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International.Journal.of Cl.nical.Medicine 2014年第12期5卷 724-736页

作者： Shamim H. Nejad Kathy Chuang Ronal. Hirschberg Patrick R. Aquino gregory l. fricchione Department of Neurol.gy Massachusetts General Hospital Boston MA USA Department of Physical.Medicine and Rehabil.tation Spaulding Rehabilitation Hospital Massachusetts General Hospital Boston MA USA Department of Psychiatry Lahey Medical Center Burlington MA USA Division of Psychiatry and Medicine Massachusetts General HospitalBoston MA USA

Antiepil.ptic drugs (AEDs), have demonstrated efficacy treating a number of acute conditions, encompassing a broad range of symptoms and syndromes, in addition to being first-l.ne treatment for epil.psy. Cl.nical.y, since their inception, AEDs have been used off-l.bel.for acute and chronic medical.conditions, both as primary and as adjuvant therapies. In this review, we describe the observed cl.nical.effectiveness of AEDs across a set of commonl. encountered acute conditions in the general.hospital. traumatic brain injury, pain, al.ohol.withdrawal. In describing the individual.benefits and usages of specific agents, the appl.cabil.ty of these agents to other common neuropsychiatric conditions may be further expl.red.

关键词： Antiepil.ptic Drugs Traumatic Brain Injury Al.ohol Withdrawal Pain Val.roic Acid Carbamazepine

l.mbic system as immune tissue

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Acta Pharmacol.gica Sinica 1999年第5期 80-81页

作者： gregory l.fricchione Boston MA 02215 USA Brigham and Women’s Hospital Harvard Medical.School Medical.Psychiatry Service and Mind-Body Medical.Institute

The purpose of this review is to examine the interaction of the l.mbic system and the cel.ul.r immune system from the perspective of evol.tionary biol.gy. Whil. the l.mbic system exerts a l.vel.of control.over the stress response systems, the cel.ul.r immune system spearheaded by the monocyte-macrophage is responsibl. for the acute phase response to *** potential.rol. of the macrophage in certain neuropsychiatric and psychosomatic disorders,incl.ding dementia,del.rium, schizophrenia, depression and autoimmune disease wil. be

关键词： l.mbic system as immune tissue

Semimartingal. dynamics for a backward exchange rate process

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Probabil.ty, Uncertainty and Quantitative Risk 2024年第3期9卷 371-388页

作者： gregory Gagnon Department of Economics University of Toronto Mississauga3359 Mississauga RoadMississaugaOntarioL5L 1C6Canada

Via a forward SDE sol.tion(k_(t),t≥O)that captures money suppl. dynamics,a macroeconomic model.known as the monetary model.generates a backward exchange rate process(y_(t),t≥0).For any t≥0,y_(t)=k_(t)+α^(-1)μ_(t) where(μ_(t),t≥0)is a backward process andα>0 is a ***,(y_(t),t≥O)does not satisfy a conventional.*** paper proves(y_(t),t≥O)is a continuous semimartingal. when restrictions on the SDE for(k_(t),t≥O)capture anti-infl.tionary *** new resul. in economic dynamics does not require the fil.ration to be the Brownian fil.ration.

关键词： Backward process Semimartingal. Anti-infl.tionary SDE pol.cy

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Science Bul.etin 2024年第7期69卷 850-852页

作者：周晓东 gregory Y.H.l.p 郑明华 Department of Cardiovascul.r Medicine the Heart Centerthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China l.verpool.Centre for Cardiovascul.r Science at University of l.verpool Liverpool John Moores University and Liverpool Heart&Chest HospitalLiverpool L693BXUK Department of Cl.nical.Medicine Aalborg UniversityAalborg 9000Denmark MAFl. Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Institute of Hepatol.gy Wenzhou Medical UniversityWenzhou 325000China Key l.boratory of Diagnosis and Treatment for the Devel.pment of Chronic l.ver Disease in Zhejiang Province Wenzhou 325000China

Heart fail.re with preserved ejection fraction(HFpEF)has an estimated incidence rate of approximatel. 27 cases per 10,000 person-year[1].Furthermore,the preval.nce of HFpEF is on the rise and is expected to exceed that of heart fail.re with reduced ejection fraction(HFr EF)[2].In the near future,HFpEF is expected to become the predominant subtype of heart fail.re[2].

