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Myocardial infarction with ST-segment elevation in old patient with history of takotsubo syndrome

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Journal of Geriatric Cardiology 2018年第5期15卷 376-378页

作者： Momka Budnik Janusz Kochanowski Radoslaw Piatkowski Robert Kowalikl Janusz Kochman grzegorz opolski First Chair and Department of Cardiology Medical University of Warsaw 1a Banacha Street 02-097 Warsaw Poland Department of Noninvasive Cardiology and Hypertension Central Clinical Hospital of the Ministry of the Interior and Administration Wotoska 137 02-507 Warsaw Poland

Takotsubo syndrome （TTS） is a rare condition that af- fects mainly aging women. TTS was first reported in 1990r and is characterized by clinical symptoms, ECG changes and regional wall motion abnormalities without changes in the coronary arteries. However, some reports admit the pos- sibility of coexistence of TTS and coronary artery disease. We present a patient who had not had any changes in coro- nary arteries until four years later when she had myocardial infarction associated with right coronary artery narrowing, despite the fact that the risk factors of coronary heart disease were closely monitored.

关键词： Myocardial infarction Recurrence of disease Takotsubo syndrome

The oldest patient with takotsubo cardiomyopathy

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Journal of Geriatric Cardiology 2015年第5期12卷 588-589页

作者： Monika Budnik Radoslaw Piatkowski Janusz Kochanowski Renata Glowczynska Dariusz Gorko Robert Kowalik Arkadiusz Pietrasik grzegorz opolski Department of Cardiology Medical University of Warsaw Warsaw Poland

Takotsubo cardiomyopathy （TTC） is a rare condition that affects mainly aging women. According to a retrospective review, patients with TTC accounted for approximately 2% of all the patients with suspected acute coronary syndrome （ACS）. A few reports indicated that the average age of TTC patients was 68 years, although children or young adults may also be affected. In US and Europe, a number of contemporary TTC studies report that 90% of patients with TTC are women aged 65-70 years. Meta analysis showed that the age ranged from 10 to 89 years.

关键词： Acute coronary syndrome Electrocardiogram Takotsubo cardiomyopathy

采用超声心动检查和血浆心房利钠肽测定评估持续性房颤患者的心脏复律预后并不可靠

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世界核心医学期刊文摘（心脏病学分册） 2006年第1期2卷 57-58页

作者： Wozakowska-Kaplon B. opolski G. 杜媛 Kaplon wietokrzyskie Centrum Kardiologii ul. Grunwaldzka 45 25-736 Kielce Poland

Atrial fibrillation(AF) is a common arrhythmia with important therapeutic and prognostic implications. An attempt to restore sinus rhythm is considered in most patients with AF. The aim of this study was to assess the value of echocardiographic examination and plasma atrial natriuretic peptide(ANP) evaluation in predicting the outcome of cardioversion and maintenance of sinus rhythm in patients with persistent AF. Methods: Eighty-one consecutive patients, aged 62±9 years, with AF of duration 4.7 months were subjected to an echocardiography examination and ANP assessment before cardioversion. The patients were predominantly hypertensive men with moderately enlarged left atrium and ejection fraction of left ventricle of about 50%. All patients were in controlled AF and had normalized blood pressure. In order to predict the outcome of cardioversion, and maintenance of sinus rhythm over a 1 month period, a multivariate logistic regression method was performed using the following variables: left atrial and left ventricular dimensions, left ventricular ejection fraction and plasma ANP levels. Results: Sixty-nine out of the 81 patients were successfully converted to sinus rhythm. At 1 month 57 patients remained in sinus rhythm. There were no statistical differences between sinus rhythm and AF group in baseline ANP levels(59.4 vs 64.2 pg/ml, consecutively), clinical and echocardiographic characteristics. In logistic regression analysis neither baseline echocardiographic variable nor ANP level, predicts successful cardioversion over a 1-month period of observation. Conclusion: Echocardiographic data and ANP level should not be included as an important variable when considering patients for cardioversion.

