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Phytochemically rich dietary components and the risk of colorectal cancer:A systematic review and meta-analysis of observational studies

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World Journal of Clinical Oncology 2021年第6期12卷 482-499页

作者： Pia Borgas guadalupe gonzalez Kirill Veselkov Reza Mirnezami Faculty of Medical Sciences University College LondonLondon WC1E 6BTUnited Kingdom Department of Computing Imperial College LondonLondon SW72RHUnited Kingdom Department of Surgery and Cancer Faculty of MedicineImperial College LondonLondon SW72AZUnited Kingdom Department of Colorectal Surgery Royal Free HospitalLondon NW32QGUnited Kingdom

BACKGROUND Personalized nutrition and protective diets and lifestyles represent a key cancer research *** association between consumption of specific dietary components and colorectal cancer(CRC)incidence has been evaluated by a number of population-based studies,which have identified certain food items as having protective potential,though the findings have been *** we present a systematic review and meta-analysis on the potential protective role of five common phytochemically rich dietary components(nuts,cruciferous vegetables,citrus fruits,garlic and tomatoes)in reducing CRC *** To investigate the independent impact of increased intake of specific dietary constituents on CRC risk in the general *** Medline and Embase were systematically searched,from time of database inception to January 31,2020,for observational studies reporting CRC incidence relative to intake of one or more of nuts,cruciferous vegetables,citrus fruits,garlic and/or tomatoes in the general *** were extracted by two independent reviewers and analyzed in accordance with the Meta-analysis of Observational Studies in Epidemiology(MOOSE)and Preferred Reporting Items for Systematic Review and Meta-analysis(PRISMA)reporting guidelines and according to predefined inclusion/exclusion *** sizes of studies were pooled using a random-effects *** Forty-six studies were *** risk was significantly reduced in patients with higher vs lower consumption of cruciferous vegetables[odds ratio(OR)=0.90;95%confidence interval(CI):0.85-0.95;P<0.005],citrus fruits(OR=0.90;95%CI:0.84-0.96;P<0.005),garlic(OR=0.83;95%CI:0.76-0.91;P<0.005)and tomatoes(OR=0.89;95%CI:0.84-0.95;P<0.005).Subgroup analysis showed that this association sustained when looking at case-control studies alone,for all of these four food items,but no significant difference was found in analysis of cohort studies *** consumption exhibited a similar trend,but

关键词： Colorectal cancer Disease prevention Diet Risk Nutrigenomics Metaanalysis

Interferon γ in patients with HIV/AIDS and suspicion or latent tuberculosis infection

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Asian Pacific Journal of Tropical Medicine 2013年第2期6卷 157-160页

作者： guadalupe Garcia-Elorriaga Mayte Martinez-Velazquez Veronica Gaona-Flores Guillermo del Rey-Pineda Cesar gonzalez-Bonilla Unidad de Investigacion en Inmunologia e Infectologia Centro Medico Nacional La Raza(CMNR)Instituto Mexicano del Seguro Social(IMSS) Mexico CityMexico Hospital de Infectologia CMNRIMSSMexico CityMexico Banco Central de Sangre CMNR.Hospital Infantil de MexicoFederico Gomez.Dpto.de Infectologia

Objective:To assess the usefulness of IGRA test(QuantiFERON? -Cell mediated immune) compared with the tuberculin skin ***:A cross-sectional study was carried out in Mexico,25 infected patients with HIV-AIDS and the suspicion or with latent tuberculous infection （LTBI） who were>18 years of age and without treatment for tuberculosis（TB）,were enrolled in the ***:Median cluster of differentiation（CD4） count was 364 cells/μL and median HIV viral load was 50 copies/***,20 patients（80%） had at least one positive diagnostic test for LTBI:four（16%） had a positive tuberculin skin test and 19（76%）,a positive QuantiFERON ? -***:No agreement is found between the two diagnostic tests:k = -0.004,95%confidence interval（-0.2219,0.2210）.Additional longitudinal studies among HIV-infected populations with high prevalence of TB are needed to further assess the usefulness of IGRAs in this patient population.

