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Anti-tumor effect of matrine combined with cisplatin on rat models of cervical cancer

Asian Pacific Journal of Tropical Medicine 2015年第12期8卷 1025-1028页

作者： guan-li zhang ling Jiang Qian Yan Rong-Hui liu Lu zhang Department of Obstetrics and Gynecology Yantaishan Hospital Affiliated to Taishan Medical University

Objective:To observe the anti-tumor effect of matrine combined with cisplatin on U14 rat models of cervical ***:A total of 80 female Kunming rats were used to establish U14 rat models of cervical cancer and then divided into groups Ⅰ,Ⅱ,Ⅲ and Ⅳ,with 20 rats in *** Group Ⅰ,the control group,injection of normal saline was given around the *** Group Ⅱ,injection of 2 mg/kg cisplatin was given around the *** Group Ⅲ,injection of 75 mg/kg matrine was given around the tumors while the combined injection of matrine and cisplatin was given for Group Ⅳ with the same doses as Groups Ⅱand Ⅲ.The animals were sacrificed 10 d after the injection and tumors were taken out for the comparisons of tumor weights after injection and calculation of anti-tumor rates,while thymus and spleen were taken for thymus index and spleen *** in eyeball was collected for determination of changes in serum creatinine and urea nitrogen *** of tumor issue were prepared and morphological changes in tumor tissue cells were observed by using immunohistochemistry ***:After injection,the thymus index and spleen index in Groups Ⅲ and Ⅳ were significantly higher than those in Groups Ⅰ and Ⅱ(P<0.05)while the two indexes in Group Ⅱ were significantly lower than Group Ⅰ(P<0.05).The tumor weights in Groups Ⅱ and Ⅳ were significantly smaller than those in Groups Ⅰ and Ⅲ(P<0.05) with significantly higher anti-tumor rates than Groups Ⅰ and Ⅲ(P<0.05).The serum creatinine and urea nitrogen levels in Groups Ⅲ and Ⅳ were significantly lower than Group Ⅱ(P<0.05) and the two indicators in Group Ⅲ were significantly lower than those in Group Ⅳ(P<0.05).The observation under the histological microscope showed densely arranged tumor cells in Group Ⅰ,growing as a crumby structure and diffuse appearance,with hyperchromatic and large nuclei,and abundant *** the case of Group Ⅱ,it showed less tumor cells,with extensive degenerative necrosis,sparse arrangement

关键词： Cervical cancer Matrine Cisplatin Anti-tumor effec

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INFLUENCING PARAMETERS OF FLOW-INDUCED STRUCTURAL DEFORMATION FOR A CIRCULAR TUBE

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Journal of Hydrodynamics 2009年第4期21卷 520-525页

作者： JIANG Bo TIAN Mao-cheng zhang guan-min li Bao-xing CHENG lin School of Energy Source and Power Engineering Shandong University Jinan 250061 China

Numerical simulations were carried out to study the effects of flow and structural parameters on structural deformation. The curves were obtained to show the structural stress and deformation varying with the flow and structural parameters. Meanwhile, the influence degree of these parameters was investigated by range analysis, and a fitting formula of the parameters and the maximum structural deformation in this model was obtained and thus the most influential parameter on structure safety was found. Results show that there is a great difference in their effect on the structural deformation for these flow and structural parameters. The influence degree of parameters is in a decreasing order for the pipe length, fluid velocity, pipe thickness, fluid density, pipe diameter, elastic modulus, Poisson ratio and fluid viscosity, among which the first four parameters play the major role. Besides, a proper parameter selection based on the influence degree shown in the fitting formula can provide an effective control of the structural deformation.

关键词： fluid and structure interaction flow-induced finite element

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Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 52-63页

作者： li zhang Sai He Hao guan Yao Zhao Di zhang Department of General Surgery the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004China Department of Breast Cancer Shaanxi Provincial Cancer HospitalXi’an 710000China

