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Genetic variations of the ADIPOQ gene and risk of prostate cancer in Chinese Han men

Asian Journal of Andrology 2014年第6期16卷 878-883页

作者： Cheng-yuan gu Department of Urology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Shanghai Medical College Fudan University Shanghai China Cancer Institute Fudan University Shanghai Cancer Center Shanghai China Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering School of life Sciences Fudan University Shanghai China Fudan-Taizhou Institute of Health Sciences Taizhou China Duke Cancer Institute Duke University Medical Center Durham North Carolina USA

Adiponectin secreted by adipose tissue has been implicated in prostate carcinogenesis. Genetic variations in ADIPOQare thought to influence the activity of adiponectin, thus relating to cancer occurrence. In this hospital-based case-control study of 917 prostate cancer （PCa） cases and 1036 cancer-free controls, we evaluated the association of single nucleotide polymorphisms in ADIPOQ with risk of PCa and adiponectin levels in Chinese Han men. Variants of ADIPOQ were genotyped by Taqman polymerase chain reaction method. The plasma adiponectin concentrations were measured by *** immunosorbent assay （ELISA） in a subset of cases and controls. We found that the ADIPOQ rs3774262 variant AA genotype was associated with both decreased PCa risk [adjusted odds ratio （OR）： 0.66, 95% confidence interval （CI） =0.48-0.92] and increased plasma adiponectin levels （P= 0.036 and 0,043）, with significant difference by tumor grade, clinical stage, and aggressiveness. A significant interaction between ADIPOQ rs3774262 and body mass index was observed in modifying the risk of PCa （P=6.7 × 10-3）. ADIPOQ rs266729 and rs182052 were not related to PCa risk or plasma adiponectin levels. Our data support that ADIPOQ rs3774262 may affect PCa risk in combination with plasma adiponectin levels in Chinese Han men. It may contribute to the molecular basis for the association between obesity and PCa.

关键词： adiponectin ADIPOQ polymorphism prostate cancer

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Synthesis of a Novel Conjugate of Bromoarene and Polyamide Containing N-Methylimidazoles

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Chinese Chemical Letters 2005年第10期16卷 1330-1332页

作者： Dan LIU gu yuan Department of Chemical Biology The Key Laboratory of Bioorganic Chemistry and MolecularEngineering of Ministry of Education College of Chemistry Peking University Beijing 100871

A novel DNA cleavage conjugate of bromoarene and polyamide containing three N-methylimidazole rings was synthesized by the chloroform reaction and the DCC/HOBT coupling reaction.

关键词： DNA cleavage bromoarene polyamide chloroform reaction.

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Computational pharmacological studies on cardiovascular disease by Qishen Yiqi Diwan

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Science China Chemistry 2009年第11期52卷 1871-1878页

作者： gu JiangYong yuan gu ZHU YongHong XU XiaoJie Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Academy of Tasly Pharmaceutical Co. LTDTianjin 300410China

Computational pharmacological methods were used to study the distribution of 1729 compounds contained in a Chinese medicine,Qishen Yiqi Diwan,in chemical *** results show that most of these compounds have good drug-like *** docking was used to study the interactions between 1729 compounds of Qishen Yiqi Diwan and 26 drug targets related to cardiovascular disease and the distribution of 1729 compounds in drug-target *** results may shed light on the action mechanism and the search for the active compounds in Qishen Yiqi Diwan.

关键词： chemical space drug-target space molecular docking computational pharmacology

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Investigation of formation of dimeric G-quadruplex of HIV-1 integrase inhibitor by nuclear magnetic resonance

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Chinese Chemical Letters 2008年第9期19卷 1108-1110页

作者： Hui Hui Li gu yuan Beifing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beifing 100871 China

In this research, an unusually dimeric G-quadruplex of d（GGGTGGGTGGGTGGGT）（SI）, the potent nanomolar HIV-1 integrase inhibitor, was detected by nuclear magnetic resonance （NMR）. This result has been confirmed b... 详细信息

关键词： G-quadruplex HIV-1 integrase inhibitor Nuclear magnetic resonance

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Study of STAT3 G-quadruplex folding patterns by CD spectroscopy and molecular modeling

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Chinese Chemical Letters 2012年第3期23卷 329-331页

作者： Sen Lin Ming Xu gu yuan Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Institute of Vascular MedicineThird HospitalPeking UniversityBeijing 100191China

The G-quadruplexes formed from G-rich strands in the telomere and oncogene-promoter regions are regarded as new promising targets in the cancer therapy.A G-quadruplex in the downstream flanking region of the signal transducer and activator of transcription 3（STAT3） gene was *** folding patterns were proposed to be 3：2：2 and 3：3：1 loop isomers by the mutation analysis by CD *** structures were constructed and refined by molecular modeling method.

