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Investigation on the thermo-chemical reaction mechanism between yttria-stabilized zirconia （YSZ） and calciummagnesium-alumino-silicate （CMAS）

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Frontiers of Materials Science 2015年第1期9卷 93-100页

作者： Dong-Bo ZHANG Bin-Yi WANG Jian CAO guan-Yu SONG juan-Bo LIU Key Laboratory of Condition Monitoring and Control for Power Plant Equipment of Ministry of Education North China Electric Power University Beijing 102206 China

Thermal barrier coatings （TBCs） with Y2O3-stabilized ZrO2 （YSZ） top coat play a very important role in advanced turbine blades by considerably increasing the engine efficiency and improving the performance of highly loaded blades. However, at high temperatures, environment factors result in the failure of TBCs. The influence of calcium-magnesium-alumino-silicate （CMAS） is one of environment factors. Although thermo-physical effect is being paid attention to, the thermo-chemical reaction becomes the hot-spot in the research area of TBCs affected by CMAS. In this paper, traditional twolayered structured TBCs were prepared by electron beam physical vapor deposition （EB- PVD） as the object of study. TBCs coated with CMAS were heated at 1240℃ for 3 h. Additionally, 15 wt.% simulated molten CMAS powder and YSZ powder were mixed and heated at 1240℃ or 1350℃ for 48 h. SEM and EDS were adopted to detect morphology and elements distribution. According to XRD and TEM results, it was revealed that CMAS react with YSZ at high temperature and form ZrSiO4, Ca0.2Zr0.8O1.8 and Ca0.15Zr0.85O1.85 after reaction, as a result, leading to the failure of TBCs and decreasing the TBC lifetime.

关键词： thermal barrier coating (TBC) yttria-stabilized zirconia (YSZ) calciummagnesium-alumino-silicate (CMAS) thermo-chemical reaction high temperature

Association of CFH and MAP1LC3B gene polymorphisms with age-related macular degeneration in a high-altitude population

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1752-1756页

作者： Rui-juan guan Xin Yan Ling Li Ze-Feng Kang Xiao-Ying Zhang Huan-juan Yang Soochow University Suzhou 215000Jiangsu ProvinceChina Department of Ophthalmology Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina Eye Hospital China Academy of Chinese Medical SciencesBeijing 100043China

AIM: To evaluate the association of complement factor H(CFH) and microtubule-associated protein 1 light chain 3 beta(MAP1LC3B) gene polymorphisms with the risk of age-related macular degeneration(AMD) in a high-altitude population. METHODS: The study group consisted of 172 participants with symptoms of AMD who were examined and diagnosed between January 2019 and June 2020. The control group was composed of 120 healthy individuals. Each participant was required to provide two milliliters of peripheral blood for DNA extraction. Two single nucleotide polymorphisms(SNPs) of CFH(rs1061170 and rs800292) and two SNPs of MAP1LC3B(rs8044820 and rs9903) were genotyped. The genotypes and allele frequencies of the SNPs in the study and control groups were further compared using Chi-square and Fisher’s exact tests. RESULTS: In a high-altitude population, the nominally significant differences of rs800292 and rs9903’s genotype AG frequencies were observed in the AMD group(P=0.034 and 0.004, respectively). The frequencies of allele G of rs800292 and allele A of rs9903 were also significantly dif ferent in the AMD group compared to the control [(P=0.034, OR=0.70, 95%CI: 0.50-0.98) and(P=0.004, OR=1.60, 95%CI: 1.15-2.22), respectively]. No significant differences in the genotype distributions(P=0.16 and 0.40, respectively) and allele frequencies(P>0.05) of rs1061170 and rs8044820 were observed in the AMD ***: Genotype AG of rs800292 may be a protective factor for AMD. Conversely, rs9903 seems to be a risk factor for AMD. Therefore, allele G of rs800292 may be a protective factor, and allele A of rs9903, a risk factor for AMD in Qinghai high-altitude population.

关键词： age-related macular degeneration complement factor H microtubule-associated protein 1 light chain 3 beta single nucleotide polymorphisms pathogenesis

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3063-3076页

作者： Wenjing Zai Min Yang Kuan Jiang juan guan Huijing Wang Kongying Hu Chao Huang Jieliang Chen Wei Fu Changyou Zhan Zhenghong Yuan Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Research Unit of Cure of Chronic Hepatitis B Virus Infection(CAMS)Shanghai Frontiers Science Center of Pathogenic Microbes and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghaiP.R.China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghaiP.R.China Shanghai Engineering Research Center for Synthetic Immunology Fudan UniversityShanghaiP.R.China Eye Institute and Department of Ophthamology Eye and ENT HospitalFudan UniversityShanghaiP.R.China Pharmacy Department of Huashan Hospital Fudan UniversityShanghaiP.R.China Institute of Pediatric Translational Medicine Shanghai Institute for Pediatric Congenital Heart DiseaseShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Institute of Infectious Disease and Biosecurity ShanghaiP.R.China

