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An antibiotic-free platform for eliminating persistent Helicobacter pylori infection without disrupting gut microbiota

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3184-3204页

作者： Yongkang Lai Tinglin Zhang Xiaojing yin Chunping zhu Yiqi Du Zhaoshen Li Jie Gao Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Gastroenterology Ganzhou People’s Hospital Affiliated to Nanchang UniversityGanzhou 341000China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices Shanghai 200433China

Helicobacter pylori(***)infection remains the leading cause of gastric adenocarcinoma,and its eradication primarily relies on the prolonged and intensive use of two ***,antibiotic resistance has become a compelling health issue,leading to *** eradication treatment failure ***,the powerlessness of antibiotics against biofilms,as well as intracellular *** and the long-term damage of antibiotics to the intestinal microbiota,have also created an urgent demand for antibiotic-free ***,we describe an antibiotic-free,multifunctional copperorganic framework(HKUST-1)platform encased in a lipid layer comprising phosphatidic acid(PA),rhamnolipid(RHL),and cholesterol(CHOL),enveloped in chitosan(CS),and loaded in an ascorbyl palmitate(AP)hydrogel:AP@CS@Lip@*** platform targets inflammatory sites where *** aggregates through electrostatic ***,hydrolysis by matrix metalloproteinases(MMPs)releases CS-encased nanoparticles,disrupting bacterial urease activity and membrane ***,RHL disperses biofilms,while PA promotes lysosomal acidification and activates host autophagy,enabling clearance of intracellular ***,AP@CS@Lip@HKUST-1 alleviates inflammation and enhances mucosal repair through delayed Cu^(2+) release while preserving the intestinal ***,this platform presents an advanced therapeutic strategy for eradicating persistent *** infection without inducing drug resistance.

关键词： Helicobacter pylori infection Antibiotic-free Biofilms Autophagy Gastric mucosal repair Drug resistance Intestinal microbiota Anti-inflammation

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Ni/Co bimetallic organic frameworks nanospheres for highperformance electrochemical energy storage

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Nano Research 2024年第6期17卷 5122-5130页

作者： Jianru guan Minlu Liu Limin zhu Jiamei Wang Qing Han Xiaoxia Yang Weibo Hua Lingling Xie Xiaoyu Cao School of Chemistry and Chemical Engineering Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou CityHenan University of TechnologyZhengzhou 450001China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China School of Environmental Engineering Henan University of TechnologyZhengzhou 450001China

In addition to their many well-known advantages(e.g.,ultra-high porosity,good pore size distribution,easy functionalization,and structural tolerability),metal-organic frameworks(MOFs)are a new class of advanced functional ***,their backbones are highly susceptible to deformation after exposure to acidic or alkaline *** a result of lithium-ion batteries embedding or detaching directly from MOFs,they irreversibly *** a result,they fail to maintain their electrochemical *** factors have hindered the development of MOFs as direct electrode materials,making the design of MOF materials with controlled morphology and stable dimensions a new *** this study,we adopted a versatile and effective method to synthesize a novel MOF material(NiCo-BP(BP=BTC/phen and BTC=1,3,5-benzenetricarboxylic acid))using the rigid ligands 1,10-phenanthroline and homobenzotrizoic acid,and the emergence of the Ni-O/N and Co-O/N coordination layers was observed by extended X-ray absorption fine structure(EXAFS)tests,indicating that Ni and Co were coordinated with heterocyclic N-given atoms to form a stable p-πconjugated ***,the metal-ion is attached to the carboxylic acid ligand on the other side,making the metal-organic skeleton complete and *** nanosphere structure of NiCo-BP(~400 nm)allows for full exposure and utilisation of the active sites,especially the Ni,Co,and phenanthroline units,and exhibit impressively high specific capacity and cycling *** a high current density of 1.0 A·g^(−1),a high discharge specific capacity of 631.6 mAh·g^(−1)was obtained after 1000 *** co-participation of two organic ligands in the coordination is in accordance with the theory of soft and hard acids and bases,which contributes to the ability of the material to maintain a high capacity in cycling as well as its cyclic stability.

