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p.otocol for the management of oral surgery p.tients on warfarin utilizing a p.int-of-Care In-Office international normalized ratio monitoring device

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Op.n Journal of Stomatology 2013年第4期3卷 255-267页

作者： gregory p. hatzis Center for Facial Oral & Implant Surgery Good Shepherd Medical Center Longview USA

p.rp.se: This study was p.rformed to assess the utility and safety of an In-Office INR Monitoring Device and p.esent a safe and efficient p.otocol for the management of p.tients on oral anticoagulants and/or antithrombolytics requiring routine office oral and maxillofacial surgery. p.tients and Methods: Sixty-one p.tients requiring “minor” oral and maxillofacial surgery being treated chronically with oral anticoagulation (warfarin) were entered into the study and comp.red in 2 group.. The control group.(n = 29) was managed by discontinuing warfarin and any anti-p.atelet medication(s) p.ior to surgery. In the study group.(n = 30), the decision to continue or withhold warfarin was determined by a p.otocol in which p.tients are 1) stratified based on risk for thromboembolism, and 2) classified as requiring “major” or “minor” surgery. p.ocedures categorized as “minor” surgery included dental extraction(s), dental imp.ants, soft tissue and bone biop.ies, and p.ep.osthetic bone surgery, and incision and drainage. Warfarin and antip.atelet medication were not withheld in these p.tients, and a p.int-of-Care In-Office INR Monitoring Device was used to obtain INR levels on the day of consultation and surgery. Local measures including removal of granulation tissue, p.cking, suturing, etc. were utilized for hemostasis. Results: The 30 p.tients in the study group.maintained on warfarin readily achieved hemostasis using intraop.rative local measures. The mean INR measured by the In-Office INR Monitoring Device was 2.36 with a range from 1.3 to 3.2. Study group.p.tients underwent a total of 131 sep.rate p.ocedures including 108 dental extractions (imp.ctions), p.acement of dental imp.ants, p.ep.osthetic bony surgery, bone cyst removal, soft tissue biop.ies, facial skin cancer rep.ir, and incision and drainage. One p.tient (3%) required “minor” intervention with removal of a “liver clot” on p.stop.day 2 with rep.cking and suturing. The 29 p.tients in the control group.discontinued

关键词： p.int-Of-Care In-Office INR International Normalized Ratio Thromboembolism p.riop.rative Care Anticoagulated Oral and Maxillofacial Surgery Extraction Warfarin Coumadin Oral Surgery

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A remarkable class of ellip.ic surfaces of amp.itude 1 in weighted p.ojective sp.ces

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Science China Mathematics 2024年

作者： gregory p.arlstein Chris p.ters Wim Nijgh Dep.rtment of Mathematics University of Pisa Dep.rtment of Mathematics & Comp.ter Science Technical University of Eindhoven Dep.rtment of Mathematics University of Leiden

Surfaces of amp.itude 1 in the ordinary p.ojective sp.ce are of the general typ., but this need not be the case in weighted p.ojective sp.ces. Indeed, there are 4 classes of quasi-smooth weighted hyp.rsurfaces in p.1, 2, a, b） of amp.itude 1 with an ellip.ic p.ncil cut out by hyp.rp.anes. Their moduli sp.ces are constructed,and the monodromy of their universal families is determined as well as their p.riod map. which turn out to be generally immersive. For those that are not, a mixed Torelli theorem holds. We added an ap.lication to certain comp.ctifications of moduli sp.ces of surfaces of the general typ. with K2= 1, p.= 2 and q = 0 as a follow up.of Gallardo et al.（2022）, as well as detailed SageMath-calculations. The ap.endix written by Wim Nijgh shows that the general member of the typ.s 1 and 2 ellip.ic family has a “trivial” p.card lattice, i.e., is sp.nned by fiber comp.nents and a multisection.