This study aimed to develop a pan-genotypic and multifunctional small interfering RNA(siRNA)against hepatitis B virus(HBV)with an efficient delivery system for treating chronic hepatitis B(CHB),and explore combined RNA interference(RNAi)and immune modulatory modalities for better viral *** synthetic siRNAs targeting consensus motifs distributed across the whole HBV genome were designed and *** lipid nanoparticle(LNP)formulation was optimized by adopting HO-PEG_(2000)-DMG lipid and modifying the molar ratio of traditional polyethylene glycol(PEG)lipid in LNP *** efficacy and safety of this formulation in delivering siHBV(tLNP/siHBV)along with the mouse IL-2(mIL-2)mRNA(tLNP/siHBVIL2)were evaluated in the rAAVHBV1.3 mouse model.A siRNA combination(terms“siHBV”)with a genotypic coverage of 98.55%was selected,chemically modified,and encapsulated within an optimized LNP(tLNP)of high efficacy and security to fabricate a therapeutic formulation for *** results revealed that tLNP/siHBV significantly reduced the expression of viral antigens and DNA(up to 3log_(10)reduction;vs PBS)in dose-and time-dependent manners at single-dose or multi-dose frequencies,with satisfactory safety *** studies showed that tLNP/siHBVIL2 enables additive antigenic and immune control of the virus,via introducing potent HBsAg clearance through RNAi and triggering strong HBV-specific CD4^(+)and CD8^(+)T cell responses by expressed mIL-2 *** adopting tLNP as nucleic acid nanocarriers,the co-delivery of siHBV and mIL-2 mRNA enables synergistic antigenic and immune control of HBV,thus offering a promising translational therapeutic strategy for treating CHB.

关键词： formulation enable offering

A Variable Stiffness Soft Robotic Gripper with Low-Melting-Point Alloy 36

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A Variable Stiffness Soft Robotic Gripper with Low-Melting-P...

Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies

第36届中国控制会议

作者： HAO Yufei WANG Tianmiao FANG Xi YANG Kang MAO Ling guan juan WEN Li School of Mechanical Engineering and Automation Beihang University School of Materials Science and Engineering Beihang University

ISBN: (纸本)9781538629185

In this paper,we present the design,fabrication and the function of a soft actuator embedded with Low-Melting-Point Alloy(LMPA).By melting the metal via joule heating,the phase of the metal transformed from the solid state to the liquid state,by which the stiffness of the actuator changed over nearly an order of *** a reheating-recrystallizing circle,the actuator can self-healing and recovered from the crack *** melting speed under different electrical currents was ***,two experiments were conducted to investigate the self-healing property and stiffness enhancement of the *** LMPA could be melted within 40 *** using three actuators embedding with LMPA,we implemented a soft gripper with variable mechanical *** results show that the actuator not only has the self-healing property but also enhance the mechanical stiffness compared to the no-LMPA actuator(control).While the LMPA was under solid(recrystallized) state,the bending stiffness of the actuator increased up to 3.5 times over that of the control;while the pull-off force of the gripper increased 6.5 *** LMPA provide the soft robots with capacities of variable mechanical stiffness,and the self-healing provide a more robust capability for the system.

关键词： Variable Stiffness Low-Melting-Point Alloy Soft Robotics

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ACTA PHARMACEUTICA SINICA B 2024年第11期14卷 4994-5007页

作者： Wu, Ercan guan, juan Yu, Yifei Lin, Shiqi Ding, Tianhao Chu, Yuxiu Pan, Feng Liu, Mengyuan Yang, Yang Zhang, Zui Zhang, Jian Zhan, Changyou Qian, Jun Fudan Univ Minist Educ Sch Pharm Key Lab Smart Drug Delivery Shanghai 201203 Peoples R China Fudan Univ Huashan Hosp Dept Pharm Shanghai 201203 Peoples R China Fudan Univ Shanghai Pudong Hosp Pudong Med Ctr Dept Pharm Shanghai 200032 Peoples R China Fudan Univ Sch Basic Med Sci Dept Pharmacol Shanghai 200032 Peoples R China Fudan Univ State Key Lab Mol Engn Polymers Shanghai 200032 Peoples R China Fudan Univ Shanghai Canc Ctr Dept Med Oncol Shanghai 200032 Peoples R China