关键词： lithium-ion batteries metal organic frame electrochemical energy storage dual ligand hard-soft-acid-base

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Lipid concentration and composition in xylem sap of woody angiosperms from a tropical savanna and a seasonal rainforest

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Plant Diversity 2024年第1期46卷 126-133页

作者： Ling-Bo Huang Xinyi guan Amy Ny Aina Aritsara Jun-Jie zhu Steven Jansen Kun-Fang Cao State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources Guangxi Key Laboratory of Forest Ecology and ConservationGuangxi UniversityDaxuedong Road 100NanningGuangxi 530004China Institute of Botany Ulm UniversityAlbert-Einstein-Allee 11Ulm89081Germany

Lipids may play an important role in preventing gas embolisms by coating nanobubbles in xylem *** studies on xylem sap lipids have been reported for temperate plants,and it remain unclear whether sap lipids have adaptational significance in tropical *** this study,we quantify the lipid composition of xylem sap for angiosperm species from a tropical savanna(seven species)and a seasonal rainforest(five species)using mass *** found that all twelve species studied contained lipids in their xylem sap,including galactolipids,phospholipids and triacylglycerol,with a total lipid concentration ranging from 0.09 to 0.26 nmol/*** was no difference in lipid concentration or composition between plants from the two sites,and the lipid concentration was negatively related to species’open vessel ***,savanna species showed little variation in lipid composition between the dry and the rainy *** results support the hypothesis that xylem sap lipids are derived from the cytoplasm of individual conduit cells,remain trapped inside individual conduits,and undergo few changes in composition over consecutive seasons.A xylem sap lipidomic data set,which includes 12 tropical tree species from this study and 11 temperate tree species from literature,revealed no phylogenetic signals in lipid composition for these *** study fills a knowledge gap in the lipid content of xylem sap in tropical trees and provides additional support for their common distribution in xylem sap of woody *** appears that xylem sap lipids have no adaptive significance.

关键词： Xylem sap Lipids Tropical savanna Tropical rainforest Vessels

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Impact of well placement and flow rate on production efficiency and stress field in the fractured geothermal reservoirs

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Deep Underground Science and Engineering 2024年第3期3卷 358-368页

作者： Xinghui Wu Meifeng Cai Xu Wu Ketong Zhang Ziqing yin Yu zhu School of City and Architecture Engineering Zaozhuang UniversityZaozhuangChina School of Civil and Resource Engineering University of Science and Technology BeijingBeijingChina Beijing Municipal Engineering Research Institute BeijingChina Department of Civil and Environmental Engineering University of StrathclydeGlasgowUK

Geothermal energy has gained wide attention as a renewable alternative for mitigating greenhouse gas *** advancements in enhanced geothermal system technology have enabled the exploitation of previously inaccessible geothermal ***,the extraction of geothermal energy from deep reservoirs poses many challenges due to high‐temperature and high‐geostress *** factors can significantly impact the surrounding rock and its fracture formation.A comprehensive understanding of the thermal–hydraulic–mechanical(THM)coupling effect is crucial to the safe and efficient exploitation of geothermal *** study presented a THM coupling numerical model for the geothermal reservoir of the Yangbajing geothermal *** proposed model investigated the geothermal exploitation performance and the stress distribution within the reservoir under various combinations of geothermal wells and mass flow *** geothermal system performance was evaluated by the criteria of outlet temperature and geothermal *** results indicate that the longer distance between wells can increase the outlet temperature of production wells and improve extraction efficiency in the short *** contrast,the shorter distance between wells can reduce the heat exchange area and thus mitigate the impact on the reservoir stress.A larger mass flow rate is conducive to the production capacity enhancement of the geothermal system and,in turn causes a wider range of stress *** findings provide valuable insights into the optimization of geothermal energy extraction while considering reservoir safety and long‐term *** study deepens the understanding of the THM coupling effects in geothermal systems and provides an efficient and environmentally friendly strategy for a geothermal energy system.

关键词： geothermal exploitation performance geothermal reservoir mass flow rate stress field well placementa

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Routing and scheduling co-design for holistic software-defined deterministic network

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Fundamental Research 2024年第1期4卷 25-34页

作者： Jinglong Zhang Fengyuan zhu Zeming Yang Cailian Chen Xiaohua Tian Xinping guan School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

As a result of the growing complexity of industrial Internet applications,traditional hardware-based network designs are encountering challenges in terms of programmability and dynamic adaptability as they struggle to meet the real-time,high-reliability transmission requirements for the vast quantities of data generated in industrial *** paper proposes a holistic software-defined deterministic network(HSDDN)design *** solution uses a centralized controller to implement a comprehensive software definition,ranging from the network layer down to the physical *** the wireless access domain,we decouple the standard radio-frequency modules from baseband processing to realize a software-defined physical layer,which then allows us to adjust the data transmission cycles and tag the trigger rates to meet demand for low-power,high-concurrency *** the wired network domain,we integrate software-defined networking with time-sensitive networking and propose a coordinated design strategy to address routing and the deterministic scheduling *** define a set of constraints to ensure collaborative transmission of the periodic and aperiodic data *** guarantee load balancing across all paths and timeslots,we introduce the Jain’s fairness index as the optimization objective and then construct a nondeterministic polynomial-time(NP)-hard joint optimization ***,an algorithm called Tabu search for routing and scheduling with dual-stages(TSRS-DS)is *** experiments demonstrate the effectiveness of the proposed HSDDN architecture.

