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A Rare Case of Thymic Carcinoma

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Surgical Science 2011年第3期2卷 144-146页

作者： Farshad Anvari Arnold m. Schwartz gregory Trachiotis 不详

Thymic carcinomas are unusual tumors of the thymus gland. Basaloid carcinoma, an unusal epithelioid varient of a thymic carcinoma, is a rare histopathological subtype, and is not well charecterized in the literature. We present the anatomical and histogical features of a basoloid thymic carcinoma, and discuss current diagnosis and imaging strategies, as well as the operative and oncologic care of this type of thymmic carcinoma. Basaloid carcinomas of the thymus after complete surgical resection and adjuvant therapy genarally have a favorable long-term prognosis.

关键词： Thymus Thymic Carcinoma

Nanoparticle-mediated Genetic Engineering of Plants

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molecular Plant 2019年第8期12卷 1037-1040页

作者： Jeffrey W.Wang Eduardo G.Grand io gregory m.Newkirk Gozde S.Demirer Salwan Butrus Juan Pablo Giraldo markita P.Landry Department of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyCA 94720USA Department of Chemical Engineering University of MichiganAnn ArborMI 48103USA Department of Botany and Plant Sciences University of CaliforniaRiversideCA 92521USA Institute of Integrative Genome Biology (IIGB) RiversideCA 92521USA Innovative Genomics Institute (IGI) BerkeleyCA 94720USA California Institute for Quantitative Biosciences QB3University of CaliforniaBerkeleyCA 94720USA Chan-Zuckerberg Biohub San FranciscoCA 94158USA

Genetic engineering of plants is at the core of sustainability efforts,natural product synthesis,and agricultural crop *** past several decades have brought remarkable progress in biotechnology with the improvement of genome editing and sequencing tools,which stand to advance plant synthetic biology and *** agriculture,genetic engineering can be employed to create crops that have in creased yields and nu tritio nal value,are resista nt to herbicides,in sects,diseases,and abiotic stresses,in cludi ng drought and heat .In pharmaceuticals and therapeutics,genetically engineered plants can be used to synthesize valuable small-molecule drugs and recombinant proteins.

关键词： Nanoparticle-mediated Genetic Engineering Plants biotechnology

Investigating the Effects of Para-methoxy Substitution in Sterically Enhanced Unsymmetrical Bis(arylimino)pyridine-cobalt Ethylene Polymerization Catalysts

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Chinese Journal of Polymer Science 2022年第3期40卷 266-279,I0007页

作者： Yi Yan Shi-Fang Yuan ming Liu gregory A.Solan Yan-Ping ma Tong-Ling Liang Wen-Hua Sun Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China Key Laboratory of Engineering Plastics and Beijing National Laboratory for molecular Sciences Institute of Chemistry Chinese Academy of SciencesBeijing 100190China Department of Chemistry University of LeicesterUniversity RoadLeicester LE17RHUK State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

A group of five bis(arylimino)pyridine-cobalt(Ⅱ)chloride complexes,[2-{(2,6-(Ph_(2)CH)_(2)-4-meOC_(6)H_(2))N=Cme}-6-(ArN=Cme)C_5 H_(3)N]CoCl_(2)(Ar=2,6-me_(2)C_(6)H_(3)Co1,2,6-Et_(2)C_(6)H_(3)Co2,2,6-iPr_(2)C_(6)H_(3)Co3,2,4,6-me_(3)C_(6)H_(2)Co4,2,6-Et_(2)-4-meC_(6)H_(2)Co5),each containing one N-4-methoxy-2,6-dibenzhydrylphenyl group and one smaller sterically/electronically variable N-aryl group,have been synthesized in good yield(>71%)from the corresponding neutral terdentate nitrogen-donor precursor,*** complexes have been characterized by^(1)H-NmR and FTIR spectroscopy with the former highlighting the paramagnetic nature of these cobaltous species and the unsymmetrical nature of the chelating *** molecular structures of Co3 and Co4 emphasize the steric differences of the two inequivalent N-aryl groups and the distorted square pyramidal geometry about the metal *** the presence of mAO or mmAO,Co1-Co5 collectively displayed high activities for ethylene polymerization producing high molecular weight polyethylenes that,in general,exhibited narrow dispersities(m_w/m_n values:2.12-4.07).Notably,the least sterically hindered Co1 when activated with mAO was the most productive(6.92×10^(6)g_(PE)·mol^(-1)_((Co))·h^(-1))at an operating temperature of60℃.Conversely,the most sterically hindered Co3/mmAO produced the highest molecular weight polyethylene(m_w=6.29×10^(5)g·mol^(-1)).All the polymers displayed high linearity as demonstrated by their melting temperatures(>130℃)and their~1 H-and^(13)C-NmR *** comparison of Co1 with its para-methyl,-chloro and-nitro counterparts,the presence of the para-methoxy substituent showed the most noticeable effect of enhancing the thermal stability of the catalyst.

