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Interfacial charge effects of supported-metal-cluster heterostructures on azo hydrogenation catalyzation

Nano Research 2024年第5期17卷 3853-3862页

作者： Zhenhua Gu Jingli Zhang Zijun Zhang Qingxue Mu Liangchong Yu Taolei Sun Lei Shen guanbin gao State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases School of ChemistryChemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China

The impact of interfacial charge on catalytic performance of supported-metal-cluster(SMC)heterostructures remains unclear,hindering efforts to develop high-performance SMC *** we systematically investigated interfacial charge effects of SMCs using a model system of graphene-supported gold-nanoclusters(AuNCs/rGO)for azo *** types of SMCs with different interfacial charges were synthesized by anchoring electropositive 2-aminoethanethiol(CSH),amphoteric cysteine(Cys),and electronegative 3-mercaptopropionic-acid(MPA)onto AuNCs/rGO,*** three SMCs exhibited high and selective catalytic activity to azo-hydrogenation in four representative azo *** catalytic activity of Cys@AuNCs/rGO was lower than that of CSH@AuNCs/rGO but higher than that of MPA@AuNCs/***,the cyclic stability of Cys@AuNCs/rGO was inferior to that of both CSH@AuNCs/rGO and MPA@AuNCs/*** mechanistic studies revealed that amino ligands modified CSH@AuNCs and Cys@AuNCs agglomerated into large-size gold nanoparticles on rGO surface during catalytic reaction under NaBH_(4) action,leading to reduced efficiency and cyclic ***,non-amino ligand modified MPA@AuNCs only partially detached from rGO surface without agglomeration,resulting in better cyclic *** of amino groups in ligands such as modifying-NH_(3)^(+)group in Cys into imine to form N-isobutyryl-L-cysteine(NIBC)substantially improved the cyclic stability while maintaining the high activity in the NIBC@AuNCs/rGO catalyst *** work provides an approach for developing a highly-active and stable SMC heterostructure catalyst via manipulating interfacial charges in SMC.

关键词： interfacial charge effect supported-metal-cluster catalyst azo hydrogenation graphene supported gold nanoclusters

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下肢外骨骼康复机器人步态相识别

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信息与控制 2024年第1期53卷 47-57页

作者：高贯斌肖纯杰那靖邢亚珊陆声昆明理工大学机电工程学院云南昆明650550 云南省智能控制及应用重点实验室云南昆明650550 云南省第一人民医院云南昆明650034 云南省数字骨科重点实验室云南昆明650034

外骨骼机器人作为一种新型的康复设备,在脊髓损伤患者的康复训练中具有广阔的应用前景。其中,人体步态相识别是实现外骨骼机器人穿戴者运动意图识别和准确控制的关键之一。首先,针对脊髓损伤患者康复训练中摆腿触地过程无法自主锁定膝... 详细信息

外骨骼机器人作为一种新型的康复设备,在脊髓损伤患者的康复训练中具有广阔的应用前景。其中,人体步态相识别是实现外骨骼机器人穿戴者运动意图识别和准确控制的关键之一。首先,针对脊髓损伤患者康复训练中摆腿触地过程无法自主锁定膝关节的问题,设计了一款绳驱下肢外骨骼康复机器人。该款外骨骼机器人通过足底开关传感器和膝关节编码器来采集患者步态信息,并在一个步态周期内不同的步态相对膝关节进行锁定或放松。其次,通过对人体行走步态的研究和脊髓损伤患者康复训练中锁膝和松膝的需求分析,提出了一种基于足底与地面接触过程信息的步态相分类方法。由于脊髓损伤患者的足底接触过程不可控且不稳定,将膝关节摆角和摆动速度信息引入步态相识别中,提出了融合脚与地面接触信息、膝关节摆角及摆动速度信息的步态相识别方法。最后,基于采集到的志愿者步态数据,进行了步态相识别方法的实验验证。结果表明,所提方法的平均步态相识别率达到99.906%,并且当足底开关传感器发生故障或未正常触发时,锁膝相和松膝相的正确识别率仍然分别达到94.488%和91.853%,从而验证了所提方法的有效性和容错能力。

