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Noninvasive ventilation for pediatric interfacility transports:a retrospective study

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World Journal of Pediatrics 2020年第4期16卷 422-425页

作者： samantha Holbird Tanya Holt Adam shaw gregory Hansen College of Medicine University of SaskatchewanSaskatoonSKCanada Division of Pediatric Critical Care Jim Pattison Children’s Hospital103 Hospital DriveSaskatoonSKS7N 0W8Canada

Background To characterize pediatric patients supported with continuous positive airway pressure and bilevel positive airway pressure(CPAP/BiPAP)or high-flow nasal cannula(HFNC)during interfacility transport(IFT).Methods A retrospective study with a provincial pediatric transport team from a tertiary hospital pediatric intensive care *** patients aged 28 days tos,who required IFT between January 2017 and December 2018,were identified through a transport registry and were included in the *** A total of 118(26.7%)patients received CPAP/BIPAP or HFNC support for *** most common respiratory diagnosis was bronchiolitis(46%).These patients were placed on respiratory support,31.4 minutes after the transport team’s *** required intubation during their IFT,despite mean transport times of 163 *** This study may provide important information for programs with large catchment areas,in which large distances and transport times should not be barriers to NIV implementation.

关键词： Children Critical illness Intubation Noninvasive ventilation Transportation of patients

spherical Parameterization of Marching Cubes Isosurfaces Based upon Nearest Neighbor Coordinates

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Journal of Computer science & Technology 2009年第1期24卷 30-38页

作者： gregory M.Nielson 张丽艳李建黄辉扬 Arizona state University TempeAZU.S.A. Nanjing University of Aeronautics and Astronautics Handong Global University National Central University

We present some new methods for parameterizing the triangle mesh surface （TMs） which result from the Marching Cubes （MC） algorithm. The methods apply to surfaces of genus zero and the parameter domain is a unit sphere. We take advantage of some special properties of the TMs resulting from the MC algorithm to obtain simple, computational efficient representations of the nearest neighbor coordinates and utilize these coordinates in the characterization of the parameterization by means of systems of equations which are solved iteratively. Examples and comparisons are presented.

关键词： isosurface marching cubes mapping parameterization spherical triangle mesh surface

On the mechanistic origins of maximum strength in nanocrystalline metals

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npj Computational Materials 2020年第1期6卷 393-404页

作者： Ankit Gupta Jacob Gruber satish s.Rajaram gregory B.Thompson David L.McDowell Garritt J.Tucker Colorado school of Mines Mechanical EngineeringGoldenCO 80401USA Department of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104USA Department of Metallurgical and Materials Engineering University of AlabamaTuscaloosaAL 35487USA Department of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The maximum strength of polycrystalline metals/alloys has been suggested to occur at nanoscale grain sizes where the governing deformation mechanism transitions from dislocation plasticity to grain boundary mediated *** tremendous progress recently uncovering links between transitions in nanoscale mechanisms and peak strength,the scientific literature is mostly devoid of any quantitative support,owing to the difficulty in measuring the resolved contribution of individual mechanisms to microstructural strain *** this study,the contribution of individual nanoscale mechanisms to the overall deformation of nanocrystalline Ni is calculated from atomistic simulations leveraging continuum-based kinematic metrics to compute mechanistic contributions to microstructural strain.

关键词： strength deformation grain

The Influence of Biological Maturity on Dynamic Force-Time Variables and Vaulting Performance in Young Female Gymnasts

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Journal of science in sport and Exercise 2020年第4期2卷 319-329页

作者： sylvia Moeskops Jon L.Oliver Paul J.Read John B.Cronin gregory D.Myer G.gregory Haff Isabel s.Moore Rhodri s.Lloyd Youth Physical Development Centre Cardiff School of Sport and Health SciencesCardiff Metropolitan UniversityCyncoed CampusCyncoed RoadCardiffCF52YBUK sports Performance Research Institute New Zealand(sPRINZ) AUT UniversityAuckland 1142New Zealand Centre for sport science and Human Performance Waikato Institute of TechnologyHamilton 3240New Zealand Athlete Health and Performance Research Centre Aspetar Orthopaedic and Sports Medicine HospitalDohaQatar Division of sports Medicine Cincinnati Children’s HospitalCincinnatiOH45229USA Department of Pediatrics and Orthopaedic surgery College of MedicineUniversity of CincinnatiCincinnatiOH 45267USA The Micheli Center for sports Injury Prevention WalthamMA 02453USA Centre for Exercise and sports science Edith Cowan UniversityJoondalupWA 6027Australia Australian Centre for Research into Injury in sport and Its Prevention(ACRIsP) Edith Cowan UniversityJoondalupWA 6027Australia University of Gloucestershire GloucesterGL502RHUK

