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Effects of positive end-expiratory pressure on intracranial pressure,cerebral perfusion pressure,and brain oxygenation in acute brain injury:Friend or foe?A scoping review

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Journal of Intensive Medicine 2024年第2期4卷 247-260页

作者： greta Zunino Denise Battaglini Daniel Agustin Godoy IrCCS Ospedale Policlinico San Martino GenovaItaly Dipartimento di Scienze Diagnostiche e Chirurgiche Integrate Universitàdegli Studi di GenovaGenovaItaly Neurointensive Care Unit Sanatorio PasteurCatamarcaArgentina

Background Patients with acute brain injury(ABI)are a peculiar population because ABI does not only affect the brain but also other organs such as the lungs,as theorized in brain–lung crosstalk *** patients often require mechanical ventilation(MV)to avoid the complications of impaired respiratory function that can follow ABI;MV should be settled with meticulousness owing to its effects on the intracranial compartment,especially regarding positive end-expiratory pressure(PEEP).This scoping review aimed to(1)describe the physiological basis and mechanisms related to the effects of PEEP in ABI;(2)examine how clinical research is conducted on this topic;(3)identify methods for setting PEEP in ABI;and(4)investigate the impact of the application of PEEP in ABI on the *** The five-stage paradigm devised by Peters et *** expanded by Arksey and O'Malley,Levac et al.,and the Joanna Briggs Institute was used for *** also adhered to the Preferred reporting Items for Systematic reviews and Meta-Analyses(PrISMA)extension *** criteria:we compiled all scientific data from peer-reviewed journals and studies that discussed the application of PEEP and its impact on intracranial pressure,cerebral perfusion pressure,and brain oxygenation in adult patients with *** criteria:studies that only examined a pediatric patient group(those under the age of 18),experiments conducted solely on animals;studies without intracranial pressure and/or cerebral perfusion pressure determinations,and studies with incomplete *** authors searched and screened for inclusion in papers published up to July 2023 using the PubMed-indexed online *** were presented in narrative and tubular *** The initial search yielded 330 references on the application of PEEP in ABI,of which 36 met our inclusion *** has recognized beneficial effects on gas exchange,but it produces hemodynamic changes that should be predicted to avoi

关键词： Acute brain injury Mechanical ventilation Positive end-expiratory pressure Intracranial pressure Brain-lung crosstalk Multimodal monitoring

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为什么我们常常会受环境的影响?

求学 2024年第6期 73-74页

作者：姚姚伞greta

在上晚自习时，只要周围有几个同学在说话，你就会被他们影响，甚至影响你整晚的学习状态。又有一次，你计划好今天一定要完成数学作业，但隔壁邻居的装修声影响了你。你开始苦恼、生气和反思，为什么“我”就是不能忽略噪音，静下心来...

在上晚自习时，只要周围有几个同学在说话，你就会被他们影响，甚至影响你整晚的学习状态。又有一次，你计划好今天一定要完成数学作业，但隔壁邻居的装修声影响了你。你开始苦恼、生气和反思，为什么“我”就是不能忽略噪音，静下心来学习呢？以上这些情景时常发生在我们的生活中，因此有同学会产生疑问，为什么我们那么容易受环境的影响呢？笔者一查，发现还真有心理学家对此做了研究，还给出了相应的对策。我们一起来看看吧！

关键词：

Ir780/Gemcitabine-conjugated metal-phenolic network enhanced photodynamic cancer therapy

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Chinese Chemical Letters 2024年第1期35卷 305-309页

作者： Songtao Zhou Hao Tian Jie Yan Zhan Zhang Guohao Wang Xinying Yu Wei Sang Bei Li greta S.P.Mok Jie Song Yunlu Dai Cancer Center and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao 999078China MoE Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesThe Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Biomedical Imaging Laboratory(BIG) Department of Electrical and Computer EngineeringFaculty of Science and TechnologyUniversity of MacaoMacao 999078China

Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. Photosensitizers are employed to absorb light and generate toxic reactive oxygen species (rOS) to damage biomolecules like DNA. At the same time, some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of PDT. However, the photosensitizer and chemotherapy drugs used in PDT is usually organic molecules, which suffers from bad solubility, fast clearance, and acute toxicity. To achieve targeted treatment, a reasonable delivery system is necessary. Therefore, we reported a metal-phenolic network where Ir780 and gemcitabine were coupled chemically to overcome these shortcomings. The enhanced PDT effects can be realized by the promoted cell death both in vitro and in vivo. Moreover, the synergistic therapy also induced T-cell mediated anti-tumor immune response, which was significant for the inhibition of distant tumor growth. This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.

