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Journal of Hydrodynamics 2022年第2期34卷 299-307页

作者： Xiu-xuan Wang Jia-zhong Qian Lei Ma Qian-kun Luo guan-qun zhou School of Resources and Environmental Engineering Hefei University of TechnologyHefei230009China

The groundwater flow in natural aquifers can change from the Darcy flow to the non-Darcian flow due to a variety of causes,such as the increase of the Reynolds number in the highly permeable media or the decrease of the hydraulic gradient below a threshold in the low-permeability media,while the representative flow regime cannot be reliably determined using the traditional *** address this challenge,this paper proposes a new term called the equivalent hydraulic gradient(EHG)by generalizing the differential form of the Darcy’s law using a spatial integral of the upstream hydraulic *** nonlocal spatial variation of the hydraulic head difference between upstream and downstream zones is assumed to be the potential cause of the transition of the groundwater flow *** assumption is analogous to the common assumption used for quantifying the anomalous pollutant transport in the geological *** of this idea show that the EHG concept could distinguish three main flow regimes,namely the Super-Darcy flow,the Darcy flow,and the Sub-Darcy flow,although the Super-Darcy flow regime is rarely observed in the laboratory column flow *** of this study therefore shed lights on the interpretation of the fundamental dynamics of the groundwater moving in various heterogeneous aquifers,and may lead to the rebuilding of the hydrodynamics of the surface water,the groundwater,and the soil.

关键词： Hydraulic head distribution spatially non-local effect flow regime Forchheimer number Reynolds number

Generating femtosecond coherent X-ray pulses in a diffractionlimited storage ring with the echo-enabled harmonic generation scheme

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Nuclear Science and Techniques 2018年第10期29卷 191-199页

作者： Wei-Hang Liu guan-qun zhou Yi Jiao Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 10004China University of Chinese Academy of Sciences Beijing 100049China

To study ultrafast processes at the sub-picosecond level, novel methods based on coherent harmonic generation technologies have been proposed to generate ultrashort radiation pulses in existing ring-based light sources. Using the High Energy Photon Source as an example, we numerically test the feasibility of implementing one coherent harmonic generation technology, i.e.,the echo-enabled harmonic generation(EEHG) scheme, in a diffraction-limited storage ring(DLSR). Two different EEHG element layouts are considered, and the effect of the EEHG process on the electron beam quality is also analyzed. Studies suggest that soft X-ray pulses, with pulse lengths of a few femtoseconds and peak powers of up to1 MW, can be generated by using the EEHG scheme, while causing little perturbation to the regular operation of a DLSR.

关键词： Echo-enabled harmonic generation Diffraction-limited storage ring High-energy photon source Femtosecond X-ray pulses

Locoregional extension patterns of nasopharyngeal carcinoma and suggestions for clinical target volume delineation

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Chinese Journal of Cancer 2012年第12期31卷 579-587页

作者： Wen-Fei Li Ying Sun Mo Chen Ling-Long Tang Li-Zhi Liu Yan-Ping Mao Lei Chen guan-qun zhou Li Li Jun Ma State Key Laboratory of Oncology in South China Department of Radiation Oncology Sun Yat-sen University Cancer Center Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer Center

Clinical target volume (CTV) delineation is crucial for tumor control and normal tissue protection. This study aimed to define the locoregional extension patterns of nasopharyngeal carcinoma (NPC) and to improve CTV delineation. Magnetic resonance imaging scans of 2366 newly diagnosed NPC patients were reviewed. According to incidence rates of tumor invasion, the anatomic sites surrounding the nasopharynx were classified into high-risk (>30%), medium-risk (5%-30%), and low-risk (<5%) groups. The lymph node (LN) level was determined according to the Radiation Therapy Oncology Group guidelines, which were further categorized into the upper neck (retropharyngeal region and level Ⅱ), middle neck (levels Ⅲ and Va), and lower neck (levels Ⅳ and Vb and the supraclavicular fossa). The high-risk anatomic sites were adjacent to the nasopharynx, whereas those at medium- or low-risk were separated from the nasopharynx. If the high-risk anatomic sites were involved, the rates of tumor invasion into the adjacent medium-risk sites increased; if not, the rates were significantly lower (P < 0.01). Among the 1920 (81.1%) patients with positive LN, the incidence rates of LN metastasis in the upper, middle, and lower neck were 99.6% , 30.2%, and 7.2%, respectively, and skip metastasis happened in only 1.2% of patients. In the 929 patients who had unilateral upper neck involvement, the rates of contralateral middle neck and lower neck involvement were 1.8% and 0.4%, respectively. Thus, local disease spreads stepwise from proximal sites to distal sites, and LN metastasis spreads from the upper neck to the lower neck. Individualized CTV delineation for NPC may be feasible.

