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Generation mechanism of quarter buckle in hot-rolled temper rolling

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Journal of Iron and Steel Research International 2022年第10期29卷 1619-1632页

作者： Hui Li guan-yu zhou An-rui He Zhi-hong Zhang Chi-huan Yao Chao Liu Jian-wei Zhao Wei-gang Li Jian Shao Institute of Engineering Technology University of Science and Technology BeijingBeijing100083China Handan Iron and Steel Group Co. Ltd.Handan056015HebeiChina Engineering Research Centre for Metallurgical Automation and Measurement Technology of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina

To reveal the generation mechanism of the quarter buckle in the process of hot-rolled temper rolling,the elastic–plastic finite element method is used to calculate the deformation of the roll and the strip during the temper *** change of the cross section of the strip and the distribution of the longitudinal stress are analysed under different bending forces to obtain the boundary conditions of the quarter *** generation of the quarter buckle is further analysed from the bending and contact flattening of the roll system and the elastic recovery of the strip after *** found that the quarter buckle is closely related to the high-order distribution of the contact flattening between the work roll and the strip and is less affected by the bending deformation of the roll and the contact flattening between the ***,a new work roll contour of the locally variable crown is proposed to change the distribution of contact flattening between the work roll and the *** is verified through theoretical calculations and industrial applications that the new contour can effectively improve the quarter buckle.

关键词： Quarter buckle Contact flattening Roll contour Finite element method Hot-rolled temper rolling

Single-fiber Electromyography in the Extensor Digitorum Communis for the Predictive Prognosis of Ocular Myasthenia Gravis： A Retrospective Study of 102 Cases

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Chinese Medical Journal 2015年第20期128卷 2783-2786页

作者： yu-zhou guan Li-Ying Cui Ming-Sheng Liu Jing-Wen Niu Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Neuroscience Center Chinese Academy of Medical Sciences Beijing 100730 China

Background： Single-fiber electromyography （SFEMG） abnormality in the extensor digitorum communis （EDC） was reported in ocular myasthenia gravis （OMG）, which indicated subclinical involvement beyond extraocular muscles in OMG patients. The relationship between the abnormal findings of SFEMG in EDC and the probability for OMG to develop generalized myasthenia gravis （GMG） is unknown, This retrospective study aimed to determine the predictive value of abnormality of SFEMG in EDC of OMG patients. Methods： One-hundred and two OMG patients underwent standard clinical diagnosis process and SFEMG test in EDC muscle when diagnosed and were clinically followed up for 5 years. The SFEMG data were compared between different clinical groups according to thymus status, onset age, and different outcome of OMG developing. Chances of progressing to GMG were compared between two different groups according to SFEMG and repetitive nerve stimulation （RNS） results, acetylcholine receptor antibody （AchRAb） titer, thymus status, and onset age. Results： Abnormal SFEMG results were observed in 84 （82.4%） patients. The mean jitter, percentage of jitter 〉55 Its （%）, and blocking were higher in OMG patients than in healthy volunteers. There were no statistical differences in jitter analysis between thymoma group and non-thymoma group （P = 0.65）, or between the later OMG group and the later GMG group （P = 0.31）, including mean jitter, percentage of jitter 〉55 Its （%）, and blocking. Elderly group （〉45 years old） had a higher mean jitter than younger group （t = 2.235, P = 0.028）. Total 55 OMG developed GMG, including 47 in abnormal SFEMG group while 8 in normal SFEMG group. There was no statistical difference in the conversion rates between the two groups （x^2 = 0.790, P = 0.140）. RNS abnormality, AchRab titer, or onset age had no correlation with OMG prognosis （P = 0.150, 0.070, 0.120, respectively） while thymoma did （x^2 = 0.510, P = 0.020）. Conclusion： SFEMG test in the EDC showed high abnormal

关键词： Extensor Digitorum Communis Generalized Myasthenia Gravis Ocular Myasthenia Gravis Prognosis Single-fiberElectromyography

Importance of Sample Size for the Estimation of Repeater F Waves in Amyotrophic Lateral Sclerosis

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Chinese Medical Journal 2015年第4期128卷 515-519页

