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水文地质技术方法 1991年第24期 29-39页

作者： gruber,j 潘世兵

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污染物质在孔隙介质中迁移时的聚集

国外地质（成都） 1991年第4期 92-101页

作者： gruber,j 吴勇

连续分析冶金炉中钢水化学成分的新型VAI-CON~Chem系统

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钢铁 2002年第10期37卷 19-22页

作者： N.Ramaseder j.gruber j.Heitz D.Baeuerle W.Meyer j.Hochoertler 孙运涌奥钢联工程技术有限公司约翰尼斯开普勒大学伯乐特殊钢有限公司奥钢联北京联络处

奥钢联同约翰尼斯开普勒大学实验物理研究所联合开发了一种可以连续分析各种冶金炉中钢水化学成分的新型系统并命名为 VAI- CON○RChem,已在真空脱气设备上成功进行了工业试验。它可以在冶金炉整个操作过程中准确给出选定元素的分析结... 详细信息

奥钢联同约翰尼斯开普勒大学实验物理研究所联合开发了一种可以连续分析各种冶金炉中钢水化学成分的新型系统并命名为 VAI- CON○RChem,已在真空脱气设备上成功进行了工业试验。它可以在冶金炉整个操作过程中准确给出选定元素的分析结果 ,为改善工艺控制提供可靠帮助。伯乐特殊钢公司订购了第一套该设备并正在安装 ,用以连续分析其 5 0 t

关键词：连续分析冶金炉钢水化学分析

Morphine has latent deleterious effects on the ventilatory responses to a hypoxic challenge

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Open journal of Molecular and Integrative physiology 2013年第3期3卷 166-180页

作者： Walter j. May Ryan B. gruber joseph F. Discala Veljko puskovic Fraser Henderson jr. Lisa A. palmer Stephen j. Lewis pediatric Respiratory Medicine University of Virginia School of Medicine Charlottesville USA Division of Biology Galleon Pharmaceuticals Horsham USA

The aim of this study was to determine whether morphine depresses the ventilatory responses elicited by a hypoxic challenge (10% O2, 90% N2) in conscious rats at a time when the effects of morphine on arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient and minute ventilation (Vm) had completely subsided. In vehicle-treated rats, each episode of hypoxia stimulated ventilatory function and the responses generally subsided during each normoxic period. Morphine (5 mg/kg, i.v.) induced an array of depressant effects on ABG chemistry, A-a gradient and Vm (via decreases in tidal volume). Despite resolution of these morphine-induced effects, the first episode of hypoxia elicited substantially smaller increases in Vm than in vehicle-treated rats, due mainly to smaller increases in frequency of breathing. The pattern of ventilatory responses during subsequent episodes of hypoxia and normoxia changed substantially in morphine-treated rats. It is evident that morphine haslatent deleterious effects on ventilatory responses elicited by hypoxic challenge.

关键词： Morphine Hypoxia Minute Ventilation Arterial Blood Gas Chemistry Conscious Rats

与双能X线吸收测量学相关的应用常规增强MDCT数据测量股骨近端骨密度

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国际医学放射学杂志 2013年第2期 200-201页

作者： M. gruber j.S. Bauer M. Dobritz A.j. Beer p. Wolf K. Woertler 赵芳 Department of Radiology Division of Neuroradiology and Musculoskeletal Radiology Medical University of Vienna Waehringer Guertel 18 -20 1090 Vienna Austria

目的以双能X线吸收测量学(DXA)作为参考标准,评价常规对比增强多层CT(ceMDCT)测量股骨骨密度(BMD)的能力。方法 41例病人(女33例,男8例)行DXA股骨近端测量。随后根据常规ceMDCT横断位像测量股骨头、颈的BMD。线性回归分析计算BMD的MDCT-... 详细信息