Purpose This cross-sectional study investigated dynamic force-time variables and vaulting performance in young female gymnasts of different maturity *** 120 gymnasts aged 5-14 years were sub-divided into maturity groupings using percent of predicted adult height(%PAH)*** performed three jumping protocols,the squat jump(sJ),countermovement jump(CMJ)and drop jump(DJ),before completing straight jump vaults that were recorded using two-dimensional *** Jumping performance improved with biological maturity evidenced by the most mature gymnasts’producing sig-nificantly more absolute force(P0.78),impulse(P0.75)and power(P0.91)than the least mature group,resulting in the greater jump heights(P0.70).While,no significant differences were observed in relative peak force across multiple tests,measures of relative peak power did significantly increase with *** upon regression analyses,maturation was found to influence vertical take-off velocity during vaulting,explaining 41%of the variance in each jumping *** all tests,the DJ was found to have the highest predictive ability of vaulting vertical take-off velocity,explaining 55%of the total *** Biological maturation impacts jump height and underpinning mechanical variables in young female *** vertical take-off velocity appears to be influenced by maturation and various dynamic force-time variables,par-ticularly those during DJ,which had the highest explained total variance.

关键词： Youth Maturation squat jump Countermovement jump Drop jump Gymnastics

Endophytic fungi alter sucking bug responses to cotton reproductive structures

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Insect science 2017年第6期24卷 1003-1014页

作者： gregory A. sword Ashley Tessnow Maria Julissa Ek-Ramos Department of Entomology Texas A&M University College Station Texas USA Ecology and Evolutionary Biology Interdisciplinary Program Texas A&M University College Station Texas USA Laboratorio de Inmunologia y Virologia Facultad de Ciencias BiolSgicas Universidad Autonoma de Nuevo Leon San Nicolas de los Garza Nuevo Leon Mexico

All plants including cotton host a wide range of microorganisms as endophytes. There is a growing appreciation of the prevalence, ecological significance and management potential of facultative fungal endophytes in protecting plants from pests, pathogens and environmental stressors. Hemipteran sucking bugs have emerged as major pests across the U.s. cotton belt, reducing yields directly by feeding on developing reproductive structures and indirectly by vectoring plant pathogens. We used no-choice and simultaneous choice assays to examine the host selection behavior of western tarnished plant bugs （Lygus hesperus） and southern green stink bugs （Nezara viridula） in response to developing flower buds and fruits from cotton plants colonized by 1 of 2 candidate beneficial fungal endophytes, Phialemonium inflatum or Beauveria bassiana. Both insect species exhibited strong negative responses to flower buds （L. hesperus） and fruits （N. viridula） from plants that had been colonized by candidate endophytic fungi relative to control plants under both no-choice and choice conditions. Behavioral responses of both species indicated that the insects were deterred prior to contact with plant tissues from endophyte-colonized plants, suggesting a putative role for volatile compounds in mediating the negative response. Our results highlight the role of fungal endophytes as plant mutualists that can have positive effects on plant resistance to pests.

关键词： behavior endophyte fungi Hemiptera mutualism sucking bug

Charge disproportionation and site-selective local magnetic moments in the post-perovskite-type Fe_(2)O_(3) under ultra-high pressures

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npj Computational Materials 2019年第1期5卷 345-351页

作者： Ivan Leonov gregory Kh.Rozenberg Igor A.Abrikosov M.N.Miheev Institute of Metal Physics Russian Academy of Sciences620137 YekaterinburgRussia Materials Modeling and Development Laboratory National University of Science and Technology‘MISIS’119049 MoscowRussia school of Physics and Astronomy Tel Aviv University69978 Tel AvivIsrael Department of Physics Chemistry and Biology(IFM)Linköping UniversitySE-58183 LinköpingSweden

The archetypal 3d Mott insulator hematite,Fe_(2)O_(3),is one of the basic oxide components playing an important role in mineralogy of Earth’s lower *** high pressure-temperature behavior,such as the electronic properties,equation of state,and phase stability is of fundamental importance for understanding the properties and evolution of the Earth’s ***,we study the electronic structure,magnetic state,and lattice stability of Fe_(2)O_(3)at ultra-high pressures using the density functional plus dynamical mean-field theory(DFT+DMFT)*** the vicinity of a Mott transition,Fe_(2)O_(3) is found to exhibit a series of complex electronic,magnetic,and structural *** particular,it makes a phase transition to a metal with a post-perovskite crystal structure and site-selective local moments upon compression above 75 *** show that the site-selective phase transition is accompanied by a charge disproportionation of Fe ions,with Fe^(3±δ)and δ~0.05–0.09,implying a complex interplay between electronic correlations and the *** results suggest that site-selective local moments in Fe_(2)O_(3) persist up to ultra-high pressures of~200–250 GPa,i.e.,sufficiently above the core-mantle *** latter can have important consequences for understanding of the velocity and density anomalies in the Earth’s lower mantle.

