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“第二个结合”引领当代文艺理论建设

中国文学批评 2024年第1期 4-11,M0003页

作者：谷鹏飞西北大学文学院西安710127

在文艺领域实现马克思主义基本原理同中华优秀传统文化相结合,即“第二个结合”,须以习近平文化思想为指南,以中国具体的文艺实际为基点,推进马克思主义文艺理论的中国化时代化与中华优秀传统文艺资源的创造性转化、创新性发展。在具体... 详细信息

在文艺领域实现马克思主义基本原理同中华优秀传统文化相结合,即“第二个结合”,须以习近平文化思想为指南,以中国具体的文艺实际为基点,推进马克思主义文艺理论的中国化时代化与中华优秀传统文艺资源的创造性转化、创新性发展。在具体的“结合”路径上,既要遵循守正创新的宏观路径,也要重视阐旧以辅新与陈新以生新的具体路径,还要援用“相通”内容、“相异”内容的“契合”实践。通过构建中国文艺与文化主体性,创建中国文艺新形态、新观念与新话语,推进中国马克思主义文艺与文艺理论的发展,最终启益于“中国式现代化的文化形态”“中华文明的现代形态”“新的文化生命体”建设。

关键词：马克思主义文艺基本原理中国具体实际中华优秀传统文艺 “第二个结合”

Hybrid Gaussian Network Intrusion Detection Method Based on CGAN and e-GraphSAGe

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Instrumentation 2024年第2期11卷 24-35页

作者： Xinyi Liang Hongyan Xing Wei gu.Tianhao Hou Zhiwei Ni Xinyi Wang School of electronics Information engineering Nanjing University of Information Science&TechnologyNanjing 210044

The rapid development of the Internet of Things(IoT)and modern information technology has led to the emergence of new types of *** poses a great potential danger to network ***,protecting against network attacks has become a pressing issue that requires urgent *** is crucial to find practical solutions to combat such malicious behavior.A network intrusion detection(NID)method,known as GMCe-GraphSAGe,was proposed to meet the detection demands of the current intricate network *** data is mapped into gaussian distribution,which helps to ensure that subsequent models can effectively learn the features of traffic *** conditional generative adversarial network(CGAN)can generate attack samples based on specified labels to create balanced traffic *** addition,we constructed a communication interaction graph based on the connection patterns of traffic *** e-GraphSAGe is designed to capture both the topology and edge features of the traffic *** it,global behavioral information is combined with traffic features,providing a solid foundation for classifying and *** on the UNSW-NB15 dataset demonstrate the great detection advantage of the proposed *** binary and multi-classification F1-score can achieve 99.36%and 89.29%,*** GMCe-GraphSAGe effectively improves the detection rate of minority class samples in the NID task.

关键词： network intrusion detection IoT deep learning

ZIF-90-loaded DNAzyme-responsive PROTAC for the self-powered degradation of NF-κB

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Science China Chemistry 2024年

作者： Min Hou Liang Sun Tianyu Ren Mingda Li Chao Hu Rong Liu Shuang gu.Mingyan Jiang Jianhui Jiang Jianjun He College of Physics and Chemistry Hunan First Normal University Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine College of Biomedical Sciences College of Chemistry and Chemical Engineering Hunan University Xiangtan Central Hospital

Transcription factors(TFs) play vital roles in regu.ating gene expressions. Dysregu.ated or mutated TFs are implicated in a wide array of diseases, highlighting their potential as drug targets. However, TFs are considered undruggable by conventional inhibitor-based modalities. The recently emerged proteolysis targeting chimeras(PROTACs) have exhibited great potential in tackling TFs. In particular, DNA-ligand chimeras that arm e3 ligase-recruiting ligands to TF-binding double-strand DNA represent a promising strategy for the targeted proteolysis of TFs. Here, we report a DNAzyme-inducible PROTAC(DzTAC)that selectively degrades NF-κB in a zinc ion-dependent manner. We further applied zinc-imidazolate metal–organic framework-90(ZIF-90) to encapsulate DzTAC(ZIF-90@DzTAC), facilitating its delivery into cancer cells while self-supplying Zn2+via adenosine triphosphate(ATP)-triggered ZIF-90 dissociation. Moreover, ZIF-90@DzTAC can enhance the treatment efficacy of doxorubicin-based chemotherapy in tumor-bearing mice. The developed DzTAC provides specific modulation over TF activity and opens an avenue for more functional nucleic acid-based control over targeted protein degradation.

