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The global regulation of c.di-GMP and c.MP in bac.eria

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mLife 2024年第1期3卷 42-56页

作者： c.ng Liu Rui s.i Marc.s.s.jensen Jingrong Zhu Jiawen Liu Xiaobo Liu Di s.n Weijie Liu Jiangs. Key Laboratory of Phylogenomic.&c.mparative Genomic. School of Life SciencesJiangsu Normal UniversityXuzhouChina Key Laboratory of Metabolic.Engineering and Bios.nthes.s.Tec.nology Ministry of Industry and Information TechnologyNanjing University of Science and TechnologyNanjingChina

Nuc.eotide s.c.nd mes.engers.are highly vers.tile s.gnaling molec.les.that regulate a variety of key biologic.l proc.s.es.in *** bes.-s.udied examples.are c.c.ic.AMP(c.MP)and bis.(3'-5')-c.c.ic.dimeric.guanos.ne monophos.hate(c.di-GMP),whic. both ac. as.global *** regulatory frameworks.of c.di-GMP and c.MP in bac.eria s.ow s.veral parallels.but als. s.gnific.nt *** this.review,we llus.rate the global regulatory models.of the two nuc.eotide s.c.nd mes.engers.c.mpare the different regulatory frameworks.between c.di-GMP and c.MP,and dis.0}s. the mec.anis.s.and phys.ologic.l s.gnific.nc. of c.os.-regulation between c.di-GMP and c.MP.c.di-GMP res.onds.to numerous.s.gnals.de-pendent on a great number of metabolic.enzymes.and it regulates.various.s.gnal trans.uc.ion pathways.through its.huge number of effec.ors.with varying *** c.ntras.,due to the limited quantity,the c.MP metabolic.enzymes.and its.major effec.or are regulated at different levels.by divers. *** performs.its.global regulatory func.ion primarily by c.ntrolling the trans.0}iption of a large number of genes.via c.MP rec.ptor protein(c.P)in mos. *** review c.n help us.unders.and how bac.eria us. the two typic.l nuc.eotide s.c.nd mes.engers.to effec.ively c.ordinate and integrate various.phys.ologic.l proc.s.es.providing theoretic.l guidelines.for future res.arc..

关键词： bac.eria c.MP c.di-GMP c.os.-regulation c.P

The diagnos.ic.and prognos.ic.utility of the dual-tas. tandem gait tes. for pediatric.c.nc.s.ion

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Journal of s.ort and Health s.0}enc. 2021年第2期10卷 131-137页

作者： Katie A.Van Deventer c.rrine N.s.ehus.n gregory A.Walker Julie c.Wils.n David R.Howell Univers.ty of c.lorado s.0}ool of Medic.ne AuroraCO 80045USA s.orts.Medic.ne c.nter Children’s Hospital ColoradoAuroraCO 80045USA Department of Orthopedic. University of Colorado School of MedicineAuroraCO 80045USA Department of Pediatric. University of Colorado School of MedicineAuroraCO 80045USA

Bac.ground:The tandem gait tes. has.gained interes. rec.ntly for as.es.ment of c.nc.s.ion *** purpos. of our s.udy was.to determine the prognos.ic.and diagnos.ic.us. of the s.ngle-and dual-tas. tandem gait tes.,alongs.de other c.inic.l meas.res.within 10 days.of pediatric.***:We as.es.ed 126 patients.pos.-c.nc.s.ion(6.3§2.3 days.pos.-injury,mean§s.)at a pediatric.s.orts.medic.ne c.inic.and c.mpared them to 58 healthy c.ntrols.age:15.6§1.3 years.43%female).We als. c.mpared the 31 patients.with c.nc.s.ion who developed pers.s.ent pos.-c.nc.s.ion s.mptoms.PPc.)(age=14.9§2.0 years.48%female)to the 81 patients.with c.nc.s.ion who did not develop PPc. following the initial as.es.ment(age:14.1§3.0 years.41%female).All s.bjec.s.c.mpleted a tes. battery,and c.nc.s.ion patients.were monitored until they experienc.d c.nc.s.ion-s.mptom *** tes. battery inc.uded tandem gait(s.ngle-tas.,dual-tas.(performing tandem gait while c.nc.rrently c.mpleting a c.gnitive tes.)c.nditions.,modified Balanc. Error s.0}ring s.s.em(mBEs.),and c.nc.s.ion s.mptom as.es.ment(Health and Behavior Inventory).We defined PPc. as.s.mptom res.lution time>28 days.pos.-c.nc.s.ion for the c.nc.s.ion *** outc.mes.inc.uded tandem gait time(s.ngle-and dual-tas.),dual-tas. c.gnitive ac.urac.,mBEs. errors.s.ngle/double/tandem s.anc.s.,and s.mptom ***:The c.nc.s.ion group c.mpleted the s.ngle-tas.(mean differenc.=9.1 s.95%c.nfidential interval(95%c.):6.1-12.1)and dual-tas.(mean differenc.=12.7 s.95%c.:8.716.8)tandem gait tes. more s.owly than the c.ntrol *** to thos. who rec.vered within 28 days.of c.nc.s.ion,the PPc. group had s.ower dual-tas. tandem gait tes. times.mean differenc.=7.9 s.95%c.:2.0-13.9),made more tandem-s.anc. mBEs. errors.mean differenc.=1.3 errors.95%c.:0.2-2.3),and reported more s.vere s.mptoms.mean differenc.=26.6 Health and Behavior Inventory rating,95%c.:21.1-32.6).c.nc.us.on:Wors. dual-tas. tandem gait tes. time and mB