关键词： Deterministic networking Software-defined networking Software-defined physical layer Time-sensitive networking Backscatter communication Routing and scheduling co-design

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Utilization of human excrement in pre-modern China,its theoretical interpretations and ecological significance

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Soil Ecology Letters 2024年第1期6卷 1-5页

作者： Xin-Hao Du Yuan-Ming Song Ji-An Cai Yong-guan zhu Institute for the History of Natural Sciences Chinese Academy of SciencesBeijing 100190China Institute for Cultural Heritage and History of Science&Technology University of Science and Technology BeijingBeijing 100083China Faculty of History Nankai UniversityTianjin 300350China Research Center for Eco Environmental Sciences Chinese Academy of SciencesBeijing 100085China

The use of human excrement as fertilizer is a characteristic of traditional Chinese agriculture..The application of excrement from urban residents in agriculture since the Song Dynasty has ensured the cleanliness and hygiene of *** early as the Ming Dynasty,the Chinese people defined the principle of fertilizing fields with human excrement from the perspective of *** concept Peri-URban ecosystems(PURE)provides inspiration forurban-rural symbiosis regarding *** use of human excrement in fertilization is a major attribute differentiating the Chinese traditional agriculture from the agriculture in other regions around the *** the fact that the exact record showing that human excrement was used as fertilizer in China emerged in the Western Han Dynasty(B.C.202-A.D.8),such records did not become prevalent until the Southern Song Dynasty(A.D.1127-1279).In the Ming and Qing eras(A.D.1368-1912),human excrement was even considered"top-class fertilizerand servedas themost essential fertilizerin farmland *** importance of human excrement in the Ming and Qing was mainly reflected by farmers'purchase of human excrement from urban *** fertilization practices became increasingly popular during the period,men of letters built a localized theoretical system centering on human *** the use of human excrement had both positive and negative impacts on public health and the ecological environment,the positive overshadowed the negativeas a ***,it is worth pondering on how the utilization of human excrement as an agricultural resource can be improved so that a material cycle system can be rebuilt to re-connect the urban and rural areas.

关键词： excrement fertilizer theorization urban and rural ecology public health

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High Areal Capacity and Long Cycle Life Flexible Mild Quasi-Solid-State Ag-Zn Battery with Dendrite-Free Anode

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Energy & Environmental Materials 2024年第1期7卷 34-41页

作者： Yanzhe zhu Renbo zhu Fandi Chen Shuo Zhang Yu-Chieh Kuo Peiyuan guan Mengyao Li Yunjian Liu Zhaojun Han Tao Wan Dawei Wang Caiyun Wang Dewei Chu School of Materials Science and Engineering The University of New South WalesSydneyNew South Wales 2052Australia School of Material science and Engineering Jiangsu UniversityZhenjiang 212013China School of Chemical Engineering The University of New South WalesSydneyNew South Wales 2052Australia Intelligent Polymer Research Institute AIIMInnovation CampusUniversity of WollongongNorth Wollongong New South Wales 2522Australia

Silver-zinc(Ag-Zn)batteries are a promising battery system for flexible electronics owing to their high safety,high energy density,and stable output ***,poor cycling performance,low areal capacity,and inferior flexibility limit the practical application of Ag-Zn ***,we develop a flexible quasi-solid-state Ag-Zn battery system with superior performance by using mild electrolyte and binder-free *** foam current collector is introduced to impede the growth of Zn dendrite,and the structure of Ag cathode is engineered by electrodeposition and chloridization process to improve the areal *** novel battery demonstrates a remarkable cycle retention of 90%for 200 cycles at 3 mA cm^(-2).More importantly,this binder-free battery can afford a high capacity of 3.5 mAh cm^(-2)at 3 mA cm^(-2),an outstanding power density of 2.42 mW cm^(-2),and a maximum energy density of 3.4 mWh cm^(-2).An energy management circuit is adopted to boost the output voltage of a single battery,which can power electronic ink display and Bluetooth temperature and humidity *** developed battery can even operate under the extreme conditions,such as being bent and sealed in solid *** work offers a path for designing electrodes and electrolyte toward high-performance flexible Ag-Zn batteries.

