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Burning mouth syndrome

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World Journal of Gastroenterology 2013年第5期19卷 665-672页

作者： grigoriy e gurv.ts Amy Tan Division of Gastroenterology New York University School of Medicine/Langone Medical CenterNew YorkNY 10016United States New York University School of Medicine New YorkNY 10016United States

Burning mouth syndrome is a debilitating medical condition affecting nearly 1.3 million of *** common features include a burning painful sensation in the mouth,often associated with dysgeusia and xerostomia,despite normal ***, symptoms are better in the morning,worsen during the day and typically subside at *** etiology is largely multifactorial,and associated medical conditions may include gastrointestinal,urogenital,psychiatric,neurologic and metabolic disorders,as well as drug *** has clear predisposition to peri-/post menopausal *** pathophysiology has not been fully elucidated and involves peripheral and central neuropathic *** diagnosis relies on careful history taking,physical examination and laboratory *** is often tedious and is aimed at correction of underlying medical conditions,supportive therapy,and behavioral *** therapy with alpha lipoic acid,clonazepam,capsaicin,and antidepressants may provide symptom *** may be *** term follow up data is promising,however,long term prognosis with treatment is *** remains an important medical condition which often places a recognizable burden on the patient and health care system and requires appropriate recognition and treatment.

关键词： Burning mouth syndrome Glossodynia Glossopyrosis Burning tongue

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enterolithiasis

World Journal of Gastroenterology 2014年第47期20卷 17819-17829页

作者： grigoriy e gurv.ts Gloria Lan Division of Gastroenterology New York University School of Medicine/Langone Medical CenterNew YorkNY 10016United States Department of Medicine New York University School of MedicineNew YorkNY 10016United States

enterolithiasis or formation of gastrointestinal concretions is an uncommon medical condition that develops in the setting of intestinal stasis in the presence of the intestinal diverticula, surgical enteroanastomoses, blind pouches, afferent loops, incarcerated hernias, small intestinal tumors, intestinal kinking from intra-abdominal adhesions, and stenosing or stricturing Crohn’s disease and intestinal tuberculosis. enterolithiasis is classified into primary and secondary types. Its prevalence ranges from 0.3% to 10% in selected populations. Proximal primary enteroliths are composed of choleic acid salts and distal enteroliths are calcified. Clinical presentation includes abdominal pains, distention, nausea, and vomiting of occasionally sudden but often fluctuating subacute nature which occurs as a result of the enterolith tumbling through the bowel lumen. Thorough history and physical exam coupled with radiologic imaging helps establish a diagnosis in a patient at risk. Complications include bowel obstruction, direct pressure injury to the intestinal mucosa, intestinal gangrene, intussusceptions, afferent loop syndrome, diverticulitis, iron deficiency anemia, gastrointestinal hemorrhage, and perforation. Mortality of primary enterolithiasis may reach 3% and secondary enterolithiasis 8%. Risk factors include poorly conditioned patients with significant obstruction and delay in diagnosis. Treatment relies on timely recognition of the disease and endoscopic or surgical intervention. With advents in new technology, improved outcome is expected for patients with enterolithiasis.

关键词： enterolithiasis Gallstone ileus Intestinal obstruction Crohn’ s disease Meckel’ s diverticulum Diverticulosis Intestinal tuberculosis

Bleeding with the artificial heart: Gastrointestinal hemorrhage in CF-LVAD patients

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World Journal of Gastroenterology 2017年第22期23卷 3945-3953页

作者： grigoriy e gurv.ts elena Fradkov Division of Gastroenterology New York University School of Medicine/Langone Medical Center Department of Medicine New York University School of Medicine/Langone Medical Center

Continuous-flow left ventricular assist devices(CF-LVADs)have significantly improved outcomes for patients with end-stage heart failure when used as a bridge to cardiac transplantation or,more recently,as destination ***,its implantations carries a risk of complications including infection,device malfunction,arrhythmias,right ventricular failure,thromboembolic disease,postoperative and nonsurgical bleeding.A significant number of left ventricular assist devices(LVAD)recipients may experience recurrent gastrointestinal hemorrhage,mainly due to combination of antiplatelet and vitamin K antagonist therapy,activation of fibrinolytic pathway,acquired von Willebrand factor deficiency,and tendency to develop small intestinal angiodysplasias due to increased rotary speed of the *** bleeding in LVAD patients remains a source of increased morbidity including the need for blood transfusions,extended hospital stays,multiple readmissions,and overall *** of gastrointestinal bleeding in LVAD patients involves multidisciplinary approach in stabilizing the patients,addressing risk factors and performing structured endoluminal evaluation with focus on upper gastrointestinal tract including jejunum to find and eradicate culprit *** and procedural intervention is largely successful and universal bleeding cessation occurs in transplanted patients.