Background:Hepatocellular carcinoma(HCC),the most common type of primary liver cancer,is the fourth leading cause of cancer-related deaths *** evidence shows that the expression of circulating RNA ZFR(circZFR)is upregulated in HCC ***,the molecular mechanism of circZFR in HCC is ***:Quantitative reverse transcriptase polymerase chain reaction(qRT-PCR)was employed to detect the expression of circZFR,microRNA-624-3p(miR-624-3p)and WEE1 in HCC tissues and *** R assay and actinomycin D treatment assay were used to analyze the characteristics of *** functional analysis,the capacities of colony formation,cell proliferation,cell apoptosis,migration and invasion were assessed by colony formation assay,5-ethynyl-2-deoxyuridine(EdU)assay,flow cytometry assay and transwell *** blot was used to examine the protein levels of WEE1 and epithelial-mesenchymal transition(EMT)-related *** interactions between miR-624-3p and circZFR or WEE1 were validated by dual-luciferase reporter assay and RNA immunoprecipitation(RIP)*** models were established to determine the role of circZFR in ***:circZFR and WEE1 were upregulated,while miR-624-3p expression was reduced in HCC tissues and *** could sponge miR-624-3p,and WEE1 was a downstream gene of *** of circZFR significantly reduced the malignant behaviors of HCC and that co-transfection with miR624-3p inhibitor restored this *** of WEE1 abolished the inhibitory effect of miR624-3p mimic on HCC ***,circZFR acted as a competitive endogenous RNA(ceRNA)to regulate WEE1 expression by targeting ***,in vivo studies have illustrated that circZFR knockdown inhibited tumor ***:circZFR knockdown reduced HCC cell proliferation,migration and invasion and promoted apoptosis by regulating the miR-624-3p/WEE1 axis,suggesting that the circZFR/miR-624-3p/WEE1 axis might

关键词： Hepatocellular carcinoma circZFR miR-624-3p WEE1 liver cancer

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Deep Learning Blockchain Integration Framework for Ureteropelvic Junction Obstruction Diagnosis Using Ultrasound Images

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Tsinghua Science and Technology 2024年第1期29卷 1-12页

作者： Yu guan Pengceng Wen Jianqiang li Jinli zhang Xianghui Xie Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Beijing Children’s Hospital Affiliated to Capital Medical University Beijing 100020China

UreteroPelvic Junction Obstruction(UPJO)is a common hydronephrosis disease in children that can result in an even progressive loss of renal *** is an economical,radiationless,noninvasive,and high noise preliminary diagnostic step for *** intelligence has been widely applied to medical fields and can greatly assist doctors'diagnostic *** demand for a highly secure network environment in transferring electronic medical data online,therefore,has led to the development of blockchain *** this study,we built and tested a framework that integrates a deep learning diagnosis model with blockchain *** diagnosis model is a combination of an attention-based pyramid semantic segmentation network and a discrete wavelet transformation-processed residual classification *** also compared the performance between benchmark models and our *** diagnosis model outperformed benchmarks on the segmentation task and classification task with MloU=87.93,MPA=93.52,and accuracy=91.77%.For the blockchain system,we applied the InterPlanetary File System protocol to build a secure and private sharing *** framework can automatically grade the severity of UPJO using ultrasound images,guarantee secure medical data sharing,assist in doctors'diagnostic ability,relieve patients'burden,and provide technical support for future federated learning and linkage of the Internet of Medical Things(loMT).

关键词： data mining image processing and computer vision machine learning medical information systems

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A multi-functional MgF_(2)/polydopamine/hyaluronan-astaxanthin coating on the biodegradable ZE21B alloy with better corrosion resistance and biocompatibility for cardiovascular application

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Journal of Magnesium and Alloys 2024年第3期12卷 1102-1116页

作者： Yachen Hou Xueqi zhang Jingan li liguo Wang Shaokang guan School of Materials Science and Engineering and Henan Key Laboratory of Advanced Magnesium Alloy and Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou UniversityZhengzhou 450001China

The cardiovascular diseases(CVD)continue to be the major threat to global public health over the years,while one of the effective methods to treat CVD is stent *** magnesium(Mg)alloys have great potential applications in cardiovascular stents benefit from their excellent biodegradability and ***,excessive degradation rate and the delayed surface endothelialization still limit their further *** this study,we modified a Mg-Zn-Y-Nd alloy(ZE21B)by preparing MgF_(2) as the corrosion resistance layer,the dopamine polymer film(PDA)as the bonding layer,and hyaluronic acid(HA)loaded astaxanthin(ASTA)as an important layer to directing the cardiovascular cells *** electrochemical test results showed that the MgF_(2)/PDA/HA-ASTA coating improved the corrosion resistance of *** cytocompatibility experiments also demonstrated that this novel composite coating also selectively promoted endothelial cells proliferation,inhibited hyperproliferation of smooth muscle cells and adhesion of *** with the HAloaded rapamycin(RAPA)coating,our MgF_(2)/PDA/HA-ASTA coating showed better blood compatibility and cytocompatibility,indicating stronger multi-functions for the ZE21B alloy on cardiovascular application.

