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Repellent and Insecticidal Activity of Naphthoquinones from the Heartwood of Tectona grandis on Incisitermes marginipennis(Latreille)

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Phyton-International Journal of Experimental Botany 2023年第7期92卷 2165-2181页

作者： Crisanto Velázquez-Becerra gu yen ambriz-ortiz Rafael Torres-Martínez Mauro Manuel Martínez-Pacheco Facultad de Ingeniería en Tecnología de la Madera Universidad Michoacana de San Nicolás de HidalgoMoreliaMéxico Escuela Nacional de Estudios Superiores Unidad MoreliaMoreliaMéxico Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMoreliaMéxico

Wood is a lignocellulosic material that,because of its organic nature,is a source of nutrients for bacteria,fungi,and *** marginipennis(Latreille)is an interesting dry wood-boring *** it is an extremely destructive pest,difficult to control due to its cryptic lifestyle,and for its role in the biogeochemical cycle of carbon and other elements;it is a fundamental *** use of less toxic and eco-friendly substances is important for protecting domestic,cultural,and historical heritage made of wood or lignocellulosic *** aim of this study was to evaluate the biological activity of various naphthoquinones extracted from the heartwood of *** on ***,heartwood flour was used for Soxhlet-type extractions to isolate and characterize the heartwood compounds by thin-layer *** identify the heartwood compounds,nuclear magnetic resonance and gas chromatography coupled to a mass spectrometer were *** information obtained was supported using the Interactive Spectroscopy *** identified heartwood compounds were lapachol,tectoquinone,deoxylapachol,dehydro-α-lapachone,tectol and *** nymphal termites of *** as a biological model,the isolated and identified molecules were under three different tests(repellent,insecticide and protective)and their biological activity was individually *** results showed that the molecules obtained have a repellent-protective effect against ***,although not in all cases,these molecules have high percentages of mortality and decreased the weight loss of the treated material exposed to ***.

关键词： Naphthoquinones dry wood termite Incisitermes marginipennis wood preservatives

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Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第47期19卷 8873-8879页

作者： De-Leung gu yen-Hsieh Chen Jou-Ho Shih Chi-Hung Lin Yuh-Shan Jou Chian-Feng Chen Institute of Biomedical Sciences Academia Sinica Institute of Microbiology and Immunology School of Life ScienceNational Yang-Ming University Bioinformatics Program Taiwan International Graduate ProgramAcademia Sinica Genome and Systems Biology Degree Program National Taiwan University VYM Genome Research Center National Yang-Ming University

High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma(HCC)cohorts confirmed previously identified frequently mutated somatic genes,such as TP53,CTNNB1 and AXIN1,and identified several novel genes with moderate mutation frequencies,including ARID1A,ARID2,MLL,MLL2,MLL3,MLL4,IRF2,ATM,CDKN2A,FGF19,PIK3CA,RPS6KA3,JAK1,KEAP1,NFE2L2,C16orf62,LEPR,RAC2,and *** classification of these mutated genes suggested that alterations in pathways participating in chromatin remodeling,Wnt/β-catenin signaling,JAK/STAT signaling,and oxidative stress play critical roles in HCC ***,because there are few druggable genes used in HCC therapy,the identification of new therapeutic targets through integrated genomic approaches remains an important *** a large amount of HCC genomic data genotyped by high density single nucleotide polymorphism arrays is deposited in the public domain,copy number alteration(CNA)analyses of these arrays is a cost-effective way to reveal target genes through profiling of recurrent and overlapping amplicons,homozygous deletions and potentially unbalanced chromosomal translocations accumulated during HCC ***,integration of CNAs with other high-throughput genomic data,such as aberrantly coding transcriptomes and non-coding gene expression in human HCC tissues and rodent HCC models,provides lines of evidence that can be used to facilitate the identification of novel HCC target genes with the potential of improving the survival of HCC patients.