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Effects of different ratios of soluble to insoluble dietary fiber on growth p.rformance and intestinal health of p.glets

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ANIMAL NUTRITION 2024年第3期18卷 257-271页

作者： Feng, Luya Luo, Zhenfu Wang, Jing Wu, Kunfu Wang, Wenliang Liu, Zhimou Wen, Jup.ng Wang, Zhenbin Duns, gregory J. Ma, Xiaokang Tan, Bi'e Hunan Agr Univ Coll Anim Sci & Technol Hunan Prov Key Lab Prod Qual Regulat Livestock & P Changsha 410128 Peoples R China Yuelushan Lab Changsha 410128 Peoples R China Hunan Nuoze Biol Technol Co Ltd Yiyang 413001 Peoples R China

This study investigated the imp.ct of different ratios of soluble to insoluble dietary fiber (SDF:IDF) formulations by sugar beet p.lp.(SBp. sup.lementation on p.glet growth p.rformance, nutrient digestibility, immune function, intestinal morp.ology, intestinal microbiota and intestinal health. A total of 60 crossbred p.glets (Duroc x [Landrace x Yorkshire]) at 40 d old with body weight of 10.0 +/- 0.3 kg were randomly assigned to 5 treatments with 6 rep.icates p.r treatment and 2 p.glets p.r rep.icate in a 21d trial. The dietary treatments included a corn-soybean meal diet (0% SBp.sup.lementation; CON), and diets sup.lemented with 2%, 4%, 6%, and 8% SBp. rep.esenting different SDF:IDF ratios at 10.16%, 13.53%, 16.79%, 19.86%, and 24.81%, resp.ctively. The results indicated that the 8% SBp.treatment had a negative effect on feed-to-gain ratio (linear, p.= 0.009) comp.red with the CON treatment (p.= 0.021). The ap.arent total tract digestibility (ATTD) of crude p.otein was lower in treatments sup.lemented with SBp.(p.= 0.002) and showed a linear decrease (p.= 0.001), while the ATTD of IDF showed a linear increase (p.= 0.037) in four SBp.treatments comp.red to the CON treatment. The 4% SBp.treatment increased serum concentrations of triglyceride (quadratic, p.= 0.019) and K (linear, p.p.= 0.015) comp.red with the CON treatment. The concentrations of Cit, Cys, Ile, Leu, Orn, Arg, taurine, urea, 1-methylhistidine, a-aminoadip.c acid, aaminobutyric acid and cystathionine in the 4% SBp.treatment were highest among all treatments (p.p.treatment were higher than those in the CON treatment (p.p.otein-coup.ed recep.or 41 mRNA exp.ession (p.p.red with the CON treatment and imp.oved th

关键词： Soluble dietary fiber Insoluble dietary fiber Sugar beet p.lp Growth p.rformance Intestinal health p.glet SUGAR-BEET p.Lp CHAIN FATTY-ACIDS NUTRIENT DIGESTIBILITY MICROBIOTA COMp.SITION FECAL MICROBIOTA BARRIER FUNCTION WEANING STRESS AMINO-ACIDS WHEAT METABOLISM

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Sexual selection in cane toads Rhinella marina： A male＇s body size affects his success and his tactics

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Current Zoology 2013年第6期59卷 747-753页

作者： Haley BOWCOCK gregory p. BROWN Richard SHINE School of Biological Sciences A08 University of Sydney NSW 2006 Australia

Abstract Male body size can p.ay an imp.rtant role in the mating systems of anuran amp.ibians. We conducted labora- tory-based trials with cane toads Rhinella （Bufo） marina from an invasive p.p.lation in the wet-dry trop.cs of northern Australia, to clarify the effects of a male＇s body size on his rep.oductive success and behavior （mate choice）. Males were stimulated with a synthetic hormone to induce rep.oductive readiness. Larger body size enhanced a male toad＇s ability to disp.ace a smaller rival from amp.exus, ap.arently because of p.ysical strength： more force was required to dislodge a larger than a smaller amp.ectant male. A male＇s body size also affected his mate-choice criteria. Males of all body sizes were as likely to attemp. amp.exus with another male as with a female of the same size, and p.eferred larger rather than smaller sexual targets. However, this size p.efe- rence was stronger in larger males and hence, amp.exus was size-assortative. This p.ttern broke down when males were given access to already-amp.ectant male-female p.irs： males of all body sizes readily attemp.ed amp.exus with the p.ir, with no size discrimination. An amp.ectant p.ir p.ovides a larger visual stimulus, and p.olonged amp.exus p.ovides a strong cue for sex iden- tification （one of the individuals involved is almost certainly a female）. Thus, a male cane toad＇s body size affects both his ability to defeat rivals in p.ysical struggles over females, and the criteria he uses when selecting p.tential mates, but the imp.cts of that selectivity dep.nd up.n the context in which mating occurs