目的以双能X线吸收测量学(DXA)作为参考标准,评价常规对比增强多层CT(ceMDCT)测量股骨骨密度(BMD)的能力。方法 41例病人(女33例,男8例)行DXA股骨近端测量。随后根据常规ceMDCT横断位像测量股骨头、颈的BMD。线性回归分析计算BMD的MDCT-to-DXA转换公式及T值。转换公式用于行MDCT的382例病人(女120例,男262例),其中74例有骨质疏松性骨折。结果应用转换公式T值=0.021×BMDMDCT-5.90计算出股骨头BMDMDCT与总股骨近端T值的相关系数r=0.84(ppp<0.05)。结论通过常规对比增强MDCT计算出的股骨近端BMD转换为DXAT值,可以区分病人是否有骨质疏松骨折。要点①可从常规腹部ceMDCT中测量股骨BMD。②获得的T值可以区分病人是否有骨质疏松骨折。③ceMDCT的股骨密度衰减测量可以预示骨折风险。

关键词：骨质疏松骨矿物密度 T值骨质疏松骨折多层CT

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ICM——二十一世纪的炼钢方案

浙江冶金 1999年第1期 49-51页

作者： j.EGGRTH L.GOULD K.gruber 冯起安徽省马鞍山钢铁设计研究院马鞍山243005

1 前言以废钢为原料的小钢厂(MM),尽管取得了令人信服的进步,但其产品钢板仍停留在中、低档次上。传统的联合钢厂(IM)不仅存在环保问题,而且投资大生产成本高。这对长期竞争的炼钢生产是不利的。ICM(紧凑联合钢厂)是钢材生产要达到优质... 详细信息

1 前言以废钢为原料的小钢厂(MM),尽管取得了令人信服的进步,但其产品钢板仍停留在中、低档次上。传统的联合钢厂(IM)不仅存在环保问题,而且投资大生产成本高。这对长期竞争的炼钢生产是不利的。ICM(紧凑联合钢厂)是钢材生产要达到优质低耗的一条可供选择的途径,按原料。

关键词：炼钢炼钢厂 ICM 能量平衡

定量检测绿色荧光蛋白-轻链蛋白3转基因小鼠角质形成细胞自噬水平

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中华皮肤科杂志 2018年第3期51卷 182-185页

作者：金婷婷 Heidemarie Rossiter Michael Mildner Florian gruber Leopold Eckhart Erwin Tschachler 赵邑浙江省人民医院整形外科杭州310000 北京大学第一医院皮肤性病科 100034 奥地利维也纳医科大学清华大学附属北京清华长庚医院皮肤科

目的探索一种高通量定量检测细胞自噬小体数量的方法。方法将绿色荧光蛋白？轻链蛋白3（GFp？LC3）转基因小鼠的角质形成细胞分为对照组（不接受照射或饥饿处理）、饥饿组（给予饥饿处理）、20 j/cm^2长波紫外线（UVA）照射组和40 j/c... 详细信息

目的探索一种高通量定量检测细胞自噬小体数量的方法。方法将绿色荧光蛋白？轻链蛋白3（GFp？LC3）转基因小鼠的角质形成细胞分为对照组（不接受照射或饥饿处理）、饥饿组（给予饥饿处理）、20 j/cm^2长波紫外线（UVA）照射组和40 j/cm^2 UVA照射组。处理后6 h，将细胞固定后在共聚焦显微镜下采集图片。用Imagej软件编辑宏指令对细胞内GFp？LC3绿色荧光点及细胞进行自动计数，并比较不同组间自噬水平。结果利用Imagej软件编辑的宏指令可以成功识别并计数荧光图片中的自噬小体。在测试计算机上分析一张420万像素的图片仅需不到0.6 s。饥饿组、20 j/cm^2 UVA照射组和40 j/cm^2 UVA照射组平均自噬小体数量高于对照组，未加胃抑素A时各组间比较，F = 5.01，p 〈 0.05；加入胃抑素A时各组间比较，F = 20.05，p 〈 0.05。该方法可以成功区分饥饿组、UVA照射组和对照组的自噬水平差异。结论成功为自噬研究提供了一种新的高通量定量检测方法，该方法能够快速准确地检测细胞自噬荧光点。

关键词：自噬角蛋白细胞绿色荧光蛋白质类显微镜检查共焦图像处理计算机辅助

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他汀类药物与结肠直肠癌风险

世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 31-32页

作者： poynter j. N. gruber S. B. Higgins p. D. R. 宁宁 Division of Molecular Medicine and Genetics University of Michigan 4301 MSRB III Ann Arbor MI 48109- 0638 United States

