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Science Bulletin 2024年第7期69卷 850-852页

作者：周晓东 gregory Y.H.lip 郑明华 Department of Cardiovascular Medicine the Heart Centerthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China liverpool Centre for Cardiovascular Science at University of liverpool Liverpool John Moores University and Liverpool Heart&Chest HospitalLiverpool L693BXUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark MAFlD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Institute of Hepatology Wenzhou Medical UniversityWenzhou 325000China Key laboratory of Diagnosis and Treatment for the Development of Chronic liver Disease in Zhejiang Province Wenzhou 325000China

Heart failure with preserved ejection fraction(HFpEF)has an estimated incidence rate of approximately 27 cases per 10,000 person-year[1].Furthermore,the prevalence of HFpEF is on the rise and is expected to exceed that of heart failure with reduced ejection fraction(HFr EF)[2].In the near future,HFpEF is expected to become the predominant subtype of heart failure[2].

关键词： predominant fraction 射血分数保留型

晶粒长大对高纯Al{111}/{111}近奇异晶界的影响

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金属学报 2024年第1期60卷 80-94页

作者：冯小铮王卫国 gregory S.Rohrer 陈松洪丽华林燕王宗谱周邦新福建理工大学晶界工程研究所福州350118 福建理工大学材料科学与工程学院福州350118 Department of Materials Science and Engineering Carnegie Mellon UniversityPittsburghPA 15213-3890USA 上海大学材料研究所上海200072

{111}/{111}近奇异晶界较比一般晶界更耐蚀,如何提高此类晶界比例以显著提高Al及其合金晶界腐蚀抗力是一个新课题。本工作选用99.99%(质量分数)高纯Al为研究对象,考察晶粒长大对{111}/{111}近奇异晶界的影响。样品经室温多向锻造和370... 详细信息

{111}/{111}近奇异晶界较比一般晶界更耐蚀,如何提高此类晶界比例以显著提高Al及其合金晶界腐蚀抗力是一个新课题。本工作选用99.99%(质量分数)高纯Al为研究对象,考察晶粒长大对{111}/{111}近奇异晶界的影响。样品经室温多向锻造和370℃再结晶退火后,再经500℃保温不同时间,采用基于EBSD和五参数分析的晶界界面匹配表征方法对样品进行测试和分析。结果表明,随着晶粒长大,{111}/{111}近奇异晶界的比例显著增加。当平均晶粒尺寸由38μm长大至77μm时,{111}/{111}近奇异晶界的比例由3.91%增加至6.56%。离线原位EBSD和晶界迹线分析表明,晶粒长大过程中,{111}/{111}近奇异晶界主要通过具有/θ(θ为取向差转角)取向差关系的两两晶粒吞并周边晶粒并相遇后形成;具有/θ取向差关系的相邻晶粒,其晶界通过再取向调整至{111}/{111}位置,亦可形成此类近奇异晶界。{111}/{111}近奇异晶界存在旋错结构,其原子排列有序度显著高于一般晶界,这是此类晶界比一般晶界更耐蚀的原因。

关键词：高纯Al 晶粒长大近奇异晶界晶界界面匹配

Transcranial electrical stimulation in neurological disease

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Neural Regeneration Research 2022年第10期17卷 2221-2222页

作者： gregory l.Brown Michael T.Brown Neurished HersheyPAUSA

Increased lifespan is one of society’s greatest achievements,but this longevity increases the prevalence of diseases of aging,such as neurological ***,neurological disorders are the leading cause of disability and the second leading cause of deaths(Feigin et al.,2019).Furthermore,these diseases affect people in low-,medium-,and high-income countries(Feigin et al.,2019).Current technology to modify neurological burden is scarce,which poses numerous challenges for healthcare,global policy,and economic stability(Feigin et al.,2019).To face these challenges,brain stimulation technology,such as transcranial electrical stimulation(TES),has displayed exciting *** et al.(2017)provide a detailed overview of the safety and application of ***,electrodes are attached to the head and a weak current(e.g.,1-2 mA)is applied through the scalp,skull,and into the brain for 10-30 minutes to activate neurons(Antal et al.,2017).The technique is extremely safe with no serious adverse effects reported from thousands of sessions(Antal et al.,2017).The most common side effects are a tingling/itching sensation or redness at the stimulation site(Antal et al.,2017).However,these side effects can be minimized by reducing the electrode-skin impedance,slowly ramping up and ramping down TES,or using topical analgesics(Antal et al.,2017).The development of TES may repair neural dysfunction and stem the oncoming incidence of neurodegenerative disease.