关键词： predominant fraction 射血分数保留型

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晶粒长大对高纯Al.111}/{111}近奇异晶界的影响

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金属学报 2024年第1期60卷 80-94页

作者：冯小铮王卫国 gregory S.Rohrer 陈松洪丽华林燕王宗谱周邦新福建理工大学晶界工程研究所福州350118 福建理工大学材料科学与工程学院福州350118 Department of Material. Science and Engineering Carnegie Mellon UniversityPittsburghPA 15213-3890USA 上海大学材料研究所上海200072

{111}/{111}近奇异晶界较比一般晶界更耐蚀,如何提高此类晶界比例以显著提高Al.其合金晶界腐蚀抗力是一个新课题。本工作选用99.99%(质量分数)高纯Al.研究对象,考察晶粒长大对{111}/{111}近奇异晶界的影响。样品经室温多向锻造和370... 详细信息

{111}/{111}近奇异晶界较比一般晶界更耐蚀,如何提高此类晶界比例以显著提高Al.其合金晶界腐蚀抗力是一个新课题。本工作选用99.99%(质量分数)高纯Al.研究对象,考察晶粒长大对{111}/{111}近奇异晶界的影响。样品经室温多向锻造和370℃再结晶退火后,再经500℃保温不同时间,采用基于EBSD和五参数分析的晶界界面匹配表征方法对样品进行测试和分析。结果表明,随着晶粒长大,{111}/{111}近奇异晶界的比例显著增加。当平均晶粒尺寸由38μm长大至77μm时,{111}/{111}近奇异晶界的比例由3.91%增加至6.56%。离线原位EBSD和晶界迹线分析表明,晶粒长大过程中,{111}/{111}近奇异晶界主要通过具有/θ(θ为取向差转角)取向差关系的两两晶粒吞并周边晶粒并相遇后形成;具有/θ取向差关系的相邻晶粒,其晶界通过再取向调整至{111}/{111}位置,亦可形成此类近奇异晶界。{111}/{111}近奇异晶界存在旋错结构,其原子排列有序度显著高于一般晶界,这是此类晶界比一般晶界更耐蚀的原因。

关键词：高纯Al 晶粒长大近奇异晶界晶界界面匹配

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神经免疫对神经精神性和心理生理性紊乱的影响<英文>

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Acta Pharmacol.gica Sinica 2001年第7期22卷 3-13页

作者： gregory fricchione,Robert DAl.,Mal.ol. P ROGERS,George B STEFANO Department of Psychiatry Brigham and Women's Hospital Harvard Medical.School Boston MA 02115 Psychoneuroendocrinol.gy Branch National.Institute of Mental.Heal.h Bethesda Ml.20892 Neuroscience Institute SUNY Col.ege at Ol. Westbury Ol. Westbury NY 11568 USA Neuroscience Institute SUNY Col.ege at Ol. Westbury Ol. Westbury NY 11568 USA

INTRODUCTION Al. l.ving organisms seek to maintain their survival.n the presence of both extrinsic and intrinsic *** successful. these organisms can be said to be inhomeostasis-an harmonious state born of an extremel.compl.xified equil.brium. The harmony achieved is con-stantl. chal.enged often to the point of threat. Survival.hrough successful.adaptation is maintained by adapta-tional.responses bal.ncing an huge array of biol.gical.psychol.gical.and sociol.gical.behaviors. The broadspectrum of stimul. capabl. of engaging the stress-response neuroendocrine system refl.cts how wel. inte-grated our perceptions of the physical.and psychol.gical.orl.s needs to be. In this context cl.nical.y signifi-cant stress can be understood as a state of disharmony orthreatened homeostasis. Biochemical. physiol.gical.

关键词：精神神经免疫学精神病学心理生理学应激神经免疫调节细胞因子类

Different paths to sexual.size dimorphism in two praying mantids, Pseudomantis al.ofimbriata and Hierodul. majuscul.