关键词：脊髓损伤外骨骼康复训练步态相识别

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金属纳米伴侣界面金属原子对淀粉样蛋白纤维化的调控作用

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Science China Materials 2024年第7期67卷 2345-2354页

作者：李虎高冠斌余良翀张子俊张斌邓昱周慕庆雪沈雷孙涛垒 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases School of ChemistryChemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China

合成具有生物分子伴侣功能的金属纳米伴侣作为调节蛋白质构象的候选物具有良好的应用前景.尽管对金属纳米伴侣已有广泛研究,但其分子中界面金属原子对蛋白质构象的调控作用及其机制尚不清楚,这严重阻碍了对高性能金属纳米伴侣的开发.本... 详细信息

合成具有生物分子伴侣功能的金属纳米伴侣作为调节蛋白质构象的候选物具有良好的应用前景.尽管对金属纳米伴侣已有广泛研究,但其分子中界面金属原子对蛋白质构象的调控作用及其机制尚不清楚,这严重阻碍了对高性能金属纳米伴侣的开发.本研究以相同配体巯基丙酸(MPA)修饰的金纳米团簇Au_(25)为模型,通过界面掺杂金属原子(Cu、Cd、Ag)精准制备出了三种单原子掺杂的纳米伴侣,分别是Au_(24)Cu_(1)、Au_(24)Cd_(1)和Au_(24)Ag_(1),系统地研究了Au_(25)、Au_(24)Cu_(1)、Au_(24)Cd_(1)和Au_(24)Ag_(1)四种纳米伴侣对Aβ40折叠与纤维化的调控作用.全原子分子动力学模拟结果表明,界面掺杂金属原子(Cu、Cd、Ag)可通过范德华力和静电相互作用等弱相互作用影响与之接触的Aβ40单体的折叠.等温滴定量热分析结果进一步表明,Au_(24)Cu_(1)与Aβ40的相互作用分别是Au_(24)Cd_(1)、Au_(24)Ag_(1)和Au_(25)的1.76、2.09、16.67倍.这些不同的相互作用会导致金属纳米伴侣对Aβ折叠与纤维化的不同调节作用,四种金属纳米伴侣抑制Aβ折叠与纤维化效率依次为Au_(24)Cu1>Au_(24)Cd_(1)>Au_(24)Ag_(1)>Au_(25).本文提供了对金属纳米团簇界面金属原子如何发挥作用的微观分子见解,并为通过操纵界面金属原子来定制金属纳米伴侣提供了基础研究数据.

关键词： customizing nano-chaperone nano-interface gold-nanoclusters peptide amyloidosis

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Au23（CR）14 nanocluster restores fibril Aβ's unfolded state with abolished cytotoxicity and dissolves endogenous Aβplaques

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National Science Review 2020年第4期7卷 763-774页

作者： Wenkang Zhang guanbin gao Zhongjie Ma Zhuoying Luo Meng He Taolei Sun State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology School of Chemistry Chemical Engineering and Life Science Wuhan University of Technology

The misfolding of amyloid-β（Aβ） peptides from the natural unfolded state to β-sheet structure is a critical step, leading to abnormal fibrillation and formation of endogenous Aβ plaques in Alzheimer's disease（AD）. Previous studies have reported inhibition of Aβ fibrillation or disassembly of exogenous Aβ fibrils in vitro. However, soluble Aβ oligomers have been reported with increased cytotoxicity; this might partly explain why current clinical trials targeting disassembly of Aβ fibrils by anti-Aβ antibodies have failed so *** we show that Au23（CR）14(a new Au nanocluster modified by Cys-Arg（CR） dipeptide) is able to completely dissolve exogenous mature Aβ fibrils into monomers and restore the natural unfolded state of Aβ peptides from misfolded β-sheets. Furthermore, the cytotoxicity of Aβ40fibrils when dissolved by Au23（CR）14is fully abolished. More importantly, Au23（CR）14is able to completely dissolve endogenous Aβ plaques in brain slices from transgenic AD model mice. In addition, Au23（CR）14has good biocompatibility and infiltration ability across the blood–brain barrier. Taken together, this work presents a promising therapeutics candidate for AD treatment, and manifests the potential of nanotechnological approaches in the development of nanomedicines.