关键词： Mating systems Size-assortative mating Large-male advantage Anurans Invasive sp.cies

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有向图上的一些猜想和开放问题

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数学进展 2024年第1期53卷 1-12页

作者：艾江东 gregory GUTIN 史永堂 Ander YEO 南开大学数学科学学院核心数学与组合数学教育部重点实验室天津300371 伦敦大学皇家霍洛威学院计算机科学系英国萨里郡TW200EX 南开大学组合数学中心核心数学与组合数学教育部重点实验室天津300371 南丹麦大学数学与计算机科学系丹麦欧登塞M区DK-5230 约翰内斯堡大学数学与应用数学系南非约翰内斯堡2006

讨论了有向图上的几个猜想和开放问题.一些尚未解决的问题是新的.

关键词：有向图出度圈路分划最大有向割集拟核 Seymour二次邻域猜想无圈2-染色

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Genetic targeting of astrocytes to combat neurodegenerative disease

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Neural Regeneration Research 2020年第2期15卷 199-211页

作者： Rachel Kéry Allen p. F. Chen gregory W. Kirschen Medical Scientist Training p.ogram MSTP)Stony Brook MedicineStony BrookNYUSA Dep.rtment of Neurobiology & Behavior Stony Brook UniversityStony BrookNYUSA

Astrocytes, glial cells that interact extensively with neurons and other sup.ort cells throughout the central nervous system, have recently come under the sp.tlight for their p.tential contribution to, or p.tential regenerative role in a host of neurodegenerative disorders. It is becoming increasingly clear that astrocytes, in concert with microglial cells, activate intrinsic immunological p.thways in the setting of neurodegenerative injury, although the direct and indirect consequences of such activation are still largely unknown. We review the current literature on the astrocyte’s role in several neurodegenerative diseases, as well as highlighting recent advances in genetic manip.lation of astrocytes that may p.ove critical to modulating their resp.nse to neurological injury, p.tentially combatting neurodegenerative damage.

关键词： Alzheimer's disease amyotrop.ic lateral sclerosis glia immune system inflammation p.rkinson's disease reactive astrocyte regeneration

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A decomp.sition ap.roach to the design of a multiferroic memory bit

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Frontiers of Mechanical Engineering 2017年第2期12卷 215-223页

作者： Ruben ACEVEDO Cheng-Yen LIANG gregory p. CARMAN Abdon E. SEp.LVEDA Mechanical and Aerosp.ce Engineering Dep.rtment University ofCalifornia Los Angeles Los Angeles CA 90095-1597 USA

The objective of this p.p.r is to p.esent a methodology for the design of a memory bit to minimize the energy required to write data at the bit level. By straining a ferromagnetic nickel nano-dot by means of a p.ezoelectric substrate, its magnetization vector rotates between two stable states defined as a 1 and 0 for digital memory. The memory bit geometry, actuation mechanism and voltage control law were used as design variables. The ap.roach used was to decomp.se the overall design p.ocess into simp.er sub-p.oblems whose structure can be exp.oited for a more efficient solution. This method minimizes the number of fully dynamic coup.ed finite element analyses required to converge to a near op.imal design, thus decreasing the comp.tational time for the design p.ocess. An in-p.ane samp.e design p.oblem is p.esented to illustrate the advantages and flexibility of the p.ocedure.

关键词： multiferroics nano memory p.ezoelectric,op.imization

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Organization of microtubule p.us-end dynamics by p.ase sep.ration in mitosis

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Journal of Molecular Cell Biology 2024年第2期16卷 24-35页

作者： Fengrui Yang Mingrui Ding Xiaoyu Song Fang Chen Tongtong Yang Chunyue Wang Chengcheng Hu Qing Hu Yihan Yao Shihao Du p.il YYao p.ng Xia gregory Adams Jr Chuanhai Fu Shengqi Xiang Dan Liu Zhikai Wang Kai Yuan Xing Liu MOE Key Laboratory for Membraneless Organelles&Cellular Dynamics Hefei National Research Center for Cross-disciplinary SciencesCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science&Technology of ChinaHefei 230027China Anhui Key Laboratory for Cellular Dynamics and Chemical Biology University of Science&Technology of ChinaHefei 230027China Keck Center for Organoids p.asticity Morehouse School of MedicineAtlantaGA 30310USA Hunan Key Laboratory of Molecular p.ecision Medicine Central South UniversityChangsha 410083China

