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A high mobility air-stable n-type organic small molecule semiconductor with high UV-visible-to-NIR photoresponse

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Light(Science & Applications) 2022年第9期11卷 2140-2146页

作者： ying-SHI guan JING QIAO yingying LIANG HARI KRISHNA BISOYI CHAO wang WEI XU DAOBEN ZHU QUAN LI Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast University211189 NanjingChina Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of Sciences100190 BeijingChina Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State UniversityKentOH 44242USA

An organic semiconductor with high carrier mobility and efficient light absorption over a wide spectral range is of the most important yet challenging material for constructing a broadband responsive organic ***,the development of such organic semiconductors,especially for air-stable n-type organic small molecule semiconductors,is still at an early *** we report the fabrication of high-performance n-type semiconducting crystalline nanosheets and the development of air-stable field-effect transistors,phototransistors,with high response over a broad *** n-type small molecule semiconductor is assembled into a crystalline nanosheet based on the solvent-phase interfacial self-assembly method.N-type field-effect transistors with high electron mobility are fabricated and their electrical performances exhibit excellent air ***,the demonstrated phototransistors exhibit an ultrahigh responsivity over a wide spectral range from 365 to 940 nm,with a maximum photoresponsivity of 9.2×10^(5) AW-1 and specific detectivity of 5.26×10^(13) Jones,which is the best performance among the reported n-type organic small molecule-based phototransistors.

关键词： high visible crystalline

EXISTENCE FOR A FREE BOUNDARY PROBLEM IN GROUND FREEZING

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Chinese Annals of Mathematics,Series B 1998年第1期19卷 97-112页

作者： guan ZHICHENG wang XUJIA Zhejiang Univ Dept Math Hangzhou 310027 Peoples R China

This paper deals with a free boundary problem that arises in ground freezing, where both the heat conduct and the mass transfer are taken into account. The authors obtain the local and global existence for the prob... 详细信息

关键词： Free boundary Existence Ground freezing

Xiao-Xu-Ming decoction extract regulates differentially expressed proteins in the hippocampus after chronic cerebral hypoperfusion

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Neural Regeneration Research 2019年第3期14卷 470-479页

作者： Yue-Hua wang ying-Lin Yang Xiao Cheng Jun Zhang Wan Li guan-Hua Du State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College

Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury. However, the global protein profile and signaling conduction pathways regulated by Xiao-Xu-Ming decoction are still unclear. This study established a two-vessel occlusion rat model by bilateral common carotid artery occlusion. Rats were intragastrically administered 50 or 150 mg/kg Xiao-Xu-Ming decoction for 4 consecutive weeks. Learning and memory abilities were measured with Morris water maze. Motor ability was detected with prehensile test. Coordination ability was examined using the inclined screen test. Neuronal plasticity was observed by immunofluorescent staining. Differentially expressed proteins of rat hippocampus were analyzed by label-free quantitative proteomics. Real time-polymerase chain reaction and western blot assay were used to identify the changes in proteins. Results showed that Xiao-Xu-Ming decoction dramatically alleviated learning and memory deficits, and motor and coordination dysfunction, and increased the expression of microtubule-associated protein 2. Xiao-Xu-Ming decoction extract remarkably decreased 13 upregulated proteins and increased 39 downregulated proteins. The regulated proteins were mainly involved in oxidation reduction process, intracellular signaling cascade process, and protein catabolic process. The signaling pathways were mainly involved in ubiquitin mediated proteolysis and the phosphatidylinositol signaling system. Furthermore, there was an interaction among Rab2 a, Ptpn1, Ppm1 e, Cdk18, Gorasp2, Eps15, Capza2, Syngap1 and Mt-nd1. Protein analyses confirmed the changes in expression of MTND1. The current findings provide new insights into the molecular mechanisms of Xiao-Xu-Ming decoction extract's effects on chronic cerebral hypoperfusion.