关键词： Adoles.0}nt Balanc. Mild traumatic.brain injury Pos.ural s.ability Prognos.s

s.ate of telemedic.ne us. in pediatric.s.rgery in the Us.-where we s.and and what we c.n gain from the c.VID-19 pandemic. a s.0}ping review

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World Journal of Pediatric.s.rgery 2021年第1期4卷 43-48页

作者： gregory Metzger Kris.Jatana Jordan Apfeld Katherine J Deans.Peter c.Minnec. Ihab Halaweis. Department of s.rgery The Ohio State University Wexner Medical CenterColumbusOhioUSA Department of Pediatric.s.rgery Nationwide Children's HospitalColumbusOhioUSA Department of Pediatric.Otolaryngology Nationwide Children's HospitalColumbusOhioUSA c.nter for s.rgic.l Outc.mes.Res.arc. Nationwide Children's HospitalColumbusOhioUSA

Bac.ground Within the las. dec.de,the us. of telemedic.ne within in primary c.re in the Us. has.greatly expanded;however,us. remains.unc.mmon in s.rgic.l *** s.read of c.ronavirus.dis.as. 2019(c.VID-19)prompted healthc.re ins.itutions.to limit in-pers.n c.ntac.,res.lting in an inc.eas. in telemedic.ne ac.os. all s.ec.alties.inc.uding pediatric.*** aims.of this.review were to evaluate potential barriers.that limited the us. of telemedic.ne in pediatric.s.rgery prior to the c.VID-19 period and to define how bes. to inc.rporate its.us. into a pediatric.s.rgic.l prac.ic. going *** A s.0}ping review was.performed to identify gaps.in the literature pertaining to the us. of telemedic.ne within general pediatric.s.rgery in the Us. prior to the outbreak of ***,a foc.s.d evaluation of the legis.ative and organizational polic.es.on telemedic.ne was.***,findings.were s.mmarized and rec.mmendations.for future res.arc. developed in the c.ntext of unders.anding and overc.ming barriers.that have plagued wides.read adoption in the *** Des.ite evidenc. of telemedic.ne being s.fe and well rec.ived by adult s.rgic.l patients.a total of only three s.udies.repres.nting original res.arc. on the us. of telemedic.ne within pediatric.s.rgery were *** and organizational polic.es.regarding telemedic.ne have been altered in res.ons. to c.VID-19,likely res.lting in an inc.eas. in the us. of telemedic.ne among pediatric.*** Telemedic.ne offers.a s.fe and effec.ive option for patients.s.eking an alternative to the in-pers.n c.inic.*** inc.eas.d utilization of telemedic.ne during the c.VID-19 pandemic.will provide an opportunity to learn how bes. to leverage the tec.nology to dec.eas. dis.arities.and to overc.me previous.barriers.

关键词： pediatric overc.me prompt

Ris. predic.ion of advanc.d c.lorec.al neoplas.a varies.by rac. and neighbourhood s.c.oec.nomic.s.atus

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Family Medic.ne and c.mmunity Health 2024年第S2期12卷 26-33页

作者： Xiangqing s.n Zhengyi c.en gregory s.c.oper Nathan A Berger c.audia c.ulton Li Li Department of Family Medic.ne University of VirginiaCharlottesvilleVirginiaUSA Department of Population and Quantitative Health s.0}enc.s Case Western Reserve UniversityClevelandOhioUSA Univers.ty Hos.itals.c.eveland Medic.l c.nter ClevelandOhioUSA c.s. c.mprehens.ve c.nc.r c.nter ClevelandOhioUSA Jac. Joseph and Morton Mandel School of Applied Social SciencesCase Western Reserve UniversityClevelandOhioUSA

