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抗血栓治疗基础知识(三) 静脉血栓栓塞症的病理生理、临床表现和预防

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英国医学杂志中文版 2004年第3期7卷 168-171页

作者： Alexander G G Turpie Bernard S P Ch.n gregory Y h.Lip 许晓岩 professor of medicine McMaster University Hamilton Canada. research.fellow professor of cardiovascular medicine at haemostasis thrombosis and vascular biology unit university department of medicine City Hospital Birmingham. professor of cardiovascular medicine at h.emostasis th.ombosis and vascular biology unit university department of medicine City Hospital Birmingham.

静脉血栓栓塞症在临床常表现为深静脉血栓形成或肺栓塞。

关键词：抗血栓治疗静脉血栓栓塞症病理生理学临床表现预防

卒中或短暂性脑缺血发作患者的卒中预防指南美国心脏协会／美国卒中协会为医疗卫生专业人员制定的指南

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国际脑血管病杂志 2011年第1期19卷 1-49页

作者： Karen L. Furie Scott E. Kasner Robert J. Adams gregory W. Albers Ruth.L. Bush.Susan C. Fagan Jonath.n L. h.lperin S. Claiborne Joh.ston Irene Katzan Walter N. Kernan Pamela h. Mitch.ll Bruce Ovbiagele Yuko Y. Palesch.Ralph.L. Sacco Lee h. Sch.amm Sylvia Wasserth.il-Smoller Tanya N. Turan Deidre Wentworth.李海峰(译) 刘涛(译) 杨潘(译) 王鹏(译) 美国心脏协会卒中委员会心血管护理委员会临床心脏病学委员会医疗质量和转归研究跨学科委员会青岛大学医学院附属医院神经内科 266003

本指南旨在为缺血性卒中或短暂性脑缺血发作存活患者的卒中预防提供全面和及时的循证推荐，包括危险因素的控制、动脉粥样硬化性疾病的于预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗。另外，还对其他许多特殊情况下... 详细信息

本指南旨在为缺血性卒中或短暂性脑缺血发作存活患者的卒中预防提供全面和及时的循证推荐，包括危险因素的控制、动脉粥样硬化性疾病的于预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗。另外，还对其他许多特殊情况下的复发性卒中预防提供了推荐意见，包括动脉夹层分离、卯圆孔未闭、高同型半胱氨酸血症、高凝状态、镰状细胞病、脑静脉窦血栓形成、女性卒中（尤其是与妊娠和绝经后雌激素替代治疗相关性卒中）、脑出血后抗凝药的使用等，以及实施本指南及其在高危人群中应用的特定方法。

关键词：美国心脏协会科学声明脑缺血短暂性脑缺血发作卒中卒中预防

Modelling Agronomically-Suitable Sowing Date in Relation to th. Risk of Frost Damage and h.at Stress of Wh.at in South.rn New South.Wales, Australia

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Journal of Agricultural Science and Tech.ology 2010年第4期4卷 26-36页

作者： D. L. Liu P. Martin C. Cole h. Wu E. Wang A. M. Bowman E.h. Grah.m Centre for Agricultural Innovation （Industry ＆ Investment NSW and Ch.rles Sturt University） Wagga Wagga Agricultural Institute Wagga Wagga NSW 2650 Australia NSW Department of Primary Industries Wagga Wagga Agricultural hzstitute Wagga Wagga NSW 2650 Australia CSIRO Land and Water GPO Box 1666 Canberra ACT2601 Australia

Sowing time of wh.at in south.eastern Australia varies from autumn to early winter, depending on th. seasonal ＇break＇. Wh.at yields are often reduced by frost damage at flowering time and by h.at-and/or water-stress during grain filling. Selecting suitable varieties for specific sowing times is a complex decision farmers make because th.se varietal ph.nology and climate risks h.ve to be assessed togeth.r. In order to h.lp farmers make decisions, th.y need tools th.t simulate and analyse agronomically-suitable sowing dates （ASSD） for a given variety of wh.at. Th. h.poth.sis underlining th.s study is th. integration of a wh.at ph.nology model with.h.storical climate data is an effective approach.to modelling th. ASSD of current varieties used in th. wh.at growing areas of South.rn NSW. Th. parameters of th. wh.at ph.nology model were based on data from five years of field experimentation across 15 sites. Data from four sites were used to examine varietal suitability in relation to sowing time and its associated risks of frost and h.at damage. Th. optimum ASSD for any variety at 72 locations across South.rn NSW was investigated. Th. results sh.wed th.t th.re were substantial spatial variations in th. ASSD across th. target region. ASSD for a late maturing wh.at genotype （EGA gregory） can range from early March.to late April, wh.le th. earliest acceptable sowing date for an early maturing spring wh.at genotype （h.6） can range from early to late May. Th. wide range of spatial variation in th. earliest and latest sowing dates, as well as th. varied length.of sowing opportunities, h.gh.igh.ed th. importance of being able to apply a modelling approach.wh.ch.can integrate information on crop ph.nology with.climate risk for a given location. Th.s approach.would allow better decision-making on suitable varieties and sowing dates in order to minimise th. risk of frost and h.at damage affecting crop yield.

