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四川盆地川中地块新元古代伸展构造的发现及其在天然气勘探中的意义

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中国科学：地球科学 2014年第11期44卷 2210-2220页

作者：谷志东汪泽成中国石油勘探开发研究院北京100083

四川盆地位于上扬子克拉通西北部,川中地块是位于四川盆地中部蒲江-巴中、华蓥山深大断裂之间的坚硬块体,这一块体一直被认为是扬子克拉通最古老、最稳定的核心,基底均一、硬化程度高.本文应用覆盖范围达5万余平方公里高分辨率地震并结... 详细信息

四川盆地位于上扬子克拉通西北部,川中地块是位于四川盆地中部蒲江-巴中、华蓥山深大断裂之间的坚硬块体,这一块体一直被认为是扬子克拉通最古老、最稳定的核心,基底均一、硬化程度高.本文应用覆盖范围达5万余平方公里高分辨率地震并结合大比例尺航磁资料,通过对川中地块深层构造的精细解释,发现川中地块新元古代发育近东西向、北东东向、北西向展布规模不等的8支伸展构造,这改变了川中地块为统一块体的传统认识.这些伸展构造纵向剖面发育一期或两期伸展作用,其内充填厚达3000-5000 m的弱磁性物质.四川盆地威远地区基底A型花岗岩与川西苏雄组双峰式火山岩的发育均证实川中地块新元古代处于伸展构造背景.初步讨论了新元古代伸展构造对川中地块烃源岩、有利沉积相带展布,储层发育及天然气成藏的作用.

关键词：川中地块新元古代伸展构造深层-超深层勘探

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Non‐chromate conversion process for zinc coating with durable hydrophobicity and enhanced corrosion resistance

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Biosurface and Biotribology 2022年第3期8卷 266-277页

作者： J.Y.Chen Z.Y.Hu Z.X.Li X.L.Wang C.d.gu J.P.Tu School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsZhejiang UniversityHangzhouChina Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province HangzhouChina Zhejiang Ecological and Environmental Monitoring Center HangzhouChina Zhejiang Key Laboratory of Ecological and Environmental Monitoring Forewarning and Quality ControlHangzhouChina

A Zn‐based coating with durable hydrophobicity and good corrosion resistance was formed on a mild steel substrate,which involves electroplating Zn from a non‐aqueous electrolyte,followed by passivation in an oleic acid(OA)*** electrodeposited Zn coatings were porous,which facilitated the formation of a chemical conversion layer of Zn oleate(ZO)during OA *** Zn coating after passivation had a twolayer structure,which included an outer layer of ZO with a thickness of~26μm and an inner layer of Zn with a thickness of~6μ*** outer layer ZO is a type of metal soap with a smooth surface and durable hydrophobicity,such that water droplets can easily slip off its *** testing and electrochemical measurements in 3.5 wt.%NaCl aqueous solution indicate that the Zn coating after OA passivation exhibits outstanding anti‐corrosion properties compared with those exhibited by pure Zn *** corrosion products and mechanism of the two‐layer coating were *** study shows that smooth metal oleate coatings can provide hydrophobicity and corrosion resistance simultaneously to mild steel substrates.

关键词： Anti‐corrosion Electrodeposition Hydrophobic coating Passivation Zn oleate

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： dian Jiao Lai Xu Zhen gu Hua Yan dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced drug delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang Yuan Liang Yixue gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor d and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli gu Kijung Sung Chengbiao Wu department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BdNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BdNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BdNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic

AI-Enhanced Secure data Aggregation for Smart Grids with Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong Wang Chen Wang Wenying Zheng Wei gu School of Software Nanjing University of Information Science and TechnologyNanjing210044China School of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Public Big data Guizhou UniversityGuiyang550025China School of Computer Science and Technology(School of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China School of Computer Science(School of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy *** research emphasizes data security and user privacy concerns within smart ***,existing methods struggle with efficiency and security when processing large-scale *** efficient data processing with stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation method designed to enhance aggregation efficiency and security by standardizing and normalizing various data *** approach optimizes data preprocessing,integrates Long Short-Term Memory(LSTM)networks for handling time-series data,and employs homomorphic encryption to safeguard user *** also explores the application of Boneh Lynn Shacham(BLS)signatures for user *** proposed scheme’s efficiency,security,and privacy protection capabilities are validated through rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation

Team experience of nasopharyngeal samples reception,decontamination,and sorting during the COVId-19 pandemic(2020)at Institut Pasteur Côte d’Ivoire

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Journal of Biosafety and Biosecurity 2021年第2期3卷 120-124页

作者： KouaméInnocent Kolia KipréBertin guédé Kan Stéphane Kouassi Koby Albert Obro Kpadraux danielle Odegue Sylvie Mireil Sina-Kouaméle Banga Victor Yepri Mireille dosso Molecular Biology Platform/Institut Pasteur Côte d’Ivoire Central Laboratory/University Hospital Center of Yopougon(Côte d’Ivoire)Cote d’Ivoire Bacteriology and Virology department National Reference Center for Antibiotics/Institut Pasteur Côte d’IvoireCôte d’Ivoire Molecular Biology Platform/Institut Pasteur Côte d’Ivoire Côte d’Ivoire Cell Biology Unit/Institut Pasteur Côte d’Ivoire Côte d’Ivoire Transport and packaging unit/Institut Pasteur Côte d’Ivoire Côte d’Ivoire Institut Pasteur Côte d’Ivoire Côte d’Ivoire

Molecular testing sensitivity,which allows for early diagnosis of the 2019 coronavirus disease(COVId-19),could be affected by sample quality,storage,and transportation timeframe to the laboratory,along with bias related to the pre-analytic *** present study reports the selection and decontamination of nasopharyngeal samples during COVId-19 management at the Institut Pasteur Côte d’*** objective of this work was to organize sample reception management and report a complete picture of sample selection and decontamination in the context of diagnosis activity *** administrative note creating the selection and decontamination unit of nasopharyngeal samples initiated activities in May *** required human resources and necessary materials were identified and put in *** activity consisted of receiving,sorting,decontaminating,and sending nasopharyngeal samples to different diagnostic *** were recorded *** a six-month period of activities,from a total amount of 11,401 containers received and decontaminated,174,085 samples were selected.A proportion of 92.0%of these specimens met the diagnostic standards,while 7.0%that were found acceptable showed minor ***,a rate of 1.0%of samples with major abnormalities could not be used for COVId-19 testing and,therefore,were ***,the non-conformity rate was reduced by 2.4%after the first term *** and decontamination of nasopharyngeal samples are crucial steps in biosafety optimization for the technical staff and quality improvement of sample care.

关键词： Sorting and decontamination Nasopharyngeal sample COVId-19 Côte d’Ivoire

THE ROAd OF dEVELOPMENT IN CHINA'S BIOMEdICAL ENGINEERING

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Chinese Journal of Biomedical Engineering(English Edition) 1993年第2期2卷 83-84页

作者： Fangzhou gu,Ph.d President of Chinese Society of Biomedical Engineering and President of Chinese Academy of Medical Sciences

Over the decade,Chinese Biomedical Engineering has made remarkle progressand accumulated much *** important problem facing us is how to takethe road ahead of *** of all,we should change our conventional concept and head for the *** three years ago,we made a special review on the connotation and char-acteristics of biomedical engineering and pointed out that Biomedical Engineering

关键词： ahead pointed connotation accumulated biomedical quarters bringing facing money weakness

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto doncel-Pérez Gabriel guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury