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Chromomagnetic dipole moments of light quarks in the bestest little higgs model

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Chinese Physics C 2024年第10期48卷 125-136页

作者： T.Cisneros-Pérez e.Cruz-Albaro A.Y.Ojeda-Castañeda S.e.Solís-Núñez Unidad Académica de Ciencias Químicas Universidad Autónoma de ZacatecasApartado Postal C-58598060 ZacatecasMexico Facultad de Física Universidad Autónoma de ZacatecasApartado Postal C-58098060 ZacatecasMexico

In this study,we investigated the anomalous Chromomagnetic Dipole Moment(CMDM),denoted as μ_(q)^(BLhM),of light quarks q=(u,c,d,s,b) within the framework of the Bestest Little higgs Model(BLhM)as an extension of the Standard Model(SM).Our investigation encompassed novel interactions among the light quarks,heavy quark B,and heavy bosons (W'^(±),h^(±),φ^(±),η^(±))incorporating the extended Cabibbo-Kobayashi-Maskawa(CKM)matrix characteristic of the *** thoroughly explored the permissible parameter space,yielding a spectrum of CMDM values ranging from 10^(-10) to 10^(-3).

关键词： beyond standard model flavor physics chromomagnetic dipole light quarks

Inhibiting the oligomerization of mycobacterial DNA-directed RNA polymerase(RNAP)using natural compound via in-silico techniques

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Medicine in Novel Technology and Devices 2024年第1期21卷 97-109页

作者： ehssan h.Moglad Department of Pharmaceutics College of PharmacyPrince Sattam Bin Abdulaziz UniversityP.O.Box 173 Alkharj 11942Saudi Arabia Department of Microbiology and Parasitology Institute of Medicinal and Aromatic Plants ResearchThe National Center for ResearchP.O.Box 2404KhartoumSudan

Mycobacterium tuberculosis(Mtb)is responsible for the spread of tuberculosis(TB).The current study employed virtual screening of 2569 natural compounds against the DNA-directed RNA polymerase(RNAP)of Mtb to identify the possible binders that can inhibit its *** in-silico methodology included molecular docking to the compounds,further,the stability and flexibility of the best complexes were studied using molecular dynamics simulation,the MM/GBSA binding free energy technique with.e.ergy decomposition,PCA,FeL,steered MD simulation,and umbrella *** virtual screenings were conducted for the five RNAP subunits(chains A,B,C,D,and e)to identify a compound capable of inhibiting RNAP oligomerization.A promising compound,isoestradiol 3-benzoate,exhibited a low binding score(−7.28kcal/mol to−8.21kcal/mol)and showed binding ability with all subunits of the ***,the five complexes with isoestradiol 3-benzoate were selected for molecular dynamics simulation ***,RMSD showed that isoestradiol 3-benzoate bound with chain e showed the lowest RMSD of 0.49nm,while with chains A and B it had the most stable and consistent conformations with RMSD of 1.75nm and 1.2nm,*** h-bond between isoestradiol 3-benzoate and chains C and e showed the highest occupancy(58.27%,45.33%,and 50.80%,42.25%,11.75%).Moreover,the MMPBSA technique showed that isoestradiol 3-benzoate had a strong association with chains B and C(ΔGbind=−126.25±2.03 and−129.27±2.25).Additionally,free energy decomposition,PCA,FeL-steered MD simulation,and umbrella sampling were also performed to validate the association of the ligand with the *** 3-benzoate binds strongly to chains B and e;therefore,it should be considered as viable candidate for inhibiting the formation of RNAP protein complex,concluded in this study.

关键词： Mycobacterium tuberculosis DNA-Directed RNA polymerase Docking Steered MD simulation Natural compounds Binding free energy Umbrella sampling

Flexible neural probes:a review of the current advantages,drawbacks,and future demands

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 153-167页

作者： Sara PIMeNTA Joao R.FReITAS Joséh.CORReIA CMeMS-UMinho University of MinhoGuimarães4800-058Portugal LABBeLS-Associate Laboratory Braga/GuimarãesPortugal

Brain diseases affect millions of people and have a huge social and economic *** use of neural probes for studies in animals has been the main approach to increasing knowledge about neural network ***,neuroscientists are trying to develop new and more effective therapeutic approaches to treating neurological *** implementation of neural probes with multifunctionalities(electrical,optical,and fluidic interactions)has been increasing in the last few years,leading to the creation of devices with high temporal and spatial *** the applicability of,and elements integrated into,neural probes has also led to the necessity to create flexible interfaces,reducing neural tissue damage during probe implantation and increasing the quality of neural acquisition *** this paper,we review the fabrication,characterization,and validation of several types of flexible neural probes,exploring the main advantages and drawbacks of these ***,future developments and applications are ***,this review aims to present the currently available flexible devices and future appropriate avenues for development as possible guidance for future engineered devices.

关键词： Brain knowledge Flexible interface Multifunctional probe

Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige hu Mich.e. h Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur hazlin hazrin-Chong Soojin Jang haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K h Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher e Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal high Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied environmental Metagenomics and Infectious Diseases Research(AeMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of energy and environment City University of Hong KongHong Kong 999077China Department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical th.e.t to global health and development,with.e.vironmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).however,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

Recent Ventures in Interdisciplinary Arctic Research:The ARCPATh Project

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Advances in Atmospheric Sciences 2024年第8期41卷 1559-1568页

作者： Astrid e.J.OGILVIe Leslie A.KING Noel KeeNLYSIDe François COUNILLON Brynhildur DAVIÐSDÓTTIR Níels eINARSSON Sergey GULeV Ke FAN Torben KOeNIGK James R.MCGOODWIN Marianne h.RASMusSON Shuting YANG Institute of Arctic and Alpine Research(INSTAAR) University of ColoradoBoulder CO 80303USA Stefansson Arctic Institute AkureyriÍS-600Iceland Royal Roads University BC V9B 5Y2Canada University of Bergen Bergen N-5007Norway Nansen environmental and Remote Sensing Centre Bergen N-5007Norway University of Iceland Reykjavík 102Iceland Shirshov Institute of Oceanology Moscow 117218Russia Moscow State University Moscow 11991Russia Chinese Academy of Sciences Beijing 100045China Swedish Meteorological and hydrological Institute SE-60176 NorrköpingSweden Danish Meteorological Institute CopenhagenØ2100Denmark Obukhov Institute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yongqi GAO's significant ach.e.ement in the field of interdisciplinary studies within the context of his final research project Arctic Climate Predictions: Pathways to Resilient Sustainable Societies-ARCPATh(https://***/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the Nordic countries, Russia, China, the United States, and Canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local knowledge holders. ARCPATh made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork was carried out for the project study areas of Iceland, Greenland, Norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ARCPATh was able to provide an improved framework for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ARCPATh served to create new and valuable knowledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： Recent Ventures in Interdisciplinary Arctic Research:The ARCPATh Project

Connections Between Induction Generator effect and Open-loop Modal Proximity to Cause Sub-synchronous Oscillations in Series-compensated Power System

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CSee Journal of Power and energy Systems 2024年第3期10卷 963-973页

作者： Wenjuan Du Yang Wang h.F.Wang Tao Zhao Tim Littler College of electrical engineering Sichuan UniversityChengduChina School of electrical engineering the Queen’s University of BelfastBelfastUK Ieee

The induction generator effect(IGe)and the openloop modal proximity(OLMP)are two different reasons why subsynchronous oscillations(SSOs)in a series-compensated power system(SCPS)may *** IGe attributes the growing SSOs to negative resistance,while the OLMP explains the SSO mechanism from the standpoint of modal *** this paper,we investigate the connections between the IGe and the OLMP through.e.uivalent RLC circuit and open-loop modal *** investigation is conducted for two types of seriescompensated power systems where either a synchronous generator or a DFIG is connected at the sending *** investigation reveals the conditions,in which the IGe and the OLMP may jointly cause the growing SSOs,i.e.,both the IGe and the OLMP can explain why the growing SSOs ***,the investigation indicates that the IGe and the OLMP may be totally irrelevant and lead to growing SSOs *** implies that it is possible that in a SCPS,the growing SSOs are only due to the IGe,and the OLMP is non-existent,and vice ***,when the growing SSOs occurs in a SCPS,examination based on both the IGe and the OLMP should be carefully conducted in order to find if the oscillatory instability is due to the IGe,or the OLMP,or both of them.

关键词： Induction generator effect open-loop modal proximity series compensation sub-synchronous oscillations

Upper extremity vascular injuries:etiology,management and outcome

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World Journal of Critical Care Medicine 2024年第2期13卷 159-167页

作者： Nikolaos Stefanou Theodoros Mylonas Fragkiskos A Angelis Christina Arnaoutoglou Sokratis e Varitimidis Zoe h Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyUniversity Hospital of LarissaLarissa 41500Greece Department of hand Upper Extremity and MicrosurgeryIASO ThessaliasLarissa 41500Greece

BACKGROUND Vascular injuries of the upper extremities are considered relatively rare injuries affecting mostly the young *** often are complex injuries accompanied by other musculoskeletal trauma or trauma in other anatomic *** management is challenging since they can lead to disabilities with major socioeconomic *** To analyze data about the mechanism of injury,the management algorithm and functional outcomes of vascular injuries of the upper *** One hundred and fifteen patients(96 males and 19 females)with arterial injuries of the upper extremity treated in a tertiary trauma center from January 2003 to December 2022 was *** patients’age was 33.7 years and the mean follow up time was 7.4 *** with Mangled extremity Severity Score≥7 and Injury Severity Score≥20,previous upper limb surgery or major trauma and any neuromuscular or psychiatric disease were excluded,from the *** A penetrating trauma was the most common cause of *** radial artery was the artery injured in most of the cases(37.4%)followed by the ulnar(29.5%),the brachial(12.1%)and the axillary(6%).A simultaneous injury of both of the forearm’s arteries was in 15.6%of the *** 93%of the cases there were other concomitant musculoskeletal injuries of the *** lacerations were the most common,followed by nerve *** postoperative functional scores(full Disabilities of the Arm,Shoulder,and hand and VAS)had very satisfactory *** Although vascular injuries of the upper extremity are rare,they may occur in the context of major combined musculoskeletal *** a multidisciplinary approach is essential to optimize outcome,the ability of trained hand surgeons to repair all injuries in combined vascular and musculoskeletal upper extremity trauma,excluding isolated vascular injuries,ensures shorter operative times and better functional outcomes.

关键词： Upper extremity Vascular injuries Complex injuries Musculoskeletal trauma Mangled extremity

exploring the effects of anthropogenic disturbance on predator inspection activity in Trinidadian guppies

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Current Zoology 2024年第1期70卷 109-111页

作者： Alix J.P Brusseau Laurence e.A.Feyten Adam L.Crane Grant e.Brown Department of Biology Concordia UniversityMontrealQCH4B 1R6Canada Department of Biomedical Sciences WCVMUniversity of SaskatchewanSaskatoonSKCanada

Prey animals are often faced with uncertainty due to having imperfect information regarding current local conditions,including predation risks and the availability of reliable foraging opportunities(Dall 2010).As this uncertainty increases,the probability of making costly behavioral errors also increases,leading to more risk averse behavioral tactics(Feyten et al.2019).For example,Trinidadian guppies Poecilia reticulata are far more risk averse when faced with multiple unknown sources of risk assessment information than when faced with a mix of known and unknown cues(Feyten et al.2019).Prey can reduce uncertainty by gathering and integrating private and social information regarding current risk levels within microhabitats(Dall 2010;Munoz and Blumstein 2012).

关键词： human disturbance information availability information reliability predator-prey interactions risk assessment uncertainty

All-electron basis sets for h to Xe specific for ZORA calculations:Applications in atoms and molecules

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Chinese Physics B 2024年第8期33卷 238-246页

作者： C.S.Gomes F.e.Jorge A.Canal Neto Departamento de Fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de Fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for h through Xe was developed to be used in conjunction with the ZORA *** set was augmented with diffuse functions to describe electrons farther away from the nuclei *** the ZORA-CCSD(T)/QZP-ZORA theoretical model,atomic ionization energies and bond lengths,harmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections has been shown to improve the agreement between theoretical and experimental results for molecular *** atomization energies,a similar observation emerges when considering spin-orbit *** the augmented QZP-ZORA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with previously published recommended and experimental *** evaluations of the ZORA and Douglas–Kroll–hess hamiltonians were made for each property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from h to Xe CCSD(T)method atomic and molecular properties