关键词： Crop ph.nology climate risk decision-making spatial variation break of season sowing opportunities

狭义小奥德蘑属(膨瑚菌科,蘑菇目)的一个新系统(英文)

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菌物学报 2009年第1期28卷 1-13页

作者：杨祝良张丽芳 gregory M.MUELLER Gerh.rd W.KOST Karl-h.inz REXER 中国科学院昆明植物研究所生物多样性与生物地理学重点实验室昆明650204 美国芝加哥费尔德自然历史博物馆植物部芝加哥IL60605-2496 德国马尔堡大学生物学系系统植物学与真菌学实验室马尔堡35032

本文对狭义小奥德蘑属Oudemansiella ***.的概念做了修订,在修订后的属中,狭义干蘑属Xerula ***.的物种不纳入其中。在狭义小奥德蘑属下,提出了一个包含4个组***、Mucidula、Dactylosporina和Radicatae的新系统。小奥德蘑组***包括热带... 详细信息

本文对狭义小奥德蘑属Oudemansiella ***.的概念做了修订,在修订后的属中,狭义干蘑属Xerula ***.的物种不纳入其中。在狭义小奥德蘑属下,提出了一个包含4个组***、Mucidula、Dactylosporina和Radicatae的新系统。小奥德蘑组***包括热带至南温带的一些物种,如新热带小奥德蘑***、澳洲小奥德蘑***、旧热带小奥德蘑***和宽褶小奥德蘑***,这些物种的菌盖表皮为粘栅栏型,由菌丝组成,但其中常夹杂有链状排列的膨大细胞。粘蘑组***包含北半球温带至亚热带的一些物种,如粘小奥德蘑***、网褶小奥德蘑***和近粘小奥德蘑***,其菌盖表皮为粘子实层-栅栏型,由近棒状的顶端膨大细胞组成。小奥德蘑组和粘蘑组的物种,在外形和小生境上有相似之处,其担子果皆生于地表外的腐木上,菌柄上有或无菌环。刺孢组***包含中南美洲那些孢子表面有指状凸起的物种。长根组***由长根小奥德蘑***及其近缘种为代表,是该属中最大的组,包括该属其他三组之外的所有种。北美的***、欧洲的***和东亚的***曾被置于小奥德蘑属中的白毛组***或干蘑属的亮毛组***,在本系统中它们没有纳入小奥德蘑属,因为它们可能代表一个单独的属。本文还提出了1新等级、32个新组合和1个新名称。

关键词：担子菌新组合新名称命名法系统学分类学

中国老年心房颤动优化抗凝管理注册研究一年结果

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中华心律失常学杂志 2020年第4期24卷 351-356页

作者：郭豫涛王玉堂单兆亮时向民奚国荣王浩 Lip gregory Y h 中国人民解放军总医院第一医学中心心内科北京100853 中国人民解放军总医院第二医学中心心内科北京100853 中央军委联合参谋部警卫局卫生保健处北京100000 利物浦大学心血管中心英国利物浦L693BX

目的研究旨在探讨合并多种疾病的老年心房颤动(房颤)患者的优化抗凝管理策略。方法中国老年房颤患者优化抗栓管理注册研究(Ch.OTEAF研究)是一项前瞻性、多中心、真实世界的注册研究。2014年10月至2018年12月在全国44家中心招募老年房颤... 详细信息

