检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

一氧化氮合酶在实验性动脉瘤中的表达及作用

中国临床神经外科杂志 2006年第12期11卷 743-745页

作者：李立杨新健 gregory j dusting 刘爱华吴中学蒋凡首都医科大学北京市神经外科研究所神经介入科北京100050 Bernard O'Brien Institute of Microsurgery(Melbourne Australia)

目的探讨一氧化氮合酶(NOS)在实验性动脉瘤中的表达及其作用。方法在13只家兔上成功复制了动脉瘤,并以正常的兔颈总动脉作为对照。用生物化学方法检测了动脉瘤组织和对照组中总一氧化氮合酶(T-NOS)和诱导型一氧化氮合酶(i-NOS)的活性,... 详细信息

目的探讨一氧化氮合酶(NOS)在实验性动脉瘤中的表达及其作用。方法在13只家兔上成功复制了动脉瘤,并以正常的兔颈总动脉作为对照。用生物化学方法检测了动脉瘤组织和对照组中总一氧化氮合酶(T-NOS)和诱导型一氧化氮合酶(i-NOS)的活性,并以免疫组化的方法对i-NOS在血管壁中的表达进行了观察定位。结果动脉瘤组织与正常血管相比,T-NOS的活性无显著性差异(P>0.05),但i-NOS显著增加(P<0.01),且i-NOS与T-NOS的比例亦显著升高(P<0.01)。动脉瘤瘤壁肌层结构明显紊乱,可见炎症细胞浸润,细胞外基质明显破坏或消失。动脉瘤组织内i-NOS的表达呈局灶性分布在血管壁,主要集中在炎症细胞浸润的区域。结论提示主要由炎症细胞产生的i-NOS在动脉瘤发生发展的病理过程中可能起重要作用。

关键词：动脉瘤一氧化氮合酶一氧化氮兔

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Global weirding at mass extinction horizons

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第1期11卷 10-12页

作者： gregory j.Retallack Department of Earth Sciences University of Oregon

A strong motivation for studying mass extinctions is understanding how current climatic and biodiversity crises will affect creatures living on land such as ourselves. Perhaps the question is: how bad can it get? In that case, terrestrial Permian-Triassic mass extinctions are an irresistible worst-case scenario [1].

关键词：

The Emeishan large igneous province:A synthesis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2014年第3期5卷 369-394页

作者： j.gregory Shellnutt National Taiwan Normal University Department of Earth Science

The late Permian Emeishan large igneous province （EL1P） covers -0.3× 10-6 kmL of the western margin of the Yangtze Block and Tibetan Plateau with displaced, correlative units in northern Vietnam （Song Da zone）. The ELIP is of particular interest because it contains numerous world-class base metal deposits and is contemporaneous with the late Capitanian （-260 Ma） mass extinction. The flood basalts are the signature feature of the ELIP but there are also ultramafic and silicic volcanic rocks and layered mafic- ultramafic and silicic plutonic rocks exposed. The EL1P is divided into three nearly concentric zones （i.e. inner, middle and outer） which correspond to progressively thicker crust from the inner to the outer zone. The eruptive age of the ELIP is constrained by geological, paleomagnetic and geochronological evidence to an interval of 〈3 Ma. The presence of picritic rocks and thick piles of flood basalts testifies to high temperature thermal regime however there is uncertainty as to whether these magmas were derived from the subcontinental lithospheric mantle or sub-lithospheric mantle （i.e. asthenosphere or mantle plume） sources or both. The range of Sr （Isr ≈ 0.7040-0.7132）, Nd （ENd（t） ≈ -14 tO ＋8）, Pb （206-pb/204-pb1 ≈ 17.9-20.6） and Os （Yos ≈ -5 to ＋11） isotope values of the ultramafic and mafic rocks does not permit a conclusive answer to ultimate source origin of the primitive rocks but it is clear that some rocks were affected by crustal contamination and the presence of near-depleted isotope compo- sitions suggests that there is a sub-lithospheric mantle component in the system. The silicic rocks are derived by basaltic magmas/rocks through fractional crystallization or partial melting, crustal melting or by interactions between mafic and crustal melts. The formation of the Fe-Ti-V oxide-ore deposits is probably due to a combination of fractional crystallization of Ti-rich basalt and fluxing of C02-rich fluids whereas the Ni-Cu-（PGE） deposits are related

