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Double-blinded,randomized clinical trial of Gegen Qinlian decoction pinpoints Faecalibacterium as key gut bacteria in alleviating hyperglycemia

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Precision Clinical Medicine 2024年第1期7卷 21-33页

作者： Zezheng Gao Wenhui Zhang Lisha He Han Wang Yufei Li Xiaotian Jiang Sha DI Xinmiao Wang Xuan Zhang Lin Han Yanwen Liu chengjuan gu Mengyi Wu Xinhui He Lei Cheng Jun Wang Xiaolin Tong Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Endocrinology Guang anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Chengdu University of Traditional Chinese Medicine Chengdu 611137China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Endocrinology Affiliated Hospital of Changchun University of Chinese MedicineChangchun 13000oChina Biologicals Science and Technology Institute Baotou Teacher's CollegeBaotou 014030China Department of Endocrinology Zhengzhou T.C.M.HospitalZhengzhou 450007China Shenzhen Hospital Guangzhou University of Chinese Medicine(Futian)Shenzhen 518000China Department of Cardiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Cardiology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650000China Key Laboratory of Development and Application of Rural Renewable Energy Biogas Institute of Ministry of Agriculture and Rural AffairsChengdu 610041China

Background:Accumulating evidence suggests that metabolic disorders,including type 2 diabetes mellitus(T2DM),can be treated with traditional Chinese medicine formulas,such as the Gegen Qinlian decoction(GQD).This study elucidates the mechanisms by which gut microbes mediate the anti-diabetic effects of ***:We conducted a double-blind randomized clinical trial involving 120 untreated participants with *** the 12-week intervention,anthropometric measurements and diabetic traits were recorded every 4 *** microbiota and serum metabolites were measured before and after the intervention using 16S rDNA sequencing,liquid chromatography-mass spectrometry,and Bio-Plex ***:Anti-diabetic effects were observed in the GQD group in the human ***,glycated hemoglobin,fasting plasma glucose,and two-hour postprandial blood glucose levels were significantly lower in the GQD group than in the placebo ***,Faecalibacterium was significantly enriched in the GQD group,and the short-chain fatty acid levels were higher and the serum inflammation-associated marker levels were lower in the GQD group compared to the placebo ***,Faecalibacterium abundance negatively correlated with the levels of serum hemoglobin,fasting plasma glucose,and pro-inflammatory ***,the diabetes-alleviating effect of Faecalibacterium was confirmed by oral administration of Faecalibacterium prausnitzi(DSMZ 17677)in ***:GQD improved type 2 diabetes primarily by modulating the abundance of Faecalibacterium in the gut microbiota,alleviating metabolic disorders and the inflammatory state.

关键词： double-blinded randomized controlled trial type 2 diabetes mellitus Gegen Qinlian decoction Faecalibacterium metabolic disorders inflammation

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仝小林院士治疗慢性心力衰竭验案1例

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吉林中医药 2024年第4期44卷 431-433页

作者：陈鹏辉杨才佳顾成娟广州中医药大学深圳医院<福田> 广东深圳518000

仝小林院士认为,慢性心力衰竭主要责之于气、血、水,气不足,则动力乏源,血必瘀滞,血不利则为水,故心衰之责,无非气、血、水,与西医强心、利尿、扩血管之治则相同。本文从态靶辨治理论出发治疗难治性心力衰竭病案一则,此患者以虚态为主,... 详细信息

仝小林院士认为,慢性心力衰竭主要责之于气、血、水,气不足,则动力乏源,血必瘀滞,血不利则为水,故心衰之责,无非气、血、水,与西医强心、利尿、扩血管之治则相同。本文从态靶辨治理论出发治疗难治性心力衰竭病案一则,此患者以虚态为主,瘀血、水停为靶,故以延命汤合真武汤态靶同调,取得了良好临床疗效。将中医传统临床诊疗思路与现代医学疑难问题有机结合,调态与打靶同施,标本兼顾,为临床治疗慢性心力衰竭提供了新的诊疗思路。

关键词：心力衰竭靶方虚态态靶辨治仝小林

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A review on pharmacological effects of Rhizoma Coptidis(Huang lian)

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World Journal of Integrated Traditional and Western Medicine 2016年第2期2卷 1-5页

作者： gu chengjuan Pang Bing Wang Han and Tong Xiaolin Department of Endocrinology Guang＇anmen Hospital of ChinaAcademy of Chinese Medical SciencesBeijing 100054China

Huang Lian(Rhizoma coptidis, RC), which has effects on clearing damp-heat, quenching fie, and counteracting poison, is a herb frequently used in many traditional formulas. At present, there are many researches on the pharmacological effects of RC. In this review, we summarize the research progress on pharmacological effects of RC from four main aspects, in order to guide clinical application and explore the prospects of the application of RC.

