower levels,mainly because of heterogeneity amon

关键词： Nonalcoholic fatty liver disease traditional chinese medicines Systematic review Meta-analysis Overview Grading of recommendations assessment,development and evaluation system