The different fate of liposomes among species has been discovered and mentioned in many studies, but the underlying mechanisms have not been explored. In the present work, we concentrated on the in vivo fate of PEGylated liposomes (sLip) in three commonly used species (mice, rats, and dogs). It was exhibited that the accelerated blood clearance (ABC) phenomenon and hypersensitivity in large animals (beagle dogs) were much more significant than that in rodents. We demonstrated that anti-PEG IgM (partially) and complement (mostly) determined the elimination of sLip and linked the distinct interspecies performances with the diverse complement capacity among species. Based on the data from animals and clinical patients, it was revealed that the fate of sLip in large animals was closer to that in humans, for the sufficient complement capacity could expose the potential adverse reactions caused by anti-PEG antibodies. Our results suggested that the distinctive interspecies performances of sLip were highly related to the physiological variabilities among species, which should not be overlooked in the innovation and translation of nanomedicines. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. This is an open access article under the CC BY license (http://***/licenses/by/4.0/).

关键词： Lipid Nanomedicine Liposome Interspecies Anti-PEG antibody Complement system ABC phenomenon In vivo fate

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俄语语气词汉译语用分析

外语研究 2011年第2期28卷 84-87页

作者：关秀娟黑龙江大学俄语语言文学研究中心黑龙江大学应用外语学院黑龙江哈尔滨150080

俄语语气词汉译是在保留原文语气即语用意义不变的情况下,变换语气表达方式,用汉语传达原文信息的语际活动。俄汉语语气词的同与异分别是翻译语用分析的基点和焦点,而零译、对译和转译等基本方法则是翻译语用分析的重点。

关键词：语气词汉译语用交际功能语境

泡沫塑料车床式切割机的研制与在制图实践课中的应用

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工程图学学报 2009年第1期30卷 160-165页

作者：管巧娟深圳职业技术学院机电工程学院广东深圳518055

研制了泡沫塑料车床式切割机,通过电热丝刀具,可切割出形状多样的泡沫材质的塑件。切割机由机架、刀架、毛坯夹紧装置以及电源装置组成。刀架装置改变了以往手持刀具切割的不稳定操作。夹紧装置可使毛坯作360o旋转运动,解决了以往毛坯... 详细信息

研制了泡沫塑料车床式切割机,通过电热丝刀具,可切割出形状多样的泡沫材质的塑件。切割机由机架、刀架、毛坯夹紧装置以及电源装置组成。刀架装置改变了以往手持刀具切割的不稳定操作。夹紧装置可使毛坯作360o旋转运动,解决了以往毛坯固定不动而限制切割方向改变的问题。切割尺寸控制机构使得操作过程准确,产品表面光滑。该切割机还可应用于制图课程的实践教学,训练学生的动手能力,提高学生的工程素质。

关键词：机械设计泡沫塑料车床式切割机工程图学实践教学

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传播学视角下的网络文学

当代传播 2006年第3期 54-56页

作者：关娟清华大学新闻与传播学院 100084

网络文学历经十余年的发展,从网上波及到网下,影响着文学的写作方式、人们的表达方式和接收阅读方式,已成为网络文化中日益活跃的力量。对网络文学的研究有多重视角,本文侧重从作者和渠道两方面入手,试图揭示网络文学传播的基本过程和... 详细信息

网络文学历经十余年的发展,从网上波及到网下,影响着文学的写作方式、人们的表达方式和接收阅读方式,已成为网络文化中日益活跃的力量。对网络文学的研究有多重视角,本文侧重从作者和渠道两方面入手,试图揭示网络文学传播的基本过程和要点。

关键词：网络文学狂欢节理论斯诺命题

基于状态观测器的催化裂化装置不可测变量在线估计

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化工学报 2011年第10期62卷 2828-2838页

作者：许锋关娟罗雄麟中国石油大学(北京)自动化研究所北京102249

采用基于非线性微分-代数方程的自适应状态观测器对催化裂化装置的油品产率、催化剂循环量等不可测变量进行在线估计。如果非线性微分-代数系统在工作点附近的线性化系统可观,则可以通过线性化系统的极点配置在线选取合适的状态观测器... 详细信息

采用基于非线性微分-代数方程的自适应状态观测器对催化裂化装置的油品产率、催化剂循环量等不可测变量进行在线估计。如果非线性微分-代数系统在工作点附近的线性化系统可观,则可以通过线性化系统的极点配置在线选取合适的状态观测器反馈增益阵,以实现能在较大范围内稳定工作的自适应状态观测器。可观性分析和观测器仿真表明,如果存在模型参数不确定性,通过增加温度测点,可以保证系统可观性并且观测器对催化裂化装置提升管反应器的不可测变量的观测结果能够稳定收敛到真值并具有较好的动态性能。

关键词：催化裂化装置提升管反应器状态观测器微分-代数系统不可测变量