关键词： AIDS HIV IGRA Interferonγ Latent tuberculosis infection

Clinical,radiological and molecular diagnosis correlation in serum samples from patients with osteoarticular tuberculosis

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Asian Pacific Journal of Tropical Biomedicine 2014年第7期4卷 581-585页

作者： guadalupe Garcia-Elorriaga Olga Martinez-Elizondo Guillermo del Rey-Pineda Cesar gonzalez-Bonilla Unidad de Investigacion Medica en Inmunologia e Infectologia Hospital de InfectologiaCentro Medico Nacional La Raza(CMNR).Instituto Mexicano del Seguro Social(IMSS)Mexico City.Mexico(Medical Research Unit in Immunology and Infectious DiseaseHospital for Infectious Disease"La Raza"National Medical Center(CMNR).Mexican Social Security Institute(IMSS)Mexico CityMexico) Hospital de Ortopedia "Dr.Victorio de la Fuente Narvaez" Instituto Mexicano del Seguro Social(IMSS)Mexico CityMexico(Orthopedics Hospital " Dr.Victorio de la Fuente Narvaez"Mexican Social Security Institute(IMSS)Mexico CityMexico) Banco Central de Sangre CMNRIMSSand Departamento de InfectologiaHospital Infantil de Mexico Federico Gomez.Secretaria de Salud(SSA)Mexico CityMexico(Central Blood BankCMNR.IMSS and Department of Infectious Disease "Federico Comez" Children's Hospital.Health Ministry (SSA)Mexico CityMexico)

Objective:To assess the role of polymerase chain reaction(PCR)in serum sauples,in the diagnosis of osteoarticular tuberculosis(OTB)in a setting where only clinical and imaging diagnoses determine the ***:A total of 44 consecutive serum specimens were collected from clinically suspected OTB patients,based on clinical and radiological[X-ray or magnetic resonance imagng/computecl tomography]*** were scrcened by in-house nested *** addition,a few specimens were examined by Gram stain,acid-fast bacilli stain,histand routine bacterial culture.A total of 39 specimens were collected from patients suffering from other bone diseases of nontuberculous origin and included as negative ***:of the 44 clinically suspected OTB patients,in-house nested PCR was positive in 40(91%)cases;PCR was negative in 38(97%)negative *** and specificity of our in—house nested PCR was 90.3%and 97.4%,*** PCR report was available within 48 *** was possible to standardize serum PCR technique and in positive cases,a good n was observed in terms of an adequate treatment ***:Nested PCR in serum samples is a rapid,highly sensitive and specific modality for OTB detection,PCR should be performed in addition to clinical evaluation,imaging studies,acidfast bacilli staining,culture and histopathology diagnosis,if possible.

关键词： Osteoarticular tuberculosis Molecular diagnosis Nested polymerase chain reaction Sensitivity Specificity

Seasonal variation in native hydraulic conductivity between two deciduous oak species

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Journal of Plant Ecology 2020年第1期13卷 78-86页

作者： Dilia Mota-Gutiérrez guadalupe Arreola-González Rafael Aguilar-Romero Horacio Paz Jeannine Cavender-Bares Ken Oyama Antonio gonzalez-Rodriguez Fernando Pineda-García Facultad de Biología Universidad Michoacana de San Nicolás de Hidalgo.Edificio RCiudad UniversitariaGral.Francisco J.Múgica S/N A-1Felicitas de Río58030 MoreliaMichoacánMexico Escuela Nacional de Estudios Superiores Unidad MoreliaUniversidad Nacional Autónoma de México.Antigua Carretera a Pátzcuaro 8701Ex-Hacienda de San Joséde La Huerta58190 MoreliaMichoacánMexico Instituto de Investigaciones en Ecosistemas y Sustentabilidad Campus MoreliaUniversidad Nacional Autónoma de México.Antigua Carretera a Pátzcuaro 8701Ex-Hacienda de San Joséde La Huerta58190 MoreliaMichoacánMexico Deparment of Ecology Evolution and BehaviorUniversity of MinnesotaSaint PaulMN 55108USA

Aims Mechanisms of plant drought resistance include both tolerance and *** vulnerability to embolism and turgor loss point are considered traits that confer tolerance,while leaf abscission and deciduousness characterizes the avoidance *** these mechanisms are thought to trade-off expressing a continuum among species,little is known on how variation in the timing and duration of leaf shedding in response to drought affect the relationship between xylem and leaf *** the present study,we explored the extent to which drought tolerance differs between two oak(Quercus)species that exhibit different leaf shedding ***,we predicted that *** Trel.,which loses leaves at the end of the dry season(late-deciduous)and is thus exposed to a greater risk of cavitation,would be more drought tolerant and more conservative in its water use than *** Liebm.,which loses its leaves for only a short period of time in the middle of the dry season(brevideciduous).Methods The study was conducted in central Mexico in a single population of each of the two oak species,separated from each other by a distance of 1.58 km,and by an altitudinal difference of 191 *** deserticola(late deciduous)is more frequent down slope,while ***(brevideciduous)tends to occur at higher elevations along the *** assessed seasonal differences(rainy versus dry season)in native stem hydraulic conductivity,and tested for variation in xylem vulnerability to cavitation,leaf water use and leaf turgor loss point between the two *** Findings The two oak species did not differ in traits conferring drought tolerance,including xylem vulnerability to embolism,leaf turgor loss point,or stomatal ***,both species had different performance during the dry season;the brevideciduous species had lower negative impact in the xylem function than the late-deciduous ***,seasonal changes in plant physiological performance