关键词： nerve regeneration chronic cerebral hypoperfusion vascular dementia bilateral common carotid artery occlusion Xiao-Xu-Ming decoction label-free quantitative proteomics Morris water maze test Nano-LC-ESI LTQ-Orbitrap MS/MS technology neural regeneration

Direct oxidative C(sp^3)-H cyanation of secondary benzylic ethers

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Chinese Chemical Letters 2019年第6期30卷 1241-1243页

作者： Zehua wang ying Mao Honghao guan Min Cao Jing Hua Lei Feng Lei Liu School of Chemistry and Chemical Engineering Shandong University Ji'nan 250100 China School of Pharmaceutical Sciences Shandong University Ji'nan 250012 China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University Guilin 541004 China

Current studies on the oxidative C--H functionalization of benzylic ethers for C--C forging process dominantly focus on primary ethers. The corresponding reaction of secondary ethers remains underdeveloped. Herein, a practical and efficient oxidative C--H cyanation of secondary benzylic ethers with TMSCN in the presence of DDQ is described. The metal-free process is well tolerated with a wide variety of electronically varied α-monosubstituted isochromans, facilely furnishing a library of isochromans bearing α-aryl α-cyano substituent patterns for further diversification and bioactive small molecule identification.

关键词： C-H functionalization Cyanation Oxidation Secondary ether Tertiary ether synthesis

主要组织相容性复合体调控帕金森病的免疫反应

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中国组织工程研究 2025年第25期29卷 5469-5477页

作者：关梦雅任彬彬王晶莹河南中医药大学康复医学院河南省郑州市450046 河南中医药大学第一附属医院河南省郑州市450000

背景:免疫反应与帕金森病的病理发展密切相关。研究表明,主要组织相容性复合体在免疫应答中发挥关键作用。目的:综述主要组织相容性复合体调控免疫反应的机制以及对帕金森病病理标志物α-突触核蛋白的影响。方法:以“Parkinson’s disea... 详细信息

背景:免疫反应与帕金森病的病理发展密切相关。研究表明,主要组织相容性复合体在免疫应答中发挥关键作用。目的:综述主要组织相容性复合体调控免疫反应的机制以及对帕金森病病理标志物α-突触核蛋白的影响。方法:以“Parkinson’s disease,the major histocompatibility complex,innate immunity,adaptive immunity,microglia,T cell,B cell,α-syn,inflammation,MHC-Ⅰ,MHC-Ⅱ,immunotherapy”为检索词在PubMed数据库检索文献,最终纳入92篇文献进行分析。结果与结论:①先天性免疫反应参与帕金森病的发生发展,小胶质细胞的促炎和抗炎表型的变化可能加剧帕金森病退行性变;②T细胞的表型和功能与帕金森病的进展有关,调节性T细胞促进抗炎小胶质细胞活化,抑制Th亚群;B细胞介导的体液免疫可清除病理性α-突触核蛋白,具体机制需要进一步研究;③主要组织相容性复合体与先天性免疫和适应性免疫的发生密切相关,对帕金森病的炎症产生影响;④α-突触核蛋白调控小胶质细胞的激活和主要组织相容性复合体的表达,导致帕金森病的炎症变化;⑤α-突触核蛋白与帕金森病的免疫反应密切相关,成为治疗帕金森病的重要靶点。

关键词：帕金森病主要组织相容性复合体先天性免疫适应性免疫小胶质细胞 T细胞 B细胞 α-突触核蛋白炎症

Dydrogesterone treatment for menstrual-cycle regularization in abnormal uterine bleeding-ovulation dysfunction patients

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World Journal of Clinical Cases 2020年第15期8卷 3259-3266页

作者： Lu wang Hai-Yun guan He-Xia Xia Xiu-ying Chen Wei Zhang Department of Reproductive Endocrinology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China

