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消膏转浊方对肥胖型非酒精性脂肪肝大鼠脂质过氧化反应与胰岛素抵抗的影响

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上海中医药大学学报 2011年第6期25卷 58-62,F0003页

作者：董柳陈良甄仲李敏赵昱段军潘琳仝小林中国中医科学院广安门医院北京100053 民航总医院北京100123 中日友好医院北京100029

目的:观察消膏转浊方对高脂饲养的肥胖大鼠脂质过氧化反应以及胰岛素抵抗(IR)的影响。方法:将Wistar雄性大鼠随机分为正常组、模型组、消膏转浊组、罗格列酮组及饮食控制组。正常组以标准饲料喂养,其余组的大鼠饲以高脂饲料。8周后,正... 详细信息

目的:观察消膏转浊方对高脂饲养的肥胖大鼠脂质过氧化反应以及胰岛素抵抗(IR)的影响。方法:将Wistar雄性大鼠随机分为正常组、模型组、消膏转浊组、罗格列酮组及饮食控制组。正常组以标准饲料喂养,其余组的大鼠饲以高脂饲料。8周后,正常组饮食同前;模型组继续高脂喂养;消膏转浊组及罗格列酮组改为普通饲料喂养,同时给予相应的药物干预;饮食控制组改为普通饲料喂养。干预12周后,检测大鼠葡萄糖输注率(GIR),肝匀浆中FFA、MDA、SOD的含量,检测肝细胞色素P4502E1的蛋白表达,以及肝脏CYP2E1、胰岛素受体(InsR)和胰岛素受体底物-2(IRS-2)的基因表达。结果:与模型组比较,消膏转浊组可以显著降低大鼠肝组织匀浆中的FFA、MDA含量(P<0.01),同时提高SOD活性(P<0.01);消膏转浊组与罗格列酮组均能够显著提高肥胖型非酒精性脂肪肝大鼠的GIR(P<0.01);消膏转浊组肝细胞中CYP2E1染色阳性的细胞面积和MOD值、CYP2E1 mRNA的表达均显著低于模型组(P<0.01);同时,消膏转浊组与罗格列酮组InsR mRNAI、RS-2 mRNA的表达均显著高于模型组(P<0.01)。结论:高脂饮食可以引起大鼠肝脏脂质过氧化反应以及胰岛素抵抗状态,消膏转浊方可减少肝脏脂质过氧化反应以保护肝脏;同时消膏转浊方通过增加肝脏组织InsR以及IRS-2的表达来改善胰岛素抵抗状态。

关键词：消膏转浊方非酒精性脂肪肝脂质过氧化反应钳夹实验胰岛素抵抗

Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro

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chinese Journal of Natural medicines 2020年第9期18卷 704-713页

作者： JING guang-Chan LIU Di LIU Yu-Qin ZHANG meng Ren Deparment of traditional chinese medicine Peking Union Medical Collge HospitalPeking Union Medical Collge and Chinese Academy of Medical SciencesBeijing 100730China Deparment 0f cell resource center Institute of Basic Medical SciencePeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

chinese herbal compound Nao-Fu-Cong(NFC) has been mainly used to treat cognitive disorders in traditional chinese medicine(TCM). The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition of JNK/CHOP/Bcl2-mediated apoptosis pathway or not. We randomly assigned STZ(60 mg·k^(-1))-induced diabetic rats into control group, diabetic model group and NFC groups(low-dose, medium-dose and high-dose). The primary culture of hippocampal neurons were transferred into different culture media on the third day. The cells were then divided into control group, high-glucose group, NFC(low-dose, medium-dose and high-dose) groups, CHOP si-RNA intervention group, JNK pathway inhibitor SP600125 group and oxidative stress inhibitor N-acetylcysteine(NAC) group. NFC significantly improved the cognitive function of diabetic rats, and had neuroprotective effect on hippocampal neurons cultured in high glucose. Further research results showed that NFC could reduce the apoptosis of hippocampal neurons in rats with diabetic cognitive dysfunction. NFC had inhibitory effects on CHOP/JNK apoptosis pathway induced by high glucose, and also decreased the levels of ROS and increased the mitochondrial membrane potential. These suggested that the neuroprotective effect of NFC might be related to the inhibition of CHOP and JNK apoptotic signaling pathways, and the cross pathway between oxidative stress and mitochondrial damage pathway.