关键词： Quercus hydraulic conductivity embolisms leaf phenology

Analysis of the Potential for Internationalization of a Medium Enterprise in the Mexican Footwear Sector

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Journal of Modern Accounting and Auditing 2017年第1期13卷 35-43页

作者： Maria guadalupe Arredondo-Hidalgo Diana Del Consuelo Caldera-gonzalez Universidad de Guanajuato Guanajuato Mexico

This research is a longitudinal case study with descriptive scope and mixed methodology： quantitative and qualitative. The aim of this paper is to analyze the potential for internationalization of a medium-sized enterprise （SME） in the footwear sector in the city of Leon Guanajuato, Mexico, in order to identify the feasibility of carrying out the plans of international trade. An analysis of both the industry and the organization was made. SME has an incipient experience for the US market. The results show that the company has potential for internationalization, but insertion into other markets must be gradual, given the nature of the organization, and must be formally planned.

关键词： internationalization enterprise strategies SMEs

Endoscopic management of massive rectal bleeding from a Dieulafoy’s lesion:Case report

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World Journal of Gastrointestinal Endoscopy 2019年第7期11卷 438-442页

作者： Mario Rene Pineda-De Paz Massiel Madelin Rosario-Morel Jose guadalupe Lopez-Fuentes Luis Ariel Waller-gonzalez Rodrigo Soto-Solis Department of Endoscopy National Medical Center November 20~(TH) ISSSTE

BACKGROUND Rectal Dieulafoy's lesions (DLs) are very rare;however, they can be life threatening when presented with massive hemorrhage. CASE SUMMARY A 44-year-old female with medical history of chronic renal failure who was on renal replacement therapy presented with lower gastrointestinal hemorrhage. Physical examination revealed signs of hypovolemic shock and massive rectal bleeding. Complete blood count revealed abrupt decrease in hematocrit. After hemodynamic stabilization, an urgent colonoscopy was performed. A rectal DL was diagnosed, and it was successfully treated with two hemoclips. There were no signs of recurrent bleeding at thirty days of follow-up. CONCLUSION Rectal DLs represent an unusual cause of lower gastrointestinal bleeding. Massive hemorrhage can increase the morbidity and mortality of these patients. Endoscopic management continues to be the reference standard in the diagnosis and therapy of these lesions. Thermal, mechanical (hemoclip or band ligation), or combination therapy (adrenaline injection combined with thermal or mechanical therapy) should be considered the first choice for treatment.

关键词： Dieulafoy's Lesion Endoscopic hemostasis Massive rectal bleeding Case report

Parasite Communities of the Pacific Mole Crab,Emerita rathbunae(Anomura:Hippidae),in Sandy Beaches from Guerrero and Michoacan,Mexico

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Open Journal of Marine Science 2015年第4期5卷 468-476页

作者： Juan Violante-gonzalez guadalupe Quiterio-Rendon Scott Monks Sergio García-Ibanez Griselda Pulido-Flores Agustín A.Rojas-Herrera Edvino Larumbe-Moran Unidad Académica de Ecología Marina Universidad Autónoma de GuerreroAcapulcoMéxico Centro de Investigaciones Biológicas Universidad Autónoma del Estado de HidalgoPachucaMéxico Centro de Estudios Tecnológicos del Mar Lazaro CardenasMexico

The species composition and infection levels were determined for helminth parasites in the mole crab, Emerita rathbunae, collected from seven sandy beaches from Guerrero and Michoacán, México. A total of 494 crabs were collected between August and December of 2009. The number of crabs that were examined from each beach varied from 40 in Lázaro Cárdenas to 114 in El Revolcadero. The cephalothorax length varied significantly between the sampled beaches, from 32.9 ± 5.5 mm (Ixtapa) to 40.5 ±1.7 mm(Las Trancas). Four species of larval parasites were identified: 1 metacercaria (Microphallus nicolli), 1 cystacanth (Profilicollis sp.), 1 cestode (Trypanorhyncha) and 1 nematode (Proleptus sp.). Infection levels (prevalence and mean abundance) varied significantly between beaches, due to possible differences in the availability of final or intermediate hosts in beaches visited by tourist and those beaches not visited by tourists, as well as the size of individual hosts. Helminth communities, at levels of component and infracommunity, were characterized by a low number of species (3 to 4) and a high dominance by the metacercaria of M. nicolli. The body size of the hosts was positively correlated with the number of parasites and species richness of helminths, indicating that larger crabs accumulate a higher number of parasites during the lifetime, and that they harbor a higher number of species of helminth than smaller crabs.

