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Effect of cyclic wetting-drying on tensile mechanical behavior and microstructure of clay-bearing sandstone

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International Journal of Coal Science & Technology 2021年第5期8卷 956-968页

作者： Pingye guo Juan gu Yi Su jiong Wang Zhanwen Ding State Key Laboratory for Geo-Mechanics and Deep Underground Engineering Beijing 100083China School of Mechanics Architecture and Civil EngineeringChina University of Mining and TechnologyBeijing 100083China Tang Steel International Engineering Technology Corp Tangshan 063000China China Henan Geological and Mineral Resources Construction Engineering(Group)Co. LtdZhengzhou 450007China

The understanding of the weakening mechanism of tensile strength of rock subjected to cyclic wetting-drying is critical for rock *** strength tests were conducted on a total of 35 sandstone specimens with different wetting-drying *** crack propagation process and acoustic emission characteristics of the tested samples were obtained through a high-speed camera and acoustic emission *** results indicate that the tensile strength is observably reduced after cyclic wetting-drying,and the extent of the reduction is not only related to the number of wettingdrying cycle,but also closely related to the clay mineral content of the *** addition,as the cycles of wetting-drying increase,the effect of each single cycle on tensile strength get reduced until it becomes ***,the crack initiation and penetration time is prolonged as the number of wetting-drying cycle increases,which indicates that cyclic wetting-drying weakens the rock stiffness and enhances the ductility of ***,the acoustic emission characteristics of the tested samples further confirmed the ductile behaviour of the sandstone samples with increasing wetting-drying ***,through the analysis of the microstructure and mineral composition of the samples with different wetting-drying cycles,it is concluded that the main weakening mechanisms of sandstones containing clay minerals are frictional reduction,chemical and corrosive deterioration.

关键词： Sandstone Wetting-drying cycle Tensile strength Weakening mechanism Failure characteristics

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jun-Ping Liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan guo-Hong Deng Liang Qiao Yan Zhang Wen-Yi gu Xiao-Mei Xiang Yi Zhou Yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao Chun-Yan Liu Wei Yuan Xue Mei Jing Li Tao Li Rong-jiong Zheng Xin-Yi Zhou Jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

GSTAR:an innovative software platform for processing space geodetic data at the observation level

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Satellite Navigation 2023年第3期4卷 122-141页

作者： Chuang Shi Shiwei guo Lei Fan Shengfeng gu Xinqi Fang Linghao Zhou Tao Zhang Zhen Li Min Li Wenwen Li Cheng Wang yidong Lou Key Laboratory of Navigation and Communication Fusion Technology Ministry of Industry and Information Technology37 Xueyuan RoadBeijing 100191China School of Electronic and Information Engineering Beihang University37 Xueyuan RoadBeijing 100191China Research Institute for Frontier Science Beihang University37 Xueyuan RoadBeijing 100191China GNSS Research Center Wuhan University129 Luoyu RoadWuhan 430079China

To meet the demands for the data combination with multiple space geodetic techniques at the observation level,we developed a new software platform with high extensibility and computation efficiency,named space Geodetic SpatioTemporal data Analysis and Research software(GSTAR).Most of the modules in the GSTAR are coded in C++with object-oriented *** layered modular theory is adopted for the design of the software,and the antenna-based data architecture is proposed for users to construct personalized geodetic application scenarios *** initial performance of the GSTAR software is evaluated by processing the Global Navigation Satellite System(GNSS)data collected from 315 globally distributed stations over two and a half *** accuracy of GNSS-based geodetic products is evaluated by comparing them with those released by International GNSS Service(IGS)Analysis Centers(AC).Taking the products released by European Space Agency(ESA)as reference,the Three-Dimension(3D)Root-Mean-Squares(RMS)of the orbit differences are 2.7/6.7/3.3/7.7/21.0 cm and the STandard Deviations(STD)of the clock differences are 19/48/16/32/25 ps for Global Positioning System(GPS),GLObal NAvigation Satellite System(GLONASS),Galileo navigation satellite system(Galileo),BeiDou Navigation Satellite System(BDS),Medium Earth Orbit(MEO),and BDS Inclined Geo-Synchronous Orbit(IGSO)satellites,*** mean values of the X and Y components of the polar coordinate and the Length of Day(LOD)with respect to the International Earth Rotation and Reference Systems Service(IERS)14 C04 products are-17.6 microarc-second(μas),9.2μas,and 14.0μs/*** to the IGS daily solution,the RMSs of the site position differences in the north/east/up direction are 1.6/1.5/3.9,3.8/2.4/7.6,2.5/2.4/7.9 and 2.7/2.3/7.4 mm for GPS-only,GLONASS-only,Galileo-only,and BDS-only solution,*** RMSs of the differences of the tropospheric Zenith Path Delay(ZPD),the north gradients,and the east gradien