关键词： Biodegradable ZE21B alloy Reendothelialization Surface modification Hyaluronic acid Astaxanthin.

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Experimental validation of adsorption filter model under dynamic VOC concentrations:Prediction of long-term efficiency

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Building Simulation 2024年第7期17卷 1201-1212页

作者： Ruiyan zhang Ziying li Xiangyuan guan Xin Wang Fei Wang lingjie Zeng Zhenhai li School of Environment and Architecture University of Shanghai for Science and TechnologyShanghai 200093China School of Mechanical Engineering Tongji UniversityShanghai 200092China

Indoor volatile organic compound(VOC)concentrations are often dynamic because the ventilation and emission rates of VOC usually *** filters used for air purification may operate with a capacity that fluctuates with unsteady VOC concentrations in *** the dynamic interactions between adsorption filters and indoor air is crucial for predicting their performance under real-world *** study presents a numerical model of partially reversible adsorption equilibrium coupled with a mass transfer model to create a predictive model for adsorption efficiency in environments with dynamic VOC concentrations.A honeycomb adsorption filter for benzene adsorption was simulated and tested,including the breakthrough and purging curve and the long-term efficiency in an experimental chamber with dynamic *** results reveal that the curve generated with the partially reversible adsorption equilibrium model closely aligns with the measured ***,the model was coupled with a chamber model and the simulation results were compared with those calculated using the filter model with a single adsorption *** VOCs were emitted intermittently in the chamber and there was sufficient ventilation,the concentration peaks in the chamber derived from the models with different assumptions on adsorption reversibility were significantly different from each ***,it was observed that the reversible adsorption capacity of the filter was crucial for long-term operation in rooms with dynamic *** the reversible adsorption capacity constituting only 6.7%of the total adsorption capacity of the tested filter,it contributes to a significant“peak shaving and valley filling”effect,even when the irreversible adsorption capacity is *** adsorption reversibility should be taken as an important parameter for selecting adsorbents for dynamic concentration conditions.

关键词： adsorption filter efficiency model indoor air partially reversible adsorption

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Flotation separation of scheelite from calcite using luteolin as a novel depressant

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 462-472页

作者： Xiaokang li Ying zhang Haiyang He Yu Wu Danyu Wu Zhenhao guan Faculty of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093China State Key Laboratory of Clean Utilization of Complex Non-Ferrous Metal Resources Kunming University of Science and TechnologyKunming 650093China

This paper proposes luteolin(LUT)as a novel depressant for the flotation-based separation of scheelite and calcite in a sodium oleate(NaOL)*** suitability of LUT as a calcite depressant is confirmed through micro-flotation *** pH=9,with LUT concentration of 50 mg·L^(-1) and NaOL concentration of 50 mg·L^(-1),scheelite recovery reaches 80.3%.Calcite,on the other hand,exhibits a recovery rate of 17.6%,indicating a significant difference in floatability between the two ***,the surface modifica-tions of scheelite and calcite following LUT treatment are characterized using adsorption capacity testing,Zeta potential analysis,Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),and atomic force microscopy(AFM).The study in-vestigates the selective depressant mechanism of LUT on *** capacity testing and Zeta potential analysis demonstrate sub-stantial absorption of LUT on the surface of calcite,impeding the further adsorption of sodium oleate,while its impact on scheelite is ***-IR and XPS analyses reveal the selective adsorption of LUT onto the surface of calcite,forming strong chemisorption bonds between the hydroxyl group and calcium ions *** directly illustrates the distinct adsorption densities of LUT on the two miner-al ***,LUT can effectively serve as a depressant for calcite,enabling the successful separation of scheelite and calcite.