关键词： Cobalt(II)precatalyst Ethylene polymerization High molecular weight polyethylene Electronic effects Thermal stability

Integrins and their potential roles in mammalian pregnancy

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Journal of Animal Science and Biotechnology 2024年第1期15卷 1-19页

作者： gregory A.Johnson Robert C.Burghardt Fuller W.Bazer Heewon Seo Joe W.Cain Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(ECm) interactions leading to assembly of integrin adhesion complexes(IACs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnancy Rodents Sheep

Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep

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Journal of Animal Science and Biotechnology 2018年第2期9卷 306-318页

作者： Yasser Y.Lenis gregory A.Johnson Xiaoqiu Wang Wendy W.Tang Kathrin A.Dunlap m.Carey Satterfield Guoyao Wu Thomas R.Hansen Fuller W.Bazer Department of Animal Science Texas A&M UniversityCollege StationTX 77843-2471USA Center for Animal Biotechnology and Genomics Texas A&M UniversityCollege StationTX 77843USA Centauro Research Group School of Veterinary MedicineFaculty of Agrarian ScienceUniversidad de AntioquiaCalle 70 No52-21 MedellínColombia Faculty of Agricultural Sciences Calle 222 No.55-37UDCABogotaColombia Present address:National Institute of Environmental Health Sciences Research Triangle ParkNC 27709USA Animal Reproduction and Biotechnology Laboratory Department of Biomedical SciencesCollege of Veterinary Medicine and Biomedical SciencesColorado State UniversityFort CollinsCO 80523USA

Background: Polyamines stimulate DNA transcription and m RNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and survival of conceptuses(embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine(Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase(ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine. In the non-classical pathway, Arg is converted to agmatine(Agm) by arginine decarboxylase(ADC), and Agm is converted to putrescine by agmatinase(AGmAT).methods: morpholino antisense oligonucleotides(mAOs) were designed and synthesized to inhibit translational initiation of the m RNAs for ODC1 and ADC, in ovine ***: The morphologies of mAO control, mAO-ODC1, and mAO-ADC conceptuses were normal. Double knockdown of ODC1 and ADC(mAO-ODC1:ADC) resulted in two phenotypes of conceptuses; 33% of conceptuses appeared to be morphological y and functional y normal(phenotype a) and 67% of the conceptuses presented an abnormal morphology and functionality(phenotype b). Furthermore, mAO-ODC1:ADC(a) conceptuses had greater tissue concentrations of Agm,putrescine, and spermidine than mAO control conceptuses, while mAO-ODC1:ADC(b) conceptuses only had greater tissue concentrations of Agm. Uterine flushes from ewes with mAO-ODC1:ADC(a) had greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with mAO-ODC1:ADC(b) conceptuses had lower amount of putrescine, spermidine, spermine, alanine, aspartate,glutamine, tyrosine, phenylalanine, isoleucine, leucine, and ***: The double-knockdown of translation of ODC1 and ADC m RNAs was most detrimental to conceptus development and their production of int