关键词： stimulation sensation electrical

Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

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Chinese Medical Journal 2024年第2期137卷 172-180页

作者： Jing lin Deyong long Chenxi Jiang Caihua Sang Ribo Tang Songnan li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na Yang Yongchen Hao Jun liu Jing liu Xin Du louise Morgan Gregg C.Fonarow Sidney C.Smith Jr gregory Y.H.lip Dong Zhao Jianzeng Dong Changsheng Ma On behalf of CCC-AF investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National Clinical Research Center for Cardiovascular Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of Cardiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of Cardiology University of North CarolinaChapel HillNC 27599USA Department of Cardiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark 不详

Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in ***:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guideline-recommended OAC use in eligible patients was ***:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low *** admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking *** use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95%confidence interval:0.43-0.68;Pligible patients with high stroke risk and 60.7%(2778/4578)in eligible patients with low stroke *** utilization in patients with high stroke risk on admission or at discharge both increased largely over time(all Pltivariate analysis showed that OAC utilization at discharge was positively associated with in-hospital rhythm control strategies,including catheter ablation(adjusted odds ratio[OR]11.63,95%confidence interval[CI]10.04-13.47;Plectronic cardioversion(adjusted OR 2.41,95%CI 1.65-3.51;Plusions:In hospitals participated in the CCC-AF project,>70%of AF patients were at a high risk of *** poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF ***

关键词： Atrial fibrillation Oral anti-coagulants OAC Stroke prevention Contraindication

Quantifying relations between altered hydrology and fish community responses for streams in Minnesota

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Ecological Processes 2022年第1期11卷 536-560页

作者： Jeffrey R.Ziegeweid gregory D.Johnson Aliesha l.Krall Kara Fitzpatrick Sara B.levin U.S.Geological Survey California Water Science Center6000 J StPlacer HallSacramentoCA 85819USA U.S.Geological Survey Upper Midwest Water Science Center2280 Woodale DrMounds ViewMN 55112USA Minnesota Pollution Control Agency 520 Lafayette RdSt.PaulMN 55155USA Minnesota Pollution Control Agency 7678 College RoadSuite 105BaxterMN 56425USA

Background:Altered hydrology is a stressor on aquatic life,but quantitative relations between specific aspects of streamflow alteration and biological responses have not been developed on a statewide scale in *** sub-sets regression analysis was used to develop linear regression models that quantify relations among five categories of hydrologic metrics(i.e.,duration,frequency,magnitude,rate-of-change,and timing)computed from streamgage records and six categories of biological metrics(i.e.,composition,habitat,life history,reproductive,tolerance,trophic)computed from fish-community samples,as well as fish-based indices of biotic integrity(FIBI)scores and FIBI scores normalized to an impairment threshold of the corresponding stream class(FIBI_BCG4).Relations between hydrology and fish community responses were examined using three hydrologic datasets that represented periods of record,long-term changes,and short-term changes to flow regimes in streams of ***:Regression models demonstrated significant relations between hydrologic explanatory metrics and fish-based biological response metrics,and the five regression models with the strongest linear relations explained over 70%of the variability in the biological metric using three hydrologic metrics as explanatory ***-based biological metrics demonstrated the strongest linear relations to hydrologic *** most commonly used hydrologic metrics were related to bankfull flows and aspects of flow ***:Final regression models represent paired streamgage records and biological samples throughout the State of Minnesota and encompass differences in stream orders,hydrologic landscape units,and watershed *** methods can support evaluations of stream fish communities and facilitate targeted efforts to improve the health of fish *** also can be applied to locations outside of Minnesota with continuous streamgage data and fish-community sampl

关键词： EflowStats Best subset regression Altered hydrology Fish community Indices of biotic integrity Ecological flows

From common gardens to candidate genes:an elegant case of homoploid hybrid speciation

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Molecular Plant 2021年第2期14卷 200-201页

作者： gregory l.Owens Department of Biology University of VictoriaVictoriaBCCanada

Homoploid hybrid speciation(HHS),where genetic contributions from two species combine to produce a third species without a change in pioidy,remains an intriguing and enigmatic evolutionary *** studies in the past decade have shown that introgression and admixture between species is common,and yet well documented cases of HHS remain rare(Schumer et al.,2014;Marques et al.,2019).This strikes at a key feature of HHS;it is a far higher bar to prove that hybridization was critical for speciation than it is to show that introgression *** former requires us to know how reproductive isolation(RI)is achieved,identify hybrid ancestry,and definitively link hybrid ancestry with reproductive *** this in mind,the work by Wang et al.(2020)fully documenting a case of HHS is particularly impressive in terms of both the scope and clarity of the results.