关键词：

Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 608-615页

作者： WeI Ya-ru HOU Yun-long YIN Yu-jie LI Zhen LIU Yi HAN Ning-xin WANG Zi-xuan LIU Lu WANG Xiao-qi HAO Yuan-jie MA Kun gu.Jiao-jiao JIA Zhen-hua Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Shijiazhuang Yiling Pharmaceutical New Drug evaluation Center Shijiazhuang050035China Hebei Institute of Integrated Traditional and Western Medicine Shijiazhuang050035China National Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang050035China Department of Cardiology Hebei Yiling HospitalShijiazhuang050091China Graduate School Hebei Medical UniversityShijiazhuang050017China

Objective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury(MIRI)in *** A MIRI mouse model was established by left anterior descending coronary artery ligation for 45 *** to a random number table,66 mice were randomly divided into 6 groups(n=11 per group):the sham group,the model group,the LY-294002 group,the TXL group,the TXL+LY-294002 group and the benazepril(BNPL)*** day after modeling,TXL and BNPL were administered by *** injection of LY-294002 was performed twice a week for 4 consecutive *** was used to measure cardiac function in *** staining was used to evaluate the degree of myocardial fibrosis in *** and quantitative analysis of endothelial mesenchymal transition(endMT)after MIRI was performed by immunohistochemistry,immunofluorescence staining and flow cytometry,*** protein expressions of platelet endothelial cell adhesion molecule-1(CD31),α-smoth muscle actin(α-SMA),phosphatidylinositol-3-kinase(PI3K)and phospho protein kinase B(p-AKT)were assessed using Western *** TXL improved cardiac function in MIRI mice,reduced the degree of myocardial fibrosis,increased the expression of CD31 and inhibited the expression ofα-SMA,thus inhibited the occurrence of endMT(Peased the protein expressions of PI3K and p-AKT(Pere was no significant difference between TXL and BNPL group(P>0.05).In addition,the use of the PI3K/AKT pathway-specific inhibitor LY-294002 to block this pathway and combination with TXL intervention,eliminated the protective effect of TXL,further supporting the protective effect of *** TXL activated the PI3K/AKT signaling pathway to inhibit endMT and attenuated myocardial fibrosis after MIRI in mice.

关键词： myocardial fibrosis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway

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基于单缝法的混凝土工作应力微损测试

铁道科学与工程学报 2024年第5期21卷 2099-2108页

作者：顾颖刘庭勇彭勇军杜义祥周子豪古松西南科技大学土木工程与建筑学院四川绵阳621010 中铁十八局集团第二工程有限公司河北唐山064099 四川振通检测股份有限公司四川绵阳621010

混凝土工作应力是相对于无应力状态的应力增量。为准确测定混凝土工作应力,基于“应变部分释放”的理念,提出一种用于混凝土工作应力的微损伤测试方法——单缝法。该方法通过切割一条较浅的弧形狭缝来释放应力,根据测试应变来计算应力... 详细信息

混凝土工作应力是相对于无应力状态的应力增量。为准确测定混凝土工作应力,基于“应变部分释放”的理念,提出一种用于混凝土工作应力的微损伤测试方法——单缝法。该方法通过切割一条较浅的弧形狭缝来释放应力,根据测试应变来计算应力。采用数值模拟验证了单缝法的有效性,并分析了混凝土弹性模量等参数对应变释放率的影响。应变释放率为切缝释放应变与混凝土初始应变的比值。通过试验研究了应力大小、切缝深度等参数对测试精度的影响。研究结果表明:应变释放率由切缝形状与大小唯一确定,与混凝土弹性模量、应力大小、切缝宽度等参数无关;给定切缝形状与大小,就可以借助数值模拟或试验确定相应的应变释放率。释放应变沿切缝两侧呈“M”形分布,远离切缝,释放应变呈先增加、后减小的趋势。应变片应尽量布置在应变较大且单调变化的位置,故建议选用50 mm的应变片,布置在距切缝边缘25 mm的位置。切缝深度越大,切割产生的扰动应变越大,当切缝深度小于35 mm,扰动应变为12~18με的压应变;扰动应变可在测试应变中扣除,以消除其对测试精度的影响。切缝深度越大,测试精度越高,但对混凝土的损伤也越大,若采用直径125 mm切割片,建议切缝深度控制在30~35 mm。单缝法能够有效测试混凝土工作应力且具有较高的精度,对于测试试样,测量误差少于8.5%。