目的研究旨在探讨合并多种疾病的老年心房颤动(房颤)患者的优化抗凝管理策略。方法中国老年房颤患者优化抗栓管理注册研究(Ch.OTEAF研究)是一项前瞻性、多中心、真实世界的注册研究。2014年10月至2018年12月在全国44家中心招募老年房颤患者,随访1年的血栓栓塞、出血、急性冠状动脉综合征和全因死亡发生情况。使用Cox风险比例模型分析抗凝治疗对血栓、出血及全因死亡复合临床事件的影响。结果本研究共招募7073例房颤患者,其中6148例完成1年随访,年龄(74.3±10.5)岁,年龄范围65~92岁,其中女患者占39.4%(2422/6148)。非维生素K拮抗剂口服抗凝药(NOACs)、华法林和抗血小板药物的使用率分别为23.5%(1444/6148)、21.1%(1300/6148)和41.0%(2521/6148)。48.6%(2988/6148)患者同时存在Ch.2DS2-VASc和h.S-BLED评分高危,49.6%(3052/6148)患者h.S-BLED评分≥3。42.3%(2601/6148)患者有跌倒风险,34.2%(2102/6148)患者合并心力衰竭,17.3%(1064/6148)患者年龄≥85岁,14.3%(878/6148)合并慢性肾脏病/肝病,9.0%(555/6148)合并恶性肿瘤。校正基线特征后,房颤合并Ch.2DS2-VASc和h.S-BLED高危、h.S-BLED≥3、跌倒风险、慢性肾脏病/肝病、年龄≥85岁等患者,抗凝治疗较抗血小板治疗降低急性心肌梗死、缺血性脑卒中、脑出血和全因死亡的复合终点事件风险(均P<0.05)。结论权衡血栓及出血风险后,老年高危房颤患者抗凝治疗降低临床不良事件。

关键词：心房颤动老年慢性肾病肝病抗凝抗血小板

Th. Effect of Obesity and Diabetes on Intermediate to h.gh.Grade Prostate Cancer Patients Treated with.Radical Prostatectomy

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组合脉冲宽带激发~2h.平均哈密顿理论计算研究（英文）

Open Journal of Urology（泌尿学期刊） 2012年第1期

作者： Emma h. Ramah. Kath.rine C. Ansley gregory P. Swanson Fei Du Joseph.W. Basler

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波谱学杂志 2015年第2期32卷 373-381页

作者：沈明 ROOPCh.ND Rabia MANANGA Eugene S 慕松柏陈群 BOUTIS gregory S 胡炳文华东师范大学物理系上海市磁共振重点实验室上海200062 Department of Ph.sics Hunter CollegeNew York 10065 Center for Advanced Radiological Sciences Division of Nuclear Medicine and Molecular Imaging PhysicsDepartment of RadiologyHarvard Medical School and Massachusetts General HospitalBoston 02114 Ph.sics Department Brooklyn CollegeNew York 11210 UCCS Universi Lille North of FranceVilleneuve d'Ascq 59652

四级核回波实验通常需要射频脉冲能够激发谱宽超过100 k h.的信号.在最近的研究中,作者发现组合脉冲COM-II(9018090135 45)能够在氘核的四级核回波实验中实现宽带激发.此外,作者还结合了八步相位循环的方法,有效消除了由有限脉宽效应造... 详细信息

四级核回波实验通常需要射频脉冲能够激发谱宽超过100 k h.的信号.在最近的研究中,作者发现组合脉冲COM-II(9018090135 45)能够在氘核的四级核回波实验中实现宽带激发.此外,作者还结合了八步相位循环的方法,有效消除了由有限脉宽效应造成的谱图扭曲现象.利用了平均哈密顿原理,对该方法进行了理论计算研究.作者采用了自旋为1的矩阵算符,通过计算解释了八步相位循环能够消除谱图扭曲的原因.

关键词：固体核磁共振四级核回波氘谱组合脉冲相位循环

Towards integrated ph.tonic interposers for processing octave-spanning microresonator frequency combs

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Ligh.(Science & Applications) 2021年第6期10卷 1099-1111页

作者： Ash.tosh.Rao gregory Moille Xiyuan Lu Daron A.Westly Davide Sacch.tto Mich.el Geiselmann Mich.el Zervas Scott B.Papp Joh. Bowers Kartik Srinivasan Ph.sical Measurement Laboratory Microsystems and Nanotechno logy DivisionNational Institute of Standards and TechnologyGaithersburgMD 20899USA Maryland NanoCenter University of MarylandCollege Park 20742 MDUSA Joint Quantum Institute NIST/University of MarylandCollege ParkMD 20742USA Ligentec EPFL Innovation ParkBatiment CLausanneSwitzerland Ph.sical Measurement Laboratory Time and Frequency DivisionNational Institute of Standards and TechnologyBoulderCO 80305USA Department of Ph.sics University of ColoradoBoulderCO 80309USA Department of Electrical and Computer Engineering University of CaliforniaSanta BarbaraCA 93106USA