关键词：超声心动检查房颤患者心房利钠肽心脏复律预后意义持续性测定血浆维持窦性心律左室射血分数

每日1次服用吗多明对稳定型心绞痛患者的有效性和安全性

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世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 41-42页

作者： Messin R. opolski G. Fenyvesi T. 杜媛 Therabel Pharma S.A./N.V. 108 rue Egide Van Ophem B-1180 Brussels Belgium

Background: The objective of this study was to compare the efficacy and tolerability of molsidomine prolonged-release 16 mg once-a-day(o.a.d.) with 8 mg twice-a-day(b.i.d.) and placebo in patients with stable angina pectoris. Methods: After a run-in placebo period of 7 days, the two formulations were compared acutely and then chronically(2 weeks) using cycloergometric tests and a randomized, multicenter, double-blind, double-dummy, crossover design in 533 patients. The quality of life was assessed using the frequency of anginal crises and nitrate sublingual tablets consumption. Results: Both formulations significantly improved exercise test parameters compared with placebo, being it after acute drug intake or after a 2-week treatment period and independently of spontaneous diurnal variation in exercise tolerance. Noninferiority of molsidomine 16 mg compared with 8 mg was demonstrated with a statistically significant superiority of the 16-mg formulation from 14 to 24 h postintake. Both treatments reduced incidence of anginal attacks and use of sublingual isosorbide dinitrate tablets. Tolerability of active drugs was satisfactory, the incidence of drug-related headache being not significantly different from placebo. Only hypotension was significantly more frequent with molsidomine 16 mg than with placebo, pretrial diastolic blood pressure being significantly lower in these patients than in those who did not develop hypotension during the study. Conclusions: Both molsidomine formulations were effective in controlling patients’angina, did not induce any habituation and were well tolerated. However, the once-daily 16-mg formulation tended to provide better 24-h protection against myocardial ischemia than the 8-mg b.i.d. formulation.

关键词：吗多明稳定型心绞痛运动耐量安慰剂消心痛舌下含服交叉试验试验参数导入期生活质量

持续性房颤患者恢复窦性心律的作用:一项临床、超声心动图及激素研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 42-43页

作者： Wozakowska Kap on B. opolski G. 王永兴 Department of Cardiology Regional District Hospital Swietokrzyskie Ctr. Kardiologii U. Kielce Poland

The hemodynamic consequences of atrial fibrillation (AF) may lead to impairme nt of the left ventricular function and a reduction in exercise capacity. Studie s on mechanical and neurohormonal remodelling in patients with AF are becoming i ncreasingly important. The results could possibly enhance treatment strategies o f these patients. The aim of this study was to assess changes in exercise capaci ty, echocardiographic findings and plasma atrial natriuretic peptide(ANP) concen trations in patients with non rheumatic persistent AF, before and 30 days after successful cardioversion. Methods: We attempted cardioversion in 42 consecutive patients, aged 58±8 years, with persistent non valvular AF of duration 7.1±7 .1 months. They underwent echocardiography examination and submaximal exercise t esting 24 h before and 30 days after cardioversion. Exercise capacity was determ ined during symptom limited exercise testing, according to a modified Bruce pro tocol with peak VO2 analysis. Plasma samples of ANP were obtained at rest: befor e, the day after, and 30 days after cardioversion therapy, and were prepared by refrigerated centrifugation and stored until radioimmunoassay. The control study group, without AF, comprised of 11 subjects. Results: Cardioversion was success ful in 35 patients. However, in six of the 35 patients, AF reappeared within 1 m onth. There were no statistical differences before cardioversion in exercise tol erance and ejection fraction of left ventricle between the group with successful cardioversion and the group with unsuccessful cardioversion or with recurrence of AF. On the 30th day after cardioversion we recorded a significant increase in exercise tolerance: duration of exercise 13.7±3.2 versus 9.5±3.4 min, (P< 0.0 5); peak oxygen consumption 32.2±3.6 versus 19.85±3.5 ml/min per kg, (P< 0.05) ; and ejection fraction of left ventricle 58.6±9.4 versus 52.7±10.2%(P< 0.05) ; in the sinus rhythm group. There was no significant improvement observed in

关键词：持续性房颤窦性心律激素研究复律超声心动图运动耐量运动试验射血分数左室功能心房利钠肽