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Diagnostic performance of intravascular ultrasound-based fractional flow reserve in evaluating of intermediate left main stenosis

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Journal of Geriatric Cardiology 2024年第1期21卷 34-43页

作者： Yong-Gang SUI Cheng YANG Chang-Dong guan Yan-Lu XU Na-Qiong wu Wei-Xian YANG Yong-Jian wu Ke-Fei DOU Yue-Jin YANG Shu-Bin QIAO Wei YU Bo XU Sheng-Xian TU Jie QIAN Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina National Clinical Research Center for Cardiovascular Diseases BeijingChina

BACKGROUND The recently introduced ultrasonic flow ratio(UFR),is a novel fast computational method to derive fractional flow reserve(FFR)from intravascular ultrasound(IVUS)*** the present study,we evaluate the diagnostic performance of UFR in patients with intermediate left main(LM)*** This is a prospective,single center study enrolling consecutive patients with presence of intermediated LM lesions(diameter stenosis of 30%-80%by visual estimation)underwent IVUS and FFR *** independent core laboratory assessed offline UFR and IVUS-derived minimal lumen area(MLA)in a blinded *** Both UFR and FFR were successfully achieved in 41 LM patients(mean age,62.0±9.9 years,46.3%diabetes).An acceptable correlation between UFR and FFR was identified(r=0.688,P50%(AUC=0.66,P<0.001)and numerically higher than IVUS-derived MLA(AUC=0.82;P=0.09).Patient level diagnostic accuracy,sensitivity and specificity for UFR to identify FFR≤0.80 was 82.9%(95%CI:70.2-95.7),93.1%(95%CI:82.2-100.0),58.3%(95%CI:26.3-90.4),*** In patients with intermediate LM diseases,UFR was proved to be associated with acceptable correlation and high accuracy with pressure wire-based FFR as standard *** present study supports the use of UFR for functional evaluation of intermediate LM stenosis.

关键词： stenosis flow fractional

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同步感应线圈发射器弹载存储测试技术研究

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电工技术学报 2024年第2期39卷 325-332页

作者：石敬斌关晓存管少华吴宝奇海军工程大学舰船综合电力技术国防科技重点实验室武汉430033

该文提出多级同步感应线圈发射器弹载存储动态测试技术。首先,基于电磁场理论定量分析了同步感应线圈发射器发射过程中存在的强脉冲和高过载环境;其次,设计具有抗电磁干扰且抗高过载能力的弹载存储测试装置,并分析了装置的屏蔽效能和承... 详细信息

该文提出多级同步感应线圈发射器弹载存储动态测试技术。首先,基于电磁场理论定量分析了同步感应线圈发射器发射过程中存在的强脉冲和高过载环境;其次,设计具有抗电磁干扰且抗高过载能力的弹载存储测试装置,并分析了装置的屏蔽效能和承载能力;最后,研制带弹载存储测试装置的测试弹,并开展了30级同步感应线圈发射器动态发射试验,得到同步感应线圈发射器动态过程中磁感应强度数据和加速度数据,与仿真数据吻合,且误差可控制在4.7%,同时揭示了发射始末测试弹存在“规律碰撞”效应和“周期章动”现象。

关键词：同步感应线圈发射器弹载存储测试磁感应强度屏蔽效能

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Chinese Guidelines for the Diagnosis and Management of Atrial Fibrillation

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Journal of Geriatric Cardiology 2024年第3期21卷 251-314页

作者： Chang-Sheng MA Shu-Lin wu Shao-Wen LIU Ya-ling HAN Chinese Society of Cardiology Chinese Medical Association Heart Rhythm Committee of Chinese Society of Biomedical Engineering Beijing Anzhen Hospital Capital Medical University guandong Provincial People’s Hospital Shanghai First People’s Hospital General Hospital of Northern Theater Command 不详

Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,significantly impacting patients’quality of life and increasing the risk of death,stroke,heart failure,and *** the past two decades,there have been significant breakthroughs in AF risk prediction and screening,stroke prevention,rhythm control,catheter ablation,and integrated *** this period,the scale,quality,and experience of AF management in China have greatly improved,providing a solid foundation for the development of guidelines for the diagnosis and management of *** further promote standardized AF management,and apply new technologies and concepts to clinical practice in a timely and comprehensive manner,the Chinese Society of Cardiology of the Chinese Medical Association and the Heart Rhythm Committee of the Chinese Society of Biomedical Engineering have jointly developed the Chinese Guidelines for the Diagnosis and Management of Atrial *** guidelines have comprehensively elaborated on various aspects of AF management and proposed the CHA2DS2-VASc-60 stroke risk score based on the characteristics of AF in the Asian *** guidelines have also reevaluated the clinical application of AF screening,emphasized the significance of early rhythm control,and highlighted the central role of catheter ablation in rhythm control.