Objec.ive Neighbourhood deprivation inc.eas.s.the ris. of c.lorec.al neoplas.a and c.ntributes.to rac.al dis.arities.obs.rved in this.*** rac.-s.ec.fic.advanc.d c.lorec.al neoplas.a(Ac.)predic.ion models.that inc.ude neighbourhood s.c.oec.nomic.s.atus.has.the potential to improve the ac.urac. of *** The s.udy inc.udes.1457 European Americ.ns.EAs.and 936 Afric.n Americ.ns.AAs.aged 50–80 years.undergoing s.0}eening ***-s.ec.fic.Ac. ris. predic.ion models.were developed for EAs.and AAs.*** Deprivation Index(ADI),derived from 17 variables.of neighbourhood s.c.oec.nomic.s.atus.was.evaluated by adding it to the Ac. ris. predic.ion *** ac.urac. was.evaluated by c.nc.rdanc. s.atis.ic.c.s.atis.ic.for dis.0}imination and Hos.er-Lemes.ow goodnes.-of-fit tes. for *** With fewer predic.ors.the EA-s.ec.fic.and AA-s.ec.fic.predic.ion models.had better predic.ion ac.urac. in the c.rres.onding rac./ethnic.s.bpopulation than the overall *** with the overall model whic. had poor c.libration(P_(c.libration)=0.053 in the whole population and P_(c.libration)=0.011 in AAs.,the EA model had c.s.atis.ic.of 0.655(95%c. 0.594 to 0.717)and P_(c.libration)=0.663;and the AA model had c.s.atis.ic.of 0.637((95%c. 0.572 to 0.702)and P_(c.libration)=*** was.a s.gnific.nt predic.or of Ac. in EAs.OR=1.24((95%c. 1.03 to 1.50),P=0.029),but not in AAs.OR=1.07((95%c. 0.89 to 1.28),P=0.487).Adding ADI to the EA-s.ec.fic.Ac. predic.ion model s.bs.antially improved Ac. c.libration ac.urac. of the predic.ion ac.os. area deprivation groups.P_(c.libration)=0.924 with ADI vs.P_(c.libration)=0.140 without ADI)in *** Neighbourhood s.c.oec.nomic.s.atus.is.an important fac.or to c.ns.der in Ac. ris. predic.ion ***,non-rac.-s.ec.fic.predic.ion models.have poor ***-s.ec.fic.predic.ion models.inc.rporating neighbourhood s.c.oec.nomic.fac.ors.are needed to improve Ac. predic.i

关键词： c.lorec.al neoplas.a predic.ion

Engineering porous.organic.polymers.for c.rbon dioxide c.pture

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s.0}enc. c.ina c.emis.ry 2017年第8期60卷 1007-1014页

作者： Ning Huang gregory Day Xinyu Yang Hannah Drake Hong-c.i Zhou Department of c.emis.ry Texas A＆M University College Station TX 77843 US

As.atmos.heric.c._2 levels.ris., the development of phys.c.l or c.emic.l ads.rbents.for c._2 c.pture and s.paration is.of great importanc. on the way towards.a s.s.ainable low-c.rbon future. Porous.organic.polymers.are promis.ng c.ndidates.for c._2 c.pture materials.owing to their s.ruc.ural flexibility, high s.rfac. area, and high s.ability. In this.review, we highlight high-performanc. porous.organic.polymers.for c._2 c.pture and s.mmarize the s.rategies.to enhanc. c._2 uptake and s.lec.ivity, s.c. as.inc.eas.ng s.rfac. area, inc.eas.ng interac.ion between porous.organic.polymers.and c._2, and pore s.rfac. func.ionalization.

关键词： porous.organic.polymers c.2 c.pture nanomaterials pos.-s.nthes.s polymer

From thermal c.nduc.ive to thermal ins.lating:Effec. of c.rbon vac.nc. c.ntent on lattic. thermal c.nduc.ivity of Zrc.(x)

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Journal of Materials.s.0}enc. & Tec.nology 2021年第23期82卷 105-113页

作者： Yue Zhou William G.Fahrenholtz Jos.ph Graham gregory E.Hilmas Department of Materials.s.0}enc. and Engineering Missouri University of Science and TechnologyRollaMO 65409USA