关键词： Agmatine Arginine Interferon tau Polyamines Trophectoderm cells

A green synthesis of carbon nanoparticles from honey and their use in real-time photoacoustic imaging

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Nano Research 2013年第5期6卷 312-325页

作者： Lina Wu Xin Cai Kate Nelson Wenxin Xing Jun Xia Ruiying Zhang Allen J. Stacy micah Luderer gregory m. Lanza Lihong V. Wang Baozhong Shen Dipanjan Pan C-TRAIN and Division of Cardiology Washington University School of Medicine 4320 Forest Park Avenue Saint Louis MO 63108 USA Key Laboratory of molecular Imaging in College of Heilongjiang Province Department of Radiology the 4th Affiliated Hospital of Harbin Medical University Harbin 1S0001 China Optical Imaging Laboratory Department of Biomedical Engineering Washington University in St. Louis Campus Box 1097 One Brookings Drive St. Louis MO 63130 USA Nano Research Facility (NNIN-NSF) Washington University in St. Louis St. Louis MO 63130 USA

Imaging sentinel lymph nodes （SLN） could provide us with critical information about the progression of a cancerous disease. Real-time high-resolution intrao- perative photoacoustic imaging （PAI） in conjunction with a near-infrared （NIR） probe may offer opportunities for the immediate imaging for direct identification and resection of SLN or collecting tissue samples. In this work a commercially amenable synthetic methodology is revealed for fabricating luminescent carbon nanoparticles with rapid clearance properties. A one-pot ＂green＂ technique is pursued, which involved rapid surface passivation of carbon nanopartides with organic macromolecules （e.g., polysorbate, polyethyleneglycol） in solvent-free conditions. Interestingly, the naked carbon nanoparticles are derived for the first time, from commercial food grade honey. Surface coated particles are markedly smaller （-7 nm） than previously explored particles （gold, single-walled carbon nanotubes, copper） for SLN imaging. The results indicate an exceptionally rapid signal enhancement （-2 min） of the SLN. Owing to their strong optical absorption in the NIR region, tiny size and rapid lymphatic transport, this platform offers great potential for faster resection of SLN and may lower complications caused in axillary investigation by mismarking with dyes or low-resolution imaging techniques.

关键词： carbon nanoparticle honey,contrast agents photoacoustictomography real-time imaging

Use of prostate-specific antigen testing in medicare beneficiaries:Association with previous evaluation

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Family medicine and Community Health 2017年第2期5卷 109-118页

作者： gregory S.Cooper Tzuyung Doug Kou mark D.Schluchter Avi Dor Siran m.Koroukian Simon P.Kim Division of Gastroenterology University Hospitals Cleveland Medical Center11100 Euclid Ave.ClevelandOH 44106USA Department of Urology University Hospitals Cleveland Medical Center11100 Euclid Ave.ClevelandOH 44106USA Case Comprehensive Cancer Center Wearn BuildingCase Western Reserve University11100 Euclid Ave.ClevelandOH 44106USA Department of Epidemiology and Biostatistics School of MedicineWood BuildingCase Western Reserve University10900 Euclid Ave.ClevelandOH 44106USA Department of Health Policy and management Milken Institute School of Public HealthGeorge Washington University950 New Hampshire Ave.NWWashingtonDC 20052USA

Objective:Determine uptake of prostate-specific antigen(PSA)testing in medicare benefi-ciaries according to previous receipt of PSA ***:A 5%random sample of men aged 67 years or older without a previous diagnosis of prostate cancer was identified through 2009-2012 medicare *** measured the annualized frequency of PSA screening among men due for PSA testing,stratified by PSA testing use in the previous 2 years,and clustered by ordering ***:Throughout the study period,PSA testing use was consistently higher for men with previous screening than for men without previous *** men without previous screening,there was a decline in testing that was most pronounced in *** with 2009,the cor-responding odds ratios were 0.98[95%confidence interval(CI)(0.96-1.00)]in 2010,0.94[95%CI(0.92-0.95)]in 2011,and 0.66[95%CI(0.65-0.68)]in *** contrast,for men with previous screening,PSA testing frequency was stable from 2009 to 2011,and declined to a lesser extent in 2012[odds ratio 0.80,95%CI(0.79-0.81)].Conclusion:Receipt of PSA testing is highly dependent on whether an individual was tested in the recent *** previously unscreened men,the largest decrease occurred in 2012,which may reflect in part the publication of US Preventive Services Task Force guidelines,but there was much less impact among men already being screened.

