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High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry

Horticulture Research 2021年第1期8卷 2391-2403页

作者： Molla F.Mengist Hamed Bostan Elisheba Young Kristine l.kay Nicholas Gillitt James Ballington Colin D.kay Mario G.Ferruzzi Hamid Ashrafi Mary Ann lila Massimo Iorizzo Plants for Human Health Institute North Carolina State UniversityKannapolisNCUSA Department of Horticultural Science North Carolina State UniversityRaleighNCUSA David H.Murdock Research Institute KannapolisNCUSA Department of Food Bioprocessing and Nutrition Sciences North Carolina State UniversityRaleighNCUSA

Fruit quality traits play a significant role in consumer preferences and consumption in blueberry(Vaccinium corymbosum l).The objectives of this study were to construct a high-density linkage map and to identify the underlying genetic basis of fruit quality traits in blueberry.A total of 287 F_(1) individuals derived from a cross between two southern highbush blueberry cultivars,‘Reveille’and‘Arlen’,were phenotyped over three years(2016–2018)for fruit quality-related traits,including titratable acidity,pH,total soluble solids,and fruit weight.A high-density linkage map was constructed using 17k single nucleotide polymorphisms *** linkage map spanned a total of 1397 cM with an average inter-loci distance of 0.08 *** quantitative trait loci interval mapping based on the hidden Markov model identified 18 loci for fruit quality traits,including seven loci for fruit weight,three loci for titratable acidity,five loci for pH,and three loci for total soluble *** of these loci were detected in more than one *** loci explained phenotypic variance ranging from 7 to 28% for titratable acidity and total soluble solid,and 8-13% for ***,the loci identified for fruit weight did not explain more than 10%of the phenotypic *** also reported the association between fruit quality traits and metabolites detected by Proton nuclear magnetic resonance analysis directly responsible for these fruit quality *** acids,citric acid,and quinic acid were significantly(Ply correlated with titratable *** molecules showed a strong and positive correlation with total soluble ***,the study dissected the genetic basis of fruit quality traits and established an association between these fruit quality traits and metabolites.

关键词： cultivar linkage traits

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From common gardens to candidate genes:an elegant case of homoploid hybrid speciation

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Molecular Plant 2021年第2期14卷 200-201页

作者： gregory l.Owens Department of Biology University of VictoriaVictoriaBCCanada

Homoploid hybrid speciation(HHS),where genetic contributions from two species combine to produce a third species without a change in pioidy,remains an intriguing and enigmatic evolutionary *** studies in the past decade have shown that introgression and admixture between species is common,and yet well documented cases of HHS remain rare(Schumer et al.,2014;Marques et al.,2019).This strikes at a key feature of HHS;it is a far higher bar to prove that hybridization was critical for speciation than it is to show that introgression *** former requires us to know how reproductive isolation(RI)is achieved,identify hybrid ancestry,and definitively link hybrid ancestry with reproductive *** this in mind,the work by Wang et al.(2020)fully documenting a case of HHS is particularly impressive in terms of both the scope and clarity of the results.

关键词： al. combine intro

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light Perception:A Matter of Time

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Molecular Plant 2020年第3期13卷 363-385页

作者： Sabrina E.Sanchez Matias l.Rugnone Steve A.kay Department of Neurology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Optimizing the perception of external cues and regulating physiology accordingly help plants to cope with the constantly changing environmental conditions to which they are *** array of photoreceptors and intricate signaling pathways allow plants to convey the surrounding light information and synchronize an endogenous timekeeping system known as the circadian *** biological clock integrates multiple cues to modulate a myriad of downstream responses,timing them to occur at the best moment of the day and the ***,the mechanism underlying entrainment of the light-mediated clock is not *** review addresses known interactions between the light-signaling and circadian-clock networks,focusing on the role of light in clock entrainment and known molecular players in this process.