关键词： al. combine intro

A Rare Case of Concordant Atrioventricular Connection to l-looped Ventricles in Situs Solitus:4-Dimensional Magnetic Resonance Imaging and 3D Printing

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Congenital Heart Disease 2022年第4期17卷 387-392页

作者： gregory Perens Takegawa Yoshida J.Paul Finn UClA Mattel Children’s Hospital Children’s Heart CenterLos AngelesCAUSA Diagnostic Cardiovascular Imaging laboratory Department of Radiology12222 David Geffen School of Medicine at UCLALos AngelesCAUSA

An infant male presented with the rare anatomy consisting of situs solitus,concordant atrioventricular connections to l-looped ventricles,double outlet right ventricle(DORV),and hypoplastic aortic arch.6 months after neonatal aortic arch repair,the morphologic right ventricle function deteriorated,and surgical evaluation was undertaken to determine if either biventricular repair with a systemic morphologic left ventricle or right ventricular exclusion was *** initial echocardiography,magnetic resonance imaging(MRI)was used to create detailed axial and 4-dimensional(4D)images and 3-dimensional(3D)printed *** detailed anatomy of this rare,complex case and its use in pre-surgical planning is presented.

关键词： Magnetic resonance imaging cardiac segments 3D printing

Reduced texaphyrin:A ratiometric optical sensor for heavy metals in aqueous solution

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 19-27页

作者： Harrison D.Root gregory Thiabaud Jonathan l.Sessler Department of Chemistry The University of Texas at AustinAustinTX 78712-1224USA

We report here a water-soluble metal cation sensor system based on the as-prepared or reduced form of an expanded porphyrin,*** metal complexation,a change in the redox state of the ligand occurs that is accompanied by a color change from red to *** long employed for synthesis in organic media,we have now found that this complexation-driven redox behavior may be used to achieve the naked eye detectable colorimetric sensing of several number of less-common metal ions in aqueous *** to In(Ⅲ),Hg(Ⅱ),Cd(Ⅱ),Mn(Ⅱ),Bi(Ⅲ),Co(Ⅱ),and Pb(Ⅱ)cations leads to a colorimetric response within 10 *** process is selective for Hg(Ⅱ)under conditions of competitive ***,among the subset of responseproducing cations,In(Ⅲ)proved unique in giving rise to a ratiometric change in the ligand-based fluorescence features,including an overall increase in *** cation selectivity observed in aqueous media stands in contrast to what is seen in organic solvents,where a wide range of texaphyrin metal complexes may be *** formation of metal cation complexes under the present aqueous conditions was confirmed by reversed phase highperformance liquid chromatography,ultra-violet-visible absorption and fluorescence spectroscopies,and highresolution mass spectrometry.

关键词： texaphyrin fluorescent sensor ion-sensing indium mercury

Diabetes exacerbates inflammatory bowel disease in mice with dietinduced obesity

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世界胃肠病学杂志:英文版 2023年第33期29卷 4991-5004页

作者： Kendra l Francis Kimberly M Alonge Maria Cristina Pacheco Shannon J Hu Cody A Krutzsch gregory J Morton Michael W Schwartz Jarrad M Scarlett Department of Pediatric Gastroenterology and Hepatology Seattle Children’s HospitalSeattleWA 98105United States 不详 Department of Medicinal Chemistry University of WashingtonSeattleWA 98195United States Department of laboratory Medicine and Pathology Seattle Children's HospitalSeattleWA 98105United States

BACKGROUND The increased prevalence of inflammatory bowel disease(IBD)among patients with obesity and type 2 diabetes suggests a causal link between these diseases,potentially involving the effect of hyperglycemia to disrupt intestinal barrier *** To investigate whether the deleterious impact of diabetes on the intestinal barrier is associated with increased IBD severity in a murine model of colitis in mice with and without diet-induced *** Mice were fed chow or a high-fat diet and subsequently received streptozotocin to induce diabetic-range *** weeks later,dextran sodium sulfate was given to induce *** select experiments,a subset of diabetic mice was treated with the antidiabetic drug dapagliflozin prior to colitis *** included both clinical and histological measures of colitis activity as well as histochemical markers of colonic epithelial barrier *** In mice given a high-fat diet,but not chow-fed animals,diabetes was associated with significantly increased clinical colitis activity and histopathologic markers of disease *** was also associated with a decrease in key components that regulate colonic epithelial barrier integrity(colonic mucin layer content and epithelial tight junction proteins)in diet-induced obese *** of these effects of diabetes in diet-induced obese mice was ameliorated by restoring *** In obese mice,diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of ***-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis *** findings suggest that effective diabetes management may decrease the clinical severity of IBD.

关键词： Inflammatory bowel disease Type 2 diabetes Obesity Intestinal barrier Hyperglycemia Colitis in mice Tight junction proteins