关键词： Prostate-specific antigen medicare mass screening clinical practice patterns

Symptomatic Scaphotrapeziotrapezoid Carpal Coalition: The Natural History and a Surgical Option for Treatment

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Open Journal of Orthopedics 2017年第5期7卷 127-139页

作者： m. Sajjad Athar George Aerialis Neil Ashwood gregory Bain Carpal Coalition Hand Symptomatic STT Coalition Capsular Interposition

Carpal coalitions are uncommon and are frequently asymptomatic. 15 Patients with persistent symptomatic scaphotrapeziotrapezoid (STT) carpal coalitions unresponsive to six months of conservative treatment with no history of trauma went for further investigations. CT scans and bone scans revealed that coalition was the only abnormality to account for the patient’s ongoing problems. The senior authors explored the carpal coalition surgically excising the affected region and interposing capsular fibrous tissue. Histologically partial bony and cartilaginous bridging was evident with no features of degenerative arthritis being noted. Good or excellent subjective results were achieved in all patients at final review an average of 2.7 (1.0 - 4.2) years after surgery. All patients described significant reduction in visual analogue pain scores from an average of 71.5 to 18.4 points. The Green and O’Brien wrist scores improved from a mean of 58.2 to 94.2, with all patients returning to work with improved function. Normally carpal coalition is treated with arthrodesis or excision of part of the carpus. A further treatment option is outlined here with recreation of the joint space in symptomatic, isolated, nonsyndromic scaphotrapezio-trapezoidal coalition.

关键词： Carpal Coalition Hand Symptomatic STT Coalition Capsular Interposition

Cardiac implications of thrombotic thrombocytopenic purpura

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World Journal of Cardiology 2018年第12期10卷 254-266页

作者： Szymon L Wiernek Bo Jiang gregory m Gustafson Xuming Dai Division of Cardiology McAllister Heart Institute University of North Carolina at Chapel Hill Division of Cardiology Lang Research Center New York Presbyterian Medical Group–Queens Hospital

Thrombotic thrombocytopenic purpura(TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on plateletmediated micro-thrombi formation, leading to microvascular *** studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, mI and sudden cardiac death. There is limited knowledge about optimal cardiac evaluation and management in patients with TTP. The absence of typical cardiac symptoms,combined with complicated multi-organ involvement in TTP, may contribute to the under-utilization of cardiac evaluation and treatment. Prompt diagnosis and timely initiation of effective therapy could be critically important in selected cases. Based on our experience and this review of the literature, we developed several recommendations for focused cardiac evaluation for patients with acute TTP:(1) patients with suspected or confirmed TTP should be screened for the potential presence of cardiac involvement with detailed history and physical,electrocardiogram and cardiac enzymes;(2) clinical deterioration of TTP patients warrants immediate cardiac reevaluation;(3) TTP patients with clinical evidence of cardiac involvement should be monitored for telemetry, cardiac biomarkers and evaluated with transthoracic echocardiography. These patients require urgent targeted TTP treatment as well as cardiac-specific treatment. Aspirin therapy is indicated for all TTP patients. Since epicardial coronary artery involvement is rare, cardiac catheterization is usually not required, given the high risk for hemorrhage and kidney injury;(4) we recommend evidence-based medical therapy for ischemic symptoms and heart failure. TTP patients with evidence of cardiac invol

关键词： Thrombotic thrombocytopenic purpura Acute myocardial infarction Coronary artery disease Anti-platelet therapy von Willebrand factor ADAmTS13