关键词： Rhizoma Coptidis Pharmacology Research progress

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Summary of Professor Tong Xiaolin's clinical experience of applying Rhizoma Coptidis(Huang Lian)

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World Journal of Integrated Traditional and Western Medicine 2017年第1期3卷 1-5页

作者： gu chengjuan Wang Han Pang Bing Tong Xiaolin Department of Endocrinology Guang＇anmen Hospital of ChinaAcademy of Chinese Medical SciencesBeijing 100054China

With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredients, could provide multiple therapeutic effects. Professor Tong Xiaolin has accumulated abundant experience during many years of clinical practice and applies Rhizoma Coptidis(RC) well with the treatment of diabetes and its complications. Rhizoma coptidis is a classical natural herb which is used frequently by professor Tong Xiaolin. In this review, we summarize Tong Xiaolin's clinical experience of applying Rhizoma Coptidis(Huang Lian) in the treatment of disease from two aspects as well as introducing some traditional Chinese medical theory and clinical experience, with a prospect of guiding clinician to use RC more suitably and reasonably.

关键词： Rhizoma Coptidis(Huang Lian) Tong Xiaolin Experience

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The Inherent Law of the Unpredictability of Financial Asset Price Fluctuations: Multistability and Chaos

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Journal of Systems Science & Complexity 2024年第2期37卷 776-804页

作者： gu Enguo Huanghe University of Science and Technology Zhengzhou 450006China

This paper aims at understanding the price dynamics generated by the interaction of traders relying on heterogeneous expectations in an asset pricing *** the present work the authors analyze a financial market populated by five types of boundedly rational speculators-two types of fundamentalists,two types of chartists and trend followers which submit buying/selling orders according to different trading *** authors formulate a stock market model represented as a 2 dimensional piecewise linear discontinuous *** proposed contribution to the existing financial literature is two ***,the authors perform study of the model involving a 2 dimensional piecewise linear discontinuous map through a combination of qualitative and quantitative *** authors focus on the existence conditions of chaos and the multi-stability regions in parameter *** border collision bifurcation curves and basins of multi-attractors are also *** authors find that chaos or quasi-period exists only in the case of fixed point being a saddle(regular or flip)and that the coexistence of multiple attractors may exist when the fixed point is an attractor,but it is common for spiral and flip fixed points.

关键词： BCB curve chaos financial market heterogeneous agents multiple attractors piecewise linear discontinuous map

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桂枝、茯苓、桃仁治疗寒湿瘀经验——仝小林三味小方撷萃

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吉林中医药 2020年第5期40卷 574-576页

作者：王涵顾成娟广州中医药大学深圳医院<福田>仝小林院士传承工作室广东深圳518034 甘肃中医药大学兰州730000

随着社会生活方式的不断改变,过食寒凉冷饮成为了现代人生活的常态,寒湿直中中焦,脾胃则首当其冲,先受其害。寒湿中阻,脾胃气机运行不畅,日久气耗阴伤而成瘀。仝小林院士提出,临床治疗此类疾病,既要追根溯源,抓住寒湿之始动因素,又要活... 详细信息

随着社会生活方式的不断改变,过食寒凉冷饮成为了现代人生活的常态,寒湿直中中焦,脾胃则首当其冲,先受其害。寒湿中阻,脾胃气机运行不畅,日久气耗阴伤而成瘀。仝小林院士提出,临床治疗此类疾病,既要追根溯源,抓住寒湿之始动因素,又要活血化瘀,从瘀论治。针对该病机,桂枝、茯苓、桃仁三味小方为治疗寒湿瘀的基础方,方中桂枝能化气而消其本寒,茯苓渗脾湿,桃仁以之破恶血,消积癖,诸药合用,“调其寒温,扶其正气”,共奏散寒除湿、活血消癥之效。临床常用剂量为桂枝9~15 g,茯苓9~30 g,桃仁9~15 g,均较安全,未见不良反应报告。

关键词：寒湿瘀桂枝茯苓桃仁仝小林

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橘核、荔枝核、沉香粉治疗糖尿病神经源性膀胱--仝小林三味小方撷萃