关键词： Nao-Fu-Cong Apoptosis High glucose Hippocampal neurons

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中成药临床合理用药处方点评北京共识

中国中药杂志 2018年第5期43卷 1049-1053页

作者：金锐赵奎君郭桂明张冰王宇光薛春苗杨毅恒王丽霞李国辉唐进法聂黎行张相林赵婷婷张毅严灿袁锁中孙路路冯兴中鄢丹无首都医科大学附属北京世纪坛医院临床合理用药评价北京市重点实验室北京100038 首都医科大学附属北京友谊医院北京100050 首都医科大学附属北京中医医院北京100010 北京中医药大学北京100029 北京中医药大学第三附属医院北京100029 北京中医药大学东直门医院北京100700 北京大学第三医院北京100191 中国中医科学院广安门医院北京100053 中国医学科学院肿瘤医院北京100021 河南中医药大学第一附属医院河南郑州450008 中国食品药品检定研究院北京100050 中日友好医院北京100029 国家食品药品监督管理总局药品审评中心北京100045 重庆市食品药品检验检测研究院重庆401121 广州中医药大学广东广州510405 北京中医药学会中药药理与中成药专业委员会北京中医药学会临床合理用药评价专业委员会

随着中成药品规数和临床使用的增长，中成药临床合理使用问题日趋严峻。由于中成药本身的复杂性和临床应用的不确定性影响，中成药处方点评长期缺乏行业技术规范，导致其临床合理使用缺乏科学的风险管控措施。遵循中医药基本理论及独特... 详细信息

随着中成药品规数和临床使用的增长，中成药临床合理使用问题日趋严峻。由于中成药本身的复杂性和临床应用的不确定性影响，中成药处方点评长期缺乏行业技术规范，导致其临床合理使用缺乏科学的风险管控措施。遵循中医药基本理论及独特的临床治疗学特点，结合中成药临床实践经验和专家意见，形成北京市中成药临床合理用药处方点评专家共识，包括中成药处方点评基本方法、技术以及主要点评要点，以期为规范中成药临床合理用药处方点评行为，提升中成药临床合理用药水平提供技术参考。

关键词：临床合理用药处方点评中成药专家共识

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甘桔冰梅片治疗急性咽炎的临床综合评价

中国药物评价 2024年第3期41卷 243-247页

作者：李博叶祖光喻蓉王嘉玺首都医科大学附属北京中医医院北京100005 中国中医科学院中药研究所北京100007 重庆市荣昌区中医院重庆402460 北京中医药大学东方医院北京100078

对甘桔冰梅片治疗急性咽炎进行6+1维度临床综合评价。安全性评价显示甘桔冰梅片临床使用中不良反应少,可以确保用药安全,评为A级;有效性系统评价显示甘桔冰梅片治疗急性咽炎的临床有效率与清咽滴丸比有优势(P<0.00001),甘桔冰梅片对急... 详细信息

对甘桔冰梅片治疗急性咽炎进行6+1维度临床综合评价。安全性评价显示甘桔冰梅片临床使用中不良反应少,可以确保用药安全,评为A级;有效性系统评价显示甘桔冰梅片治疗急性咽炎的临床有效率与清咽滴丸比有优势(P<0.00001),甘桔冰梅片对急性咽炎(风热犯肺证)与甘桔清咽颗粒比较有明显的优效性(P<0.05),评为A级;经济学研究显示与清咽滴丸和甘桔清咽颗粒相比,甘桔冰梅片成本更低,是一个绝对优势方案,评为A级;甘桔冰梅片在临床创新和产业创新方面资料充足,创新性评为B级;甘桔冰梅片满足技术需求,适宜性好,评为A级;处方限制较小,药材资源有可持续性,价格处于基药目录与医保目录中咽喉类中成药的低位水平,可及性好,评为A级;甘桔冰梅片组方出自名方“清音丸”,配伍抓住疾病风热犯肺的病机特点,上市后研究总例数超2000例,中医特色较突出,评为A级。临床价值综合评价认为甘桔冰梅片临床价值证据充分,结果确定。

关键词：甘桔冰梅片急性咽炎安全性有效性临床综合评价

智能响应性材料在股骨头坏死精准修复中的应用

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解放军医学杂志 2024年第7期49卷 841-847页