关键词： Copy number alteration High-density single nucleotide polymorphism arrays Driver genes Hepatocellular carcinoma

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Trogocytosis of CD80 and CD86 by induced regulatory 7 cells

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Cellular & Molecular Immunology 2012年第2期9卷 136-146页

作者： Peng gu Julia Fang Gao Cheryl A D＇Souza Aleksandra Kowalczyk Kuang-yen Chou Li Zhang University of Toronto Transplant Institute Toronto General Research Institute University Health Network Toronto Ontario Canada Shanghai Institute of Immunology Shanghai Jiaotong University School of Medicine Shanghai China Department of Immunology University of Toronto Toronto Ontario Canada These authors contributed equally to this paper.

Trogocytosis is a process which involves the transfer of membrane fragments and cell surface proteins between cells. Various types of T cells have been shown to be able to acquire membrane-bound proteins from antigen-presenting cells and their functions can be modulated following trogocytosis. However, it is not known whether induced regulatory T cells （iTregs） can undergo trogocytosis, and if so, what the functional consequences of this process might entail. In this study, we show that iTregs can be generated from CD80-/-CD86-/- double knockout （DKO） mice. Using flow cytometry and confocal fluorescence microscopy, we demonstrate that iTregs generated from DKO mice are able to acquire both CD80 and CD86 from mature dendritic cells （mDCs） and that the acquisition of CD86 occurs to a higher extent than that of CD80. Furthermore, we found that after co-incubation with iTregs, dendritic cells （DCs） downregulate their surface expression of CD80 and CD86. The trogocytosis of both CD80 and CD86 occurs in a cytotoxic T lymphocyte-associated antigen-4 （CTLA-4）, CD28 and programmed death ligand-1 （PDL1）-independent manner. Importantly, we showed that iTregs that acquired CD86 from mDCs expressed higher activation markers and their ability to suppress naive CD4＋ T-cell proliferation was enhanced, compared to iTregs that did not acquire CD86. These data demonstrate, for the first time, that iTregs can acquire CD80 and CD86 from mDCs, and the acquisition of CD86 may enhance their suppressive function. These findings provide novel understanding of the interaction between iTregs and DCs, suggesting that trogocytosis may play a significant role in iTreg-mediated immune suppression.

关键词： CD80 CD86 CTLA-4 iTregs trogocytosis

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Notch信号及其对T细胞发育和分化的调节

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细胞生物学杂志 2008年第4期30卷 440-444页

作者：顾鹏周光炎上海交通大学医学院上海市免疫学研究所上海200025

哺乳动物Notch蛋白包括四种(Notch1～Notch4),其配体分为两个家族:Jagged家族(Jagged1,Jagged2)和Delta样家族(DLL1,DLL3,DLL4)。Notch信号途径涉及一些蛋白质裂解过程,随后反式作用因子RBP-J及协同激活因子MAML等参与,最终导致靶基因... 详细信息

哺乳动物Notch蛋白包括四种(Notch1～Notch4),其配体分为两个家族:Jagged家族(Jagged1,Jagged2)和Delta样家族(DLL1,DLL3,DLL4)。Notch信号途径涉及一些蛋白质裂解过程,随后反式作用因子RBP-J及协同激活因子MAML等参与,最终导致靶基因的转录。在早期T细胞发育过程中起关键作用,还调节外周T细胞的活化增殖以及诱导Th细胞亚群的分化。Notch信号途径对转录因子GATA-3激活而诱导的Th2细胞分化非常重要。

关键词： Notch Jagged家族 Delta样家族 T细胞 GATA-3

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Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif

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Journal of Molecular Cell Biology 2019年第11期11卷 1006-1017页

作者： Thi Hai yen Tran Dae-Wook Yang Minchul Kim Da-Hye Lee Marta Gai Ferdinando Di Cunto Kwang-Wook Choi Dae-Sik Lim Department of Biological Sciences KAIST 291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Molecular Biotechnology and Health Sciences University of Turin10126 TurinItaly

