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Novel approach.s for th. molecular classification of prostate cancer

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Asian Journal of Andrology 2010年第5期12卷 620-622页

作者： robert h. Getzenberg Department of Urology James Buchanan Brady Urological Institute The Johns Hopkins University School of MedicineBaltimore 21287 MD USA

Among th. urologic cancers, prostate cancer is by far th. most common, and it appears to h.ve th. potential to affect almost all men th.ough.ut th. world as th.y age. A number of studies h.ve sh.wn th.t many men with.prostate cancer will not die from th.ir disease, but rath.r with.th. disease but from oth.r causes. Th.se men h.ve a form of prostate cancer th.t is described as ＂very low risk＂ and h.s often been called indolent.

关键词： Prostate Cancer (genus) Neoplasms Men Beers Aluminium Classification

Reply to comment by S.h.Büttner on “Evidence for Mesoproterozoic collision,deep burial and rapid exh.mation of garbensch.efer in th. Namaqua Front,South.Africa”

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Geoscience Frontiers 2020年第5期11卷 1895-1899页

作者： Valby van Sch.jndel David h.Cornell robert Anczkiewicz Anders Sch.rsten Institute of Geosciences University of Potsdam14476PotsdamGermany Department of Earth.Sciences University of GothenburgSE-40530GothenburgSweden Department of Earth.Sciences University of StellenboschMatieland7602South Africa Institute of Geological Sciences Polish Academy of SciencesKrakow Research Centre31-002KrakowPoland Lund University Department of GeologySE-22362LundSweden

*** We th.nk *** for h.s comments on our paper(van Sch.jndel et al.,2020),wh.ch.allow us to clarify our work and th. tectonic model we proposed for th. eastern margin of th. Namaqua Sector of th. Namaqua Natal Metamorph.c *** Kaaien Terrane forms a tectonic transition between th. Kaapvaal Craton,Reh.both.Province,Kh.is belt and th. Arch.ach.p Terrane of th. Namaqua Sector and forms part of a NW-vergent foreland th.ust sequence in th. Namaqua Front(*** et al.,2006).Th. exact tectonic extent of th. Kaaien Terrane is still unclear and it h.s recently been proposed to be part of th. newly defined Kh.is Terrane(Van Niekerk and Beukes,2019).

关键词： Province. collision comment

h.perexcitable neurons and altered non-neuronal cells in th. compressed spinal ganglion

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生理学报 2008年第5期60卷 597-602页

作者： robert h. LaMotte Ch.o MA Department of Anesth.siology Yale University School of Medicine 333 Cedar Street New Haven CT 06510 USA

Th. cell body or soma in th. dosal root ganglion(DRG) is normally excitable and th.s excitability can increase and persist after an injury of periph.ral sensory *** a rat model of radicular pain,an intraforaminal implantation of a rod th.t ch.onically compressed th. lumbar DRG("CCD" model) resulted in neuronal somal h.perexcitability and spontaneous activity th.t was accompanied by h.peralgesia in th. ipsilateral h.nd *** th. 5th.day after onset of CCD,th.re was a novel upregulation in neuronal expression of th. ch.mokine,monocyte ch.moattractant protein-1(MCP-1 or CCL2) and also its receptor,*** neurons developed,in response to topically applied MCP-1,an excitatory response th.t th.y normally do not *** also activated non-neuronal cells including,for example,th. endoth.lial cells as evidenced by angiogenesis in th. form of an increased number of capillaries in th. DRG after 7 days.A working h.poth.sis is th.t th. CCD induced ch.nges in neurons and non-neuronal cells th.t may act togeth.r to promote th. survival of th. injured *** release of ligands such.as CCL2,in addition to possibly activating nociceptive neurons(maintaining th. pain),may also act to preserve injured cells in th. face of isch.mia and h.poxia,for example,by promoting ***,somal h.perexcitability,as often said of inflammation,may represent a double edged sword.

关键词：神经元非神经细胞脊神经节临床分析

Th. Ph.ton Polarization Parameter of 2h.n, γ）3h.reaction with.Inclusion of th. Electric Quadrupole Contribution

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Ch.nese Ph.sics Letters 2014年第9期31卷 32-35页

作者： h. Sadegh. M. Mosavi-Kh.nsari Department of Ph.sics Faculty of Science Arak University Arak 8349-8-38156 Iran

We use effective field th.ory （EFT） for th. calculation of neutron-deuteron radiative capture at very low energies. We present h.re th. use of EFT to calculate a low-energy ph.to-nuclear observable in th.ee-body systems, th. ph.ton polarization parameter and and fore-aft asymmetry at th.rmal neutron energies up to next-to-next to leading order （N2 LO）, with.inclasion of th. electric quadrupole contribution. Th. ph.ton polarization parameter in total is found to be Rc = -0.421±0.003 and is in good agreement with.th. oth.r modern th.oretical calculations based on modern nucleon-nucleon potentials. In comparison with.our previous work, a satisfactory agreement with.th. available experimental data is found by inclusion of th. electric quadrupole contribution.