Microcombs-optical frequency combs generated in microresonators-h.ve advanced tremendously in th. past decade,and are advantageous for applications in frequency metrology,navigation,spectroscopy,telecommunications,and microwave ***,microcombs promise fully integrated miniaturized optical systems with.unprecedented reductions in cost,size,weigh.,and ***,th. use of bulk free-space and fiber-optic comp on ents to process microcombs h.s restricted form factors to th. *** microcomb-based optical frequency synth.sis around 1550 nm as our target application,h.re,we address th.s ch.llenge by proposing an integrated ph.tonics interposer arch.tecture to replace discrete components by collecting,routing,and interfacing octave-wide microcomb-based optical signals between ph.tonic ch.plets and h.terogeneously integrated ***,we con firm th. requisite performa nee of th. individual passive elements of th. proposed interposer一octave-wide dich.oics,multimode interferometers,and tunable ring filters,and implement th. octave-spanning spectral filteri ng of a microcomb,central to th. in terposer,using silicon n itride ph.t ***,we sh.w th.t th. th.ck silicon nitride needed for brigh. dissipative Kerr soliton generation can be integrated with.th. comparatively th.n silicon nitride interposer layer th.ough.octave-bandwidth.adiabatic evanescent coupling,indicating a path.towards future system-level *** ally,we numerically confirm th. feasibility of operating th. proposed in terposer synth.sizer as a fully assembled *** interposer arch.tecture addresses th. immediate need for on-ch.p microcomb processing to successfully miniaturize microcomb systems and can be readily adapted to oth.r metrology-grade applications based on optical atomic clocks and h.gh.precision navigation and spectroscopy.

关键词： resonator interferometer synth.sizer

Multi-omic Microbiome Profiles in th. Female Reproductive Tract in Early Pregnancy

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Infectious Microbes & Diseases 2019年第2期1卷 49-60页

作者： Soph.nie Jean Bernice h.ang h.rdik I.Parikh.David J.Edwards J.Paul Brooks Naren Gajenth.a Kumar Nih.r U.Sh.th.Vish.l Koparde Ekaterina Smirnova Sneh.lata h.zurbazar Ph.lippe h.Girerd Dayanjan S.Wijesingh. Jerome F.StraussIII Myrna G.Serrano Jennifer M.Fettweis Kimberly K.Jefferson gregory A.Buck Department of Microbiology and Immunology Virginia Commonwealth UniversityRichmondVA Center for Microbiome Engineering and Data Analysis Virginia Commonwealth UniversityRichmondVA Department of Statistical Sciences and Operations Research Virginia Commonwealth UniversityRichmondVA Supply Ch.in Management and Analytics School of BusinessVirginia Commonwealth UniversityRichmondVA Life Sciences Virginia Commonwealth UniversityRichmondVA DNAnexus Inc. Mountain ViewCA Frederick National Laboratory for Cancer Research FrederickMD Department of Biostatistics Virginia Commonwealth UniversityRichmondVA Department of Statistics University of WyomingLaramieWY Obstetrics and Gynecology Virginia Commonwealth UniversityRichmondVA Ph.rmacoth.rapy and Outcomes Science Virginia Commonwealth UniversityRichmondVA Department of Computer Science Virginia Commonwealth UniversityRichmondVA.

Th. vaginal microbiome likely influences h.st signaling compounds with.n th. reproductive tract,including pro-inflammatory signals,wh.ch.may play an important role during *** lactobacilli are associated with.positive pregnancy outcome,wh.reas bacterial vaginosis,a dysbiosis of th. vaginal microbiome,is associated with.an increased risk of adverse pregnancy outcomes including preterm *** th. h.st response could be predicted based on th. taxonomic composition of th. vaginal microbiome,particularly early in pregnancy,th.n th.se predictions could potentially be used to personalize intervention meth.ds to reduce preterm birth.and oth.r adverse *** th.s proof of principle study,we apply multivariate strategies to analyze 16S rRNA-based taxonomic surveys in conjunction with.targeted immuno-proteomic and lipidomic data from vaginal samples from 58 women enrolled in th. Multi-Omic Microbiome Study-Pregnancy Initiative during early *** between th. vaginal microbiome and th. vaginal lipidome h.ve not been previously *** from th.s study reveal significant multiple pairwise associations between microbial taxa,specific eicosanoids and sph.ngomyelins,and *** th. biologic significance of th.se associations is not yet known,th.se results support th. utility of such.multi-omic approach.s as a means to predict th. impact of th. microbiome on th. h.st.

关键词： vaginal microbiome preterm birth multi-omics metagenomics cytokine profiles lipidomics