检索结果-南通市图书馆

Enhancing insights into Global Cancer Statistics 2022: implications for cancer control

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 294-296页

作者： Jingtong xu Runtian Wang Xiaoxiang guan Department of Oncology the First Affiliated Hospital of Nanjing Medical University Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical University

Globally, there has been a marked escalation in tumor morbidity and mortality,cementing tumors as the predominant cause of death in numerous *** the current tumor burden across various regions is imperative to discern potential risk factors and formulate efficacious strategies for tumor ***, the International Agency for Research on Cancer(IARC) provided a status report on the global tumor burden,estimating the incidence and mortality of 36 cancers in 185 countries(Bray et al.,2024).

关键词：

Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 337-349页

作者： Meiyun xu Song Gu Fulong Chen Zhe Zhao Peng Liu Daoben hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

关键词： quaternized polymer networks adsorption pertechnetate iodide liquid radioactive streams

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

在线全文

学校读者我要写书评

暂无评论

光电子谱的峰开关效应

物理学报 1989年第5期38卷 864-868页

作者：姚关华徐至展中国科学院上海光学精密机械研究所中国高等科学技术中心(世界实验室)凝聚态和辐射物理分中心

在文献[12]的基础上研究了强激光场作用下自电离原子的光电子谱,发现了与强场多光子电离中相类似的峰开关效应,从而进一步证实了强场下二阶离化过程和光电子谱中高阶峰的重要作用.本文结果对已有的强场自电离理论作了重要修正.

关键词：光电子谱开关效应电离原子

Multiple dynamic bonds enable high mechanical strength and efficient room-temperature self-healable polyurethane for triboelectric nanogenerators

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Wenwen Zhang Huixia xuan Xiaofei xu Jiaming Lou Qingbao guan Zhengwei You State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Institute of Functional Materials College of Materials Science and Engineering Shanghai Key Laboratory of Lightweight Composite Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine Donghua University

For room temperature self-healing triboelectric nanogenerators（TENGs）, the inherent contradiction between mechanical strength and self-healing properties was an urgent problem to be solved. Based on the phenol-carbamate bond, this paper proposed a strategy to design a new molecular structure and coordinate the triple dynamic bonds, which provided a feasible strategy to solve this contradiction. With polytetramethylene ether glycol（M_n= 1,000） as the soft segment in the main chain of polyurethane（PU）, meanwhile methylene diphenyl diisocyanate and 4,4′-dihydroxybiphenyl（BP） as the hard segment and chain extension agent, respectively, the combination of tetrad benzene ring endowed the resultant 4BP-PU with π-π interaction. The effective reversible dissociation and association with hydrogen bond not only bestowed 4BP-PU with high mechanical strength（16.14 MPa）, but also promoted high self-healing efficiency（94.8%） at room temperature. 4BP-PU was selected as the elastic substrate between polydimethylsiloxane and copper sheet to prepare a self-healing TENG to collect energy from natural ***, the rational molecular structure design provided new ideas for developing self-healing materials and fabricating energy harvest electronics.

关键词：

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing xuyun hua Yuwen Zhang Xin xue Jiajia Wu Mouxiong Zheng He Wang Jianguang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan xu hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

在线全文

学校读者我要写书评

暂无评论

湖北省横纹肌溶解综合征病例回顾性调查

中国公共卫生 2020年第9期36卷 1339-1342页

作者：李世聪马会来官旭华吴杨邢学森张皓广东省疾病预防控制中心广州510430 中国疾病预防控制中心湖北省疾病预防控制中心宜昌市疾病预防控制中心

目的了解湖北省近年来横纹肌溶解综合征病例的临床及流行病学特征,为横纹肌溶解综合征预防提供依据。方法采用回顾性调查方法,对2013年1月-2017年4月湖北省9家三甲医院收治的横纹肌溶解综合征病例进行回顾性调查。结果9家医院共诊断横... 详细信息

目的了解湖北省近年来横纹肌溶解综合征病例的临床及流行病学特征,为横纹肌溶解综合征预防提供依据。方法采用回顾性调查方法,对2013年1月-2017年4月湖北省9家三甲医院收治的横纹肌溶解综合征病例进行回顾性调查。结果9家医院共诊断横纹肌溶解综合征病例367例,其中2016年发生220例,与食用小龙虾相关者102例。这些病例中,与食用小龙虾相关的病例主要出现在2014和2016年,其余年度以剧烈运动、动物咬伤等多种病因为主。食用小龙虾相关病例的临床特征以肌痛和乏力为主,多数病程为10 d左右,预后较好;病例主要在长江沿岸分布,且有明显的季节性,以中青年和女性为主。2016年湖北省食源性疾病监测系统共报告41例病例,占9家医院2016年诊断食源性病例数的40%(41/102)。结论湖北省实际发生的食源性病例数远超过食源性疾病监测系统的报告病例数,应加强对医疗机构的督导和培训,提高监测系统报告的敏感性,横纹肌溶解综合征病例沿长江沿岸分布,呈一定的规律性。

关键词：横纹肌溶解综合征小龙虾湖北回顾性调查

重症71型肠道病毒感染的临床特征与治疗12例分析

在线全文

学校读者我要写书评

暂无评论

中华儿科杂志 2010年第1期48卷 24-28页

作者：刘京涛彭丹官旭华邹典定赵东赤武汉大学中南医院儿科 430071 湖北省疾病预防控制中心传染病防治研究所

目的探讨肠道病毒71型（enterovirus 71，EV71）感染所致重症病例的临床特征、病理生理变化，评估治疗效果。方法对2008年湖北省9家定点医院收治的EV71感染重症手足口病（hand，foot and mouth disease，HHMD）病例的临床资料进行回顾... 详细信息

目的探讨肠道病毒71型（enterovirus 71，EV71）感染所致重症病例的临床特征、病理生理变化，评估治疗效果。方法对2008年湖北省9家定点医院收治的EV71感染重症手足口病（hand，foot and mouth disease，HHMD）病例的临床资料进行回顾性分析。结果12例重症病例经RT—PCR检查EV71核酸阳性，其中男10例，女2例，中位数年龄1．96岁。发热持续时间6．5d，皮疹持续时间7d，起病至出现重症表现时间为3．7d。神经系统受累10例，合并呼吸循环衰竭5例。5例X线胸片显示两肺或单侧片状阴影，4例为肺部纹理增多。白细胞计数、血糖、血沉和C-反应蛋白无特征性变化。11例选择大剂量静脉注射丙种球蛋白，7例使用甲泼尼龙治疗；4例肺水肿-呼吸衰竭患儿经呼吸机辅助通气，平均支持72（48—96）h。11例治愈，1例死亡。结论EV71重症主要发生在年龄小于3岁患儿，以中枢神经系统感染为主，半数可发展为呼吸循环衰竭。早期使用呼吸机辅助呼吸对纠正呼吸循环衰竭，防止多脏器功能不全和降低死亡率尤为重要。

关键词：手足口病肠道病毒感染疾病特征治疗结果