关键词：鼻咽癌局部区域靶区临床圈定解剖部位磁共振成像肿瘤学

Clinical practice guideline for acupuncture and moxibustion: Female urinary incontinence

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Journal of Integrative Medicine 2024年第3期22卷 258-269页

作者： Chao Yang Shan-ze Wang Sheng Chen Shuo Du guan-qun Wang Wei Guo Xiao-long Xie Bi-hui Peng Shi-hao Du Ji-ping Zhao Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong provincial hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineShanghai 200011China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China

Urinary incontinence (UI) is a common problem *** has a major impact on physical and social activities and interpersonal *** is common in women,but is under-reported and *** affects the quality of life of female patients *** and moxibustion have been proposed as potentially effective interventions for female ***,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies initiated a project to develop a clinical practice guideline (CPG) for the use of acupuncture and moxibustion to treat female *** CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation (GRADE) methodology,referring to the principles of the World Health Organization Handbook for Guideline *** the development of the CPG,the guideline development group (GDG) played an important *** clinical questions,recommendations and therapeutic protocols were all formulated by GDG using the modified Delphi *** CPG contains ten recommendations about the use of acupuncture and moxibustion interventions for ten clinical questions,which include nine conditional recommendations for the intervention and one conditional recommendation for either the intervention or the *** CPG also provides one protocol for conventional filiform needle therapy,two therapy protocols for deep needling stimulation on lumbosacral acupoints,and four moxibustion therapy protocols,based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Acupuncture Clinical practice guideline Female urinary incontinence Moxibustion GRADE

Clinical practice guideline for acupuncture and moxibustion:Allergic rhinitis

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Journal of Integrative Medicine 2024年第3期22卷 245-257页

作者： Shi-hao Du Sheng Chen Shan-ze Wang guan-qun Wang Shuo Du Wei Guo Xiao-long Xie Bi-hui Peng Chao Yang Ji-ping Zhao Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Traditional Chinese Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Acupuncture is one of the most effective complementary therapies for allergic rhinitis(AR)and has been recommended by several clinical practice guidelines(CPGs)for ***,these CPGs mentioned acupuncture without making recommendations for clinical implementation and therapeutic protocols,therefore limiting the applicability of acupuncture therapies for ***,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies have initiated a project to develop the CPG for the use of acupuncture and moxibustion to treat *** CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology,referring to the principles of the World Health Organization Handbook for Guideline *** the development of the CPG,the guideline development group(GDG)played an important *** clinical questions,recommendations and therapeutic protocols were all formulated by the GDG using the modified Delphi *** CPG contains recommendations for 15 clinical questions about the use of acupuncture and moxibustion *** include one strong recommendation for the intervention based on high-quality evidence,three conditional recommendations for either the intervention or standard care,and 11 conditional recommendations for the intervention based on very low quality of *** CPG also provides one filiform needle acupuncture protocol and five moxibustion protocols extracted based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Clinical practice guideline Allergic rhinitis Acupuncture Moxibustion GRADE

Prognostic factors and failure patterns in non-metastatic nasopharyngeal carcinoma after intensity-modulated radiotherapy

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Chinese Journal of Cancer 2016年第12期35卷 673-682页

作者： Yan-Ping Mao Ling-Long Tang Lei Chen Ying Sun Zhen-Yu Qi guan-qun zhou Li-Zhi Liu Li Li Ai-Hua Lin Jun Ma State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center Department of Radiation Oncology Sun Yat-sen University Cancer Center Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer Center Department of Medical Statistics and Epidemiology School of Public HealthSun Yat-sen University