BACKGROUND Dydrogesterone has shown significant efficacy in treatment of irregular menstrual cycle due to abnormal uterine bleeding-ovulation dysfunction(AUB-O),but there were few relevant *** observational study was designed to evaluate the effectiveness of dydrogesterone for the treatment of Chinese patients with *** To evaluate the effects of dydrogesterone on menstrual-cycle(MC)regularization and metabolism in the patients with *** A prospective,non-interventional,single-arm,post-marketing observational study was *** women aged 16 years or above with AUB-O who had been prescribed dydrogesterone were *** patients were treated with dydrogesterone 10 mg from day 16 to day 25 of each cycle,consecutively for at least 3 *** main outcome was defined as the percentage of patients whose MCs returned to normal(defined as 21 d

关键词： Dydrogesterone Abnormal uterine bleeding-ovulation dysfunction Menstrual cycle Hormone Testosterone Dehydroepiandrosterone sulfate

Understanding the Initial Decomposition Pathways of the n-Alkane/Nitroalkane Binary Mixture

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Chinese Journal of Chemistry 2013年第8期31卷 1087-1094页

作者： Yulei guan ying Zhang Chunhai Yi Bolun Yang Department of Chemical Engineering State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University Xi'an Shannxi 710049 China

Addition of nitroalkanes into n-alkanes can lower the activation barriers of free-radical production and acceler- ate the decomposition of n-alkanes at relatively low temperatures. Four initial decomposition mechanisms of the n-butane/nitroethane binary mixture were proposed for the promoting effect and considered theoretically at the B3LYP, BB1K, BMK, MPW1K, and M06-2X levels with MG3S basis set. Energetics above was compared to high-level CBS-QB3 and G4 calculations. Calculated results confirm the feasibility of the four initial decomposition pathways：（I） the C--NO2 bond rupture of nitroethane to produce ethyl and .NO2, （II） HONO elimination from nitroethane followed by decomposition to .OH and .NO, （1II） rearrangement of nitroethane to ethyl nitrite which further dissociates into CH3CH20. and .NO, and （IV） direct hydrogen-abstraction ofnitroethane with n-butane.

关键词： free radical initial decomposition mechanism computational chemistry hydrogen-abstraction bimol-ecular

Estimation of Wave Crest Amplitudes Distribution and Freak Wave Occurrence in A Short Crested Mixed Sea

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China Ocean Engineering 2019年第4期33卷 484-492页

作者： wang ying-guang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University

In this study we have for the first time proposed a novel transformed linear simulation method for the estimation of wave crest amplitudes distribution and freak wave occurrence in a short crested mixed sea with a bimodal 3D spectrum. For implementing the proposed transformed linear simulation method, a Hermite transformation model expressed in a monotonic cubic polynomial has been constructed so that the first four moments of the original true process match the corresponding moments of the transformed model. The proposed novel simulation method has been applied to forecast the freak wave occurrence in two short crested mixed sea states, one with a directional wave spectrum based on the measured surface elevation data at the coast of Yura, and the other one with a typical directional bimodal Torsethaugen wave spectrum. It is shown in the two cases that the proposed novel simulation method can offer more accurate forecasting results than those obtained from the traditional linear simulation method or by using Rayleigh distribution model. It is also demonstrated in this article that the proposed novel simulation method is more efficient than the nonlinear simulation method.

关键词： freak waves short crested mixed sea transformed linear simulation Rayleigh distribution model

Prediction of Height and Period Joint Distributions for Stochastic Ocean Waves

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China Ocean Engineering 2017年第3期31卷 291-298页

作者： wang ying-guang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Shanghai 200240 China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration (CISSE) Shanghai 200240 China School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China

This article proposes a new methodology to predict the wave height and period joint distributions by utilizing a transformed linear simulation method. The proposed transformed linear simulation method is based on a Hermite transformation model where the transformation is chosen to be a monotonic cubic polynomial, calibrated such that the first four moments of the transformed model match the moments of the true process. The proposed new approach is applied for calculating the wave height and period joint distributions of a sea state with the surface elevation data measured at an offshore site, and its accuracy and efficiency are favorably validated by using comparisons with the results from an empirical joint distribution model, from a linear simulation model and from a second-order nonlinear simulation model.

关键词： wave height and period transformed linear simulation Hermite transformation linear simulation nonlinearsimulation