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In Vitroand in VivoEfficacy of an Experimental Compound against Rhipicephalus (Boophilus) microplusTicks

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Pharmacology & Pharmacy 2013年第1期4卷 41-45页

作者： guadalupe santillán-velazquez Froylán Ibarra-Velarde Blas Flores Pérez Margarita Romero-Avila Yazmin Alcalá-Canto Héctor Salgado-Zamora Yolanda Vera Montenegro Department of Parasitology Veterinary Faculty of Medicin and Zootechnics National University Autonomus of Mexico Mexico City Mexico Faculty of Chemistry National University Autonomus of Mexico Mexico City Mexico Laboratory of Organic Chemistry School of Biological Sciences National Politechnic Institute Mexico City Mexico

The aim of the present study was to evaluate the ixodicide efficacy of the experimental compound 712-BF-016 against Rhipicephalus (Boophilus) microplus ticks in vitro and in cattle. The in vitro efficacy was initially tested against R. Boophilus microplus larvae using the Larval Packet Test (LPT). In a 2nd study the ixodicide efficacy was tested against adult ticks using the Adult Inmersion Test (AIT). Finally, a field test with the compound was carried out using 24 steers experimentally infested with R. (Boophilus) microplus ticks which were divided into 4 groups of 6 animals each for treatment. Groups 1 and 2 received the experimental compound at concentrations of 16% and 20%, respectively, which were applied as an aspersion in a total volume of 4 liters/animal. Group 3 was equally treated but with a commercial ixodicide containing cipermethrin at a 16% concentration. Group 4 served as untreated control. The efficacy was measured on days 1, 2, 3 after treatment as the percentage of ticks present from the treated groups, relative to the ticks present in the untreated control. The results indicated a percentage mortality of 93.21% for LPT and 98.02% for AIT. The efficacy produced in cattle was 61.78%, 76.43% and 85.34% for groups 1, 2 y 3, respectively. It is concluded that there was no concordance between the results obtained in vitro with those found in cattle. Possibly the excipient used for the formulation of the experimental compound was not suitable and had some influence on the results.

关键词： Rhipicephalus (Boophilus) microplus Ixodicide LPT AIT Cattle

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Bioinformatic Analysis of Potential Pathogenicity Effectors of CandidatusLiberibacter asiaticus, Causal Agent of Citrus Huanglongbing

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American Journal of Plant Sciences 2020年第8期11卷 1319-1330页

作者： Felipe Roberto Flores-de la Rosa Cynthia guadalupe Rodríguez-Quibrera Cristian Matilde-Hernández Ricardo santillán-Mendoza Campo Experimental Ixtacuaco Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias (INIFAP) Km 4.5 Carretera Federal Martínez de la Torre-Tlapacoyan Tlapacoyan Veracruz México

Huanglongbing (HLB) or citrus greening is currently the most important citrus disease, caused by the bacterium Candidatus Liberibacter asiaticus (CLas). The impossibility of isolating it causes understanding its patho... 详细信息

Huanglongbing (HLB) or citrus greening is currently the most important citrus disease, caused by the bacterium n>Candidatus Liberibacter asiaticus (CLas). The impossibility of isolating it causes understanding its pathogenic mechanisms to be a complicated task. Recent studies identified 16 proteins with the signal peptide needed to be secreted in the plant and cause the disease. The present study aims to perform a bioinformatic analysis of these proteins with the function prediction approach by gene ontology (GO) and the detection of conserved domains. It was observed that of the 16 proteins analyzed not all are found in different infective strains reported in the literature. The GO analysis allowed us to relate different proteins with the biological process of energy and pathogenic activity, especially CLIBASIA_03315 and CLIBASIA_05115, respectively. The domain analysis allowed the observation of a n>β-CA domain, tentatively related to the damage caused to the chloroplast and a PAAR domain associated with the T6SS secretory system. Our results provide information on the possible function of potential pathogenicity effectors in Cn style="font-family:Verdana;">Las.

关键词： Effectors Proteins Function Prediction Gen Ontology Domains Citrus Greening

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