Background: The prognostic values of staging parameters require continual re?assessment amid changes in diag?nostic and therapeutic methods. This study aimed to identify the prognostic factors and failure patterns of non?meta?static nasopharyngeal carcinoma(NPC) in the intensity?modulated radiotherapy(IMRT) ***: We reviewed the data from 749 patients with newly diagnosed, biopsy?proven, non?metastatic NPC in our cancer center(South China, an NPC endemic area) between January 2003 and December 2007. All patients under?went magnetic resonance imaging(MRI) before receiving IMRT. The actuarial survival rates were estimated using the Kaplan–Meier method, and survival curves were compared using the log?rank test. Multivariate analyses with the Cox proportional hazards model were used to test for the independent prognostic factors by backward eliminating insigniicant explanatory ***: The 5?year occurrence rates of local failure, regional failure, locoregional failure, and distant failure were 5.4, 3.0, 7.4, and 17.4%, respectively. The 5?year survival rates were as follows: local relapse?free survival, 94.6%; nodal relapse?free survival, 97.0%; distant metastasis?free survival, 82.6%; disease?free survival, 75.1%; and overall survival, 82.0%. Multivariate Cox regression analysis revealed that orbit involvement was the only signiicant prognostic fac?tor for local failure(P = 0.011). Parapharyngeal tumor extension, retropharyngeal lymph node involvement, and the laterality, longest diameter, and Ho's location of the cervical lymph nodes were signiicant prognostic factors for both distant failure and disease failure(all P < 0.05). Intracranial extension had signiicant prognostic value for distant failure(P = 0.040).Conclusions: The key failure pattern for NPC was distant metastasis in the IMRT era. With changes in diagnostic and therapeutic technologies as well as treatment modalities, the signiicant prognostic parameters for local control have also been

关键词： Nasopharyngeal carcinoma Intensity-modulated radiotherapy Prognosis Failure pattern Tumor staging

Individualized elective irradiation of the clinically node-negative neck in definitive radiotherapy for head and neck squamous cell carcinoma

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Cancer Communications 2021年第4期41卷 303-315页

作者： Jia Kou Li Lin Cheng-Yang Jiao Meng-Qiu Tian guan-qun zhou Xue Jiang Jun Ma Zhen-Yu Qi Yao Lu Ying Sun Department of Radiation Oncology Sun Yat-sen University Cancer Center/State Key Laboratory of Oncology in South China/Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhouGuangdong 510060P.R.China Perception vision medical technology co.LTD GuangzhouGuangdong 510275P.R.China School of Data and Computer Science Sun Yat-sen UniversityGuangdong Province Key Laboratory of Computational ScienceGuangzhouGuangdong 510275P.R.China

Background:Oral cavity(OC),oropharyngeal(OP),hypopharyngeal(HP),and laryngeal(LA)squamous cell carcinoma(SCC)have a high incidence of regional lymph node metastasis(LNM).Elective irradiation for clinically node-negative neck is routinely administered to treat lymph nodes harboring occult ***,the optimal elective irradiation schemes are still *** this study,we aimed to establish individualized elective irradiation schemes for the ipsilateral and contralateral node-negative neck of these four types of ***:From July 2005 to December 2018,793 patients with OC-SCC,464 with OP-SCC,413 with HP-SCC,and 645 with LA-SCC were recruited *** on the actual incidence of LNM and the tumor characteristics,risk factors for contralateral LNM,as well as node level coverage schemes for elective irradiation,were determined using logistic regression ***,we developed a publicly available online tool to facilitate the widespread clinical use of these ***:For the ipsilateral node-negative neck,elective irradiation at levels Ⅰ-Ⅲ for OC-SCC and levels Ⅱ-Ⅳa for OP-,HP-and LA-SCC are generally *** addition,level Ⅶa should be included in patients with *** analyses revealed that posterior hypopharyngeal wall and post-cricoid region involvement were independently associated with level Ⅶa metastasis in HP-SCC(all P<0.05).For the contralateral node-negative neck,multivariate analyses revealed that ipsilateral N2b2-N3,tumors with body midline involvement,and degree of tumor invasion were the independent factors for contralateral LNM(all P<0.05).In patients who require contralateral neck irradiation,levels Ⅰ-Ⅱ are recommended for OC-SCC,and additional level Ⅲ is recommended for patients with ipsilateral N3 *** Ⅱ-Ⅲ are recommended for OP-,HP-,and LA-SCC,and additional level Ⅳa is recommended for patients with advanced T or ***,additional level Ⅶa

关键词： clinically node-negative neck elective irradiation head and neck squamous cell carcinoma individualization neck node level

Comparative role of real-world study and traditional randomized controlled trials in head and neck cancer:a literature-based analysis

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Chinese Medical Journal 2021年第4期134卷 489-491页

作者： guang-Li Zhu Cheng Xu Si-Qi Tang Lei Chen Yan-Ping Mao Ling-Long Tang guan-qun zhou Qing Liu Ying Sun Jun Ma Department of Radiation Oncology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhouGuangdong 510060China

To the Editor:In the era of evidence-based medicine,the traditional randomized controlled trials(RCT)is on the top of the pyramid of evidence *** well-controlled inclusion and exclusion criteria,randomization,and strict intervention protocol,traditional RCT construct the ideal medical circumstance,under which the causal relationship between the outcome and intervention can be better ***,it will also make the external validity and generalizability of traditional RCT limited.