关键词： circadian clock light signaling Arabidopsis thaliana light entrainment photoreceptors signal integration

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Incidence of Subclinical Hypothyroidism in Cardiac Surgery Patients. Comparison of Presentation Characteristics, Hospital and Medium-Term Outcomes with Euthyroid Patients

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World Journal of Cardiovascular Surgery 2012年第3期2卷 54-59页

作者： Aarne Jyrala Nicole M Gatto gregory l.kay Department of Cardiothoracic Surgery Good Samaritan Hospital Los Angeles USA Department of Epidemiology UCLA School of Public Health Los Angeles USA

Subclinical hypothyroidism (SCHT) is common, with an occurrence of up to 10% of the adult population and defined biochemically only by elevated TSH and normal T4. SCHT affects negatively on lipid and carbohydrate metabolism increasing the risk of ischemic heart disease, affects negatively on cardiac performance and have a close correlation with renal function. The aim of this study is to compare presentation characteristics and outcomes between euthyroid pts and pts with SCHT who underwent cardiac surgery. Methods: 474 pts from June 2003 through September 2004 had TSH and T4 measured. 365 pts were euthyroid (Group 1), 41 pts had SCHT (Group 2). Groups were compared by demographics and EuroSCORE (ES) risk profiles. Operative and hospital outcomes were compared as was follow-up mortality up to 96 months. Results: There were more females in Group 2, p = 0.04, more pts with CHF and number of NYHA III-IV pts (p levated s-crea (p l fibrillation (p = 0.007). Comparing the Groups by EuroSCORE (ES) showed higher risk scores in Group 2 pts (Additive ES 6.8 vs 8.5 and logistic ES 12.3% vs 18.1%, p = 0.01 and 0.03). Hospital mortality was higher in Group 2 (12.2% vs 4.1%, p = 0.04) and the number of pts needing extended care was higher in Group 2 (p = 0.01). Follow up mortality was doubled in Group 2 pts up to 96 months compared to Group 1 (p lusions: Presentation characteristics and risk scores are different and worse in SCHT pts compared with euthyroid pts. Hospital and follow-up mortality are increased in SCHT pts.

关键词： Hypothyroidism Cardiac Surgery Outcomes

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Reduced texaphyrin:A ratiometric optical sensor for heavy metals in aqueous solution

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 19-27页

作者： Harrison D.Root gregory Thiabaud Jonathan l.Sessler Department of Chemistry The University of Texas at AustinAustinTX 78712-1224USA

We report here a water-soluble metal cation sensor system based on the as-prepared or reduced form of an expanded porphyrin,*** metal complexation,a change in the redox state of the ligand occurs that is accompanied by a color change from red to *** long employed for synthesis in organic media,we have now found that this complexation-driven redox behavior may be used to achieve the naked eye detectable colorimetric sensing of several number of less-common metal ions in aqueous *** to In(Ⅲ),Hg(Ⅱ),Cd(Ⅱ),Mn(Ⅱ),Bi(Ⅲ),Co(Ⅱ),and Pb(Ⅱ)cations leads to a colorimetric response within 10 *** process is selective for Hg(Ⅱ)under conditions of competitive ***,among the subset of responseproducing cations,In(Ⅲ)proved unique in giving rise to a ratiometric change in the ligand-based fluorescence features,including an overall increase in *** cation selectivity observed in aqueous media stands in contrast to what is seen in organic solvents,where a wide range of texaphyrin metal complexes may be *** formation of metal cation complexes under the present aqueous conditions was confirmed by reversed phase highperformance liquid chromatography,ultra-violet-visible absorption and fluorescence spectroscopies,and highresolution mass spectrometry.

