检索结果-南通市图书馆

Petroleum Science 2021年第5期18卷 1323-1341页

作者： Zhan-Feng Qiao shao-Nan Zhang An-Jiang Shen guan-ming shao Min She Peng Cao Xiao-Wei Sun Jie Zhang Rui-Xin Guo Xiu-Cheng Tan State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengduSichuan 610500China PetroChina Hangzhou Research Institute of Geology HangzhouZhejiang 310023China Key Laboratory of Carbonate Reservoir China National Petroleum CorporationHangzhouZhejiang 310023China

An integrated petrographical and geochemical study of the massive dolomite of the lower Ordovician Penglaiba Formation of the Tarim Basin,outcropping at Yonganba recognized three dolomite types:very finely to finely crystalline nonplanar-a to planar-s dolomite(D1);medium crystalline planar-s to planar-e dolomite(D2);and coarse crystalline nonplanar-a dolomite(D3).All have been affected by burial.D1 and D2 dolomites developed initially before or during shallow burial and later recrystallized,whereas D3 dolomite replaced the initial limestone entirely during *** three dolomites have similar geochemical *** D2 dolomite tends to have more inter-crystalline pores(inherited from primary pores)and higher porosity due to its outstanding compaction resistance during shallow burial;whereas D3 dolomite does not retain appreciable primary pores due to strong cementation and pressure dissolution before *** study provides a useful model for understanding the origin and porosity development of burial dolomite,in particular Paleozoic dolomite.

关键词： Burial dolomite Dolomitization Massive dolomite Lower Ordovician Penglaiba Formation Tarim Basin

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying guan Mengyuan Guo Qianqian shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Primary parenchymal squamous cell carcinoma of the kidney:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo shao Chao-Min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

多模式镇痛在人工髋关节置换术中的应用效果

中国当代医药 2017年第6期24卷 44-46页

作者：陈希聪周观明刘少华彭健泓广东省佛山市中医院骨科广东佛山528000 广东省佛山市中医院麻醉科广东佛山528000

目的探讨多模式镇痛在人工髋关节置换术中的应用效果。方法选取2015年1~12月我院收治的110例行人工髋关节置换术患者为研究对象,采用随机数字表法分为观察组和对照组,各55例。对照组术中行关节周围注射盐酸罗哌卡因,术后静脉自控镇痛泵... 详细信息

目的探讨多模式镇痛在人工髋关节置换术中的应用效果。方法选取2015年1~12月我院收治的110例行人工髋关节置换术患者为研究对象,采用随机数字表法分为观察组和对照组,各55例。对照组术中行关节周围注射盐酸罗哌卡因,术后静脉自控镇痛泵镇痛;观察组术中静脉注射帕瑞昔布及盐酸罗哌卡因,术后则给予帕瑞昔布钠、盐酸曲马多、塞来昔布进行镇痛,采用视觉模拟评分法(VAS)进行疼痛程度评价,对比两组患者术后返回病房时,术后6、12、24、48、72 h的疼痛情况、不良反应情况及康复运动依从性。结果观察组患者在术后返回病房时,术后6、12、24、48、72 h的VAS评分均显著低于对照组,差异有统计学意义(P0.05)。观察组患者术后康复运动依从率为96.4%,显著高于对照组的83.6%,差异有统计学意义(P<0.05)。结论对人工髋关节置换术患者实施多模式镇痛能够有效地减轻患者术后的疼痛程度,安全性较好,患者可更好地在术后进行康复运动,值得临床上推广应用。

关键词：人工髋关节置换术多模式镇痛康复运动不良反应

Sealing Performance and Optimization of a Subsea Pipeline Mechanical Connector

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2018年第1期31卷 142-155页

作者： Li-Quan Wang Zong-Liang Wei shao-ming Yao Yu guan shao-Kai Li College of Mechanical and Electrical Engineering Harbin Engineering University Advanced Manufacturing Research Centre with Boeing The University of Sheffield

Researchers seldom study the optimum design of a mechanical connector for subsea oil-gas pipeline based upon the sealing performance. An optimal design method of a novel subsea pipeline mechanical connector is presented. By analyzing the static metal sealing mechanism, the critical condition of the sealing performance is established for this connector and the formulation method of the contact pressure on the sealing surface is created. By the method the minimum mean contact pressure of the 8.625 inch connector is calculated as 361 MPa, which is the constraint condition in the optimum design of *** finite element model is created in ANSYS Parametric Design Language(APDL) and the structure is optimized by the zero-order method, with variance of contact pressure as the objective function, and mean contact pressures and plastic strains as constraint variables. The optimization shows that variances of contact pressure on two sealing surfaces decrease by 72.41% and 89.33%, respectively, and mean contact pressures increase by 31.18% and 52.84%, respectively. The comparison of the optimal connectors and non-optimal connectors in the water pressure experiments and bending experiments shows that the sealing ability of optimized connectors is much higher than the rated pressure of 4.5 MPa, and the optimal connectors don’t leak under the bending moment of 52.2 kN·*** research provides the formulation to solve contact pressure on the sealing surface and a structure optimization method to design the connectors with various dimensions.