作者： Jia Fang Ming-Sheng Liu yu-zhou guan Bo Cui Li-Ying Cui Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background：In amyotrophic lateral sclerosis （ALS）,repeater F waves are *** assessment of repeater F waves requires an adequate sample ***：We studied the F waves of left ulnar nerves in ALS *** on the presence or absence of pyramidal signs in the left upper limb,the ALS patients were divided into two groups：One group with pyramidal signs designated as P group and the other without pyramidal signs designated as NP *** Index repeating neurons （RN） and Index repeater F waves （Freps） were compared among the P,NP and control groups following 20 and 100 stimuli *** each group,the Index RN and Index Freps obtained from 20 and 100 stimuli were ***：In the P group,the Index RN （P =0.004） and Index Freps （P =0.001） obtained from 100 stimuli were significantly higher than from 20 *** F waves obtained from 20 stimuli,no significant differences were identified between the P and NP groups for Index RN （P =0.052） and Index Freps （P =0.079）; The Index RN （P ＜ 0.001） and Index Freps （P ＜ 0.001） of the P group were significantly higher than the control group; The Index RN （P =0.002） of the NP group was significantly higher than the control *** F waves obtained from 100 stimuli,the Index RN （P ＜ 0.001） and Index Freps （P ＜ 0.001） of the P group were significantly higher than the NP group; The Index RN （P ＜ 0.001） and Index Freps （P ＜ 0.001） of the P and NP groups were significantly higher than the control ***：Increased repeater F waves reflect increased excitability of motor neuron pool and indicate upper motor neuron dysfunction in *** an accurate evaluation of repeater F waves in ALS patients especially those with moderate to severe muscle atrophy,100 stimuli would be required.

关键词： Amyotrophic Lateral Sclerosis Repeater F waves Upper Motor Neuron

Asynchronization in Changes of Electrophysiology and Pathology of Spinal Cord Motor Neurons in Rats Following Middle Cerebral Artery Occlusion

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Chinese Medical Journal 2015年第21期128卷 2919-2925页

作者： Nan Lin Ming-Sheng Liu Si-yuan Fan yu-zhou guan Li-Ying Cui Department of Neurology Peking Union Medical College Hospital Beijing 100730 China

Background： Motor dysfunction is common in stroke patients. Clinical electrophysiological studies suggest that transsynaptic degeneration occurred in the lower motor neurons, while pathological evidence is lacked. This study aimed to combine the electrophysiological and pathological results to prove the existence of transsynaptic degeneration in the motor system after stroke. Methods： Modified neurologic severity score, electrophysiological, and pathological assessments were evaluated in rats before middle cerebral artery occlusion （MCAO）, and at 24 hours, 7 days, and 14 days after MCAO. Paired and independent-sample t-tests were applied to assess the changes of electrophysiological and pathological data. Results： Compound motor action potential amplitude in the paretic side was significantly lower than the nonparetic side at both 24 hours （61.9 ± 10.4 vs. 66.6 ± 8.9, P 〈 0.05） and 7 days （60.9 ± 8.4 vs. 67.3 ±9.6, P 〈 0.05） after MCAO. Motor unit number estimation of the paretic side was significantly less than the nonparetic side （379.0 ± 84.6 vs. 445.0 ±9.5, P 〈 0.05） at 7 days after MCAO. Until 14 days after stroke, the pathological loss of motor neurons was detected. Motor neurons in 14-day MCAO group were significantly decreased, compared with control group （5.3 ± 0.7 vs. 7.3 ± 1.8, P 〈 0.05）. Conclusions： Both electrophysiological and pathological studies showed transsynaptic degeneration after stroke. This study identified the asynchronization in changes of electrophysiology and pathology. The abnormal physiological changes and function impairment can be detected in the early stage and recovered quickly, while the pathological loss of motor neuron can be detected only in a later stage.

关键词： Middle Cerebral Artery Occlusion Electrophysiology Lower Motor Neurons Pathology Stroke

Quantitating Changes in Jitter and Spike Number Using Concentric Needle Electrodes in Amyotrophic Lateral Sclerosis Patients

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Chinese Medical Journal 2016年第9期129卷 1036-1040页

作者： Ming-Sheng Liu Jing-Wen Niu Yi Li yu-zhou guan Li-Ying Cui Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China