关键词： Gastrointestinal bleeding Left ventricular assist devices Heart failure Angioectasia endoscopy

Video capsule endoscopy and CT enterography in diagnosing adult hypertrophic pyloric stenosis

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World Journal of Gastroenterology 2013年第37期19卷 6292-6295页

作者： grigoriy e gurv.ts Amy Tan Dmitri Volkov Department of Gastroenterology New York University School of Medicine/Langone Medical Center Department of Medicine New York University School of Medicine Department of Anesthesiology New York University School of Medicine/Langone Medical Center

Primary adult hypertrophic pyloric stenosis is a rare but important cause of gastric outlet obstruction that may be misdiagnosed as idiopathic ***,patients present with early satiety,abdominal fullness,nausea,epigastric discomfort and *** gastric retention of a video capsule endoscope is diagnostic in differentiating between the two diseases,in the absence of an organic gastric outlet *** case presents the longest video capsule retention in the medical literature to *** is also the first case report of adult hypertrophic pyloric stenosis diagnosed with video capsule endoscopy or a computed tomography ***,an unusual"plugging"of the gastric outlet with free floating capsule has an augmented effect on disease physiology and on patient’s symptoms.

关键词： Video capsule endoscopy Hypertrophic pyloric stenosis Gastroparesis endoscopy Computed tomography enterography

Black esophagus: Acute esophageal necrosis syndrome

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World Journal of Gastroenterology 2010年第26期16卷 3219-3225页

作者： grigoriy e gurv.ts Department of Gastroenterology St. Vincent’s Medical Center/New York Medical College170 West 12th StreetNew YorkNY 10011United States

Acute esophageal necrosis (AeN), commonly referred to as "black esophagus", is a rare clinical entity arising from a combination of ischemic insult seen in hemodynamic compromise and low-flow states, corrosive injury from gastric contents in the setting of esophago-gastroparesis and gastric outlet obstruction, and decreased function of mucosal barrier systems and reparative mechanisms present in malnourished and debilitated physical states. AeN may arise in the setting of multiorgan dysfunction, hypoperfusion, vasculopathy, sepsis, diabetic ketoacidosis, alcohol intoxication, gastric volvulus, traumatic transection of the thoracic aorta, thromboembolic phenomena, and malignancy. Clinical presentation is remarkable for upper gastrointestinal bleeding. Notable symptoms may include epigastric/abdominal pain, vomiting, dysphagia, fever, nausea, and syncope. Associated laboratory f indings may reflect anemia and leukocytosis. The hallmark of this syndrome is the development of diffuse circumferential black mucosal discoloration in the distal esophagus that may extend proximally to involve variable length of the organ. Classic "black esophagus" abruptly stops at the gastroesophageal junction. Biopsy is recommended but not required for the diagnosis. Histologically, necrotic debris, absence of viable squamous epithelium, and necrosis of esophageal mucosa, with possible involvement of submucosa and muscularis propria, are present. Classif ication of the disease spectrumis best described by a staging system. Treatment is directed at correcting coexisting clinical conditions, restoring hemodynamic stability, nil-per-os restriction, supportive red blood cell transfusion, and intravenous acid suppression with proton pump inhibitors. Complications include perforation with mediastinal infection/abscess, esophageal stricture and stenosis, superinfection, and death. A high mortality of 32% seen in the setting of AeN syndrome is usually related to the underlying medical co-morbiditi

关键词： Acute esophageal necrosis Black esophagus Acute necrotizing esophagitis Ischemia endoscopy Gastrointestinal hemorrhage

Spatiospectral transformation of noncollimated light beams diffracted by ultrasound in birefringent crystals

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Photonics Research 2021年第5期9卷 687-693页

作者： ALeXeY V.GOReVOY ALeXANDeR S.MACHIKHIN grigoriy N.MARTYNOV VITOLD e.POZHAR Laboratory of Acousto-optic Spectroscopy Scientific and Technological Center of Unique InstrumentationRussian Academy of SciencesMoscow 117342Russia

Spatiospectral structure of wave phase matching in birefringent crystals has a strong dependence on the geometry of the acousto-optic interaction and incident light spectrum. This dependence defines details of light beam profile transformation. It is especially important for imaging applications related to a large angular aperture and a wide spectral bandwidth of the incident light. In this paper, we demonstrate accurate three-dimensional plotting of a light transmission pattern without small birefringence approximation. The rather complicated shape of the phase-matching locus in the spatiospectral domain inevitably leads to residual spatially nonuniform chromatic aberrations in the spectral image. Theoretical consideration and computational modeling are confirmed by the experiments on Bragg diffraction in paratellurite crystal. The results are especially important for the development of acousto-optical imaging devices and laser beam shaping technologies.