作者：陈浩席洪钟薛鹏何帅谈小雪孙光权刘锌江晓红杜斌南京中医药大学附属医院骨伤科江苏南京210029 南京理工大学化工学院江苏南京210094

股骨头坏死(ONFH)是骨科常见病,在疾病早期进行保髋治疗对于中青年患者具有重要的临床意义。然而,ONFH的修复具有异质性,导致个体间的保髋疗效存在差异。目前,保髋领域现有的组织工程支架均属于不可调控支架,在植入后无法根据股骨头内... 详细信息

股骨头坏死(ONFH)是骨科常见病,在疾病早期进行保髋治疗对于中青年患者具有重要的临床意义。然而,ONFH的修复具有异质性,导致个体间的保髋疗效存在差异。目前,保髋领域现有的组织工程支架均属于不可调控支架,在植入后无法根据股骨头内修复情况进行精准调控,难以满足精准修复的需求。智能响应性材料具有良好的生物安全性和自我反馈能力,将其与治疗药物结合构建成刺激-响应性药物递送系统,为ONFH的精准修复提供了新的选择。本文对国内外智能响应性材料的研究进展进行综述,并根据各种材料的响应原理及ONFH的修复特点,探讨活性氧响应性、剪切应力响应性、光/磁响应性等多种智能响应性材料在ONFH精准修复领域的应用前景,以期为ONFH的精准治疗提供新的思路。

关键词：智能响应性材料股骨头坏死修复异质性精准修复应用展望

Appraisal of treatment outcomes in integrative medicine using metabonomics:Taking non-alcoholic fatty liver disease with spleen deficiency syndrome as an example

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Journal of Integrative medicine 2022年第6期20卷 524-533页

作者： Liang Dai Jing-juan Xu Wen-jun Zhou Ai-ping Lü guang Ji Clinical Research academy Peking University Shenzhen HospitalPeking UniversityShenzhen 518032Guangdong ProvinceChina Institute of Digestive Disease Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Integrated traditional and Western medicine Jinling HospitalSchool of MedicineNanjing UniversityNanjing 210002Jiangsu ProvinceChina academy of Integrative medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China School of chinese medicine Hong Kong Baptist UniversityHong Kong 999077China

Objective:Appraisal of treatment outcomes in integrative medicine is a challenge due to a gap between the concepts of Western medicine(WM)disease and traditional chinese medicine(TCM)*** study presents an approach for the appraisal of integrative medicine that is based on targeted *** use non-alcoholic fatty liver disease with spleen deficiency syndrome as a test ***:A patient-reported outcome(PRO)scale was developed based on literature review,Delphi consensus survey,and reliability and validity test,to quantitatively evaluate spleen deficiency ***,a metabonomic foundation for the treatment of non-alcoholic fatty liver disease with spleen deficiency syndrome was identified via a longitudinal interventional trial and targeted ***,an integrated appraisal model was established by identifying metabolites that responded in the treatment of WM disease and TCM syndrome as positive outcomes and using other aspects of the metabonomic foundation as independent ***:Ten symptoms and signs were included in the spleen deficiency PRO *** internal reliability,content validity,discriminative validity and structural validity of the scale were all *** on treatment responses to treatments for WM disease(homeostasis model assessment of insulin resistance)or TCM syndrome(spleen deficiency PRO scale score)from a previous randomized controlled trial,two cohorts comprised of 30 participants each were established for targeted metabolomics ***-five metabolites were found to be involved in successful treatment outcomes to both WM and TCM,following quantitative comparison and multivariate ***,the model of the integrated appraisal system was exploratively established using binary logistic regression;it included 9 core metabolites and had the prediction probability of 83.3%.Conclusion:This study presented a new and comprehensive research route for integrative appraisal of treatment

关键词： Complementary and alternative medicine Integrative medicine Patient-reported outcome measures Metabolomics Non-alcoholic fatty liver disease Spleen deficiency syndrome

Triple Puncture for Primary Trigeminal Neuralgia:A Randomized Clinical Trial

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Current Medical Science 2019年第4期39卷 638-644页

作者： Yang-pu ZHANG Yan WANG Wen-guang XIA Ai-qun SONG Department of Physical medicine and Rehabilitation Hubei Provincial Hospital of Integrated Chinese and Western MedicineWuhan 430015China Sector of P.E. China University of GeosciencesWuhan 430074China Hubei Provincial hospital of traditional chinese medicine Wuhan 430061China Hubei Province academy of traditional chinese medicine Wuhan 430074China