The inhibitory effect of large tumor suppressor kinase(LATS1/2)on the activity of the oncoprotein yes-associated protein(YAP)is crucial to maintain tissue *** studies have identified several new regulators of this ***,citron kinase(CIT)was listed as a potential binding candidate of Hippo-related components,suggesting a new connection between CIT and the Hippo *** from CITs role in cytokinesis,the molecular crosstalk between CIT and the Hippo pathway is largely ***,we demonstrate a role for CIT as a scaffold protein Unking LATS2 and *** importantly,CIT interacts with LATS2 to directly suppress LATS2 phosphorylation at the hydrophobic motif—targeted by MST1,leading to LATS2 inactivation and YAP *** studying their genetic interactions,we found that Sticky,the CIT homolog in Drosophila melanogaster,functions with Warts to control Drosophila eye ***,our study confirms citron kinase as a novel regulator of the Hippo pathway.

关键词： citron kinase LATS2-YAP interaction LATS2 inhibition sticky-warts Hippo pathway

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Single-Phase Ternary Compounds with a Disordered Lattice and Liquid Metal Phase for High-Performance Li-Ion Battery Anodes

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Nano-Micro Letters 2023年第5期15卷 36-50页

作者： Yanhong Li Lei Zhang Hung-Yu yen Yucun Zhou gun Jang Songliu Yuan Jeng-Han Wang Peixun Xiong Meilin Liu Ho Seok Park Wenwu Li School of Chemical Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-SiGyeonggi-Do 440-746Korea School of Physics Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Department of Chemistry National Taiwan Normal UniversityTaipei 11677TaiwanPeople’s Republic of China Samsung Advanced Institute for Health Sciences and Technology(SAIHST) Sungkyunkwan University2066 SeoburoJangan-guSuwon 440-746Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University2066 SeoburoJangan-guSuwon 440-746Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan University2066 SeoburoJangan-guSuwon 440-746Korea

Si is considered as the promising anode materials for lithium-ion batteries(LIBs)owing to their high capacities of 4200 mAh g-1and natural ***,severe electrode pulverization and poor electronic and Li-ionic conductivities hinder their practical *** resolve the afore-mentioned problems,we first demonstrate a cation-mixed disordered lattice and unique Li storage mechanism of single-phase ternary GaSiP_(2)compound,where the liquid metallic Ga and highly reactive P are incorporated into Si through a ball milling *** confirmed by experimental and theoretical analyses,the introduced Ga and P enables to achieve the stronger resistance against volume variation and metallic conductivity,respectively,while the cation-mixed lattice provides the faster Li-ionic diffusion capability than those of the parent GaP and Si *** resulting GaSiP_(2)electrodes delivered the high specific capacity of 1615 mAh g-1and high initial Coulombic efficiency of 91%,while the graphite-modified GaSiP_(2)(GaSiP_(2)@C)achieved 83%of capacity retention after 900 cycles and high-rate capacity of 800 at 10,000 mA ***,the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)//Ga SiP_(2)@C full cells achieved the high specific capacity of 1049 mAh g-1after 100 cycles,paving a way for the rational design of high-performance LIB anode materials.

关键词： Multinary compounds Liquid metal GaSiP_(2) Disordered lattice Li-ion batteries

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The Roles of acyI-CoA： Diacylglycerol Acyltransferase 2 Genes in the Biosynthesis of Triacylglycerols by the Green Algae Chlamydomonas reinhardtii

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Molecular Plant 2012年第4期5卷 945-947页

作者： Xiao-Dong Deng Bo gu Ya-Jun Li Xin-Wen Hu Jian-Chun guo Xiao-Wen Fei Key Laboratory of Biology and Genetic Resources of Tropical Crops Ministry of AgricultureInstitute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural ScienceHaikou 571101China Department of Biochemistry Hainan Medical CollegeHaikou571101China College of Agronomy Hainan UniversityHaikou571101China

Dear Editor, Triacylglycerols （triglycerides）（TAGs）, as the major storage forms of energy, mainly are stored in adipocytes, myocytes, enterocytes, hepatocytes, and mammary epithelial cells in mammals, oilseeds in plants, and lipid droplets in microorgan- isms （yen et al., 2008）. Aside from energy storage, TAGs have essential functions in multiple physiological processes. In plants, TAGs are crucial for seed oil accumulation, germina- tion, and seedling development （Zhang et al., 2005, 2009）. Notably, TAGs derived from plants and microorganisms could serve as the feedstock for biofuels production （Deng et al., 2009）. Therefore, understanding of the molecular basis of TAGs bio- synthesis and storage is of considerable economic importance.