Background： Single-fiber electromyography （SFEMG） has been suggested as a quantitative method for supporting chronic partial denervation in amyotrophic lateral sclerosis （ALS） by the revised El Escorial criteria. Although concentric needle （CN） electrodes have been used to assess jitter in myasthenia gravis patients and healthy controls, there are few reports using CN electrodes to assess motor unit instability and denervation in neurogenic diseases. The aim of this study was to determine whether quantitative changes in jitter and spike number using CN electrodes could be used for ALS studies. Methods： Twenty-seven healthy controls and 23 ALS patients were studied using both CN and single-fiber needle （SFN） electrodes on the extensor digitorum communis muscle with an SFEMG program. The SFN-jitter and SFN-fiber density data were measured using SFN electrodes. The CN-jitter and spike number were measured using CN electrodes. Results： The mean CN-j itter was significantly increased in ALS patients （47.3 ±17.0 μs） than in healthy controls （27.4 ± 3.3 las）（P 〈 0.001 ）. Besides, the mean spike number was significantly increased in ALS patients （2.5 ± 0.5） than in healthy controls （1.7 ± 0.3）（P 〈 0.001）. The sensitivity and specificity in the diagnosis of ALS were 82.6% and 92.6% for CN-jitter （cut-offvalue： 32 gs）, and 91.3% and 96.3% for the spike number （cut-off value： 2.0）, respectively. There was no significant difference between the SFN-jitter and CN-jitter in ALS patients; meanwhile, there was no significant difference between the SFN-jitter and CN-jitter in healthy controls. Conclusion： CN-jitter and spike number could be used to quantitatively evaluate changes due to denervation-reinnervation in ALS.

关键词： Amyotrophic Lateral Sclerosis Concentric Needle Electrode Jitter Single-fiber Electromyography Spike Number

A clinical neurophysiology study of Hirayama disease

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Chinese Medical Journal 2012年第6期125卷 1115-1120页

作者： WANG Xin-ning CUI Li-ying LIU Ming-sheng guan yu-zhou LI Ben-hong DU Hua Department of Neurology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

Background Hirayama disease is a rare disease characterized by juvenile-onset of asymmetric amyotrophy, of which etiology has not been clarified. The aim of our study was to investigate the clinical and neurophysiologic characteristics of Hirayama disease. Methods Neurophysiological tests, including nerve conduction studies （NCS）, F-wave and routine electromyography （EMG）, were performed in seventy-three patients with Hirayama disease. EMG was selectively performed on upper and lower extremities, sternocleidomast and thoracic paravertebral muscles according to the clinical features of the patients. Results Abnormal NCS parameters, including decreased compound muscle action potentials or delayed distal motor latency, were found in 34.2% （25/73） and 12.3% （9/73） of the patients, respectively. A total of 24.6% （18/73） of the patients showed decreased F-wave frequency. EMG demonstrated the presence of neurogenic lesions in all patients with spontaneous potentials, prolonged duration or augmentation of amplitude in motor unit potentials （MUPs）, or a single pattern of MUP recruitment. About 17.8% （13/73） of the patients showed neurogenic lesions, mostly in the C7-8 level of the cervical cord, only in the upper extremity of affected side, whereas 35.6% （26/73） of the patients possessed lesions in the upper extremities bilaterally. A total of 46.6% （34/73） of patients exhibited abnormalities in the lower extremities, sterno- cleidomast or thoracic paravertebral muscle. Changes in motor NCS were significantly correlated with muscle strength. Conclusions EMG detects diffused subclinical neurogenic lesion in a high proportion of patients with Hirayama disease. Results of our study challenge the hypothesis that Hirayama disease is a type of cervical myelopathy.

关键词： Hirayama disease nerve conduction study electromyography F-wave

Rapidly Progressing Fatal Case of Natural Killer/T-Cell Lymphoma Presenting as Orbital Inflammation

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Chinese Medical Journal 2018年第16期131卷 2013-2014页

作者： guang-Min Tang Tian-Cong Chang Xiang Tu guan-yu zhou Zhen-Zhen Liu Center of Infectious Diseases West China Hospital Sichuan University Chengdu Sichuan 610041 China Department of Ophthalmology West China Hospital Sichuan University Chengdu Sichuan 610041 China West China Medical School Sichuan University Chengdu Sichuan 610041 China

To the Editor： Natural killer T-cell lymphoma （NKTCL） is a rare form of non-Hodgkin＇s lymphoma （NHL） that constitutes 1 3% of all cases of orbital NHL. Orbital NKTCL is known as a ＂masquerade syndrome＂ with myriad presentations This case reported a 45-year-old male with primary NKTCL of the orbit initially presenting as orbit inflammation but eventually progressing to systemic aggressive disease.