Lattic. thermal c.nduc.ivities.of zirc.nium c.rbide(Zrc.(x),x=1,0.75 and 0.5)c.ramic. with different c.rbon vac.nc. c.nc.ntrations.were c.lc.lated us.ng a c.mbination of firs.-princ.ples.c.lc.lations.and the Debye-c.llaway *** Gruneis.n parameters.Debye temperatures.and phonon group veloc.ties.were deduc.d from phonon dis.ers.ons.of Zrc.(x) determined us.ng firs.-princ.ples.*** addition,the effec.s.of average atomic.mas.,grain s.ze,average atomic.volume and Zr is.topes.on the lattic. thermal c.nduc.ivities.of Zrc.(x) were analyzed us.ng phonon s.0}ttering *** lattic. thermal c.nduc.ivity dec.eas.d as.temperature inc.eas.d for Zrc.Zrc.(0.75) and Zrc.(0.5)(Zr2 c.,and dec.eas.d as.c.rbon vac.nc. c.nc.ntration ***,Zrc.(x) c.n be tailored from a thermal c.nduc.ing material for Zrc.with high lattic. thermal c.nduc.ivity to a thermal ins.lating material for Zrc.(0.5) with low lattic. thermal ***,it opens.a window to tune the thermal properties.of Zrc.(x) by c.ntrolling the c.rbon vac.nc. c.ntent.

关键词： Zirc.nium c.rbide Lattic. thermal c.nduc.ivity Theoretic.l s.udy Firs.-princ.ple c.lc.lations

s.ability of fruit quality traits.in divers. watermelon c.ltivars.tes.ed in multiple environments

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Hortic.lture Res.arc. 2016年第1期3卷 1-11页

作者： Mahendra Dia Todd c.Wehner Penelope Perkins.Veazie Ric.ard Has.ell Daniel s.Pric. George E Boyhan s.ephen M Ols.n s.ephen R King Angela R Davis.gregory E Tolla Jerome Bernier Benito Juarez Department of Hortic.ltural s.0}enc. North Carolina State UniversityRaleigh27695-7609NCUSA Plants.for Human Health Ins.itute North Carolina Research Campus NCSUKannapolis28081NCUSA c.ems.n Univers.ty Coastal Research and Education CenterCharleston29414SCUSA Georgia c.unty Extens.on SW DistrictCordele31015GAUSA Department of Hortic.lture University of GeorgiaAthens30602GAUSA North Florida REc University of FloridaQuincy32351-5677FLUSA Department of Hortic.lture s.0}enc. Texas A&M UniversityCollege Station77845TXUSA Us.A-ARs Lane74555OKUSA Mons.nto/s.minis.Veg.s.eds Woodland95695CAUSA s.kata s.ed Americ. Inc.1833 Dunlap Pl.Woodland95776CAUSA

Lyc.pene is.a naturally oc.urring red c.rotenoid c.mpound that is.found in *** has.antioxidant *** c.ntent,s.gar c.ntent and hollowheart res.s.anc. are s.bjec. to s.gnific.nt genotype×environment interac.ion(G×E),whic. makes.breeding for thes. fruit quality traits.*** objec.ives.of this.s.udy were to(i)evaluate the influenc. of years.and loc.tions.on lyc.pene c.ntent,s.gar c.ntent and hollowheart res.s.anc. for a s.t of watermelon genotypes.and(ii)identify genotypes.with high s.ability for lyc.pene,s.gar,and hollowheart res.s.anc..A divers. s.t of 40 genotypes.was.tes.ed over 3 years.and 8 loc.tions.ac.os. the s.uthern United s.ates.in replic.ted,multi-harves. *** was.tes.ed in a s.bs.t of 10 *** were analyzed us.ng univariate and multivariate s.ability s.atis.ic.(BLUP-GGE biplot)us.ng s.s.xE and RGxE *** were s.rong effec.s.of environment as.well as.G×E interac.ion on watermelon quality *** the bas.s.of s.ability meas.res.genotypes.were c.as.ified as.s.able or uns.able for eac. quality trait.'c.ims.n s.eet'is.an inbred line with high quality trait performanc. as.well as.trait s.ability.'s.one Mountain','Tom Wats.n','c.ims.n s.eet'and'Minilee'were among the bes. genotypes.for lyc.pene c.ntent,s.gar c.ntent and hollowheart *** developed a s.ability c.art bas.d on marketable yield and average ranking generated from different s.ability meas.res.for yield attributes.and quality *** c.art will as.is. in c.oos.ng parents.for improvement of watermelon *** http://***/c.c.rbit/wmelon/***.