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吉林中医药 2020年第7期40卷 854-857页

作者：杜林顾成娟广州中医药大学深圳医院<福田> 广东深圳518000

糖尿病神经源性膀胱(DNB)是糖尿病常见的慢性并发症之一。仝小林院士认为,糖尿病神经源性膀胱主要病机为肾阳亏虚,气滞、湿热、瘀血等蕴结膀胱,膀胱气化不利,治疗上行气、利水、祛瘀三方兼顾,重在行气。橘核、荔枝核、沉香粉是治疗糖尿... 详细信息

糖尿病神经源性膀胱(DNB)是糖尿病常见的慢性并发症之一。仝小林院士认为,糖尿病神经源性膀胱主要病机为肾阳亏虚,气滞、湿热、瘀血等蕴结膀胱,膀胱气化不利,治疗上行气、利水、祛瘀三方兼顾,重在行气。橘核、荔枝核、沉香粉是治疗糖尿病神经源性膀胱行气的常用药对,橘核、荔枝核入肝经,长于理气通络,沉香粉疏膀胱郁气。夹瘀配伍琥珀粉、生大黄散瘀止血,利水通淋,无论寒热虚实,皆可作为基础之药。常用剂量橘核为15~30 g,荔枝核为15~30 g,沉香粉为1~3 g分冲。

关键词：糖尿病神经源性膀胱橘核荔枝核沉香粉仝小林

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Volume of fluid simulation of single argon bubble dynamics in liquid steel under RH vacuum conditions

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Journal of Iron and Steel Research International 2024年第4期31卷 828-837页

作者： gu-jun Chen Sheng-ping He College of Materials Science and Engineering Yangtze Normal UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Single argon bubble dynamics in liquid steel under Ruhrstahl-Heraeus(RH)vacuum conditions were simulated using the volume of fluid method,and the ideal gas law was used to consider bubble growth due to heat transfer and pressure *** simulation with a constant bubble density was also performed to validate the numerical method,and the predicted terminal bubble shape and velocity were found to agree with those presented in the Grace diagram and calculated by drag correlation,*** simulation results under RH conditions indicate that the terminal bubble shape and velocity cannot be *** primary bubble growth occurs within a rising distance of 0.3 m owing to heating by the high-temperature liquid steel;subsequently,the bubble continues to grow under equilibrium with the hydrostatic *** the initial diameter is 8-32 mm,the bubble diameter and rising velocity near the liquid surface are 80-200 mm and 0.5-0.8 m/s,*** bubble rises rectilinearly with an axisymmetric shape,and the shape evolution history includes an initial sphere,(dimpled)ellipsoid,and spherical cap with satellite bubbles.

关键词： Bubble dynamics Liquid steel Volume of fluid Bubble growth Bubble shape Rising velocity

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Ultra-simplified diffraction-based computational spectrometer

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Light(Science & Applications) 2024年第6期13卷 1022-1031页

作者： Chuangchuang Chen Honggang gu Shiyuan Liu State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhanHubei430074China Optics Valley Laboratory WuhanHubei430074China

Miniaturizing spectrometers for compact and cost-effective mobile platforms is a major challenge in current spectroscopy research,where conventional spectrometers are impractical due to their bulky *** miniaturized designs primarily rely on precalibrated response functions of nanophotonic structures to encode spectral information captured in a snapshot by detector *** spectrum reconstruction is achieved through computational techniques,but this requires precise component design,high-precision fabrication,and *** propose an ultra-simplified computational spectrometer that employs a one-to-broadband diffraction decomposition strategy facilitated by a numerical regularized transform that depends only on the spectrum of the diffracted *** key feature of our design is the use of a simple,arbitrarily shaped pinhole as the partial disperser,eliminating the need for complex encoding designs and full spectrum *** spectrometer achieves a reconstructed spectral peak location accuracy of better than 1 nm over a 200 nm bandwidth and excellent resolution for peaks separated by 3 nm in a bimodal spectrum,all within a compact footprint of under half an ***,our approach also reveals a breakthrough in broadband coherent diffractive imaging without requiring any prior knowledge of the broadband illumination spectrum,assumptions of non-dispersive specimens,or correction for detector quantum efficiency.

关键词： simplified spectrum illumination

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An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation

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Defence Technology（防务技术） 2024年第2期32卷 254-261页

作者： Benfeng gu Haiyuan Li Baoming Li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China

To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore *** this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried *** test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of *** the simulation results and experimental data,the damage condition of the contact surface is analyzed.

关键词： Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling Experimental validation PFN

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