关键词： randomized pyramid validity

Radiotherapy with neoadjuvant chemotherapy versus concurrent chemoradiotherapy for ascending-type nasopharyngeal carcinoma:a retrospective comparison of toxicity and prognosis

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Chinese Journal of Cancer 2017年第4期36卷 176-183页

作者： Ji-Jin Yao Xiao-Li Yu Fan Zhang Ji-Jin Yao Xiao-Li Yu Fan Zhang Wang-Jian Zhang guan-qun zhou Ling-Long Tang Yan-Ping Mao Lei Chen Jun Ma Ying Sun Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Department of Radiation Oncology The Fifth Affiliated Hospital of Sun Yat-sen University Department of Radiation Oncology Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Medical Statistics and Epidemiology & Health Information Research Center & guangdong Key Laboratory of Medicine School of Public Health Sun Yat-sen University

Background:In the era of intensity?modulated radiotherapy(IMRT),the role of neoadjuvant chemotherapy(NACT)in treating ascending?type nasopharyngeal carcinoma(NPC)is under?*** study was to compare the efficacy of NACT followed by IMRT(NACT+RT)with the efficacy of concurrent chemoradiotherapy(CCRT)on ascending?type ***:Clinical data of 214 patients with ascending?type NPC treated with NACT+RT or CCRT between Decem?ber 2009 and July 2011 were *** the 214 patients,98 were treated with NACT followed by IMRT,and 116 were treated with *** survival rates were assessed using Kaplan–Meier analysis,and the survival curves were compared using a log?rank ***:The 4?year overall survival,locoregional failure?free survival,distant failure?free survival,and failure?free sur?vival rates were not significantly different between the two groups(all P>0.05).However,patients in the CCRT group exhibited more severe acute adverse events than did patients in the NACT+RT group during radiotherapy,includ?ing leukopenia(30.2%vs.15.3%,P=0.016),neutropenia(25.9%vs.11.2%,P=0.011),and mucositis(57.8%vs.40.8%,P=0.028).After radiotherapy,patients in the CCRT group exhibited significantly higher rates of xerostomia(21.6%***:The treatment outcomes of the NACT+RT and CCRT groups were similar;however,CCRT led to higher rates of acute and late ***+RT may therefore be a better treatment strategy for ascending?type NPC.

关键词： Nasopharyngeal carcinoma Ascending-type Intensity-modulated radiotherapy Neoadjuvant chemotherapy Concurrent chemoradiotherapy

Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma

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Chinese Journal of Cancer 2017年第12期36卷 737-743页

作者： Ji‑Jin Yao guan‑qun zhou Ya‑Qin Wang Si‑Yang Wang Wang‑Jian Zhang Ya‑Nan Jin Fan Zhang Li Li Li‑Zhi Liu Zhi‑Bin Cheng Jun Ma Zhen‑Yu Qi Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat‑sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology The Fifth Afliated Hospital of Sun Yat‑sen UniversityZhuhaiGuangdong 519001P.R.China Department of Medi‑cal Statistics and Epidemiology&Health Information Research Center&guangdong Key Laboratory of Medicine School of Public HealthSun Yat‑sen UniversityGuangzhouGuangdong 510080P.R.China Department of Imag‑ing Diagnosis and Interventional Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat‑sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Background: According to the 7 th edition of the American Joint Committee on Cancer(AJCC) staging system, over50% of patients with nasopharyngeal carcinoma(NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node(GTVnd) and pretreatment serum copy number of Epstein-Barr virus(EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of ***: The medical records of 787 newly diagnosed patients with nonmetastatic, histologically proven N1 NPC who were treated at Sun Yat-sen University Cancer Center between November 2009 and February 2012 were analyzed. Computed tomography-derived GTVnd was measured using the summation-of-area technique. Blood samples were collected before treatment to quantify plasma EBV DNA. The receiver operating characteristic(ROC) curve analysis was used to evaluate the cut-off point for GTVnd, and the area under the ROC curve was used to assess the predicted validity of GTVnd. The survival rates were assessed by Kaplan-Meier analysis, and the survival curves were compared using a log-rank test. Multivariate analysis was conducted using the Cox proportional hazard regression ***: The 5-year distant metastasis-free survival(DMFS) rates for patients with GTVnd > 18.9 vs.≤ 18.9 mL were82.2% vs. 93.2%(P 4000 vs. 18.9 mL and EBV DNA copy number > 4000 copies/mL were significantly associated with poor prognosis(both P < 0.05). According to combination of GTVnd and EBV DNA copy number, all patients

关键词： Nasopharyngeal carcinoma Lymph node volume Epstein–Barr virus DNA Distant metastasis Prognostic model