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IR780/Gemcitabine-conjugated metal-phenolic network enhanced photodynamic cancer therapy

Chinese Chemical Letters 2024年第1期35卷 305-309页

作者： songtao Zhou Hao Tian Jie Yan Zhan Zhang Guohao Wang Xinying Yu Wei sang Bei Li greta s.p.mok Jie song Yunlu Dai Cancer Center and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao 999078China MoE Frontiers science Center for precision Oncology University of MacaoMacao 999078China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesThe Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Biomedical Imaging Laboratory(BIG) Department of Electrical and Computer EngineeringFaculty of Science and TechnologyUniversity of MacaoMacao 999078China

photodynamic therapy (pDT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. photosensitizers are employed to absorb light and generate toxic reactive oxygen species (ROs) to damage biomolecules like DNA. At the same time, some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of pDT. However, the photosensitizer and chemotherapy drugs used in pDT is usually organic molecules, which suffers from bad solubility, fast clearance, and acute toxicity. To achieve targeted treatment, a reasonable delivery system is necessary. Therefore, we reported a metal-phenolic network where IR780 and gemcitabine were coupled chemically to overcome these shortcomings. The enhanced pDT effects can be realized by the promoted cell death both in vitro and in vivo. Moreover, the synergistic therapy also induced T-cell mediated anti-tumor immune response, which was significant for the inhibition of distant tumor growth. This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.

关键词： Metal phenolic network IR780 photodynamic therapy Breast cancer Gemcitabine

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spECT和CT系列图用于放射性核素靶向治疗内照射吸收剂量的估算

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中华核医学与分子影像杂志 2018年第7期38卷 516-517页

作者：唐军 Tiantian Li Nien-Yun Wu Na song greta s.p.mok 上海交通大学医学院附属苏州九龙医院核医学科 Biomedical Imaging Laboratory Department of Electrical and Computer EngineeringFaculty of Science and Technologyand Faculty of Health SciencesUniversity of Macau

目的在放射性核素靶向治疗（TRT）时,事先知道药物吸收剂量的分布是非常必要的。在以往研究中,作者发现用于定量计算的spECT系列图像的非刚性配准可提高吸收剂量估算的准确性。该研究目的是评估CT系列图像能否进一步提高TRT吸收剂量估... 详细信息

目的在放射性核素靶向治疗（TRT）时,事先知道药物吸收剂量的分布是非常必要的。在以往研究中,作者发现用于定量计算的spECT系列图像的非刚性配准可提高吸收剂量估算的准确性。该研究目的是评估CT系列图像能否进一步提高TRT吸收剂量估算的准确性。方法用一台投影机模拟配中能通用（MEGp）准直器的spECT/CT采集;In标记的泽娃灵（Zevalin）注射后1、12、24、72及144 h的图像,在此过程中模拟了衰减、散射和准直器-探头间的响应。随后给1例神经内分泌肿瘤患者注射了222 MBq;In-DTpA-奥曲肽（DTpAOC）,注射后24、48和72 h行spECT/CT显像。评价4种不同时间点采集图像的配准方法:基于全身显像系列图的配准（1）spECT（***）或（2）CT（WB-CT）;基于器官的单个器官配准（3）spECT（O-spECT）或（4）CT（O-CT）。使用;Y基于体素的s因子（源器官或源组织对靶器官或靶组织的内照射吸收剂量贡献因子）对体素与体素的配准进行积分卷积。生成并分析靶器官的器官吸收剂量、等剂量曲线和剂量容积直方图。结果在模拟研究中,肝、脾O-spECT、O-CT、WB-spECT和WB-CT 4种配准方法的器官吸收剂量误差分别是（-8.66±2.83）%、（-2.51±3.69）%、（-9.23±3.28）%、（-7.17±2.53）%和（-14.81±4.91）%、（-3.60±4.37）%、（-18.13±4.44）%、（-11.34±4.22）%。对所有器官而言,O-CT配准法的结果最好。等剂量曲线和剂量容积直方图的结果与吸收剂量估算结果一致。病例研究的结果同样显示O-CT配准法的误差最小。结论对比CT和spECT系列图,在CT系列图上进行器官配准可更有效地提高3D剂量估算的准确性,也许应把低剂量CT扫描纳入标准TRT方案中。