Statins are inhibitors of 3- hydroxy-3-methylglutaryl coenzyme A reductase and effective lipid-lowering agents. Statins inhibit the growth of coloncancer cell lines, and secondary analyses of some, but not all, clinical trials suggest that they reduce the risk of colorectal cancer. METHODS: The Molecular Epidemiology of Colorectal Cancer study is a population-based case-control study of patients who received a diagnosis of colorectal cancer in northern Israel between 1998 and 2004 and controls matched according to age, sex, clinic, and ethnic group. We used a structured interview to determine the use of statins in the two groups and verified self-reported statin use by examining prescription records in a subgroup of patients for whom prescription records were available. RESULTS: In analyses including 1953 patients with colorectal cancer and 2015 controls, the use of statins for at least five years(vs. the nonuse of statins) was associated with a significantly reduced relative risk of colorectal cancer(odds ratio, 0.50; 95 percent confidence interval, 0.40 to 0.63). This association remained significant after adjustment for the use or nonuse of aspirin or other nonsteroidal antiinflammatory drugs; the presence or absence of physical activity, hypercholesterolemia, and a family history of colorectal cancer; ethnic group; and level of vegetable consumption(odds ratio, 0.53; 95 percent confidence interval, 0.38 to 0.74). The use of fibric-acid derivatives was not associated with a significantly reduced risk of colorectal cancer(odds ratio, 1.08; 95 percent confidence interval, 0.59 to 2.01). Self-reported statin use was confirmed for 276 of the 286 participants(96.5 percent) who reported using statins and whose records were available. CONCLUSIONS: The use of statins was associated with a 47 percent relative reduction in the risk of colorectal cancer after adjustment for other known risk factors. Because the absolute risk reduction is likely low, further investigation of

关键词：结肠直肠癌他汀类药物结肠癌细胞系非甾体抗炎药物降脂药物高胆固醇血症临床试验还原酶抑制剂病例对照研究相对风险

早产和胎膜早破以及随后的剖宫产分娩的孕妇宫内感染机会增加

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世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 18-19页

作者： Witt A. Berger A. gruber C.j. 高雪莲 Department of Obstetrics and Gynaecology University of Vienna Medical School Austria Whringer Gürtel 18-20 A-1090 Vienna Austria Dr.

Objective: The purpose of this study was to evaluate the prevalence of microbial invasion of the amniotic cavity at the time of preterm cesarean delivery for therapy-resistant preterm labor or preterm premature rupture of membranes, which are events that commonly are induced by infection, and to compare this group of patients with a group of patients who underwent preterm cesarean delivery for indications other than preterm labor or preterm premature rupture of membranes. Study design: We studied 207 consecutive women between 23 and 34 weeks of gestation who underwent cesarean delivery. These patients were divided into 3 groups according to the indication for cesarean delivery: patients with preterm labor (group 1), patients with preterm premature rupture of membranes (group 2), and patients with other indications (group 3). In the course of the surgical procedure, amniotic fluid, amniotic membrane, and placental tissue specimens were collected for the detection of pathogens. Results: Ureaplasma urealyticum was detected in 43.9%(58/132) of the patients of groups 1 and 2, with no significant difference between these 2 subgroups. In group 3, which served as the comparison group,Ureaplasma urealyticum was isolated in only 2.7%(2/75) of the patients. Ureaplasma urealyticum as a single pathogen was more frequent than all obligate pathogens together (43.9%vs 39.3%). Conclusion: Our results provide evidence for an association between intrauterine colonization with Ureaplasma urealyticum and both therapy-resistant preterm labor and preterm premature rupture of membranes.

关键词：剖宫产分娩胎膜早破宫内感染胎盘组织羊膜腔病例发现致病源研究设计专性

Mapping Short Affinity Tags on Bacterial S-Layer Nanoarrays with Molecule Recognition Imaging

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Mapping Short Affinity Tags on Bacterial S-Layer Nanoarrays ...