关键词：混凝土工作应力释放应变应变释放率单缝法

Overlooked uneven progress across sustainable development goals at the global scale: Challenges and opportunities

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The Innovation 2024年第2期5卷 42-50页

作者： Yali Liu Jianqing Du Yanfen Wang Xiaoyong Cui Jichang Dong Pan gu.Yanbin Hao Kai Xue Hongbo Duan Anquan Xia Yi Hu Zhi Dong Bingfang Wu Jüurgen P.Kropp Bojie Fu School of Grassland Science Beijing Forestry UniversityBeijing 100083China Beijing Yanshan earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China College of Resources and environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Tibetan Plateau earth System Environment and ResourcesChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China School of economics and Management University of Chinese Academy of SciencesBeijing 100190China School of Humanities University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Adaptation and evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China School of Innovation and entrepreneurship University of Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China Potsdam Institute for Climate Impact Research 14412 PotsdamGermany Institute for environmental Science and Geography University of Potsdam14412 PotsdamGermany State Key Laboratory of Urban and Regional ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Differences in progress across sustainable development goals(SDGs)are widespread globally;meanwhile,the rising call for prioritizing specific SDGs may exacerbate such ***,how these progress differences would influence global sustainable development has been long ***,we present the first quantitative assessment of SDGs’progress differences globally by adopting the SDGs progress evenness *** results highlight that the uneven progress across SDGs has been a hindrance to sustainable development because(1)it is strongly associated with many public health risks(e.g.,air pollution),social inequalities(e.g.,gender inequality,modern slavery,wealth gap),and a reduction in life expectancy;(2)it is also associated with deforestation and habitat loss in terrestrial and marine ecosystems,increasing the challenges related to biodiversity conservation;(3)most countries with low average SDGs performance show lower progress evenness,which further hinders their fulfillment of SDGs;and(4)many countries with high average SDGs performance also showcase stagnation or even retrogression in progress evenness,which is partly ascribed to the antagonism between climate actions and other *** findings highlight that while setting SDGs priorities may be more realistic under the constraints of multiple global stressors,caution must be exercised to avoid new problems from intensifying uneven progress across ***,our study reveals that the urgent needs regarding SDGs of different regions seem complementary,emphasizing that regional collaborations(e.g.,demand-oriented carbon trading between SDGs poorly performed and well-performed countries)may promote sustainable development achievements at the global scale.

关键词： globally priori inequality

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以学习操作系统构建数字化转型的数智动能

电化教育研究 2024年第2期45卷 55-61,70页

作者：顾小清王羽萱华东师范大学教育信息技术学系上海200062

伴随着数据要素价值的凸显,如何以教育数据的有效治理,充分发挥数智驱动教育变革的强大潜力,成为教育数字化转型的关键所在。在智能教育大脑的隐喻下,学习技术系统依托于充当“数智大脑”角色的核心构件,搭建“数据组织—数据建模—数... 详细信息

伴随着数据要素价值的凸显,如何以教育数据的有效治理,充分发挥数智驱动教育变革的强大潜力,成为教育数字化转型的关键所在。在智能教育大脑的隐喻下,学习技术系统依托于充当“数智大脑”角色的核心构件,搭建“数据组织—数据建模—数据分析”的教育数据治理通路,深度挖掘并最大化释放教育数据价值。基于此,文章以数据为主线重塑新一代学习技术系统框架,并以学习操作系统作为核心构件的隐喻,从“为何”“是何”及“如何”三个方面深度阐释其来源、内涵与体系架构,聚焦于数智动能的系统实现。同时,基于团队研发的“数智大脑”平台,文章以案例故事的形式描绘其在学校教育中的多元化使用场景,展现出以学习操作系统构建的数智动能的强大应用潜力,以期为数智驱动教育数字化转型提供全新的视角和思路。