关键词： Late Permian Mantle plume Large igneous province Flood basalts Mineral deposits Uplift and doming

Potential of the neonicotinoid imidacloprid and the oxadiazine indoxacarb for controlling five coleopteran pests of stored grain

在线全文

学校读者我要写书评

暂无评论

Insect Science 2012年第1期19卷 96-101页

作者： gregory j. Daglish Manoj K. Nayak Agri-Science Queensland Department of Employment Economic Development and Innovation Brisbane Queensland Australia

The potential for using imidacloprid （a neonicotinoid） and indoxacarb （an oxadiazine） as grain protectants was investigated in bioassays against resistant strains of five stored grain beetles. The species investigated were Rhyzopertha dominica （E）（the lesser grain borer）, Sitophilus oryzae （L.）（the rice weevil）, Tribolium castaneum （Herbst）（the rust-red flour beetle）, Oryzaephilus surinamensis （L.）（the saw tooth flour beetle）, and Cryptolestesferrugineus （Stephens）（the fiat grain beetle）. Each of these species has developed resistance to one or more protectants, including organophosphorus insecticides, synthetic pyrethroids and the juvenile hormone analogue methoprene. Mortality and re- production after a 2-week exposure of adults to treated wheat depended on species, dose and insecticide. Imidacloprid had no effect on S. oryzae at any dose, but none of the other species produced any live progeny at 10 mg/kg. Indoxacarb had no effect on T. castaneum at any dose, but none of the other species produced any live progeny at 5 mg/kg. The results show that although both imidacloprid and indoxacarb can control at least four of the five key pests tested at doses comparable to those used for organophosphorus protectants, more potent neonicotinoid or oxadiazine insecticides would be needed than either of these to provide broad spectrum protection of stored grain .

关键词： beetles imidacloprid indoxacarb stored grain

Enhancing sintering resistance of atomically dispersed catalysts in reducing environments with organic monolayers

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2022年第6期7卷 1263-1269页

作者： jing Zhang Chithra Asokan gregory Zakem Phillip Christopher j.Will Medlin Department of Chemical and Biological Engineering University of ColoradoBoulderCOUSA Department of Chemical Engineering University of CaliforniaSanta BarbaraSanta BarbaraCAUSA

Atomically dispersed precious metal catalysts maximize atom efficiency and exhibit unique ***,they are susceptible to *** reactions occurring in reducing environments tend to result in atomically dispersed metals sintering at lower temperatures than in oxidative or inert atmospheres due to the formation of mobile metal-H or metal-CO ***,we develop a new approach to mitigate sintering of oxide supported atomically dispersed metals in a reducing atmosphere using organophosphonate self-assembled monolayers(SAMs).We demonstrate this for the case of atomically dispersed Rh on Al_(2)O_(3) and TiO_(2) using a combination of CO probe molecule FTIR,temperature programmed desorption,and alkene hydrogenation rate *** suggests that SAM functionalization of the oxide provides physical diffusion barriers for the metal and weakens the interactions between the reducing gas and metal,thereby discouraging the adsorbate-promoted diffusion of metal atoms on oxide *** results show that support functionalization by organic species can provide improved resistance to sintering of atomically dispersed metals with maintained catalytic reactivity.

关键词： Atomically dispersed catalysts Organic monolayers Rh Single atom catalysis Sintering

Characterization of particle deposition during crossflow filtration as influenced by permeate flux and crossflow velocity using a microfluidic filtration system

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2021年第3期15卷 552-561页

作者： Hongzhan Di gregory j.O.Martin Dave E.Dunstan Department of Chemical and Biomolecular Engineering University of MelbourneParkvilleVictoria 3010Australia

Particle deposition during crossflow filtration is significantly influenced by the operating conditions,in particular the permeate flux and crossflow ***,there is a lack of detailed knowledge about how deposit layer structures and distributions depend on operating *** study uses a microfluidic visualisation filtration system to examine the influence of operating conditions on the deposition process during crossflow ultrafiltration from a microscopic *** the permeate flux caused an increasing amount of deposition and a thicker deposit *** crossflow velocities reduced the extent of *** degree of deposition varied over a range of operating conditions due to the altered hydrodynamic forces exerted on the particles,which can be examined by the deposition probability according to an existing *** on this,an empirical correlation between the deposition probability and volume of deposition as a function of filtration time was developed,which gave good agreement with experimental *** effect of solution conditions was also involved in this correlation as a interaction *** could be useful for predicting the dynamic deposition process during crossflow filtration over a range of operating and solution conditions.