关键词： Polarization

MAGNA CARTA AND Th. AMERICAN POLITICAL IMAGINATION： Two INSTANCES OF h.BEAS CORPUS VINDICATED

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Frontiers of Law in Ch.na-Selected Publications from Ch.nese Universities 2016年第2期11卷 215-235页

作者： h. robert Baker Department of h.story College of Arts & Sciences Georgia State University Atlanta US

Magna Carta h.s long been understood as a source of inspiration for th. U.S. Constitution, and especially its ensh.inement of th. writ of h.beas corpus -- th. righ. of any prisoner to test h.s or h.r detention according to th. law. In th. ＂Suspension Clause＂ of th. U.S. Constitution （Article I, Section 8）, Congress is granted permission to suspend h.beas corpus only ＂wh.n in cases of Rebellion or Invasion th. public Safety may require it.＂ Th.s article surveys two failed attempts by th. U.S. government to suspend th. writ of h.beas corpus. Th. first （wh.ch.was actually th. very first such.attempt） was in 1807 and followed revelations of th. so-called Burr Conspiracy. Th. second （incidentally th. most recent in American h.story） occurred during th. War on Terror and culminated with.th. Supreme Court＇s decision ofBoumediene vs Bush.in 2008. A close examination of th.se two h.storical episodes reveals just h.w different were th. constitutional processes of th. early republic and contemporary times. Additionally, comparing th. uses of Magna Carta during th. two episodes demonstrates marked ch.nges in American political culture. h.storical consciousness, vital to early Americans＇ understanding of th.ir political system, h.s sh.fted to an elite level. Likewise, th. protection of fundamental liberties h.s migrated from th. popular branch.of government （Congress） to th. elite one （th. Supreme Court）. Th.s article considers th. implication of th.s sh.ft in both.constitutional processes and h.storical consciousness.

关键词： Constitutional Law legal h.story h.beas corpus suspension clause MagnaCarta

FLOW STRESS MODEL FOR h.RD MACh.NING OF AISI h.3 WORK TOOL STEEL

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Acta Metallurgica Sinica(English.Letters) 2005年第6期18卷 741-748页

作者： h. Yan J. h.a R. Sh.vpuri Sch.ol of Mech.nical-Electrical Engineering Nanchang University Nanchang 330029China Th. Oh.o State University Columbus OH 43210 USA

An approach.is presented to ch.racterize th. stress response of workpiece in h.rd mach.ning, accounted for th. effect of th. initial workpiece h.rdness, temperature, strain and strain rate on flow stress. AISI h.3 work tool steel was ch.sen to verify th.s meth.dology. Th. proposed flow stress model demonstrates a good agreement with.data collected from publish.d experiments. Th.refore, th. proposed model can be used to predict th. corresponding flow stress-strain response of AISI h.3 work tool steel with.variation of th. initial workpiece h.rdness in h.rd mach.ning.

关键词： flow stress model h.rd mach.ning AISI h.3 work tool steel

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point sph.rical source embedded with.n a fluid-saturated poroelastic formation of infinite extent

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Applied Math.matics and Mech.nics(English.Edition) 2025年第1期46卷 139-156页

作者： h.h.SSEINI O.BALILASh.KI Department of Mech.nical Engineering Faculty of EngineeringGolestan University

Th. effects of a h.rmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely with.n a fluid-saturated poroelastic formation of infinite extent are examined th.oretically. It is assumed th.t th. source is located outside th. cavity at a specified distance from th. boreh.le axis. Th. magnitudes of th. h.op and radial stresses beside th. pore pressures exerted on th. interface and inside th. porous medium surrounding th. boreh.le are calculated and discussed. Biot's poroelastic modeling along with.th.ee types of boundary conditions for th. cylindrical interface including th. ideal fluid, empty boreh.le, and rigid inclusion with.a h.rd boundary is employed for th. analysis. Utilizing a proper translational addition th.orem for expressing th. incident sph.rical wave in terms of cylindrical wave expansions, th. proposed boundary conditions at th. interface are satisfied. Stresses are formulated by means of wave potential functions in a th.ee-dimensional(3D) manner. Th. effects of th. frequency and th. radial distance between th. source and boreh.le on th. induced stresses are examined for th. first cylindrical modes over frequency spectra. Two permeability conditions for th. interface and th.ee types of soils for th. porous formation are considered th.ough.ut th. analysis. To give an overall outline of th. study, a numerical example is presented. Th. results clearly indicate th.t th. distance is a key parameter and h.s considerable effects on th. induced stress values. In addition, th. interface permeability condition and soil ch.racteristics play an important role in determining th. dynamic response of th. boreh.le. Finally,th. obtained results are compared with.th. relevant analyses existing in th. literature for some limit cases, and good agreement is ach.eved.

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Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

Glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAG repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex