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Long-Lifetime Optical Trapping of a ^(40)Ca^(+) Ion

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Chinese Physics Letters 2024年第11期41卷 45-52页

作者： Zheng Chen Miao Wang Baolin Zhang huaqing Zhang Zixiao Ma Ruming Hu Yao huang Kelin Gao hua guan State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China Key Laboratory of Atomic Frequency Standards Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Wuhan Institute of Quantum Technology Wuhan 430206China

We have experimentally achieved the all-optical trapping of a ^(40)Ca^(+)*** optical dipole trap was established using a high-power,far-detuned,tightly focused laser with a wavelength of 532 *** single ^(40)Ca^(+)ion was trapped without any RF fields and demonstrated a long lifetime of over 3 *** this experiment,we implemented several measures to improve the optical trapping probability,including focusing the dipole beam waist near the diffraction limit,precisely compensating for stray electric fields,and mitigating electron shelving in metastable *** optical trapping of a ^(40)Ca^(+)ion eliminates the influence of micromotion induced by RF fields,potentially paving the way for development of all-optical trapping ion optical clocks.

关键词： trapping dipole eliminate

Hypoglycemic activity of puerarin through modulation of oxidative stress and mitochondrial function via AMPK

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Chinese Journal of Natural Medicines 2020年第11期18卷 818-826页

作者： HOU Bi-Yu ZHAO Yue Rong MA Peng XU Chun-Yang HE Ping YANG Xiu-Ying ZHANG Li QIANG Gui-Fen DU guan-hua State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College and Beijing Ke|Laboralory of Drug Target and Screening ResearchBeijing 100050China Beiing Obstetrics and Gynecology Hospital Capital Medical UniversityBeijing 100026China

Hyperglycemia is the dominant phenotype of diabetes and the main contributor of diabetic complications. Puerarin is widely used in cardiovascular diseases and diabetic vascular complications. However, little is known about its direct effects on diabetes. The aim of our study is to investigate its antidiabetic effect in vivo and in vitro, and explore the underlying mechanism. We used type I diabetic mice induced by streptozotocin to observe the effects of puerarin on glucose metabolism. In addition, oxidative stress and hepatic mitochondrial respiratory activity were evaluated in type I diabetic mice. In vitro, glucose consumption in Hep G2 cells was assayed along with the q PCR detection of glucogenesis genes expression. Moreover, ATP production was examined and phosphorylation of AMPK was determined using Western blot. Finally, the molecular docking was performed to predict the potential interaction of puerarin with AMPK utilizing program Lib Dock of Discovery Studio 2018 software. The results showed that puerarin improved Hep G2 glucose consumption and upregulated the glucogenesis related genes expression. Also, puerarin lowered fasting and fed blood glucose with improvement of glucose tolerance in type I diabetic mice. Further mechanism investigation showed that puerarin suppressed oxidative stress and improved hepatic mitochondrial respiratory function with enhancing ATP production and activating phosphorylation of AMPK. Docking study showed that puerarin interacted with AMPK activate site and enhancing phosphorylation. Taken together, these findings indicated that puerarin exhibited the hypoglycemic effect through attenuating oxidative stress and improving mitochondrial function via AMPK regulation, which may serve as a potential therapeutic option for diabetes treatment.

关键词： Puerarin Diabetes Hypoglycemic Oxidative stress Mitochondrial function

Investigation into the structures and physicochemical properties of multi-component crystals of voriconazole

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Chinese Chemical Letters 2023年第6期34卷 504-511页

作者： Hong-Mei Yu Bao-Xi Zhang Wen-Hui Xing Mei-Ju Liu Feng-Feng Wang Ning-Bo Gong Li Zhang Yang Lu guan-hua Du Beijing Key Laboratory of Polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China National Institutes for Food and Drug Control Beijing 102629China Beijing City Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Voriconazole(VZL)is a second-generation and broad-spectrum triazole against fungal *** a BCS(biopharmaceutics classification system)class II compound,the poor aqueous solubility has limited its bioavailability and clinical *** to overcome this disadvantage,a cocrystallization strategy based on crystal engineering principles has resulted in five new multi-component crystals of VZL with maleic acid,L-tartaric,protocatechuic,gallic,and 3,5-dinitrobenzoic *** analysis revealed that the hydroxyl/carboxylic acid···triazole N_(3)hydrogen bonding interaction appears as a main supramolecular heterosynthon in the VZL multi-component crystals with organic *** VZL molecule has a flexible conformation in each of the five multi-component *** newly synthesized multi-component crystals showed impressive solubility improvement compared to that of the raw material of *** electrostatic potential surfaces(MEPS)analysis based on density functional(DFT)calculations revealed that hydrogen bond interactions in cocrystals mainly involved pairwise interactions in the global maxima and minima sites,but this rule is not always *** study indicates the potential of cocrystals to improve the solubility and dissolution rate of VZL.