关键词：放射性核素靶向治疗定量spECT CT剂量估算图像配准

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou greta seng peng mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of pharmaceutical sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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High-resolution multi-scale air pollution system:Evaluation of modelling performance and emission control strategies

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Journal of Environmental sciences 2024年第3期137卷 65-81页

作者： Diogo Lopes Joana Ferreira sandra Rafael Ka In Hoi Xin Li Yuan Liu Ka-Veng Yuen Kai Meng mok Ana Isabel Miranda Department of Environment and planning&CEsAM University of AveiroAveiroPortugal Department of Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric *** also allows furthering the design and assessment of air pollution control measures for a specific *** evaluate its performance and suitability,the system was applied to the Macao special Administrative Region(sAR),China,one of the most densely populated areas on earth,during a winter period when this area is affected by high levels of particulate Matter(pM).Although the developed system tends to underestimate the pM concentrations,it revealed a good performance in reproducing the temporal and spatial air pollution *** exceedances of the Chinese air quality standards were calculated and high population exposure to pM pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should focus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in Macao *** approach developed in this work can support policymakers in defining new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory particulate matter population exposure

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Exploring the landscape of minimally invasive pancreatic surgery: progress, challenges, and future directions

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World Journal of Gastrointestinal surgery 2024年第10期16卷 3094-3103页

作者： greta Donisi Alessandro Zerbi Department of Biomedical sciences Humanitas UniversityPieve Emanuele 20090MilanItaly Department of pancreatic surgery IRCCS Humanitas Research HospitalRozzano 20089MilanItaly

Minimally invasive surgery(MI)has become the standard of care for many surgical procedures aimed at reducing the burden on ***,its adoption in pancreatic surgery(ps)has been limited by the pancreas’s unique location and the complexity of the dissection and reconstruction *** factors continue to contribute to ps having one of the highest morbidity and mortality rates in general *** a rough start,MIps has gained widespread acceptance in clinical practice *** evidence supports MI distal pancreatectomy safety,even in oncological cases,indicating its potential superiority over open ***,definitive evidence of MI pancre-aticoduodenectomy(MIpD)feasibility and safety,particularly for malignant lesions,is still ***,reports from high-volume centers are emer-ging,suggesting outcomes comparable to those of the open *** robotic ps increasing adoption,facilitated by the wider availability of robotic platforms,may further facilitate the transition to MIpD by overcoming the technical con-straints associated with laparoscopy and accelerating the learning ***-ough the MIps implementation process cannot be stopped in this evolving world,ensuring patient safety through strict outcome monitoring is *** in younger surgeons with structured and recognized training programs can promote safe expansion.

关键词： Minimally invasive surgery Minimally invasive pancreatic surgery pancreatic surgery Robotic Laparoscopic pancreaticoduodenectomy Distal pancrea-tectomy

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Organic X-Ray Image sensors Using a Medium Bandgap polymer Donor with Low Dark Current

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ENERGY & ENVIRONMENTAL MATERIALs 2024年第6期7卷 230-237页

作者： Ha, Jong-Woon Eom, seung Hun Cha, Bo Kyung song, seyeong Eun, Hyeong Ju Kim, Jong H. park, Jong mok Kim, Bongsoo park, Byoungwook Ko, seo-Jin Yoon, sung Cheol Lee, Changjin Jung, In Hwan Hwang, Do-Hoon pusan Natl Univ Chem Inst Funct Mat Dept Chem Busan 46241 South Korea Korea Res Inst Chem Technol KRICT Div Adv Energy Mat Res Ctr Daejeon 34114 South Korea Korea Electrotechnol Res Inst KERI Electromed Device Res Ctr Ansan 15588 South Korea Ulsan Natl Inst sci & Technol UNIsT Grad Sch Carbon Neutral Sch Energy & Chem Engn Ulsan 44919 South Korea Ajou Univ Dept Mol Sci & Technol Suwon 16449 South Korea Korea Res Inst Chem Technol Res Ctr Adv Specialty Chem Ulsan 44412 South Korea Ulsan Natl Inst sci & Technol UNIsT Dept Chem Ulsan 44919 South Korea Hanyang Univ Dept Organ & Nano Engn Human Tech Convergence Program 222 Wangsimni Ro Seoul 04763 South Korea