关键词： magnetic local high

Immuno-oncology combinations： raising the tail of the survival curve

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Cancer Biology & Medicine 2016年第2期13卷 171-193页

作者： samuel J. harris Jessica Brown Juanita Lopez Timothy A. Yap Drug Development Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK Lung Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK

There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.s. Food and Drug Administration for advanced melanoma and non-small cell lung cancer,immune checkpoint inhibitors also appears to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, not all patients benefit, and efforts should thus now focus on improving the efficacy of immunotherapy through the use of combination approaches and predictive biomarkers of response and resistance. There are multiple potential rational combinations using an immunotherapy backbone, including existing treatments such as radiotherapy, chemotherapy or molecularly targeted agents, as well as other immunotherapeutics. The aim of such antitumor strategies will be to raise the tail on the survival curve by increasing the number of long term survivors, while managing any additive or synergistic toxicities that may arise with immunotherapy combinations. Rational trial designs based on a clear understanding of tumor biology and drug pharmacology remain paramount. This article reviews the biology underpinning immuno-oncology, discusses existing and novel immunotherapeutic combinations currently in development, the challenges of predictive biomarkers of response and resistance and the impact of immuno-oncology on early phase clinical trial design.

关键词： Combination drug therapy oncology clinical trials PD-1 PD-L1 CTLA4 biomarkers immunotherapy

short history of Harry *** MD

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中华显微外科杂志 2020年第1期43卷 I0009-I0010页

作者： gregory M.Buncke 不详

我的父亲哈里本克(Harry ***),被公认为“显微外科之父”。他在格拉斯哥医务室作为专科培训生、师从托马斯吉布森(Thomas Gibson)教授时,便开始对修复直径1 mm的血管感兴趣.在参与Gibson教授的移植免疫学工作以及缩短分离蒂转移时间... 详细信息

我的父亲哈里本克(Harry ***),被公认为“显微外科之父”。他在格拉斯哥医务室作为专科培训生、师从托马斯吉布森(Thomas Gibson)教授时,便开始对修复直径1 mm的血管感兴趣.在参与Gibson教授的移植免疫学工作以及缩短分离蒂转移时间的研究中,Buncke博士便设想仅通过一次手术将营养动脉/静脉修复到受体部位的皮瓣来移植同源组织,从而避免附着皮瓣。

关键词：受体部位专科培训移植免疫学显微外科医务室吉布森托马斯

From thermal conductive to thermal insulating:Effect of carbon vacancy content on lattice thermal conductivity of ZrC_(x)

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Journal of Materials science & Technology 2021年第23期82卷 105-113页

作者： Yue Zhou William G.Fahrenholtz Joseph Graham gregory E.Hilmas Department of Materials science and Engineering Missouri University of Science and TechnologyRollaMO 65409USA

Lattice thermal conductivities of zirconium carbide(ZrC_(x),x=1,0.75 and 0.5)ceramics with different carbon vacancy concentrations were calculated using a combination of first-principles calculations and the Debye-Callaway *** Gruneisen parameters,Debye temperatures,and phonon group velocities were deduced from phonon dispersions of ZrC_(x) determined using first-principles *** addition,the effects of average atomic mass,grain size,average atomic volume and Zr isotopes on the lattice thermal conductivities of ZrC_(x) were analyzed using phonon scattering *** lattice thermal conductivity decreased as temperature increased for ZrC,ZrC_(0.75) and ZrC_(0.5)(Zr2 C),and decreased as carbon vacancy concentration ***,ZrC_(x) can be tailored from a thermal conducting material for ZrC with high lattice thermal conductivity to a thermal insulating material for ZrC_(0.5) with low lattice thermal ***,it opens a window to tune the thermal properties of ZrC_(x) by controlling the carbon vacancy content.

关键词： Zirconium carbide Lattice thermal conductivity Theoretical study First-principle calculations