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Artificial intelligence empowers the second-observer strategy for colonoscopy:a randomized clinical trial

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Gastroenterology Report 2023年第1期11卷 216-223页

作者： Pu Wang Xiao-Gang Liu Min Kang Xue Peng Mei-Ling Shu guan-yu zhou Pei-Xi Liu Fei Xiong Ming-Ming Deng Hong-Fen Xia Jian-Jun Li Xiao-Qi Long Yan Song Liang-Ping Li Department of Gastroenterology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanP.R.China Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanP.R.China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqingP.R.China Department of Gastroenterology Suining Central HospitalSuiningSichuanP.R.China

Background:In colonoscopy screening for colorectal cancer,human vision limitationsmay lead to highermiss rate of lesions;artificial intelligence(AI)assistance has been demonstrated to improve polyp ***,there still lacks direct evidence to demonstrate whether AI is superior to trainees or experienced nurses as a second observer to increase adenoma detection during *** this study,we aimed to compare the effectiveness of assistance fromAI and human observer during ***:A prospective multicenter randomized study was conducted from 2 September 2019 to 29 May 2020 at four endoscopy centers in *** patients were randomized to either computer-aided detection(CADe)-assisted group or observer-assisted *** primary outcome was adenoma per colonoscopy(APC).Secondary outcomes included polyp per colonoscopy(PPC),adenoma detection rate(ADR),and polyp detection rate(PDR).We compared continuous variables and categorical variables by using R studio(version 3.4.4).Results:A total of 1,261(636 in the CADe-assisted group and 625 in the observer-assisted group)eligible patients were ***(0.42 vs 0.35,P=0.034),PPC(1.13 vs 0.81,P<0.001),PDR(47.5%vs 37.4%,P<0.001),ADR(25.8%vs 24.0%,P=0.464),the number of detected sessile polyps(683 vs 464,P<0.001),and sessile adenomas(244 vs 182,P=0.005)were significantly higher in the CADe-assisted group than in the observer-assisted *** detections of the CADe system were lower than those of the human observer(122 vs 191,P<0.001).Conclusions:Compared with the human observer,the CADe system may improve the clinical outcome of colonoscopy and reduce disturbance to routine practice(*** No.:ChiCTR1900025235).

关键词： artificial intelligence colon cancer screening adenoma early detection computer-aided detection

F Wave Study in Amyotrophic Lateral Sclerosis： Assessmen of Segmental Motoneuronal Dysfunction

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Chinese Medical Journal 2015年第13期128卷 1738-1742页

作者： Jia Fang Li-Ying Cui Ming-Sheng Liu yu-zhou guan Xiao-guang Li Bo Cui Qing-yun Ding Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Dysfunctional spinal circuit may play a role in the pathophysiology ofarnyotrophic lateral sclerosis （ALS）. The purpose of this study was to use F waves for assessment of segmental motoneuronal excitability following upper motor neuron （UMN） dysfunctions in ALS. Meihods： We studied the F waves of 152 ulnar nerves recorded fi＇om abductor digiti minimi in 82 patients with ALS. Two groups of hands were defined based on the presence or absence of pyramidal signs in the same upper limb. The group with pyramidal signs in tile upper limbs was designated as the P group, and the group without pyramidal signs in the upper limbs was designated as the NP group. Results： The mean （P 〈 0.001）, median （P 〈 0.001） and maximum （P = 0.035） F wave amplitudes, mean （P 〈 0.001 ）, median （P 〈 0.001） and maximum （P - 0.003） F/M amplitude ratio, index repeating neuron （P 〈 0.001 ） and index repeater F waves （P 〈 0.001 ） of the P group were significantly increased compared with the NP group. No significant differences were identified for F wave chronodispersion （P= 0.628）, mean F wave latency （P 0.151 ）, minimum F wave latency （P = 0.211 ）, maximum F wave latency （13 = 0. 199）. F wave persistence （P = 0.738）. F wave duration （P = 0. 152）, F wave conduction velocity （P = 0.813） and number of giant F waves （P = 0.072） between the two groups. Conclusions＂ In this study, increased F wave amplitude, F/M amplitude ratio and number of repeater F waves reflected enhanced segmental lnotoneuronal excitability following UMN dysfunctions in ALS.

关键词： Amyotrophic Lateral Sclerosis: Excitability F wave Segmental Motoneuron Upper Motor Neuron