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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 3-4页

作者： groszmann r.j Garcia-Tsao G Bosch j. 廖新华 Yale University School of Medicine VA CT Healthcare System Digestive Disease Section/ 111H 950 Campbell AveWest Haven CT 06516 United StatesDr.

BACKGrOUND: Nonselective beta-adrenergic blockers decrease portal pressure and prevent variceal hemorrhage. Their effectiveness in preventing varices is unknown. METHODS: We randomly assigned 213 patients with cirrhosis and portal hypertension (minimal hepatic venous pressure gradient [HVPG] of 6 mm Hg) to receive t imolol, a nonselective beta-blocker (108 patients), or placebo (105 patients). The primary end point was the development of gastroesophageal varices or variceal hemorrhage. Endoscopy and HVPG measurements were repeated yearly. rESULTS: During a median follow-up of 54.9 months, the rate of the primary end point did not differ significantly between the timolol group and the placebo group (39 percent and 40 percent, respectively; P = 0.89), nor were there significant differences in the rates of ascites, encephalopathy, liver transplantation, or death. Serious adverse events were more common among patients in the timolol group than among those in the placebo group (18 percent vs. 6 percent, P = 0.006). Varices developed less frequently among patients with a baseline HVPG of less than 10 mm Hg and among those in whom the HVPG decreased by more than 10 percent at one year and more frequently among those in whom the HVPG increased by more than 10 percent at one year. CONCLUSIONS: Nonselective beta-blockers are ineffective in preventing varices in unselected patients with cirrhosis and portal hypertension and are associated with an increased number of adverse events.

关键词： β-阻断剂肝静脉压力梯度门静脉压力终点指标噻吗洛尔死亡发生率安慰剂肝性脑病肝移植内

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维普期刊数据库

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β受体阻断剂用于预防肝硬化患者出现胃食管静脉曲张

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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 16-16页

作者： groszmann r.j Garcia-Tsao G Bosch j. 马超 Yale University School of Medicine VA CT Healthcare System Digestive Disease Section/ 111H 950 Campbell AveWest Haven CT 06516 United StatesDr.

BACKGrOUND: Nonselective beta-adrenergic blockers decrease portal pressure and prevent variceal hemorrhage. Their effectiveness in preventing varices is unknown. METHODS: We randomly assigned 213 patients with cirrhosis and portal hypertension(minimal hepatic venous pressure gradient[HVPG] of 6 mm Hg) to receive timolol, a nonselective beta-blocker(108 patients), or placebo(105 patients). The primary end point was the development of gastroesophageal varices or variceal hemorrhage. Endoscopy and HVPG measurements were repeated yearly. rESULTS: During a median follow-up of 54.9 months, the rate of the primary end point did not differ significantly between the timolol group and the placebo group(39 percent and 40 percent, respectively; P=0.89), nor were there significant differences in the rates of ascites, encephalopathy, liver transplantation, or death. Serious adverse events were more common among patients in the timolol group than among those in the placebo group(18 percent vs. 6 percent, P=0.006). Varices developed less frequently among patients with a baseline HVPG of less than 10 mm Hg and among those in whom the HVPG decreased by more than 10 percent at one year and more frequently among those in whom the HVPG increased by more than 10 percent at one year. CONCLUSIONS: Nonselective beta-blockers are ineffective in preventing varices in unselected patients with cirrhosis and portal hypertension and are associated with an increased number of adverse events.(*** number, NCT00006398.)

关键词：胃食管静脉曲张 β受体阻断剂肝硬化患者预防出现肝硬化门静脉高压静脉曲张破裂出血安慰剂治疗门静脉压力显著性差异

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维普期刊数据库

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门脉高压的药物疗法(摘要)

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淮海医药 1988年第2期 87-90页

作者： r.j.groszmann M.D. 李明礼蚌埠市第三人民医院

食道和胃的静脉曲张,最据有临床意义。由于血流及压力的增加,使此静脉发生渐进性扩张,直到曲张的静脉破裂为止。资料证明,门脉压力低于12mmHg者,很少发生静脉曲张或出血。了解促使门脉高压发生和持续、静脉破裂的循环因素,是寻找治疗门... 详细信息

食道和胃的静脉曲张,最据有临床意义。由于血流及压力的增加,使此静脉发生渐进性扩张,直到曲张的静脉破裂为止。资料证明,门脉压力低于12mmHg者,很少发生静脉曲张或出血。了解促使门脉高压发生和持续、静脉破裂的循环因素,是寻找治疗门脉高压药物的合理前提。门脉中的压力梯度与血流量及血流阻力的关系可用公式:p1-P2=F×r表

关键词：门脉高压血流量压力梯度加压素静脉曲张食道激素类药物静脉瘤静脉疾病门脉血流门脉压力

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β受体阻滞剂预防肝硬化患者发生胃食管血管曲张无效

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中国处方药 2006年第1期5卷 25-25页

作者： groszmann rj Garcia-Tsao G Bosch j 任美峰

背景:非选择性β受体阻滞剂可以降低门静脉高压,从而可预防静脉曲张出血。但是尚不清楚其预防血管曲张的疗效。[第一段]

关键词：非选择性β受体阻滞剂血管曲张肝硬化患者预防胃食管无效静脉曲张出血门静脉高压

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维普期刊数据库

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