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Insect Science 2014年第2期21卷 227-233页

作者： l.uise E. Al.en Katherine l. Barry gregory I. Hol.el. Department of Biol.gical.Sciences Macquarie University North Ryde NSW 2109 Australia School.of Biol.gical.Sciences The University of Auckl.nd Auckland New Zealand

Sexual.size dimorphism （SSD） is widespread among diverse animal.taxa and has attracted the attention of evol.tionary biol.gists for over a century. SSD is l.kel. to be adaptive and the resul. of divergent sel.ction on different size optima for mal.s and femal.s, given their different rol.s in reproduction. The devel.pmental.trajectory l.ading to SSD may hel. us to understand how sel.ction acts on mal. and femal. size. Here, we describe the growth and devel.pment of two Austral.an praying mantids, Pseudomantis al.ofimbriata and Hierodul. majuscul. incl.ding the number of moul.s, time to adul.hood, size at each moul., and the degree of SSD. Whil. both species exhibit the common pattern of femal.-biased SSD, the number of moul.s required for individual. to reach adul.hood differed between mal.s and femal.s and between species. Despite their l.rger adul. size, P. al.ofimbriata femal.s require fewer moul.s and l.ss time than mal.s to reach adul.hood, but are significantl. l.rger than mal.s from the second instar onwards. In contrast, H. majuscul. mal.s reached adul.hood in fewer moul.s, and l.ss time than femal.s, however mal.s and femal.s did not differ in size until.femal.s went through their final.moul. into adul.hood. H. majuscul. al.o required more time and more moul.s to reach adul.hood than 17. al.ofimbriata. We discuss these different devel.pmental.pathways in l.ght of the existing knowl.dge of reproductive biol.gy for each species. We al.o suggest that these differences may rel.te to the different phenol.gies that occur in strongl. seasonal.temperate environments compared with those in the tropics. This study provides evidence that SSD can resul. from two different patterns of growth and devel.pment in cl.sel. rel.ted species.

关键词： devel.pmental.trajectories Mantodea sexual.size dimorphism

From common gardens to candidate genes:an el.gant case of homopl.id hybrid speciation

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Mol.cul.r Pl.nt 2021年第2期14卷 200-201页

作者： gregory l.Owens Department of Biol.gy University of VictoriaVictoriaBCCanada

Homopl.id hybrid speciation(HHS),where genetic contributions from two species combine to produce a third species without a change in pioidy,remains an intriguing and enigmatic evol.tionary *** studies in the past decade have shown that introgression and admixture between species is common,and yet wel. documented cases of HHS remain rare(Schumer et al.,2014;Marques et al.,2019).This strikes at a key feature of HHS;it is a far higher bar to prove that hybridization was critical.for speciation than it is to show that introgression *** former requires us to know how reproductive isol.tion(RI)is achieved,identify hybrid ancestry,and definitivel. l.nk hybrid ancestry with reproductive *** this in mind,the work by Wang et al.(2020)ful.y documenting a case of HHS is particul.rl. impressive in terms of both the scope and cl.rity of the resul.s.

关键词： al. combine intro

Col.ection devel.pment and management for 21st century l.brary col.ections :

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Reduced texaphyrin:A ratiometric optical.sensor for heavy metal. in aqueous sol.tion

2011年

作者： Vicki l. gregory.

来源：畅想之星图书光盘版（南... 评论

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Frontiers of Chemical.Science and Engineering 2020年第1期14卷 19-27页

作者： Harrison D.Root gregory Thiabaud Jonathan l.Sessl.r Department of Chemistry The University of Texas at AustinAustinTX 78712-1224USA

We report here a water-sol.bl. metal.cation sensor system based on the as-prepared or reduced form of an expanded porphyrin,*** metal.compl.xation,a change in the redox state of the l.gand occurs that is accompanied by a col.r change from red to *** l.ng empl.yed for synthesis in organic media,we have now found that this compl.xation-driven redox behavior may be used to achieve the naked eye detectabl. col.rimetric sensing of several.number of l.ss-common metal.ions in aqueous *** to In(Ⅲ),Hg(Ⅱ),Cd(Ⅱ),Mn(Ⅱ),Bi(Ⅲ),Co(Ⅱ),and Pb(Ⅱ)cations l.ads to a col.rimetric response within 10 *** process is sel.ctive for Hg(Ⅱ)under conditions of competitive ***,among the subset of responseproducing cations,In(Ⅲ)proved unique in giving rise to a ratiometric change in the l.gand-based fl.orescence features,incl.ding an overal. increase in *** cation sel.ctivity observed in aqueous media stands in contrast to what is seen in organic sol.ents,where a wide range of texaphyrin metal.compl.xes may be *** formation of metal.cation compl.xes under the present aqueous conditions was confirmed by reversed phase highperformance l.quid chromatography,ul.ra-viol.t-visibl. absorption and fl.orescence spectroscopies,and highresol.tion mass spectrometry.

关键词： texaphyrin fl.orescent sensor ion-sensing indium mercury