关键词： spectral light matching

Plasma-Catalytic Decomposition of 2,4-Dichlorophenol in a Dielectric Barrier Discharge with a Vermiculite ZiO2 Composite

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Advances in Chemical engineering and Science 2023年第4期13卷 318-335页

作者： grigoriy I. Gusev Andrey A. Gushchin Vladimir I. Grinevich ekaterina M. Baburina ekaterina S. Severgina Natalya e. Gordina Department of Industrial ecology Ivanovo State University of Chemical Technology Ivanovo Russia Department of Technology of Inorganic Substances Ivanovo State University of Chemistry and Technology Ivanovo Russia

The paper presents comparative kinetic characteristics of the decomposition of 2,4-dichlorophenol in a dielectric barrier discharge and a combined plasma-catalytic process. Vermiculite containing 5% zirconium was used as a catalyst. The destruction processes of 2,4-DCP proceed efficiently, the degree of decomposition increases in the combined plasma-catalytic process by a factor of 1.33 and reaches 80%. The experimental results were processed according to the first-order kinetic law (R2 > 0.97), according to which the effective constants (0.36 ± 0.04) and (0.51 ± 0.03) s-1 and the decomposition rates of 2,4-DCP (106 and 123 μmol/l·s) when treating model solutions without a catalyst and with vermiculite + Zr 5%, respectively, and the energy costs are 0.012 and 0.017 molecules/100eV. The main decomposition products present in the solution have been determined to be carboxylic acids, aldehydes, the contribution of which does not exceed 2%, as well as chloride ions, and in the gas phase they are carbon dioxide and molecular chlorine (the share of which does not exceed 1.5% of total chlorine content in the system).

关键词： 2 4-Dichlorophenol Dielectric Barrier Discharge Plasma Oxygen Treatment Water Treatment Catalyst Zirconium Vermiculite

Large-scale genome-wide SNP analysis reveals the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 324-340页

作者： Natalia V.DeMeNTIeVA Yuri S.SHCHeRBAKOV Olga I.STANISHeVSKAYA Anatoly B.VAKHRAMeeV Tatiana A.LARKINA Artem P.DYSIN Olga A.NIKOLAeVA Anna e.RYABOVA Anastasiia I.AZOVtseVA Olga V.MITROFANOVA grigoriy K.PeGLIVANYAN Natalia R.ReINBACH Darren K.GRIFFIN Michael N.ROMANOV Russian Research Institute of Farm Animal Genetics and Breeding-Branch of the L.K.ernst Federal Research Centre for Animal Husbandry.Pushkin St.Petersburg196601Russia School of Biosciences University of KentCanterburyCT27NJUK L.K.ernst Federal Research Center for Animal Husbandry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of divergently selected breeds of diverse *** study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture,genetic variability,and detailed structure among 49 *** populations represent a significant sample of the world's chicken breeds from europe(Russia,Czech Republic,France,Spain,UK,etc.),Asia(China),North America(USA),and Oceania(Australia).Based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism(SNP)chip,a bioinformatic analysis was carried *** included the calculation of heterozygosity/homozygosity statistics,inbreeding coefficients,and effective population *** also included assessment of linkage disequilibrium and construction of phylogenetic *** multidimensional scaling,principal component analysis,and ADMIXTURe-assisted global ancestry analysis,we explored the genetic structure of populations and subpopulations in each *** overall 49-population phylogeny analysis was also performed,and a refined evolutionary model of chicken breed formation was proposed,which included egg,meat,dual-purpose types,and ambiguous *** a large-scale survey of genetic resources in poultry farming using modern genomic methods is of great interest both from the viewpoint of a general understanding of the genetics of the domestic chicken and for the further development of genomic technologies and approaches in poultry *** general,whole genome SNP genotyping of promising chicken breeds from the worldwide gene pool will promote the further development of modern genomic science as applied to poultry.

关键词： Chicken genome diversity Single nucleotide polymorphism(SNP)analysis Gene pool Global ancestry Phylogeny Demographic history