关键词： prevention sustained diagnosis

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Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang wu Jia Qu Lin-zhi wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis

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Resilience-incorporated seismic risk assessment of precast concrete frames with“dry”connections

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 403-425页

作者： wu Chenhao Tang Yuchuan Cao Xuyang wu Gang Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education Nanjing 211102China Department of Civil and Environmental Engineering University of CaliforniaLos AngelesCA 90095USA School of Civil Engineering Southeast UniversityNanjing 211102China College of Civil and Transportation Engineering Hohai UniversityNanjing 210024China

A resilience-incorporated risk assessment framework is proposed and demonstrated in this study to manifest the advantageous seismic resilience of precast concrete frame(PCF)structures with“dry”connections in terms of their low damage and rapid *** framework integrates various uncertainties in the seismic hazard,fragility,capacity,demand,loss functions,and post-earthquake *** this study,the PCF structures are distinguished from ordinary reinforced concrete frame(RCF)structures by characterizing multiple limit states for the PCF based on its unique damage ***,probabilistic story-wise pushover analyses are performed to yield story-wise capacities for the predefined limit *** the seismic resilience analysis,a step-wise recovery model is proposed to idealize the functionality recovery process,with separate considerations of the repair and non-repair *** recovery model leverages the economic loss and downtime to delineate the stochastic post-earthquake recovery curves for the resilience loss *** such,contingencies in the probabilistic post-earthquake repairs are incorporated and the empirical judgments on the recovery parameters are largely *** proposed framework is demonstrated through a comparative study between two“dry”connected PCFs and one RCF designed as alternative structural systems for a prototype *** results from the risk quantification indicate that the PCFs show reduced loss hazards and lower expected losses relative to the ***,the PCF equipped with energy dissipation devices at the“dry”connections largely reduces the expected economic loss,downtime,and resilience loss by 29%,56%,and 60%,respectively,compared to the RCF.

关键词： precast concrete frame non-emulative precast system seismic resilience seismic risk functional recovery

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Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

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World Journal of Gastroenterology 2024年第14期30卷 2018-2037页

作者： Qi-Long wu Xiao-Ting Fang Xin-Xin Wan Qing-Yong Ding Yan-Jun Zhang ling Ji Yong-Liang Lou Xiang Li School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks among the most prevalent malignant tumors *** reports suggest that Fusobacterium nucleatum(***)contributes to the initiation,progression,and prognosis of ***,a short-chain fatty acid derived from the bacterial fermentation of soluble dietary fiber,is known to inhibit various *** study is designed to explore whether *** influences the onset and progression of CRC by impacting the intestinal metabolite butyric *** To investigate the mechanism by which *** affects CRC occurrence and *** Alterations in the gut microbiota of BALB/c mice were observed following the oral administration of ***,DLD-1 and HCT116 cell lines were exposed to sodium butyrate(NaB)and *** in vitro to examine the effects on proliferative proteins and mitochondrial *** Our research indicates that the prevalence of *** in fecal samples from CRC patients is significantly greater than in healthy counterparts,while the prevalence of butyrate-producing bacteria is notably *** mice colonized with ***,the population of butyrate-producing bacteria decreased,resulting in altered levels of butyric acid,a key intestinal metabolite of *** to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HCT116 CRC ***,this leads to modulated production of adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell ***,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HCT116 and DLD-1 cells,and curtails the proliferation of CRC *** combined presence of *** and NaB attenuated the effects of the *** employing small interfering RNA to suppress AMPK,it was demonstrated that AMPK is essential for NaB’s inhibition of CRC cell *** F.n

关键词： Colorectal cancer Fusobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway

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Dietary copper improves intestinal structural integrity in juvenile grass carp(Ctenopharyngodon idella)probably related to its increased intestinal antioxidant capacity and apical junction complex

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Animal Nutrition 2024年第3期18卷 96-106页

作者： Rui Ma Lin Feng Pei wu Yang Liu Hong Mei Ren Xiao Wan Jin Shu Wei Li ling Tang Xiao Qiu Zhou Wei Dan Jiang Animal Nutrition Institute Sichuan Agricultural UniversityChengdu611130China Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu611130China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu611130China Animal Nutrition Institute Sichuan Academy of Animal ScienceSichuan Animtech Feed Co.Ltd.Chengdu610066China