The development of portable X-ray detectors is necessary for diagnosing fractures in unconscious patients in emergency situations. However, this is quite challenging because of the heavy weight of the scintillator and silicon photodetectors. The weight and thickness of X-ray detectors can be reduced by replacing the silicon layer with an organic photodetectors. This study presents a novel bithienopyrroledione-based polymer donor that exhibits excellent photodetection properties even in a thick photoactive layer (similar to 700 nm), owing to the symmetric backbone and highly soluble molecular structure of bithienopyrroledione. The ability of bithienopyrroledione-based polymer donor to strongly suppress the dark current density (J(d) similar to 10(-10) A cm(-2)) at a negative bias (-2.0 V) while maintaining high responsivity (R = 0.29 A W-1) even at a thickness of 700 nm results in a maximum shot-noise-limited specific detectivity of D-sh* = 2.18 x 10(13) Jones in the organic photodetectors. printed organic photodetectors are developed by slot-die coating for use in X-ray detectors, which exhibit D-sh* = 2.73 x 10(12) Jones with clear rising (0.26 s) and falling (0.29 s) response times upon X-ray irradiation. Detection reliability is also proven by linear response of the X-ray detector, and the X-ray detection limit is 3 mA.

关键词： low dark current low detection limit organic photodetector printable X-ray DETECTORs pHOTOCONDUCTORs sENsITIVITY

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In-situ production of ozone and ultraviolet light using a barrier discharge reactor for wastewater treatment

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Journal of Zhejiang University-science A(Applied physics & Engineering) 2009年第9期10卷 1359-1366页

作者： Jin-Oh JO Y.s.mok Department of Chemical and Biological Engineering Jeju National University

A dielectric barrier discharge (DBD) reactor consisting of water-filled dielectric tube electrodes was used for the treatment of wastewater. The inner dielectric tube, which acted as the discharging electrode, was filled with an aqueous electrolyte solution. The outer dielectric tube, which served as the other electrode, was in contact with the wastewater, which was grounded. The present reactor system was energy-efficient for the production of ozone, not only because the perfect contact between the aqueous electrode and the dielectric surface minimized the loss of the electrical energy, but also because the DBD reactor was cooled by the wastewater. In addition, the ultraviolet (UV) light produced in the DBD reactor was able to assist in the wastewater treatment since the quartz tube used as the dielectric material was UV-transparent. The performance of the present DBD system was evaluated using a synthetic wastewater formed from distilled water and an azo dye, amaranth. The experimental parameters were the concentration of the electrolyte in the aqueous electrode, the discharge power, the initial pH of the wastewater and the concentration of hydrogen peroxide added to the wastewater. The wastewater treatment system was found to be effective for achieving decomposition of the dye.

关键词： Dielectric barrier discharge (DBD) Aqueous electrode Ozone Ultraviolet (UV) Wastewater

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Holomorphic Retractions of Bounded symmetric Domains onto Totally Geodesic Complex submanifolds

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Chinese Annals of Mathematics,series B 2022年第6期43卷 1125-1142页

作者： Ngaiming mok Department of Mathematics The University of Hong KongPokfulam RoadHong Kong