关键词： binder-free electrodes dendrite-free flexible Ag-Zn battery mild electrolyte quasi-solid-state

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Remote copper-catalyzed enantioselective substitution of yne-thiophene carbonates

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Science China Chemistry 2024年第4期67卷 1175-1180页

作者： Hao-Dong Qian Xiang Li Tingrui yin Wei-Feng Qian Chunhui Zhao Cuiju zhu Hao Xu CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology of Ministry of EducationInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Here,we describe a strategy for the copper-catalyzed asymmetric heteroarylation of yne-thiophene carbonates with indoles via remote *** key to the success of this strategy lies in the design of the alkynyl group at the ortho-position of the heterocycle thiophene,enabling the formation of a triarylmethane moiety via very remote ***,the concept of remote copper-catalyzed asymmetric transformation extends not only to yne-allylic esters but also to yne-aryl *** reaction readily provides a diverse array of chiral triarylmethanes with high efficiency,enantioselectivity,and excellent functional group ***,facile follow-up transformations underscore their potential utility in the synthesis of various enantioenriched building *** mechanistic studies support the plausibility of the remote substitution pathway.

关键词： remote substitution copper catalyst asymmetric catalysis triaryl methanes

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End-to-End Paired Ambisonic-Binaural Audio Rendering

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 502-513页

作者： yin zhu Qiuqiang Kong Junjie Shi Shilei Liu Xuzhou Ye Ju-Chiang Wang Hongming Shan Junping Zhang Shanghai Key Laboratory of Intelligent Information Processing School of Computer ScienceFudan UniversityShanghai 200433China Beijing ByteDance Technology Co.Ltd. Shanghai 201102China. Chinese University of Hong Kong Hong KongChina IEEE Institute of Science and Technology for Brain-Inspired Intelligence and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433 Shanghai Center for Brain Science and Brain-Inspired Technology Shanghai 200031China

Binaural rendering is of great interest to virtual reality and immersive media. Although humans can naturally use their two ears to perceive the spatial information contained in sounds, it is a challenging task for machines to achieve binaural rendering since the description of a sound field often requires multiple channels and even the metadata of the sound sources. In addition, the perceived sound varies from person to person even in the same sound field. Previous methods generally rely on individual-dependent head-related transferred function(HRTF)datasets and optimization algorithms that act on HRTFs. In practical applications, there are two major drawbacks to existing methods. The first is a high personalization cost, as traditional methods achieve personalized needs by measuring HRTFs. The second is insufficient accuracy because the optimization goal of traditional methods is to retain another part of information that is more important in perception at the cost of discarding a part of the information. Therefore, it is desirable to develop novel techniques to achieve personalization and accuracy at a low cost. To this end, we focus on the binaural rendering of ambisonic and propose 1) channel-shared encoder and channel-compared attention integrated into neural networks and 2) a loss function quantifying interaural level differences to deal with spatial information. To verify the proposed method, we collect and release the first paired ambisonic-binaural dataset and introduce three metrics to evaluate the content information and spatial information accuracy of the end-to-end methods. Extensive experimental results on the collected dataset demonstrate the superior performance of the proposed method and the shortcomings of previous methods.

关键词： Ambisonic attention binaural rendering neural network

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A lateral-immobilization zebrafish microfluidic chip-based system for in vivo real-time evaluation of antithrombotic agents

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Chinese Chemical Letters 2024年第3期35卷 312-315页

作者： Lijuan He Hongxia Du Yi Yang Zhihua guan Jinjin Li Honglin Li Xudong Lin Lili zhu Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&TechnologyShanghai 200237China guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China

Thrombosis remains a major global health concern mainly characterized by high rates of morbidity and *** models serve as an indispensable tool to understand the underlying pathogenesis of thrombosis and assess the efficacy of novel antithrombotic ***,zebrafish has emerged as a valuable model organism for thrombosis ***,the traditional method of studying zebrafish thrombosis requires a laborious and time-consuming procedure,including anesthesia and manual immobilization of *** this study,based on hydrodynamic force,a lateral-immobilization zebrafish microfluidic chip(LIZMC)was designed to evaluate the cardiovascular system of multiple larvae within a single microscope field of ***,coupling with microscope imaging,real-time monitoring of the peripheral blood circulation in the tail of phenylhydrazine(PHZ)-induced zebrafish thrombosis was ***,the reliability of LIZMC for in vivo evaluation of antithrombotic agents in zebrafish was verified using ***,this novel LIZMC-based system can be used for in vivo zebrafish thrombosis studies and rapid screening of antithrombotic agents.

关键词： Microfluidic chip Zebrafish Thrombosis In vivo evaluation Real-time monitor

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