关键词： G-quadruplex STAT3 gene CD spectroscopy Molecular modeling

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Recognition of hairpin DNA from coil DNA by electrospray mass spectrometry with annealing strategy

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Chinese Chemical Letters 2012年第4期23卷 500-503页

作者： Bo Zheng Yi Quan Liu gu yuan Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100086China Shanghai Research Institute of Chemical Industry Shanghai 200062China

This research presented an annealing strategy to identify hairpin DNA from coil DNA with the same base composition but different arrangements using electrospray mass spectrometry（ESI-MS）.A series of single-stranded DNA were annealed with their complementary sequences,*** the five pairs of hairpin DNA and coil DNA were unambiguously distinguished by ESIMS with annealing *** research offers a potential method to probe the DNA structure by comparing with mass spectral characteristics.

关键词： Hairpin DNA Annealing Mass spectrometry

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Metabonomics delineates allergic reactions induced by Shuang-huang-lian injection in rats using ultra performance liquid chromatography-mass spectrometry

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Chinese Journal of Natural Medicines 2018年第8期16卷 628-640页

作者： gu yuan-yuan SHI Lang ZHANG Dan-Dan HUANG Xin CHEN Da-Zhong Research Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine First Clinical Medical College Heilongjiang University of Chinese Medicine

Shuang-huang-lian Injection(SHLI) is the first successfully developed drug from traditional Chinese medicine(TCM) powder for injection,since its use for the treatment of acute respiratory tract infection,pneumonia,influenza,*** the same time,its allergic reactions have also emerged,which limits clinical ***,few scholars pay attention to the mechanism of allergic *** this present study,metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction;we and analyzed the metabolites,metabolic pathway,and the mechanism which were closely related to the allergic *** levels of serum histamine and tryptase were examined and changes in histomorphology were also *** on the UPLC-Q-TOF/MS metabonomics,we carried out the pattern recognition analysis,selected potential biomarkers associated with allergic reactions,and explored the pathological mechanism for SHLI induced allergic reaction,which laid the foundation for the safety research of *** results showed that SHLI increased the levels of serum histamine and tryptase in rats with allergic reaction;we determined 15 biomarkers in rat allergic reaction model induced by SHLI and found multiple metabolic pathways involved,such as metabolism of linolenic acid,phenylalanine,amino acid,2-oxo acid,and purine and other metabolic pathways.

关键词： Shuang-huang-lian injection Biomarker Metabonomics Allergic mechanism Metabolites

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Effects of acute low temperature stress on the endocrine reactions of the Qinghai toad-headed lizard

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Current Zoology 2011年第6期57卷 775-780页

作者： Chunwang LI yuan gu Songhua TANG Hongxia FANG guohua JIANG Zhigang JIANG Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China Analytical and Testing Center Beijing Normal University Beijing 100875 China

Endoctinological action is generally thought to be a way for animals to respond to stress at low temperatures. To learn the role of hormones in ectotherms inhabiting alpine environments, we studied the effects of acute low temperature exposure on tile endocrinological reactions of Qinghai toad-headed lizards in the Qinghai-Tibetan Plateau. We monitored plasma corticos- terone and insulin concentration of the lizards under five low temperature treatments. We found no significant difference in plasma corticosterone or insulin in lizards among our five different treatments. For males and females the correlation between plasma corticosterone and insulin concentrations was not significant. In contrast to other studies on reptiles at low altitude, we suggest that due to the alpine environment （low temperature and low oxygen concentration） they inhabit, Qinghai toad-headed lizards respond to experimental cold stress slightly to mobilize energy and live their vivid life. In addition, corticosterone and insulin of Qinghai toad-headed lizards are secreted independently along with low temperature treatments

关键词： Adrenal gland Alpine environment Cold stress Pancreas Phrynocephalus vlangalii, Qinghai toad-headed agamids

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A　CONVENIENT　METHOD　FOR　SYNTHESIZING　AND　CHARACTERIZATION　OF　（Z）－ALKENOLS　AND　THEIR　ACETATES

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Chinese Chemical Letters 1995年第11期6卷 943-944页

作者： gu yuan(Department of Chemistry,Peking University, Beijing 100871) Beijing Univ Dept Chem Beijing 100871 Peoples R China

All double bond positional isomers of (Z)-dodecenol, (Z)-tetradecenol, (Z)hexadecenol and their acetates were synthesized by the Wittig reaction and the coupling reaction, and a novel procedure for the identification ...

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A New Method for Phase Retrieval in the Optical System

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Chinese Physics Letters 1998年第1期15卷 24-26页

作者： CONG Wen-xiang CHEN Nan-xian gu Ben-yuan Institute of Applied Physics Beijing University of Science and TechnologyBeijing 100083 Institute of Physics Chinese Academy of SciencesBeijing 100080

In this letter,a new recursive algorithm to implement phase retrieval from two intensities in the two-dimensional Fourier transform domain is *** terms of the cascading property and additivity of the order of the fractional Fourier transform,a set of convolution equations is exactly *** recursive algorithm,these equations can be easily *** approach simplifies significantly computational manipulations comparing with conventional iterative algorithms and does not need initial phase distribution.

关键词： recursive letter equations

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