This research evaluated the effects of copper(Cu)on intestinal antioxidant capacity and apical junctional complex(AJC)in juvenile grass carp.A total of 1080 healthy juvenile grass carp(11.16±0.01 g)were fed six diets including different dosages of Cu,namely 0,2,4,6,8 mg/kg(Cu citrate[CuCit]as Cu source)and 3 mg/kg(CuSO4·5H2O as Cu source).The trial lasted for 9 *** findings revealed that dietary optimal Cu supplementation(2.2 to 4.1 mg/kg)promoted intestinal growth,including intestinal length,intestinal length index,intestinal weight,and intestinal somatic index(P 0.05).On the other hand,optimal Cu increased intestinal tight junction(TJ)proteins(except for claudin 15b)and adherens junction(AJ)proteins(E-cadherin,α-catenin,β-catenin,nectin and afadin)mRNA levels(Pling pathway formed by the Ras homolog gene family,member A(RhoA),Rho-associated kinase(ROCK),and myosin light chain kinase(MLCK).Finally,based on serum indicator D-lactate and intestinal oxidative damage index(ROS),Cu requirement(CuCit as Cu source)for juvenile grass carp from initial weight to final weight(from 11 to 173 g)was determined to be 4.14 and 4.12 mg/kg diet,*** work may provide a theoretical foundation for identifying putative Cu regulation pathways on fish intestinal health.

关键词： Copper Ctenopharyngodon idella Structural integrity Intestine

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New findings on the influence of El Nino events on tropical cyclone formation

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Science China Earth Sciences 2024年第3期67卷 892-893页

作者： Liguang wu Department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China

Tropical cyclones typically form over warm tropical and subtropical ocean surfaces, as their formation and intensification rely primarily on the energy provided by the ocean. Pioneering research by Gray (1968) revealed that the formation of tropical cyclones requires the sea surface temperature (SST) to be no less than 26.5℃. Consequently, SST is commonly recognized as a crucial parameter among the environmental factors influencing tropical cyclone formation(Gray, 1979;Emanuel and Nolan, 2004).

关键词： tropical cyclone ocean

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Identification of the non-stationarity of extreme temperature events and teleconnections with solar activity and large-scale atmospheric circulation: A case study in the Yangtze River Economic Belt

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Journal of Earth Science 2024年

作者： Lin Zhang Jingyun ling Shengzhi Huang Hongbin Zhan Yi wu Menggui Jin Qiang Huang State Key Laboratory of Eco-hydraulics in Northwest Arid Region， Xi'an University of Technology College of Design and Engineering， National University of Singapore Yinshanbeilu Grassland Eco-Hydrology National Observation and Research Station， China Institute of Water Resources and Hydropower Research Department of Geology and Geophysics， Texas A&M University， College Station School of Earth System Science， Tianjin University School of Environmental Studies， China University of Geosciences

In recent decades， extreme climate events have become a major problem worldwide. To understand the uncertainty in the response of extreme events to global warming， regional assessments are required for various climatic and geographic regions. The spatiotemporal distribution of extreme temperature events in the Yangtze River Economic Belt (YREB) from 1960 to 2019， including interannual changes and their teleconnections with solar activity and large-scale atmospheric circulation， were analyzed using eight indices of extreme temperature events. Over the past six decades， the climate in the YREB region has seen a warming trend， characterized by an increase in extreme warm events and a decrease in extreme cold events. The extreme temperature indices exhibit strong spatial variability. The warm extremes display a significant upward trend across the YREB， while cold extremes are primarily concentrated in the western part of the region. In recent decades， both warm and cold extremes have significant interannual variations， and these events predominantly oscillate over periods of less than four years. After 1985， the relationship between El Ni?o-Southern Oscillation (ENSO)， Arctic Oscillation (AO)， Pacific Decadal Oscillation (PDO) and extreme temperature events has changed significantly compared with pre-1985， and the direction of the phase angle can determine the positive and negative effects of the two time-series. ENSO， AO and PDO mainly have positive impacts on extreme temperature events， with ENSO and AO exerting greater impacts than PDO. In contrast， solar activity mainly has a negative impact on these events. Furthermore， the notable interdecadal changes in extreme temperature events， especially warm extremes， may be caused by the shift in the PDO phase. Therefore， the results of the study are important for the YREB region to take effective measures to mitigate the potential impacts of human activities on regional warming.

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Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224-4234]

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Acta Pharmaceutica Sinica B 2024年第2期14卷 897-899页

作者： Zekun Li Yongchun Pan Shiyu Du Yayao Li Chao Chen Hongxiu Song Yueyao wu Xiaowei Luan Qin Xu Xiaoxiang guan Yujun Song Xin Han Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Medicine&Holistic Integrative MedicineJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative MedicineNanjing University of Chinese MedicineNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsState Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The authors regret that there is an error in the article Fig.5E due to the mistake of copying and pasting in the process of assembling figures and negligence in the *** it does not affect the conclusion,it is an obvio... 详细信息

关键词： journal correction conclusion

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