关键词： texaphyrin fluorescent sensor ion-sensing indium mercury

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Transcranial electrical stimulation in neurological disease

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Neural Regeneration Research 2022年第10期17卷 2221-2222页

作者： gregory l.Brown Michael T.Brown Neurished HersheyPAUSA

Increased lifespan is one of society’s greatest achievements,but this longevity increases the prevalence of diseases of aging,such as neurological ***,neurological disorders are the leading cause of disability and the second leading cause of deaths(Feigin et al.,2019).Furthermore,these diseases affect people in low-,medium-,and high-income countries(Feigin et al.,2019).Current technology to modify neurological burden is scarce,which poses numerous challenges for healthcare,global policy,and economic stability(Feigin et al.,2019).To face these challenges,brain stimulation technology,such as transcranial electrical stimulation(TES),has displayed exciting *** et al.(2017)provide a detailed overview of the safety and application of ***,electrodes are attached to the head and a weak current(e.g.,1-2 mA)is applied through the scalp,skull,and into the brain for 10-30 minutes to activate neurons(Antal et al.,2017).The technique is extremely safe with no serious adverse effects reported from thousands of sessions(Antal et al.,2017).The most common side effects are a tingling/itching sensation or redness at the stimulation site(Antal et al.,2017).However,these side effects can be minimized by reducing the electrode-skin impedance,slowly ramping up and ramping down TES,or using topical analgesics(Antal et al.,2017).The development of TES may repair neural dysfunction and stem the oncoming incidence of neurodegenerative disease.

关键词： stimulation sensation electrical

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Changes in presentation and outcomes in cardiac surgery patients aged 70 to 79 years versus patients 80 years or older

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World Journal of Cardiovascular Diseases 2012年第3期2卷 141-147页

作者： Aarne Jyrala Nicole M. Gatto gregory l. kay Department of Biostatistics School of Public Health University of Los Angeles Los Angeles USA Department of Cardiothoracic Surgery Heart Institute at Good Samaritan Hospital Los Angeles USA

Background: To establish which variables between cardiac surgery pts aged 70 - 79 years and 80 years or over are individually different for age group status. Methods: Group 1, 70 - 79 years, n = 351 and Group 2, age 80 or over n = 94. Demographics, operative and hospital outcomes were identified and EuroSCORE (ES) scores applied. logistic regression uni- and mul-tivariate analysis was used to detect pre- and postop-erative variables which might be independently different between the Groups. Results: Difference (p lass, atrial fibrillation, aortic valve disease, both ES algorithms. Group 2 pts had lower ejection fraction and less coronary artery disease. Group 1 had more pts with diabetes. Operative mortality was low (1.7% total) with no difference between the Groups. length of stay in the postoperative intensive care unit and total hospitalization was equal but Group 2 pts needed more often prolonged stay. Group 2 pts had more postoperative renal failure (p = 0.002) and were more often not discharged home (p = 0.03). Hospital mortality did not reach statistical significance (Group 1 18/5.2%, Group 2 10/10.7%, p = 0.06). Univariate analysis detected 12 pre- and post-operative variables which identified Group status. Multivariate analysis using univariate results detected only diabetes (for Group 1 status) and additive ES (for Group 2 status) to be independently different between the Groups. Conclusions: Elderly pts may be operated with low operative and hospital mortality. Only diabetes and additive ES (=comorbidities) were independently different between the Groups.

关键词： Cardiac Surgery in Elderly Differences Outcomes

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Single Dose Inamrinone in Terminal Warm Cardioplegia in On-Pump Coronary Artery Bypass Patients

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Open Journal of Thoracic Surgery 2012年第1期2卷 5-9页

作者： Aarne Jyrala Nicole M. Gatto gregory l. kay School of Public Health Department of Biostatistics University of California Los Angeles USA. The Heart institute at Good Samaritan Hospital Department of Cardiothoracic Surgery Los Angeles USA