关键词： Metal phenolic network Ir780 Photodynamic therapy Breast cancer Gemcitabine

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Laser additive manufacturing of Si/ZrO_(2)tunable crystalline phase 3D nanostructures

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Opto-Electronic Advances 2022年第5期5卷 22-32页

作者： greta Merkininkaitė Edvinas Aleksandravičius Mangirdas Malinauskas Darius Gailevičius SimasŠakirzanovas Faculty of Chemistry and Geosciences Vilnius UniversityNaugarduko Str.24Vilnius LT-03225Lithuania Femtika Sauletekio Ave.15Vilnius LT-10224Lithuania Laser research Center Physics FacultyVilnius UniversitySauletekio Ave.10Vilnius LT-10223Lithuania Department of Chemical Engineering and Technology Center for Physical Sciences and TechnologySauletekio Ave.3Vilnius LT-10257Lithuania

The current study is directed to the rapidly developing field of inorganic material 3D object production at nano-/micro *** fabrication method includes laser lithography of hybrid organic-inorganic materials with subsequent heat treatment leading to a variety of crystalline phases in 3D *** this work,it was examined a series of organometallic polymer precursors with different silicon(Si)and zirconium(Zr)molar ratios,ranging from 9:1 to 5:5,prepared via sol-gel *** mixtures were examined for perspective to be used in 3D laser manufacturing by fabricating nano-and micro-feature sized *** spatial downscaling and surface morphology were evaluated depending on chemical composition and crystallographic *** appearance of a crystalline phase was proven using single-crystal X-ray diffraction analysis,which revealed a lower crystallization temperature for microstructures compared to bulk *** 3D objects retained a complex geometry without any distortion after heat treatment up to 1400℃.Under the proper conditions,a wide variety of crystalline phases as well as zircon(ZrSiO_(4)-a highly stable material)can be *** addition,the highest new record of achieved resolution below 60 nm has been *** proposed preparation protocol can be used to manufacture micro/nano-devices with high precision and resistance to high temperature and aggressive environment.

关键词： 3D nanostructures additive manufacturing crystalline phases laser lithography 3D printing high resilience inorganic materials SZ2080^(TM)

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元宇宙技术赋能高校教育教学新业态策略探究

教育教学研究前沿

教育教学研究前沿 2024年第1期2卷 5-8页

作者：格雷塔·艾肯多夫弗里德里希·迈尔霍芬德国莱比锡孔子学院德国莱比锡999035

随着信息技术的不断发展和普及,元宇宙技术作为一种虚拟现实和增强现实的综合体,已逐渐成为教育领域的新趋势。在高校教育教学中,合适使用元宇宙技术能够实现教学内容的创新、教学方法的革新以及学生学习体验的提升,使教学更加生动、直... 详细信息

随着信息技术的不断发展和普及,元宇宙技术作为一种虚拟现实和增强现实的综合体,已逐渐成为教育领域的新趋势。在高校教育教学中,合适使用元宇宙技术能够实现教学内容的创新、教学方法的革新以及学生学习体验的提升,使教学更加生动、直观和有效。因而研究元宇宙技术赋能高校教育教学新业态的策略有重要意义。对此,本文首先阐述了元宇宙技术的定义和构成,进而分析元宇宙技术在高校教育教学的适用性,在此基础上探究元宇宙技术赋能高校教育教学新业态的策略,以期为高校教育教学的发展提供新的思路和方法。

关键词：元宇宙技术高校教育教学新业态

One-step hydrothermal synthesis of hierarchical Ag/Bi_2WO_6 composites: In situ growth monitoring and photocatalytic activity studies