关键词： Mechanical connector Sealing mechanism Sealing performance Critical condition Minimum mean contact pressure Variance

Some Numerical Quadrature Schemes of a Non-conforming Quadrilateral Finite Element

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2012年第1期28卷 117-126页

作者： Xiao-fei guan ming-xia LI shao-chun CHEN Department of Mathematics Tongji UniversityShanghai 200092China School of Information Engineering China University of Ceosciences(Beijing)Beijing 100083China Department of Mathematics Zhengzhou UniversityZhengzhou 450052China

Numerical quadrature schemes of a non-conforming finite element method for general second order elliptic problems in two dimensional （2-D） and three dimensional （3-D） space are discussed in this paper. We present and analyze some optimal numerical quadrature schemes. One of the schemes contains only three sampling points, which greatly improves the efficiency of numerical computations. The optimal error estimates are derived by using some traditional approaches and techniques. Lastly, some numerical results are provided to verify our theoretical analysis.

关键词： numerical integration non-conforming quadrilateral finite element optimal error estimate

在线全文

学校读者我要写书评

暂无评论

米团花色素的提取及其在油炸方便面中的应用

食品与机械 2009年第6期25卷 87-89,166页

作者：欧仕益李宗新武艳梅关少明赖燕娜林满吴清林暨南大学食品科学与工程系广东广州510632 东莞理工学院化学生物系广东东莞523106

测定米团花不同温度水浸提液和不同浓度乙醇浸提液中色价、固形物、还原糖和多糖4项指标,同时研究乙醇沉淀法除多糖的效果。试验表明,采用乙醇水溶液提取色素优于纯水作溶剂,且提高提取温度和适当提高乙醇浓度均能提高色素的浸出率。米... 详细信息

测定米团花不同温度水浸提液和不同浓度乙醇浸提液中色价、固形物、还原糖和多糖4项指标,同时研究乙醇沉淀法除多糖的效果。试验表明,采用乙醇水溶液提取色素优于纯水作溶剂,且提高提取温度和适当提高乙醇浓度均能提高色素的浸出率。米团花色素提取最佳的工艺条件是:采用60%～80%乙醇水溶液在60℃下搅拌浸提30min2次,固液比1∶10(W∶V)。乙醇沉淀法能有效地除去水提液中的多糖,但色素损失也较大;活性炭对米团花色素具有强烈的吸附作用,色素吸附率达99.6%,采用热水洗涤能除去92%的多糖和95%的还原糖,但未发现有效的色素洗脱方法。将米团花色素应用到油炸方便面中,其着色效果与柠檬黄相当,热稳定性好。

关键词：米团花色素提取纯化方便面

在线全文

学校读者我要写书评

暂无评论

米团花色素在果汁、果冻中的应用

食品与机械 2012年第2期28卷 216-218页

作者：吴清林伍艳梅关少明赖燕娜张广文欧仕益东莞理工学院化学与环境工程学院广东东莞523808 暨南大学食品科学与工程系广东广州510632

考察米团花色素在果汁和果冻中的应用效果,探讨该色素的应用范围。将米团花色素添加到果汁和果冻中,以柠檬黄为对照,研究其对食品感官的影响及其在储藏过程中的稳定性。结果表明:果汁和果冻添加米团花色素后色泽良好,储藏7周后,果汁和... 详细信息

考察米团花色素在果汁和果冻中的应用效果,探讨该色素的应用范围。将米团花色素添加到果汁和果冻中,以柠檬黄为对照,研究其对食品感官的影响及其在储藏过程中的稳定性。结果表明:果汁和果冻添加米团花色素后色泽良好,储藏7周后,果汁和果冻中米团花色素含量分别降低4.1%和0.6%;米团花色素可用作果汁和果冻着色剂。

关键词：色素米团花果汁果冻

Role of Wnt/β-Catenin Pathway in the Arterial Medial Calcification and Its Effect on the OPG/RANKL System

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2019年第1期39卷 28-36页

作者： Bin NIE shao-ying ZHANG Si-ming guan shao-qiong ZHOU Xin FANG Department of Geriatrics the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of Geriatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

In this study,the hypothesis that Wnt/β-catenin pathway is involved in the arterial calcification by regulating the osteoprotegerin(OPG)/receptor activator of NF-κB ligand(RANKL)system was ***β-catenin expression was measured in the warfarin-induced calcified arteries and the osteoblast-like cells differentiating from smooth muscle cells(SMCs)by immunohistochemistry and Western *** Wnt/β-catenin pathway was activated or inhibited by lithium chloride(LiCl)or dickkopf 1(DKK1)in vitro and in *** the calcification level was determined by von Kossa staining,Ca^2+content assay,and alkaline phosphatase(ALP)activity *** expression levels of osteocalcin,OPG and RANKL were detected by Western blotting or real-time *** results showed that in calcified arteries and OBL cells,the activation of Wnt/β-catenin pathway significantly enhanced the calcification as evidenced by increased von Kossa stains,Ca^2+contcnts,ALP activities,and osteocalcin expression levels(P<0.05),and it promoted the RANKL expression(P<0.05),but slightly affected the OPG *** results indicated that the activation of Wnt/β-catenin pathway worsens the arterial calcification,probably by promoting the RANKL expression.

关键词： arterial calcification Wnt/β-catenin pathway osteoprotegerin receptor activator of NF-κB ligand