To evaluate the effect of triple puncture on primary trigeminal neuralgia (pTN),64 patients with pTN were randomly assigned to two groups:treatment group and control *** participants in the treatment group received triple puncture treatment of 6 times per week for 4 weeks,and those in control group were given carbamazepine (300-600 mg per day) for at least 1 *** and after treatment,the primary outcomes including the total efficiency rate and the VAS pain scores,and the secondary outcomes including the frequency of pain attack and adverse events were ***-two participants finished the study (33 in treatment group and 29 in control group individually).After treatment,the symptoms (mainly pain) of the two groups were *** total efficiency rate in the treatment group and control group was 90.9% and 75.9% *** VAS pain scores and frequency of pain attack were significantly reduced in the treatment group as compared with the control group (Pment group and control group was 9.1% and 24.1% *** can be inferred that triple puncture can effectively improve the quality of life of patients with pTN and has less side effects.

关键词： triple puncture primary trigeminal neuralgia randomized clinical trial

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中国纤维肌痛综合征诊疗指南

中华内科杂志 2023年第2期62卷 129-146页

作者：中华中医药学会风湿病分会海峡两岸医药卫生交流协会风湿免疫病学专业委员会纤维肌痛综合征中西医研究学组首都中西医结合风湿免疫病研究所姜泉黄慈波曾小峰焦娟巩勋不详中国中医科学院广安门医院风湿病科北京100053 深圳大学附属华南医院风湿免疫科深圳518061 中国医学科学院北京协和医学院北京协和医院风湿免疫科北京100730

纤维肌痛综合征(FMS)是一种临床常见疾病,目前我国尚缺少大样本的流行病学数据,临床诊治亦存在诸多难点,制订我国FMS的诊疗指南势在必行。中华中医药学会风湿病分会、海峡两岸医药卫生交流协会风湿免疫病学专业委员会纤维肌痛综合征中... 详细信息

纤维肌痛综合征(FMS)是一种临床常见疾病,目前我国尚缺少大样本的流行病学数据,临床诊治亦存在诸多难点,制订我国FMS的诊疗指南势在必行。中华中医药学会风湿病分会、海峡两岸医药卫生交流协会风湿免疫病学专业委员会纤维肌痛综合征中西医研究学组、首都中西医结合风湿免疫病研究所联合牵头发起,采用推荐意见分级的评估、制订及评价(GRADE)分级体系及国际实践指南报告标准(RIGHT),对我国一线医师关注的FMS的11个临床问题,给出了较为详细的循证推荐意见,旨在推动风湿免疫科、心理科、疼痛科等相关科室高度重视FMS的综合管理及早期识别与干预,早筛查、早评估、早治疗,提高患者的生活质量。

关键词：纤维肌痛诊断治疗指南

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全球化视角布局中药资源基地可行性分析

中国食品药品监管 2024年第2期 130-135页

作者：李新月程蒙于志斌马海光池秀莲高峰苏芳芳张辰辰杨光河北中医药大学药学院中国中医科学院中药资源中心中国医药保健品进出口商会河北百草康神药业有限公司中国中医科学院西苑医院

中药资源是中医药事业发展的物质基础,自古以来便有海外来源,现今仍有许多中药材品种依赖进口,如乳香、没药等。随着中药现代化和国际化的发展,中药产品需求增加,野生资源不断减少,而种植(养殖)又面临人均耕地不足、进口药材引种栽培质... 详细信息

中药资源是中医药事业发展的物质基础,自古以来便有海外来源,现今仍有许多中药材品种依赖进口,如乳香、没药等。随着中药现代化和国际化的发展,中药产品需求增加,野生资源不断减少,而种植(养殖)又面临人均耕地不足、进口药材引种栽培质量不佳等问题。因此,以全球化视角审视中药资源供求,关注海外原料基地建设,实现中药资源的高效、可持续供应,具有非常重要的现实意义。本文对进口药材的发展历程及现状进行了梳理,探讨了建立中药资源海外原料基地的可行性,并提出了建设全球中药资源供应体系的建议。

关键词：中药资源中药材国际化进口海外原料基地