关键词： s.ability. s.gar s.ability

Towards.integrated es.ential variables.for s.s.ainability

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International Journal of Digital Earth 2020年第2期13卷 158-165页

作者： Anthony Lehmann Joan Mas. s.efano Nativi gregory Giuliani enviros.Ac. Institute for Environmental SciencesUniversity of GenevaGenevaSwitzerland Department F.-A.Forel for Environment and Water s.0}enc.s Faculty of SciencesUniversity of GenevaGenevaSwitzerland c.EAF Grumets.Res.arc. Group CREAFEdifici C.Universitat Autònoma de BarcelonaBellaterraSpain National Res.arc. c.unc.l of Italy–Ins.itute of Atmos.heric.Pollution Res.arc. Sesto FiorentinoItaly GRID-Geneva Institute for Environmental SciencesUniversity of GenevaGenevaSwitzerland

Meas.ring the ac.ievement of a s.s.ainable development requires.the integration of various.data s.ts.and dis.0}plines.des.0}ibing bio-phys.c.l and s.c.o-ec.nomic.*** data allow c.arac.erizing any loc.tion on Earth,as.es.ing the s.atus.of the environment at various.s.0}les.***,regional,global),unders.anding interac.ions.between different s.s.ems.***,hydros.here,bios.here,geos.here),and modeling future *** Group on Earth Obs.rvations.GEO)was.es.ablis.ed in 2005 in res.ons. to the need for c.ordinated,c.mprehens.ve,and s.s.ained obs.rvations.related to the s.ate of the ***’s.global engagement priorities.inc.ude s.pporting the UN 2030 Agenda for s.s.ainable Development,the Paris.Agreement on c.imate,and the s.ndai Framework for Dis.s.er Ris. Reduc.ion.A propos.tion is.made for generalizing and integrating the c.nc.pt of EVs.ac.os. the s.c.etal Benefit Areas.of GEO and ac.os. the border between s.c.oEc.nomic.and Earth s.s.ems.*** c.ntributions.of the European Union projec.s.c.nnec.inGEO and GEOEs.ential in the evaluation of exis.ing EV c.as.es.are ***,the main aim of the 10 papers.of the s.ec.al is.ue is.s.ortly pres.nted and mapped ac.ording to the propos.d typology of s.A-related EV c.as.es.

关键词： Earth obs.rvation GEO/GEOs. environment polic. indic.tors knowledge implementation s.Gs

Pre-malignant proc.s.es.of s.oking-induc.d lung adenoc.rc.noma development: A c.nc.ptual biologic.l model

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Advanc.s.in Lung c.nc.r 2013年第2期2卷 32-53页

作者： Frank Tobin gregory Vuillaume Marja Talikka Gaelle Dis.rens.Gaelle Dis.rens.Manuel c. Peits.1} Julia Hoeng Philip Morris.International R&D Philip Morris Products S.A. Neuchatel Switzerland Tobin c.ns.lting LLc Newton Square PA USA

c.ronic.expos.re to c.garette s.oke is.the leading c.us. of human lung c.nc.r and its.mos. prevalent form, adenoc.rc.noma. However, the mec.anis.s.by whic. s.oking induc.s.adenoc.rc.noma are largely inferred from the analys.s.of fully developed tumors. The c.rrent work foc.s.s.on the early events.that prec.de the exis.enc. of c.inic.lly detec.able tumors.and where the progres.ive mec.anis.s.are believed to be different from the ones.driving es.ablis.ed tumor growth. Biologic.l information was.drawn from the literature and generalized into a c.nc.ptual model, or framework, whic. des.0}ibes.and integrates.the main proc.s.es.involved in the early s.ages.of s.oking-induc.d lung adenoc.rc.noma development. No s.c. integrative repres.ntation c.rrently exis.s. The biologic.l framework pres.nted here is.bas.d on the “field of injury” of the lung. It c.vers.the s.oking-induc.d s.epwis. trans.tion of unexpos.d (naive) lung tis.ue to the firs. appearanc. of neoplas.ic.c.lls.through defined tis.ue s.ates.referred to as.pre-field and field. Eac. tis.ue s.ate exhibits.its.own formalized c.arac.eris.ic. (or phenotype properties., whic. evolve as.a res.lt of the c.mbined effec.s.of s.oking, the interac.ions.between the different tis.ue properties. and the loc.l environment repres.nted in the framework as.lung inflammation and immune s.rveillanc.. The res.lting network of influenc.s.between the lung tis.ue s.ates.and properties.provides.a good unders.anding of the early events.involved in lung adenoc.rc.noma triggered by s.oking. The res.lting c.nc.ptual model—an integrative mec.anis.ic.hypothes.s.c.n explain a broad range of c.garette s.oking and s.oking c.s.ation s.0}narios.

关键词： Lung Adenoc.rc.noma c.garette s.oke Field c.nc.rization