关键词： gold nanoclusters Alzheimer’s disease restores fibril Aβ’s unfolded state abolished cytotoxicity dissolves endogenous Aβ plaques

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Chiral effect on Aβ fibrillation from molecular-scale to nanoscale

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Nano Research 2022年第7期15卷 6721-6729页

作者： guanbin gao Guowei Zhu Liangchong Yu Zijun Zhang Ting Zhang Xinglin Liu Cheng Zhang Lin Zhou Taolei Sun State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Chemistry Chemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China

β-Amyloid(Aβ)peptide fibrillation,one of the characteristic hallmarks of Alzheimer’s disease,is determined by many interfacial physical-chemical factors,e.g.,charge,hydrophobicity,*** extensive research,chiral effect in different-scales on the fibrillation process of Aβremains ***,molecular-scale,sub-nanoscale,and nanoscale chiral-structures were constructed to investigate their chiral effect on the fibrillation of Aβ_(40) *** structures from molecular-scale to nanoscale were obtained from the different periods of the chemosynthesis process of chiral ZnS quantum-dots(QDs),confirmed by real-time monitoring of circular dichroism *** molecular-scale,both L-penicillamine(L-P)and D-P ligands accelerated the fibrillation of Aβ_(40),and the speed-up effect of D-P was slightly stronger than *** sub-nanoscale,both two chiral Zncomplexes(L-Zn and D-Zn)induced the agglomeration of Aβ_(40) without chirality *** nanoscale,both L-ZnS and DZnS QDs inhibited the fibrillation of Aβ_(40),and the inhibition effect of L-ZnS was notably better than that of ***-situ kinetics experiments of Aβ_(40) co-incubated with two chiral QDs demonstrated that L-ZnS completely prevents the misfolding of Aβ_(40) from unfolded toβ-sheet,while D-ZnS cannot achieve *** site-replacement experiments and simulation results revealed the underlying molecular mechanisms of the different inhibition efficiency of chiral ZnS QDs on Aβ_(40) fibrillation,which mainly attribute to the stereoselectivity interaction between the chiral ligands of ZnS QDs and electro-positive amino acid residues(R5,K16,and K28)of Aβ_(40).This work offers a microscopic insight of chiral effect on Aβfibrillation exerted by structures in different-scales,and provides a guidance in precise regulation of protein fibrillation via manipulating chiral structures in different-scales.

关键词： chirality molecular-scale sub-nanoscale nanoscale Aβ_(40) fibrillation

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Further Modification on CRM-based Model Reference Adaptive Control

Further Modification on CRM-based Model Reference Adaptive C...

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第37届中国控制会议

作者： Yafei Liu Jing Na Jun Yang guanbin gao Faculty of Mechanical and Electrical Engineering Kunming University of Science and Technology

In order to achieve better transient performance of model reference adaptive control(MRAC), a new idea, named closed-loop reference model(CRM), has been recently proposed. However, there exists a potential peaking phenomenon in the CRM-based MRAC systems due to the introduced feedback gain in the CRM, which may deteriorate the original tracking control response. In this paper, we revisit the CRM-based MRAC design, and provide a new prospective to analyze the bound of peaking value by using L norm and Cauchy-Schwartz inequality. Following the analysis, we further provide a potential solution to alleviate the peaking phenomenon by reducing the impact of the unknown system dynamics. This has been achieved by introducing a modification term on the control action. This new framework allows to use large feedback gains in the CRM to improve transient control performance, while the peaking phenomenon can be reduced. A wing rock aircraft model is used as the numerical example to validate the effectiveness of the proposed method and the improved performance over the traditional CRM-based MRAC.