关键词：学习操作系统学习技术系统数智动能数智大脑教育数据治理

electrochemical Analysis of Zirconiumin Aqueous and Organic Media

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American Journal of Analytical Chemistry 2024年第2期15卷 99-118页

作者： Paul Mendy Démo Koita Theodore Tzedakis Cheikhou Kane Codou gu.ye Mar-Diop ecole Supérieure Polytechnique Université Cheikh Anta DIOP Dakar Sénégal Laboratoire de Génie Chimique Université de Toulouse III—Paul Sabatier Toulouse France

For the challenging nature of the zirconium environment analysis, this study consists to analyze the electrochemical behavior of Zirconium in both aqueous and organic media. To that end first the electrolytic media was selected on the basis of the Pourbaix potential-pH diagram, which provides informations on the predominance of Zr(IV) ion and Zr in aqueous media. In aqueous media, analyzes were first carried out in acidic media then in basic media. Studies have thus revealed that the acidic environment is not favourable for the electrochemical analysis of zirconium. Voltammograms obtained in an acidic environment show no zirconium detection signal;this is due to the strong presence of H+ ions in the solution. We have also observed in acidic media the phenomenon of passivation of the electrode surface. In aqueous alkaline media (pH = 13), we have drawn in reduction several Intensity-Potential curves by fixingsome technical parameterslike scanning speed, rotation speed of the electrode. The obtained voltammograms show cathodic waves, starting from -1.5 V/DHW and attributed to the reduction of Zr (IV) to Zr (0). The last phase of this study focused on the electrochemical analysis of zirconium in an organic media. In this media, several intensity-potential curves were plotted in reduction and in cyclic voltammetry with various parameters. Through several reduction analysis, the Zr (IV) was reduced to Zr (0) to the potential of -1.5 V/DHW. The electrochemical analysis of zirconium in organic media seems globally easier to achieve thanks to its large solvent window (i.e. dimethylformamide (DMF) solvent window > 6 V).

关键词： Zirconium electrochemical Reduction Cyclic Voltammetry Voltammogram Dymethylformamide

Profibrotic role of the SOX9-MMP10-eCM biosynthesis axis in the tracheal fibrosis after injury and repair

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Genes & Diseases 2024年第5期11卷 360-373页

作者： Lei gu.Anmao Li Chunyan He Rui Xiao Jiaxin Liao Li Xu Junhao Mu Xiaohui Wang Mingjin Yang Jinyue Jiang Yang Bai Xingxing Jin Meiling Xiao Xia Zhang Tairong Tan Yang Xiao Jing Lin Yishi Li Shuliang gu. Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Infection Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China

Fibroblast activation and extracellular matrix(eCM)deposition play an important role in the tracheal abnormal repair process and *** a transcription factor,SOX9 is involved in fibroblast activation and eCM ***,the mechanism of how SOX9 regu.ates fibrosis after tracheal injury remains *** investigated the role of SOX9 in TGF-b1-induced fibroblast activation and eCM deposition in rat tracheal fibroblast(RTF)***9 overexpression adenovirus(Ad-SOX9)and siRNA were transfected into RTF *** found that SOX9 expression was up-regu.ated in RTF cells treated with ***9 overexpression activated fibroblasts and promoted eCM *** SOX9 inhibited cell proliferation,migration,and eCM deposition,induced G2 arrest,and increased apoptosis in RTF ***-seq and chromatin immunoprecipitation sequencing(ChIP-seq)assays identified MMP10,a matrix metalloproteinase involved in eCM deposition,as a direct target of SOX9,which promotes eCM degradation by increasing MMP10 expression through the Wnt/b-catenin signaling ***,in vivo,SOX9 knockdown ameliorated granulation proliferation and tracheal fibrosis,as manifested by reduced tracheal *** conclusion,our findings indicate that SOX9 can drive fibroblast activation,cell proliferation,and apoptosis resistance in tracheal fibrosis via the Wnt/b-catenin signaling *** SOX9eMMP10 eeCM biosynthesis axis plays an important role in tracheal injury and *** SOX9 and its downstream target MMP10 may represent a promising therapeutic approach for tracheal fibrosis.

关键词： extracellular matrix deposition Fibroblast activation MMP10 SOX9 Tracheal fibrosis