关键词： Multi-component crystal Voriconazole Solubility Dissolution Stability

Ecology and social system of northern gibbons living in cold seasonal forests

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Zoological Research 2018年第4期39卷 255-265页

作者： Zhen-hua guan Chang-Yong Ma Han-Lan Fei Bei huang Wen-He Ning Qing-Yong Ni Xue-Long Jiang Peng-Fei Fan Yunnan Academy of Biodiversity Forest Disaster Warning and Control Key Laboratory Southwest Forestry University School of Life Sciences Sun Yat-Sen University State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences College of Animal Sciences and Technology Sichuan Agricultural University

Gibbons in China represent the northernmost margin of present day gibbon species distribution （around N25°）. Compared to tropical habitats, northern gibbon habitats are characterized by low temperatures and remarkable seasonal variation in fruit abundance How gibbons adapt to their cold and seasonal habitats and what ecological factors affect their sociality are key questions for understanding their ecology and social system evolution, the elucidation of which will contribute to the conservation of these special populations/species. According to preliminary short-term studies, northern gibbons consume more leaves and use larger home ranges than tropical gibbons. Interestingly, some Nomascus groups consist of more than one adult female. However, these preliminary results are not well understood or incorporated into current socio-ecological theories regarding gibbon species. To better understand northern gibbons, our team has systematically studied three habituated groups of Nomascus concolor, three groups of N. nasutus, and two habituated groups of Hoolock tianxing since 2002. In this paper, we stress the challenges facing gibbons living in northern habitats and summarize their behavioral adaptations to their harsh environments. We also describe the northern gibbon social system and discuss the potential relationships between their ecology and sociality. Finally, we highlight future research questions related to northern gibbons in China.

关键词： Northern gibbon Ecology Social system Adaptation Group size

Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors

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World Journal of Gastroenterology 2024年第11期30卷 1533-1544页

作者： Li-Min Yang Hong-Juan Wang Shan-Lin Li guan-hua Gan Wen-Wen Deng Yong-Sheng Chang Lian-Feng Zhang Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Gastroenterology Zhoukou Central Hospital of Henan ProvinceZhoukou 466000Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453000Henan ProvinceChina

BACKGROUND Patients with liver cancer complicated by portal hypertension present complex challenges in *** To evaluate the efficacy of radiofrequency ablation in combination with sorafenib for improving liver function and its impact on the prognosis of patients with this *** Data from 100 patients with liver cancer complicated with portal hypertension from May 2014 to March 2019 were analyzed and divided into a study group(n=50)and a control group(n=50)according to the treatment *** research group received radiofrequency ablation(RFA)in combination with sorafenib,and the control group only received *** short-term efficacy of both the research and control groups was *** function and portal hypertension were compared before and after ***-fetoprotein(AFP),glypican-3(GPC-3),and AFP-L3 levels were compared between the two groups prior to and after *** occurrence of adverse reactions in both groups was *** 3-year survival rate was compared between the two *** data were compared between the survival and non-surviving *** identify the independent risk factors for poor prognosis in patients with liver cancer complicated by portal hypertension,multivariate logistic regression analysis was *** When comparing the two groups,the research group's total effective rate(82.00%)was significantly greater than that of the control group(56.00%;P<0.05).Following treatment,alanine aminotransferase and aspartate aminotransferase levels increased,and portal vein pressure decreased in both *** degree of improvement for every index was substantially greater in the research group than in the control group(P<0.05).Following treatment,the AFP,GPC-3,and AFP-L3 levels in both groups decreased,with the research group having significantly lower levels than the control group(P<0.05).The incidence of diarrhea,rash,nausea and vomiting,and fatigue in the research group was significantly great

关键词： Radiofrequency ablation Sorafenib Liver cancer Portal hypertension Efficacy Prognosis analysis

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轮轨横向碰撞引起的脱轨研究

振动与冲击 2009年第12期28卷 38-42页

作者：关庆华曾京西南交通大学牵引动力国家重点实验室成都610031

建立了车轮和钢轨的三维摩擦碰撞方程,根据刚体碰撞力学理论推导出碰撞后车轮的瞬时速度,讨论了摩擦碰撞过程中切向状态的变化。根据运动学关系和能量守恒定律推导出车轮横向碰撞钢轨的跳轨脱轨判别准则,包括车轮的横向碰撞临界速度和... 详细信息

建立了车轮和钢轨的三维摩擦碰撞方程,根据刚体碰撞力学理论推导出碰撞后车轮的瞬时速度,讨论了摩擦碰撞过程中切向状态的变化。根据运动学关系和能量守恒定律推导出车轮横向碰撞钢轨的跳轨脱轨判别准则,包括车轮的横向碰撞临界速度和以车轮横向力峰值、轮重和碰撞时间确定的判别公式。参数分析表明:增大轮缘角、摩擦系数和轮缘有效高度均能够提高跳轨脱轨限值;轮缘角越大出现粘滞状态的临界摩擦系数越小;车轮接触点纵向相对速度减弱了阻碍车轮跳轨的切向摩擦阻力,加大了脱轨的危险性。