关键词： biosynthesis TAGGING Lipid Droplets Microbes plants breast epithelium cell Physiological Processes Storage Diacylglycerol O-Acyltransferase Chlamydomonas reinhardtii aluminium Triglycerides Chlorophyceae

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运动终板及其神经末梢的染色法

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军事医学科学院院刊 1980年第1期 105-110页

作者：许小珊沈菊英

哺乳动物横纹肌神经肌肉接头处呈现比较集中的运动末梢,其外围有神经后装置(Subneural apparatus),加上附近的间质(雪旺氏细胞等)形成一种特殊的板状结构,贴附于肌纤维的表面,称为运动终板。在神经化学传导理论占统治地位的今天,神经肌... 详细信息

哺乳动物横纹肌神经肌肉接头处呈现比较集中的运动末梢,其外围有神经后装置(Subneural apparatus),加上附近的间质(雪旺氏细胞等)形成一种特殊的板状结构,贴附于肌纤维的表面,称为运动终板。在神经化学传导理论占统治地位的今天,神经肌肉接头是较典型的纯胆碱能神经传导;欲深入研究乙酰胆碱及胆碱酯酶的生理功能、胆碱能受体的分子药理学作用和神经冲动对肌肉营养的关系等诸问题,都需要以运动终板的形态结构为基础。目前通过光学显微镜和电

关键词：运动终板形态结构神经-肌肉接头(点) 神经末梢周围神经系统福尔马林水溶液染色法复合染色肌纤维肌细胞胆碱能

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光学薄膜发射光谱分析中的标样应用

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光学机械 1989年第3期 35-40页

作者：郭永廉初真林任兵谷松海

通过对导电的铝镁合金膜、不导电的Ti○_2一Ta_2○_5介质膜和半导体ZnSe光学膜层成份直接分析,提出了三种光学薄膜光谱标样制备的新方法。在考察测定系统误差和放电机制之后,提出了光学薄膜成份分析和一般光谱分析对标样不同要求的三点... 详细信息

通过对导电的铝镁合金膜、不导电的Ti○_2一Ta_2○_5介质膜和半导体ZnSe光学膜层成份直接分析,提出了三种光学薄膜光谱标样制备的新方法。在考察测定系统误差和放电机制之后,提出了光学薄膜成份分析和一般光谱分析对标样不同要求的三点新看法。

关键词：光学薄膜发射光谱标样分析

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斜索-桥面耦合面内参数振动Ⅰ：理论模型

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土木工程学报 2009年第5期42卷 79-84页

作者：任淑琰顾明同济大学土木工程防灾国家重点实验室上海200092 上海林同炎李国豪土建工程咨询有限公司上海200092

斜拉桥拉索具有质量小、阻尼小、刚度小的特点,在外部激励作用下容易产生各种振动,其中拉索在桥面或桥塔的位移激励下的参数振动为主要振动形式之一。考虑拉索垂度、倾角、拉索重力的弦向分力及拉索张力沿索长的变化,将桥面模拟成质量-... 详细信息

斜拉桥拉索具有质量小、阻尼小、刚度小的特点,在外部激励作用下容易产生各种振动,其中拉索在桥面或桥塔的位移激励下的参数振动为主要振动形式之一。考虑拉索垂度、倾角、拉索重力的弦向分力及拉索张力沿索长的变化,将桥面模拟成质量-弹簧系统,建立索-桥耦合振动的两自由度模型,取斜拉索的第一阶模态,采用多尺度法对运动方程进行求解,给出系统在参数共振以及非共振情况下的近似理论解,特别根据理论解得到典型频率处系统响应特征、共振时系统频率匹配关系及振幅发展规律,对于研究索-桥耦合振动这种非线性振动体系的振动特性具有理论指导意义。

关键词：斜索-桥面系统参数激振理论方法

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