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Science China Chemistry 2013年第4期56卷 435-442页

作者： ZHOU Ying ZHANG Qian LIN YuanHua ANTONOVA Elena BENSCH Wolfgang PATZKE greta r. State Key Laboratory of Oil and Gas reservoir Geology and Exploitation Southwest Petroleum University School of Materials Science and Engineering Southwest Petroleum University Institute of Inorganic Chemistry University of Kiel Institute of Inorganic Chemistry University of Zurich

Hierarchical Ag/Bi2WO6 nanomaterials were prepared by a facile one-step hydrothermal method in mixed acetic acid and ethylene glycol (EG) medium. EG is employed as mild reducing agent for the formation of metallic Ag from Ag+ precursors. In situ energy dispersive X-ray diffraction (EDXrD) monitoring showed that the hydrothermal formation kinetics of Bi2WO6 in the presence of EG was significantly slowed down due to its very high viscosity. The photocatalytic activities of Ag/Bi2WO6 composites were evaluated by the photodegradation of methylene blue (MB) under visible light irradiation. The photocatalytic activity of Bi2WO6 is strongly influenced by the Ag loading. The enhanced catalytic activity of the composites is based on the cooperative effects of plasmon absorption band and separation of photogenerated electron-hole pairs.

关键词：光催化活性水热法合成复合材料生长发育监测原位 X-射线衍射一步水热法

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Structure and principles of self-assembly of giant“sea urchin”type sulfonatophenyl porphine aggregates

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Nano research 2022年第6期15卷 5527-5537页

作者： Marijus Pleckaitis Fayez Habach Lukas Kontenis Gábor Steinbach greta Jarockyte Agne Kalnaityte IldikóDomonkos Parveen Akhtar Mehdi Alizadeh Saulius Bagdonas Vitalijus Karabanovas GyőzőGarab ricardas rotomskis Virginijus Barzda Laser research Center Faculty of PhysicsVilnius UniversitySauletekio av.10Vilnius LT-10223Lithuania Biomedical Physics Laboratory National Cancer InstituteP.Baublio str.3bVilnius LT-08406Lithuania Department of Chemical and Physical Sciences University of Toronto Mississauga3359 Mississauga RdMississauga L5L 1C6Canada Light Conversion Keramiku str.2BVilnius LT-10233Lithuania Cellular Imaging Laboratory Biological Research CentreEötvös Loránd Research NetworkTemesvári körút 62Szeged 6726Hungary Institute of Biophysics Biological Research CentreEötvös Loránd Research NetworkTemesvári körút 62Szeged 6726Hungary Biofotonika research and Development Ltd. Dózsa u.7Szeged 6720Hungary Institute of Plant Biology Biological Research CentreEötvös Loránd Research NetworkTemesvári körút 62Szeged 6726Hungary Department of Chemistry and Bioengineering Vilnius Gediminas Technical UniversitySauletekio av.11Vilnius LT-10223Lithuania Department of Physics Faculty of ScienceUniversity of OstravaChittussiho 10Ostrava CZ-71000Czech Republic Department of Physics University of Toronto60 St.George St.TorontoToronto M5S 1A7Canada

Principles of molecular self-assembly into giant hierarchical structures of hundreds of micrometers in size are studied in aggregates of meso-tetra(4-sulfonatophenyl)porphine(TPPS_(4)).The aggregates form a central tubular core,which is covered with radially protruding filamentous non-branching *** filaments cluster and orient at varying angles from the core surface and some filaments form *** to shape resemblance,the structures are termed giant sea urchin(GSU)*** resolved fluorescence microscopy reveals J-and H-bands of TPPS_(4)aggregates in both the central core and the *** fluorescence of the core is quenched while filaments exhibit strong *** drying,the filament fluorescence gets quenched while the core is less affected,showing stronger relative *** linear dichroism(FDLD)microscopy reveals that absorption dipoles corresponding to J-bands are oriented along the filament *** comparison of FDLD with scanning electron microscopy(SEM)reveals the structure of central core comprised of multilayer ribbons,which wind around the core axis forming a *** second-harmonic generation(SHG)and thirdharmonic generation microscopy exhibits strong signal from the filaments with nonlinear dipoles oriented close to the filament axis,while central core displays very low SHG due to close to centrosymmetric *** chiral nonlinear susceptibility points to helical arrangement of the *** investigation shows that TPPS_(4)molecules form distinct aggregate types,including chiral nanotubes and nanogranular aggregates that associate into the hierarchical GSU structure,prototypical to complex biological *** chiral TPPS_(4)aggregates can serve as harmonophores for nonlinear microscopy.