关键词： scheelite calcite luteolin flotation depressant separation

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Real-time tracking of fast-moving object in occlusion scene

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Journal of Systems Engineering and Electronics 2024年第3期35卷 741-752页

作者： li Yuran li Yichen zhang Monan YU Wenbin guan Xinping Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Systems Control and Information Processing Ministry of Education of ChinaShanghai 200240China

Tracking the fast-moving object in occlusion situations is an important research topic in computer vision. Despite numerous notable contributions have been made in this field,few of them simultaneously incorporate both object's extrinsic features and intrinsic motion patterns into their methodologies,thereby restricting the potential for tracking accuracy improvement. In this paper, on the basis of efficient convolution operators(ECO) model, a speed-accuracy-balanced model is put forward. This model uses the simple correlation filter to track the object in real-time, and adopts the sophisticated deep-learning neural network to extract high-level features to train a more complex filter correcting the tracking mistakes, when the tracking state is judged to be poor. Furthermore, in the context of scenarios involving regular fast-moving, a motion model based on Kalman filter is designed which greatly promotes the tracking stability, because this motion model could predict the object's future location from its previous movement pattern. Additionally,instead of periodically updating our tracking model and training samples, a constrained condition for updating is proposed,which effectively mitigates contamination to the tracker from the background and undesirable samples avoiding model degradation when occlusion happens. From comprehensive experiments, our tracking model obtains better performance than ECO on object tracking benchmark 2015(OTB100), and improves the area under curve(AUC) by about 8% and 32% compared with ECO, in the scenarios of fast-moving and occlusion on our own collected dataset.

关键词： speed-accuracy balanced motion modeling constrained updater

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Roles and application of exosomes in the development,diagnosis and treatment of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 630-642页

作者： Xiao-li guan Xiao-Ying guan Zheng-Yi zhang Department of General Medicine The Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Pathology The Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

As important messengers of intercellular communication,exosomes can regulate local and distant cellular communication by transporting specific exosomal con-tents and can also promote or suppress the development and progression of gas-tric cancer(GC)by regulating the growth and proliferation of tumor cells,the tumor-related immune response and tumor *** transport bioactive molecules including DNA,proteins,and RNA(coding and noncoding)from donor cells to recipient cells,causing reprogramming of the target *** this review,we will describe how exosomes regulate the cellular immune respon-se,tumor angiogenesis,proliferation and metastasis of GC cells,and the role and mechanism of exosome-based therapy in human *** will also discuss the potential application value of exosomes as biomarkers in the diagnosis and treat-ment of GC and their relationship with drug resistance.

关键词： Exosomes Gastric cancer Immune regulation Diagnosis Cancer therapy

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Enhanced photocatalytic ammonia oxidation activity and nitrogen selectivity over Ag/AgCl/N-TiO_(2) photocatalyst

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Journal of Environmental Sciences 2024年第4期138卷 395-405页

作者： Jiaojiao guan Daorong li Jiahui Feng Peng Xu Zhaonian li Siqi Ge Hongxia Chen Kunfeng zhang College of Environmental Engineering Henan University of TechnologyZhengzhou 450001China CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and TechnologyBeijing 100190China Department of Chemistry Tsinghua UniversityBeijing 100084China

The removal of ammonia(NH_(3))emitted from agricultural and industrial activities is of great significance to protect human health and ecological *** NH_(3)oxidation to N2under mild conditions is a promising ***,developing visible light photocatalysts for NH_(3)oxidation is still in its ***,we fabricate N-TiO_(2)and Ag/AgCl/N-TiO_(2)photocatalysts by sol-gel and photodeposition methods,*** introduction of N not only endows TiO_(2)with visible light response(absorption edge at460 nm)but also results in the formation of heterophase junction(anatase and rutile).Thus,N-TiO_(2)shows 2.0 and 1.8 times higher than those over anatase TiO_(2)and commercial TiO_(2)for NH_(3)oxidation under full spectrum ***,surface modification of Ag can simultaneously enhance visible light absorption(generating localized surface plasmon resonance effect)and charge separation ***,the photocatalytic activity of Ag/AgCl/N-TiO_(2)is further ***,the presence of N and Ag also enhances the selectivity of N2product owing to the change of reaction *** work simultaneously regulates photocatalytic conversion efficiency and product selectivity,providing some guidance for developing highly efficient photocatalysts for NH_(3)elimination.

关键词： TiO_(2) Doping Surface modification Photocatalysis NH_(3)elimination

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