关键词： particle deposition crossflow filtration microfluidics confocal microscopy

Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome

在线全文

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2023年第28期29卷 4451-4465页

作者： Christopher j Martoni Shalini Srivastava Anders Damholt gregory j Leyer Clinical Development Human HealthChr.Hansen A/SHoersholm 2970Denmark Clinical Development Vedic LifesciencesMumbai 400053India Scientific Affairs Human HealthChr.Hansen A/SHoersholm 2970Denmark

BACKGROUND Probiotics have shown promise in alleviating symptoms of diarrhea-predominant irritable bowel syndrome(IBS-D);however,the certainty of evidence is *** randomized controlled dose-ranging trials are warranted on promising single-strain *** To investigate the clinical efficacy of Lactiplantibacillus plantarum(***)Lpla33(DSM34428)in adults with *** This is a randomized,double-blind,placebo-controlled,multi-center,and doseranging *** hundred and seven adults,18-70 years of age,with IBS-D,according to Rome IV criteria,were allocated(1:1:1)to receive placebo or *** Lpla33 at 1×10^(9)(1B)or 1×10^(10)(10B)colony-forming units/d over an 8-wk intervention *** primary outcome was the change in IBS severity scoring system(IBS-SSS)total score after 8 wk,while secondary and exploratory outcomes included abdominal pain severity,IBS related quality of life,stool and microbial profile,and perceived *** IBS-SSS was significantly reduced,after 8 wk,in participants receiving *** 1B(-128.45±83.30;P<0.001)and *** 10B(-156.77±99.06;P<0.001),compared to placebo(-58.82±74.75).Further,a dose-ranging effect was observed,with a greater absolute reduction in the *** 10B group(P<0.05).A reduction in sub-scores related to abdominal pain,abdominal distension,bowel habits,and quality of life was observed in both *** groups compared to placebo(P<0.001).Further,62.5%and 88.4%of participants administered *** 1B and 10B,respectively,were classified as stool consistency responders based on a reduction in diarrheal stool form,as compared to 26.3%in the placebo group(P<0.001).In contrast,no significant shifts were observed in microbial *** *** Lpla33(DSM34428)is well tolerated and improves IBS symptom severity with a dose-ranging effect and a corresponding normalization of bowel habits in adults with IBS-D.

关键词： Randomized clinical trial Diarrhea-predominant irritable bowel syndrome Microbiome Probiotic Lactiplantibacillus plantarum

A Rare Case of Concordant Atrioventricular Connection to L-Looped Ventricles in Situs Solitus:4-Dimensional Magnetic Resonance Imaging and 3D Printing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Congenital Heart Disease 2022年第4期17卷 387-392页

作者： gregory Perens Takegawa Yoshida j.Paul Finn UCLA Mattel Children’s Hospital Children’s Heart CenterLos AngelesCAUSA Diagnostic Cardiovascular Imaging Laboratory Department of Radiology12222 David Geffen School of Medicine at UCLALos AngelesCAUSA

An infant male presented with the rare anatomy consisting of situs solitus,concordant atrioventricular connections to L-looped ventricles,double outlet right ventricle(DORV),and hypoplastic aortic arch.6 months after neonatal aortic arch repair,the morphologic right ventricle function deteriorated,and surgical evaluation was undertaken to determine if either biventricular repair with a systemic morphologic left ventricle or right ventricular exclusion was *** initial echocardiography,magnetic resonance imaging(MRI)was used to create detailed axial and 4-dimensional(4D)images and 3-dimensional(3D)printed *** detailed anatomy of this rare,complex case and its use in pre-surgical planning is presented.

关键词： Magnetic resonance imaging cardiac segments 3D printing