关键词： Model reference adaptive control(MRAC) Closed-loop reference model(CRM) Peaking phenomenon Adaptive control designs

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基于复合标定和极限学习机的关节臂式坐标测量机残差建模及补偿

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光学精密工程 2023年第22期31卷 3289-3304页

作者：高贯斌谢佩刘飞那靖昆明理工大学机电工程学院云南昆明650500

运动学标定是提高关节臂式坐标测量机精度的主要方法,但运动学标定后的残余误差对其测量精度和稳定性仍有很大影响。本文提出一种基于复合标定和极限学习机的关节臂式坐标测量机残差建模及补偿方法,以提高关节臂式坐标测量机的测量精度... 详细信息

运动学标定是提高关节臂式坐标测量机精度的主要方法,但运动学标定后的残余误差对其测量精度和稳定性仍有很大影响。本文提出一种基于复合标定和极限学习机的关节臂式坐标测量机残差建模及补偿方法,以提高关节臂式坐标测量机的测量精度。首先,在关节臂式坐标测量机运动学建模和误差建模的基础上,建立了运动学参数辨识模型,并依次进行角度参数辨识、长度参数辨识和长度参数等比例缩放的复合辨识,完成了七自由度关节臂式坐标测量机的运动学标定。其次,通过对标定后残余误差图谱的分析,发现残余误差与测量构型有关联,进而构建了以测量摆角、仰角、距离和转角为变量的测量构型。由于测量构型变量与残余误差存在强非线性关系,提出一种基于极限学习机的残余误差预测和补偿方法。通过实验对本文所提模型及方法的有效性进行验证,结果表明:进行残差修正后关节臂式坐标测量机的单点测量误差最大值由0.061 mm下降到0.044 mm,误差均值由0.023 mm下降到0.017 mm,误差标准差由0.011mm下降到0.007 mm;长度测量误差最大值由0.137 mm下降到0.074 mm,误差均值由0.033 mm下降到0.021 mm、误差标准差由0.037 mm下降到0.019 mm。

关键词：关节臂式坐标测量机残余误差测量构型极限学习机复合标定

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Knowledge-embedded spatio-temporal analysis for euploidy embryos identification in couples with chromosomal rearrangements

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Chinese Medical Journal 2024年第6期137卷 694-703页

作者： Fangying Chen Xiang Xie Du Cai Pengxiang Yan Chenhui Ding Yangxing Wen Yanwen Xu Feng gao Canquan Zhou guanbin Li Qingyun Mai Reproductive Medicine Center The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Guangdong Provincial Key Laboratory of Reproductive Medicine GuangzhouGuangdong 510080China School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong 510006China Department of General Surgery(Colorectal Surgery) The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655China Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655China Shanghai Artificial Intelligence Laboratory Shanghai 200232China

Background:The goal of the assisted reproductive treatment is to transfer one euploid blastocyst and to help infertile women giving birth one healthy *** algorithms have been used to assess the ploidy status of embryos derived from couples with normal chromosome,who subjected to preimplantation genetic testing for aneuploidy(PGT-A)***,it is currently unknown whether artificial intelligence model can be used to assess the euploidy status of blastocyst derived from populations with chromosomal ***:From February 2020 to May 2021,we collected the whole raw time-lapse videos at multiple focal planes from in vitro cultured embryos,the clinical information of couples,and the comprehensive chromosome screening results of those blastocysts that had received PGT ***,we developed a novel deep learning model called the Attentive Multi-Focus Selection Network(AMSNet)to analyze time-lapse videos in real time and predict blastocyst *** upon AMSNet,we integrated additional clinically predictive variables and created a second deep learning model,the Attentive Multi-Focus Video and Clinical Information Fusion Network(AMCFNet),to assess the euploidy status of *** efficacy of the AMCFNet was further tested in embryos with parental chromosomal *** receiver operating characteristic curve(ROC)was used to evaluate the superiority of the ***:A total of 4112 embryos with complete time-lapse videos were enrolled for the blastocyst formation prediction task,and 1422 qualified blastocysts received PGT-A(n=589)or PGT for chromosomal structural rearrangement(PGT-SR,n=833)were enrolled for the euploidy assessment task in this *** AMSNet model using seven focal raw time-lapse videos has the best real-time *** real-time accuracy for AMSNet to predict blastocyst formation reached above 70%on the day 2 of embryo culture,and then increased to 80%on the day 4 of embryo ***