Background: Phosphodiesterase inhibitors (PDI) are used in cardiac surgery to improve and stabilize cardiac function after surgery. The aim of this study is to evaluate changes in hemodynamics and early outcomes when PDI (Inocor/inamrinone) is given in terminal warm blood cardioplegia to on-pump CABG only patients and compare results with patients who did not receive the drug. Material and methods: From April 2003 through September 2004 241 pts underwent elective on-pump CABG only surgery. 141 pts received Inocor in the terminal warm blood cardioplegia (Group 1) and 100 pts did not (Group 2). Results: Demographic data, preoperative EuroSCORE risk scores and operative details were similar. Of pts preoperatively in sinus rhythm (SR) 80.15% in Group 1 and 69.79% in Group 2 regained spontaneous SR (p = 0.07) after release of crossclamp. Inotropic support was needed in 5 pts in Group 1 and in 12 pts in Group 2, p = 0.02. Post cardiopulmonary by-pass (CPB) IABP support was needed for 4 pts in Group 2 and none for Group 1 pts, p = 0.01. There was no operative mortality in either Group and hospital/30 day mortality was similar (3/2.13% vs 3/3.00%, p = 0.69). There were no statistical difference in stay in postoperative intensive care unit (p = 0.15), total hospital stay (p = 0.07), appearance of postoperative atrial fibrillation (p = 0.23) or appearance of postoperative kidney injury (p = 0.27). Post CPB cardiac index improved 16.90% in Group1but decreased 1.49% in Group 2, p l pressure decreased 7.46%in Group 1 pts and 5.08% in Group 2 pts, p = 0.002, but no pts in either Group needed medication for too low blood pressure. Systemic vascular resistance decreased 28.40% in Group 1 and 9.02% in Group 2, p lusions: Inamrinone in terminal warm blood cardioplegia (hot shot) is safe and effective way to improve and stabilize cardiac function after on-pump CABG surgery but does not affect short-term outcomes.

关键词： Phosphodiesterase Inhibitors Postoperative Cardiac Function

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limbic system as immune tissue

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Acta Pharmacologica Sinica 1999年第5期 80-81页

作者： gregory l FRICCHIONE Boston MA 02215 USA Brigham and Women’s Hospital Harvard Medical School Medical Psychiatry Service and Mind-Body Medical Institute

The purpose of this review is to examine the interaction of the limbic system and the cellular immune system from the perspective of evolutionary biology. While the limbic system exerts a level of control over the stress response systems, the cellular immune system spearheaded by the monocyte-macrophage is responsible for the acute phase response to *** potential role of the macrophage in certain neuropsychiatric and psychosomatic disorders,including dementia,delirium, schizophrenia, depression and autoimmune disease will be

关键词： limbic system as immune tissue

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Glycemic targets in critically ill adults: A mini-review

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World Journal of Diabetes 2021年第10期12卷 1719-1730页

作者： kay Choong See Division of Respiratory and Critical Care Medicine Department of MedicineNational University HospitalSingapore 119228Singapore

Illness-induced hyperglycemia impairs neutrophil function,increases pro-inflammatory cytokines,inhibits fibrinolysis,and promotes cellular *** turn,these mechanisms lead to pneumonia and surgical site infections,prolonged mechanical ventilation,prolonged hospitalization,and increased *** optimal glucose control,blood glucose measurements need to be done accurately,frequently,and *** choosing glycemic targets,one should keep the glycemic variabilityl/l and avoid targeting a lower limit of blood glucosel/*** upper limit of blood glucose should be set according to casemix and the quality of glucose control.A lower glycemic target range(i.e.,blood glucose 4.5-7.8 mmol/l)would be favored for patients without diabetes mellitus,with traumatic brain injury,or who are at risk of surgical site *** avoid harm from hypoglycemia,strict adherence to glycemic control protocols and timely glucose measurements are *** contrast,a higher glycemic target range(i.e.,blood glucose 7.8-10 mmol/l)would be favored as a default choice for medical-surgical patients and patients with diabetes *** targets may be modified if technical advances for blood glucose measurement and control can be achieved.

关键词： Brain injuries Traumatic Critical care Diabetes mellitus Glycemic control Insulin infusion systems Sepsis

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