关键词：轮轨摩擦碰撞跳轨脱轨判别准则

Withaferin A arrested glioblastoma cells at G2/M phase and induced apoptosis through intrinsic pathway

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中国药理学与毒理学杂志 2019年第9期33卷 696-697页

作者： TANG Qin REN Li-wen LIU Jin-yi LI Wan ZHENG Xiang-jin WANG Jin-hua DU guan-hua The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

OBJECTIVE To explore the efficacy and mechanism of withaferin A(WA)in Glioblastoma multiforme(GBM,WHO gradeⅣastrocytoma).METHODS Cell viability assay and nude mice xenograft model were used to evaluate the efficacy of WA in *** cytometry was performed to detection the effects of WA on apoptosis and cell cycle of *** blotting and siRNA transfection were carried out to check signaling pathway induced by *** WA significantly inhibited the growth of GBM in vivo and in *** treatment triggered the intrinsic apoptosis of GBM cells by upregulating expression of Bim and Bad,and arrested GBM cells at G2/M phase through dephosphorylating Thr161 of CDK1 by activating p53-independent p21 *** addition,p21 knockdown restored progress of cell cycle and cell viability by down-regulating the expression of Bad rather than *** WA arrested GBM cells at G2/M phase and triggered the intrinsic apoptosis through p21-Bad axis.

关键词： glioblastoma apoptosis cell cycle p21 Bad

Network mechanism on effective constituents from Polygala Tenuifolia for anti-Alzheimer Disease

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中国药理学与毒理学杂志 2018年第4期32卷 287-288页

作者： Hao JIA Xiao-cong PANG Bao-yue ZHANG Zhe WANG Ai-lin LIU guan-hua DU Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

OBJECTIVE To clarify out the network pharmacology mechanism of Polygala tenuifolia against Alzheimer disease(AD).METHODS Firstly,we collected the chemical constituents from Polygala tenuifolia and key targets toward *** learning algorithms were applied to construct *** for predicting the effective ***,docking models were utilized for further ***,we built constituent-target,target-target network and target-biology pathway *** 104 chemical constituents Polygala tenuifolia from were *** prediction of bloodbrain penetration and validation,36 chemical constituents were selected among 100 chemical ***,their action targets mainly focused on AChE,COX-2,TNF-α,insulin-degrading enzyme and *** main structure types include Polygala saponins,Polygala glycosides,Polygala shrubby ketones,polygala xanthones and sterols,which acted on AchE,APP,M-TAU,GSK3β and 5 HT1A with high ***-Ontology and KEGG enrichment analysis showed that the main pathways of these *** involve in neurotransmitter release,synaptic conduction and synaptic plasticity,apoptosis ***,phosphorylation pathway,Ca^(2+) signaling pathway,and so *** This study *** a network mechanism of Polygala tenuifolia against Alzheimer disease,which may provide *** information for the further study and new drug development.

关键词：阿尔茨海默病中药治疗方法临床分析

Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation

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Chinese Journal of Natural Medicines 2018年第3期16卷 184-193页

作者： ZHANG Wen SONG Jun-Ke ZHANG Xue ZHOU Qi-Meng HE Guo-Rong XU Xiao-Na Yan Rong ZHOU Wen-Xia DU guan-hua Beijing Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Department of Neuroimmunopharmacology Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical Countermeasures

Salvianolic acid A （SAA） is a water-soluble component from the root of Salvia Miltiorrhiza Bge, a traditional Chinese medicine, which has been used for the treatment of cerebrovascular diseases for centuries. The present study aimed to determine the brain protective effects of SAA against cerebral ischemia reperfusion injury in rats, and to figure out whether SAA could protect the blood brain barrier （BBB） through matrix metallopeptidase 9 （MMP-9） inhibition. A focal cerebral ischemia reperfusion model was induced by middle cerebral artery occlusion （MCAO） for 1.5-h followed by 24-h reperfusion. SAA was administered intravenously at doses of 5, 10, and 20 ***-l. SAA significantly reduced the infarct volumes and neurological deficit scores. Immunohistochemical analyses showed that SAA treatments could also improve the morphology of neurons in hippocampus CA1 and CA3 regions and increase the number of neurons. Western blotting analyses showed that SAA downregulated the levels of MMP-9 and upregulated the levels of tissue inhibitor of metalloproteinase 1 （TIMP-1） to attenuate BBB injury. SAA treatment significantly prevented MMP-9-induced degradation of ZO-1, claudin-5 and occludin proteins. SAA also prevented cerebral NF-κB p65 activation and reduced inflammation response. Our results suggested that SAA could be a promising agent to attenuate cerebral ischemia reperfusion injury through MMP-9 inhibition and anti-inflammation activities.

关键词： Salvianolic acid A Ischemia MCAO Blood brain barrier NF-κB MMP-9