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Vaccination versus SARS-CoV-2 Omicron:three vaccine doses win the battle

Signal Transduction and Targeted Therapy 2022年第5期7卷 1373-1374页

作者： grzegorz maria popowicz Krzysztof Pyrc Kamyar Hadian Helmholtz Zentrum München German Research Center for Environmental Health(GmbH)Institute of Structural BiologyIngolstädter Landstrasse 185764NeuherbergGermany Virogenetics Laboratory of Virology Malopolska Centre of BiotechnologyJagiellonian UniversityGronostajowa 7a30-387KrakowPoland Helmholtz Zentrum München German Research Center for Environmental Health(GmbH)Research Group Cell Signaling and Chemical BiologyInstitute of Molecular Toxicology and PharmacologyIngolstädter Landstrasse 185764NeuherbergGermany

The here highlighted study by Garcia-Beltran et *** that SARS-CoV-2 Omicron can largely escape the immune ***,while two doses of COVID-19 vaccines seem to be insufficient to provide protection against Omicron,a third dose provides mature neutralizing antibodies to enhance the response.1 Since March 2020,when the World Health Organization(WHO;***)officially declared the COVID-19 pandemic caused by the SARS-CoV-2.

关键词： doses neutral Omi

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Photometric and Spectroscopic Study of Ten Low Mass Ratio Contact Binary Systems:Orbital Stability,O'Connell Effect and Infrared Calcium Line Filling

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Research in Astronomy and Astrophysics 2024年第8期24卷 212-222页

作者： Surjit S.Wadhwa Adam popowicz Raúl Michel Petar Kostić Oliver Vince Nick F.H.Tothill Ain Y.De Horta Miroslav D.Filipović School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Department of Electronics Electrical Engineering and MicroelectronicsSilesian University of TechnologyAkademicka 1644120 GliwicePoland Instituto de Astronomía UNAM.A.P.87722800 EnsenadaBCMéxico Astronomical Observatory Volgina 711060 BelgradeSerbia

Low mass ratio contact binary systems are more likely to have unstable orbits and potentially *** addition,such systems exhibit characteristics such as starspots and high energy emissions(UV)suggestive of chromospheric and magnetic *** curve modeling of ten contact binary systems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and three were found to be potentially unstable and possible merger *** of the infrared calcium absorption lines is a marker of increased chromospheric *** use the available Large Sky Area Multi-Object Fiber Spectroscopic Telescope spectra along with matched standard spectra(broadened for rotation)to measure the excess filling of the central core depression flux of the two main infrared calcium absorption linesλ8542 andλ*** find that all reported contact binaries have excess filling of the core flux in the infrared calcium *** of the systems reported were also observed by the Galaxy Evolution Explorer mission and we find that all three have features of excess ultraviolet emissions further adding evidence for increased chromospheric activity in low mass ratio contact *** of both orbital stability and absorption line filling is dependent on the determination of geometric and absolute parameters from light curve *** an insignificant number of contact binary light curves exhibit the O’Connell effect,usually attributed to *** discuss the inclusion of starspots in light curve solutions and how they influence the geometric and absolute parameters.

关键词： (stars)binaries eclipsing-techniques photometric-stars chromospheres

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The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells

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Journal of Molecular Cell Biology 2014年第4期8卷 312-323页

作者： Tim Ammon Shravan Kumar Mishra Kaja Kowalska grzegorz M. popowicz Tad A. Holak Stefan Jentsch Department of Molecular Cell Biology Max Planck Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried Germany NMR Spectroscopy Max Planck Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried Germany Department of Biological Sciences Indian Institute of Science Education and Research (IISER) Mohali Knowledge City Sector 81 SAS Nagar 140306 Punjab India Institute of Structural Biology Helmholtz Zentrum MLinchen Ingolst~idter Landstrasse 1 85764 Neuherberg Germany Faculty of Chemistry Jagiellonian University Ingardena 3 30-060 Cracow Poland

Different from canonical ubiquitin-like proteins, Hub1 does not form covalent conjugates with substrates but binds proteins noncovalently. In Socchoromyces cerevisioe, Hub1 associates with spUceosomes and mediates alternative splicing of SRCI, without affecting pre-mRNA splicing generaity. Human Hub1 is highty similar to its yeast homotog, but its cellular function remains largely unexplored. Here, we show that human Hub1 binds to the spliceosomal protein Snu66 as in yeast; however, unlike its 5. cerevisioe homolos, human Hub1 is essential for viability. Prolonged in vivo depletion of human Hub1 leads to various cellular defects, including splicing speckle abnormalities, partial nuclear retention of mRNAs, mitotic catastrophe, and consequently cell death by apoptosis. Early consequences of Hub1 depletion are severe splicing defects, however, only for specific splice sites leading to exon skipping and intron retention. Thus, the ubiquitin-iike protein Hub1 is not a canonlcal spliceosomal factor needed generally for splicing, but rather a modulator of spliceosome performance and facilitator of alternative splicing.

关键词： apoptosis Hubl splicing spliceosome ubiquitin-like proteins

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The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization

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Cell Research 2005年第4期15卷 219-227页

作者： Anne BENZINGER, grzegorz M. popowicz, Joma K. JOY,Sudipta MAJUMDAR,Tad A. HOLAK,Heiko HERMEKING Molecular Oncology Group Max-Planck-Institute for Biochemistry Am Klopferspitz 18 D-82152 Martinsried Germany NMR Group Max-Planck-Institute for Biochemistry Am Klopferspitz 18 D-82152 Martinsried Germany NMR Group Max-Planck-Institute for Biochemistry Am Klopferspitz 18 D-82152 Martinsried Germany NMR Group Max-Planck-Institute for Biochemistry Am Klopferspitz 18 D-82152 Martinsried Germany NMR Group Max-Planck-Institute for Biochemistry Am Klopferspitz 18 D-82152 Martinsried Germany Molecular Oncology Group Max-Planck-Institute for Biochemistry Am Klopferspitz 18 D-82152 Martinsried Germany

Seven different, but highly conserved 14-3-3 proteins are involved in diverse signaling pathways in human cells. It isunclear how the 14-3-3σ isoform, a transcriptional target of p53, exerts its inhibitory effect on the cell cycle in thepresence of other 14-3-3 isoforms, which are constitutively expressed at high levels. In order to identify structuraldifferences between the 14-3-3 isoforms, we solved the crystal structure of the human 14-3-3σ protein at a resolutionof 2.8 ? and compared it to the known structures of 14-3-3ζ and 14-3-3τ. The global architecture of the 14-3-3σ foldis similar to the previously determined structures of 14-3-3ζ and 14-3-3τ: two 14-3-3σ molecules form a cup-shapeddimer. Significant differences between these 14-3-3 isoforms were detected adjacent to the amphipathic groove, whichmediates the binding to phosphorylated consensus motifs in 14-3-3-ligands. Another specificity determining region islocalized between amino-acids 203 to 215. These differences presumably select for the interaction with specific ligands,which may explain the different biological functions of the respective 14-3-3 isoforms. Furthermore, the two 14-3-3σmolecules forming a dimer differ by the spatial position of the ninth helix, which is shifted to the inside of the ligandinteraction surface, thus indicating adaptability of this part of the molecule. In addition, 5 non-conserved residues arelocated at the interface between two 14-3-3σ proteins forming a dimer and represent candidate determinants of homo-and hetero-dimerization specificity. The structural differences among the 14-3-3 isoforms described here presumablycontribute to isoform-specific interactions and functions.

关键词： 14-3-3σ p53 crystal structure tumor suppression 14-3-3 isoform specificity.

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