关键词： meso-tetra(4-sulfonatophenyl)porphine(TPPS_(4))aggregates self-assembly nanostructures harmonophores polarimetric second harmonic generation microscopy third harmonic generation microscopy

This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGrOUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"Or"bladder pain syndrome")AND("mood disorder"Or depressive Or antidepressant Or depression Or depressed Or hyperthymic Or mania Or manic Or rapid cyclasterisk Or dysthymiasterisk Or dysphoriasterisk).rESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycArTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

Atrophic gastritis and gastric cancer tissue mirNome analysis reveals hsa-mir-129-1 and hsa-mir-196a as potential early diagnostic biomarkers

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World Journal of Gastroenterology 2022年第6期28卷 653-664页

作者： greta Varkalaite Evelina Vaitkeviciute ruta Inciuraite Violeta Salteniene Simonas Juzenas Vytenis Petkevicius rita Gudaityte Antanas Mickevicius Alexander Link Limas Kupcinskas Marcis Leja Juozas Kupcinskas Jurgita Skieceviciene Institute for Digestive research Lithuanian University of Health SciencesKaunas 44307Lithuania Department of Gastroenterology Lithuanian University of Health SciencesKaunas 44307Lithuania Department of Surgery Lithuanian University of Health SciencesKaunas 44307Lithuania Department of Gastroenterology Hepatology and Infectious DiseasesOttovon-Guericke University HospitalMagdeburg 39120Germany Institute of Clinical and Preventive Medicine&Faculty of Medicine University of LatviaRiga 1586Latvia

BACKGrOUND Gastric cancer(GC)is one of the most frequently diagnosed tumor *** most cases,GC develops in a stepwise manner from chronic gastritis or atrophic gastritis(AG)to *** of the major issues in clinical settings of GC is diagnosis at advanced disease stages resulting in poor *** rNAs(mi rNAs)are small noncoding molecules that play an essential role in a variety of fundamental biological ***,clinical potential of mi rNA profiling in the gastric cancerogenesis,especially in premalignant GC cases,remains *** To evaluate the AG and GC tissue mi rNomes and identify specific mi rNAs’potential for clinical applications(e.g.,non-invasive diagnostics).METHODS Study included a total of 125 subjects:Controls(CON),AG,and GC *** study subjects were recruited at the Departments of Surgery or Gastroenterology,Hospital of Lithuanian University of Health Sciences and divided into the profiling(n=60)and validation(n=65)*** rNA isolated from tissue samples was used for preparation of small rNA sequencing libraries and profiled using next-generation sequencing(NGS).Based on NGS data,deregulated mi rNAs hsa-mi r-129-1-3 p and hsa-mi r-196 a-5 p were analyzed in plasma samples of independent cohort consisting of CON,AG,and GC *** level of hsa-mi r-129-1-3 p and hsa-mi r-196 a-5 p was determined using the quantitative real-time polymerase chain reaction and 2-ΔΔCt *** results of tissue analysis revealed 20 differentially expressed mi rNAs in AG group compared to CON group,129 deregulated mi rNAs in GC compared to CON,and 99 altered mi rNAs comparing GC and AG *** 2 mi rNAs(hsa-mi r-129-1-3 p and hsa-mi r-196 a-5 p)were identified to be step-wise deregulated in healthy-premalignant-malignant *** under the curve(AUC)-receiver operating characteristic analysis revealed that expression level of hsa-mi r-196 a-5 p is significant for discrimination of CON vs AG,CON vs GC and A

关键词： Gastric cancer Atrophic gastritis Tumorigenesis Helicobacter pylori MicrorNAs Biomarkers