Given a bounded symmetric domain Ω the author considers the geometry of its totally geodesic complex submanifolds s■Ω.In terms of the Harish-Chandra realization Ω and taking s to pass through the origin 0∈Ω,so that s=E∩Ω for some complex vector subspace of C^(n),the author shows that the orthogonal projectionρ:Ω→E maps Ω onto s,and deduces that s■Ω is a holomorphic isometry with respect to the Caratheodory *** first theorem gives a new derivation of a result of Yeung’s deduced from the classification theory by satake and Ihara in the special case of totally geodesic complex submanifolds of rank 1 and of complex dimension≥2 in the siegel upper half plane Hg,a result which was crucial for proving the nonexistence of totally geodesic complex sub or bifolds of dimension≥2 on the open Torelli locus of the siegel modular variety Ag by the same *** proof relies on the characterization of totally geodesic submanifolds of Riemannian symmetric spaces in terms of Lie triple systems and a variant of the Hermann Convexity Theorem giving a new characterization of the Harish-Chandra realization in terms of bisectional curvatures.

关键词： Bounded symmetric domain Harish-Chandra embedding Holomorphic retraction Totally geodesy

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Decomposition of trifluoromethane in a dielectric barrier discharge non-thermal plasma reactor

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Journal of Environmental sciences 2012年第7期24卷 1234-1239页

作者： M. sanjeeva Gandhi Y. s. mok Department of Chemical and Biological Engineering Jeju National University

The decomposition of trifluoromethane （CHF3） was carried out using non-thermal plasma generated in a dielectric barrier discharge （DBD） reactor. The effects of reactor temperature, electric power, initial concentration and oxygen content were examined. The DBD reactor was able to completely destroy CHF3 with alumina beads as a packing material. The decomposition efficiency increased with increasing electric power and reactor temperature. The destruction of CHF3 gradually increased with the addition of O2 up to 2%, but further increase in the oxygen content led to a decrease in the decomposition efficiency. The degradation pathways were explained with the identified by-products. The main by-products from CHF3 were found to be COF2, CF4, CO2 and CO although the COF2 and CF4 disappeared when the plasma were combined with alumina catalyst.

关键词： trifluoromethane plasma alumina dielectric barrier discharge decomposition

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Rigidity of certain admissible pairs of rational homogeneous spaces of picard number 1 which are not of the subdiagram type

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science China Mathematics 2019年第11期62卷 2335-2354页

作者： Ngaiming mok Department of Mathematics The University of Hong Kong

Recently, mok and Zhang(2019) introduced the notion of admissible pairs(X0, X) of rational homogeneous spaces of picard number 1 and proved rigidity of admissible pairs(X0, X) of the subdiagram type whenever X0 is nonlinear. It remains unsolved whether rigidity holds when(X0, X) is an admissible pair NOT of the subdiagram type of nonlinear irreducible Hermitian symmetric spaces such that(X0, X) is nondegenerate for substructures. In this article we provide sufficient conditions for confirming rigidity of such an admissible pair. In a nutshell our solution consists of an enhancement of the method of propagation of sub-VMRT(varieties of minimal rational tangents) structures along chains of minimal rational curves as is already implemented in the proof of the Thickening Lemma of mok and Zhang(2019). There it was proven that, for a sub-VMRT structure? : C(s) → s on a uniruled projective manifold(X, K) equipped with a minimal rational component and satisfying certain conditions so that in particular s is "uniruled" by open subsets of certain minimal rational curves on X, for a "good" minimal rational curve ? emanating from a general point x ∈ s, there exists an immersed neighborhood N?of ? which is in some sense "uniruled" by minimal rational curves. By means of the Algebraicity Theorem of mok and Zhang(2019), s can be completed to a projective subvariety Z ? X. By the author’s solution of the Recognition problem for irreducible Hermitian symmetric spaces of rank 2(2008)and under Condition(F), which symbolizes the fitting of sub-VMRTs into VMRTs, we further prove that Z is the image under a holomorphic immersion of X0 into X which induces an isomorphism on second homology groups. By studying C*-actions we prove that Z can be deformed via a one-parameter family of automorphisms to converge to X0 ? X. Under the additional hypothesis that all holomorphic sections in Γ(X0, TX |X0) lift to global holomorphic vector fields on X, we prove that the admissible pair(X0, X) is rigi

关键词： rational homogeneous spaces rigidity uniruled projective manifolds sub-VMRT structures

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