关键词： GSTAR GNSS BDS LEO Precise orbit determination Precise clock estimation Earth rotation parameter Tropospheric zenith path delay Geocenter motion Rapid data processing

Integrated precise orbit determination of Shenzhou IV unmanned spacecraft

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Science China(Technological Sciences) 2004年第5期47卷 518-525页

作者： L Congmin1,2, gu yidong3, LIN Baojun3 & guo jiong3 1. Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100080, China 2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 3. General Establishment of Space Science and Application, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to L Congmin Center for Space Science and Applied Research Chinese Academy of Sciences Beijing China Graduate School of the Chinese Academy of Sciences Beijing China General Establishment of Space Science and Application Chinese Academy of Sciences Beijing China

Considering the characteristic orbit of Shenzhou IV spacecraft and the advantages and disadvantages of several types of domestic orbit measurements, a scheme of IPOD is determined, which uses GPS, SLR and USB observation data jointly plus precise ionosphere corrections to GPS observation data. IPOD system and mathematic models of OD are introduced. The results of different joint OD are analyzed using true observation data, and show that radial accuracy is better than 2 m.

关键词： Shenzhou IV unmanned spacecraft integrated precise orbit determination GPS SLR USB.

高校运动员目标取向和能力知觉对恐惧失败之预测

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北京体育大学学报 2008年第4期31卷 529-531页

作者：古国华李炯煌北京体育大学北京100084 铭传大学体育室中国台北

目的在探讨高校运动员目标取向和能力知觉对恐惧失败之预测力及其交互作用影响。方法:研究对象为360名来自台湾四所高校的甲组运动员,平均年龄为20.03岁,皆自愿完成填写一组测量运动目标取向、能力知觉以及恐惧失败等问卷。结果:经由多... 详细信息

目的在探讨高校运动员目标取向和能力知觉对恐惧失败之预测力及其交互作用影响。方法:研究对象为360名来自台湾四所高校的甲组运动员,平均年龄为20.03岁,皆自愿完成填写一组测量运动目标取向、能力知觉以及恐惧失败等问卷。结果:经由多元阶层回归分析,发现任务取向、自我取向和能力知觉皆能有效预测恐惧失败。结论:本研究认为当运动员的动机倾向愈强调努力、进步和精熟技巧或者运动员自觉拥有较高的运动能力时,这些运动员就愈不怕表现失败;反之,如果运动员的目标取向偏好以打败他人作为能力指标时,他们就会更恐惧输掉比赛或表现不佳的后果。

关键词：或就目标能力知觉恐惧失败多元回归

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胃窦部平滑肌增生肥大误诊为恶性肿瘤1例

中华消化内镜杂志 2023年第12期40卷 1020-1021页

作者：安晓静刘炯蔡毅东王洋袁果中国中医科学院西苑医院病理科北京100091 中国中医科学院西苑医院消化科北京100091

本文报告了1例内镜下显示胃窦部环状隆起型占位,形成假幽门,内镜考虑为恶性肿瘤,经活检病理组织形态学证实为黏膜固有层内平滑肌增生肥大所致,避免了患者的过度治疗。

关键词：胃窦平滑肌增生幽门梗阻误诊

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

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Signal Transduction and Targeted Therapy 2022年第2期7卷 502-518页

作者： Zhen Wang Fan-lian Zeng Ya-wen Hu Xiao-yan Wang Fu-lei Zhao Pei Zhou Jing Hu Yuan-yuan Xiao Zhong-lan Hu Ming-feng guo Xiao-qiong Wei Xiao Liu Nong-yu Huang Jun Zhang Shu-wen Chen Juan Cheng Hua-ping Zheng Hong Zhou Qi-xiang Zhao Chen Zhang Yan Hao Song Zou Yi-yue gui Jia-dong Yu Lin-na gu Cheng-cheng Yue Hao-zhou Zhang Wen-ling Wu Yi-fan Zhou Xi-kun Zhou guo-bo Shen Xiu Teng jiong Li State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041China Department of Liver Surgery&Liver Transplantation West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041China Laboratory of Liver Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengdu 610041China Department of Cardiovascular Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Human Disease and Immunotherapies West China HospitalSichuan UniversityChengduSichuan 610041China

Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired *** molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been ***,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in ***,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and ***,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA ***8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune *** dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC *** findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC.