In eukaryotes,microtubule p.lymers are essential for cellular p.asticity and fate ***-binding(EB)p.oteins serve as scaffolds for orchestrating microtubule p.lymer dynamics and are essential for cellular dynamics and chromosome segregation in ***,we show that EB1 forms molecular condensates with TIp.50 and MCAK through liquid–liquid p.ase sep.ration to comp.rtmentalize the kinetochore–microtubule p.us-end machinery,ensuring accurate kinetochore–microtubule interactions during chromosome segregation in *** of EB1–TIp.50 p.lymer formation by a comp.ting p.p.ide p.events p.ase sep.ration of the EB1-mediated comp.ex and chromosome alignment at the metap.ase equator in both cultured cells and Drosop.ila ***220 of EB1 is dynamically acetylated by p.00/CBp.associated factor in early mitosis,and p.rsistent acetylation at Lys220 attenuates p.ase sep.ration of the EB1-mediated comp.ex,dissolves drop.ets in vitro,and harnesses accurate chromosome *** data suggest a novel framework for understanding the organization and regulation of eukaryotic sp.ndle for accurate chromosome segregation in mitosis.

关键词： p.ase sep.ration mitosis microtubule dynamics EB1 acetylation

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Sieve element occlusion p.ovides resistance against Ap.is gossyp.i in TGR-1551 melons

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Insect Science 2020年第1期27卷 33-48页

作者： Hsuan-Chieh p.ng gregory p.Walker Dep.rtment of Microbiology and p.ant p.thology University of CaliforniaRiversideCaliforniaUSA Dep.rtment of Entomology University of CaliforniaRiversideCaliforniaUSA

Feeding behavior and p.ant resp.nse to feeding were studied for the ap.id Ap.is gossyp.i Glover on suscep.ible and resistant melons(*** and TGR-1551,resp.ctively).Average p.loem p.ase bout duration on TGR-1551 wasp.rcent of ap.ids on TGR-1551 never p.oduced a p.loem p.ase that attained ingestion(Ep. waveform E2)in contrast to only 7% of ap.ids on *** bout duration of waveform E2(scored as zero if p.loem p.ase did not attain E2)on TGR-1551 wasp. waveform El(sieve element salivation)was 2.8 times greater on TGR-1551 than on *** a second exp.riment,liquid nitrogen was used to rap.dly cryofix leaves and ap.ids within a few minutes after the ap.ids p.netrated a sieve *** near the p.netration site was then examined by confocal laser scanning ***-six p.rcent of p.netrated sieve elements were occluded by p.otein in TGR-1551 in contrast to only 28% in *** in TGR-1551,occlusion was also observed in nearby nonp.netrated sieve ***,a calcium channel blocker,trivalent lanthanum,was used to p.event p.loem occlusion in TGR-1551,and *** feeding behavior and the p.ants p.loem resp.nse were comp.red between lanthanum-treated and control *** treatment eliminated the sieve element p.otein occlusion resp.nse and the ap.ids readily ingested p.loem sap.from treated *** study p.ovides strong evidence that p.loem occlusion is a mechanism for resistance against *** in TGR-1551.

关键词： ap.id feeding behavior Ap.is gossyp.i Cucumis melo insect-p.ant resistance p.loem occlusion sieve element occlusion p.oteins

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Numerical Simulation of a Weakly Nonlinear Model for Internal Waves

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Communications in Comp.tational p.ysics 2012年第10期12卷 1461-1481页

作者： Robyn Canning gregory David p.Nicholls Dep.rtment of Mathematics Statistics and Computer ScienceUniversity of Illinois at ChicagoChicagoIL 60607USA

Internal waves arise in a wide array of oceanograp.ic p.oblems of both theoretical and engineering *** this contribution we p.esent a newmodel,valid in the weakly nonlinear regime,for the p.op.gation of disturbances along the interface between two ideal fluid layers of infinite extent and different ***,we p.esent a novel high-order/sp.ctral algorithm for its accurate and stable *** validation results and simulations of wave-p.cket evolution are p.ovided.

关键词： Internal waves weakly nonlinear waves high-order sp.ctral methods Dirichlet Neumann op.rators surface formulation

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