关键词： Parasite Community Emerita rathbunae Hippidae Mexican Pacific Coast

Chemical Structure of TiO Organometallic Particles Obtained by Plasma

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Advances in Nanoparticles 2013年第3期2卷 229-235页

作者： Ma. guadalupe Olayo Francisco González-Salgado Guillermo J. Cruz Lidia Ma. Gómez Genoveva García-Rosales Maribel gonzalez-Torres Osvaldo G. Lopez-Gracia Departamento de Física Instituto Nacional de Investigaciones Nucleares Ocoyoacac México Departamento de Física Instituto Nacional de Investigaciones Nucleares Ocoyoacac México Departamento de Posgrado Instituto Tecnológico de Toluca Metepec México Departamento de Física Instituto Nacional de Investigaciones Nucleares Ocoyoacac México Posgrado en Ciencia de Materiales Facultad de Química Universidad Autónoma del Estado de México Toluca México Departamento de Física Instituto Nacional de Investigaciones Nucleares Ocoyoacac México Posgrado en Ciencias Químicas Facultad de Química Universidad Autónoma del Estado de México Toluca México Departamento de Posgrado Instituto Tecnológico de Toluca Metepec México

This work presents a study about the chemical structure of titanium oxide (TiO) particles synthesized by plasmas using titanium tetrapropoxide, Ti(-O-CH2-CH2-CH3)4. In plasmas, practically all chemical bonds are susceptible to participate in the reactions producing different results than those obtained by the traditional chemical routes. The particles obtained this way are semispheres and fibers grouped in random and layered structures in the 120-500 nm interval and mean diameter of 86.4 nm (fibers) and 308.6 nm (semispheres). The analysis of the resulting TiO structure was performed by IR and XPS finding that the main chemical state of Ti in these conditions was O2-Ti-O2 (Ti surrounded by O) which is part of the precursor structure, however, in O, the main chemical state was Ti-O-Ti formed with the rupture of the pre- cursor Ti-O-C bonds. These last bonds reduce the conjugation between the structure of both elements, O2-Ti-O2 and Ti-O-Ti, to produce organometallic compounds. Other chemical states appeared showing consecutive dehydrogenation steps during the synthesis with the formation of multiple bonds as a consequence of the continuous collisions in the plasma. These results allow us to follow the chemical reactions promoted by this kind of plasmas to produce TiO nanoparticles which are essentially conformed of intensive dehydrogenation.

关键词： TiO Particles Plasma Degradation XPS TTP

Sunitinib effectiveness and safety as first line treatment in metastatic renal cell carcinoma,in the Costa Rican population

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 396-401页

作者： Esteban gonzalez Silvia Alfaro Allan Ramos-Esquivel Denis Ulises Landaverde Department of Hemato-Oncology Hospital MexicoLa UrucaSan Jose 10107Costa Rica Department of Hemato-Oncology Hospital Calderon GuardiaGuadalupeSan Jose 10801Costa Rica Department of Hemato-Oncology Hospital San Juan de DiosDistrito HospitalSan Jose 10103Costa Rica Department of Medicine Universidad de Costa RicaSan Pedro de Montes de OcaSan José2060Costa Rica

Aim:Tyrosine kinase inhibitors are part of the armamentarium to treat metastatic renal cell carcinomas(mRCC).Costa Rica has approved sunitinib in the first line *** authors conducted a retrospective study to address the effectiveness and safety profile of sunitinib in our population in terms of overall survival(OS)and progression free survival(PFS).Methods:The authors analyzed all patients who were treated with sunitinib diagnosed with mRCC in the three National Hospitals(Hospital Mexico,Hospital San Juan de Dios,and Hospital Calderon Guardia)from February 2007 to June ***,safety profile,and efficacy(OS and PFS)were obtained from medical *** and PFS were calculated using the Kaplan Meier method and a Cox Proportional Model Analysis was used when OS and PFS were compared in subset of ***:Seventy-seven patients were included;mean age was 58.9 ***-four patients were male(70.1%).The most common histologic type was clear cell carcinoma(87%),followed by papillary(9.1%)and chromophobe(2.0%)*** OS was 21.0 months[95%confidence interval(CI):13.42-28.58].Median PFS was 13.7 months(95%CI:11.24-16.16).Patients aged 65 years or older experienced worse PFS and OS than younger patients(median PFS:8.2 vs.17.6 months;P=0.011)(median OS:19.0 vs.29.0 months;P=0.022).Sunitinib was well tolerated and no serious side effects were ***:This is the first study in Central America showing that sunitinib,first line,in mRCC is as effective as reported in pivotal clinical trials and expanded use studies in terms of PFS and OS.

关键词： Sunitinib renal cell carcinoma effectiveness Latin America Costa Rica