关键词： immunity cytotoxic Interleukin

超敏肌钙蛋白对维持性血液透析患者的短期预后作用

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复旦学报（医学版） 2017年第4期44卷 447-452页

作者：顾佳芸沈波吴炯戴谦曹旻璐陈曦旻郭玮潘柏申复旦大学附属中山医院检验科上海200032 复旦大学附属中山医院肾内科上海200032

目的探讨超敏肌钙蛋白(high-sensitivity cardiac troponin T,hs-cTnT)对维持性血液透析(maintainance hemodialysis,MHD)患者的短期预后作用。方法入组296例MHD患者,回顾性分析其临床资料,患者血液透析前采集血清检测hs-cTnT和相关心... 详细信息

目的探讨超敏肌钙蛋白(high-sensitivity cardiac troponin T,hs-cTnT)对维持性血液透析(maintainance hemodialysis,MHD)患者的短期预后作用。方法入组296例MHD患者,回顾性分析其临床资料,患者血液透析前采集血清检测hs-cTnT和相关心血管风险标志物。随访时间总长为13个月,记录主要终点事件(全因死亡)及发生时间;用t检验、Mann-Whitney U检验和χ2检验分析比较全因死亡与生存组风险标志物之间的差异,使用X-tile计算出hs-cTnT的最佳二分位切点,绘制Kaplan-Meier生存曲线,用Logistic回归分析高危及非高危hs-cTnT之间的死亡风险比。根据hs-cTnT健康人群第99百分位点将非高危组细分为中危组和低危组来进一步评估其对MHD患者短期预后的影响。结果 MHD患者生存与全因死亡组的血清hs-cTnT水平分别为0.05(0.03~0.07)ng/mL和0.07(0.04~0.14)ng/mL(P=0.027);hs-cTnT的最佳二分位切点为0.1 ng/mL;高危组(hs-cTnT>0.1 ng/mL)患者生存率(76.67%)显著低于非高危组(hs-cTnT≤0.1 ng/mL)患者生存率(96.62%)(P0.014 ng/mL)患者生存率低于低危组(hs-cTnT≤0.014 ng/mL)患者生存率,低危组在随访期间无死亡事件发生。结论 hs-cTnT是MHD患者死亡的独立危险因素,并可作为MHD患者短期的死亡风险分级和预后评估的有力指标。

关键词：超敏肌钙蛋白维持性血液透析危险分级预后评估

脑挫伤后的进展性脑挫伤与凝血指标变化的临床研究

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中国现代医学杂志 2015年第24期25卷 49-52页

作者：郭衍高文伟王韧顾奕陈炯丁军陈浩上海交通大学附属上海第六人民医院神经外科上海200233

目的通过对进展性脑挫伤患者的凝血指标进行动态检测,探讨在进展过程中关键凝血指标的变化。方法对95例进展性脑挫伤患者进行临床资料分析,检测伤后24 h^7 d内格拉斯哥昏迷评分(GCS)、凝血酶原时间(PT)、激活部分凝血酶原时间(APTT)、... 详细信息

目的通过对进展性脑挫伤患者的凝血指标进行动态检测,探讨在进展过程中关键凝血指标的变化。方法对95例进展性脑挫伤患者进行临床资料分析,检测伤后24 h^7 d内格拉斯哥昏迷评分(GCS)、凝血酶原时间(PT)、激活部分凝血酶原时间(APTT)、纤维蛋白原含量(FIB)、D-二聚体浓度(D-dimer)、纤维蛋白降解产物(FDP)以及其变化趋势。分析其中与死亡率、格拉斯哥预后评分(GOS)相关的危险因素。结果进展性脑挫伤各组患者中入院评分、D-二聚体及纤维蛋白原含量与死亡率、GOS评分相关。结论凝血指标对进展性脑挫伤患者预后判断具有临床指导意义,入院评分越低,D-二聚体浓度越高,纤维蛋白原含量越高预后越差。其中以双额叶及颞叶部位进展性脑挫伤预后较差。

关键词：进展性脑挫伤预后 D-二聚体