关键词： Euploidy status Embryo Time-lapse imaging Deep learning Spatio-temporal analysis Preimplantation genetic testing for chromosomal structural rearrangement

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β-HgS量子点的制备、性质及应用

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化学进展 2017年第7期29卷 776-784页

作者：刘康高冠斌孙涛垒武汉理工大学材料复合新技术国家重点实验室武汉430070

β-HgS量子点因其具有可调谐的可见-近红外荧光和带间荧光而在光转换和荧光成像等多个领域有着广阔的应用前景。本文综述了β-HgS量子点的制备、性质及应用,重点梳理了β-HgS量子点在有机相和水相中的两大类共计五种制备方法,阐述了其... 详细信息

β-HgS量子点因其具有可调谐的可见-近红外荧光和带间荧光而在光转换和荧光成像等多个领域有着广阔的应用前景。本文综述了β-HgS量子点的制备、性质及应用,重点梳理了β-HgS量子点在有机相和水相中的两大类共计五种制备方法,阐述了其不同于块状β-HgS的独特性质,总结了其在离子探测、细胞成像、活体成像、光转换器和荧光油墨等领域的最新应用。最后针对制约β-HgS量子点应用的主要问题(如应用于光转换器件中的转换效率和荧光量子产率不高、应用于生物荧光成像中的特异性识别能力不足和生物相容性较差等),提出了我们的解决方案:一方面,将β-HgS量子点自组装形成特定的纳米结构,以期提高其光转换效率和荧光量子产率;另一方面,通过将手性生物分子引入到β-HgS量子点表面来制备手性β-HgS量子点,以期增强其在体内和体外荧光成像中的特异性识别能力和改善其生物相容性。本文将为β-HgS量子点的发展提供新的思路。

关键词： β-HgS量子点制备性质应用

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基于标定和关节空间插值的工业机器人轨迹误差补偿

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机械工程学报 2021年第21期57卷 55-67页

作者：高贯斌张石文那靖刘飞昆明理工大学机电工程学院昆明650500

轨迹精度是工业机器人重要的动态性能,目前工业机器人的轨迹精度远低于定位精度,提出一种基于机器人运动学标定和关节空间插值误差补偿的方法来提高机器人轨迹精度。基于MD-H方法建立机器人的运动学模型,在此基础上运用机器人微分运动... 详细信息

轨迹精度是工业机器人重要的动态性能,目前工业机器人的轨迹精度远低于定位精度,提出一种基于机器人运动学标定和关节空间插值误差补偿的方法来提高机器人轨迹精度。基于MD-H方法建立机器人的运动学模型,在此基础上运用机器人微分运动学理论建立末端位置误差模型和轨迹误差模型。为克服最小二乘法等传统方法在数据噪声较大且不符合高斯分布时收敛慢甚至发散的问题,提出一种基于扩展卡尔曼滤波算法的机器人运动学参数辨识方法,实现运动学参数辨识的快速收敛。经过分析发现机器人误差在关节空间具有连续性的特点,为此提出一种关节空间插值误差补偿方法,建立网格形式的误差补偿数据库,并利用关节空间距离权重函数和已知的网格顶点误差计算各控制点的关节转角误差。通过试验对所提出的参数辨识和关节空间误差补偿方法进行了验证,试验结果表明:经过运动学参数辨识和补偿后机器人的绝对定位精度由1.039 mm提高到0.226mm,轨迹精度由2.532mm提高到1.873mm,应用关节空间插值误差补偿后机器人的轨迹精度进一步提高到1.464 mm。

关键词：工业机器人轨迹精度扩展卡尔曼滤波误差补偿参数辨识

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